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Pathway Description
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Homo sapiens
Protein Pathway
The 5-HT6 receptor is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity. The 5-HT6 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin References
Woolley ML, Marsden CA, Fone KC: 5-ht6 receptors. Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):59-79.
Pubmed: 14965245
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
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