Loading Pathway...
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1.0 P62834 UniProt Dual specificity mitogen-activated protein kinase kinase 7 1.0 cAMP-dependent protein kinase catalytic subunit beta Q13153 UniProt Cyclic AMP-dependent transcription factor ATF-2 Rap guanine nucleotide exchange factor 3 Cyclic AMP SubPathwayInput P28482 UniProt 2.7.12.2 false 2.7.12.2 Mitogen-activated protein kinase 8 → Mitogen-activated protein kinase 8 + Phosphate LEFT_TO_RIGHT 2.7.11.24 false 2.7.11.24 Transcription factor AP-1 → Phosphate + Transcription factor AP-1 LEFT_TO_RIGHT Mitogen-activated protein kinase 11 2.7.11.24 false 2.7.11.24 Cyclic AMP-dependent transcription factor ATF-2 → Cyclic AMP-dependent transcription factor ATF-2 + Phosphate LEFT_TO_RIGHT Reaction2109 false PIP3(16:0/16:0) → PIP3(16:0/16:0) LEFT_TO_RIGHT C10H13N5O4 Adenosine 267.09674 2.7.11.1 false 2.7.11.1 Dual specificity mitogen-activated protein kinase kinase 6 → Dual specificity mitogen-activated protein kinase kinase 6 + Phosphate LEFT_TO_RIGHT Inhibitor of nuclear factor kappa-B kinase subunit beta 2.7.12.2 false 2.7.12.2 Mitogen-activated protein kinase 11 → Mitogen-activated protein kinase 11 + Phosphate LEFT_TO_RIGHT Reaction2104 false Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1 → Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1 LEFT_TO_RIGHT 1.0 1.0 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Mitogen-activated protein kinase 8 3-phosphoinositide-dependent protein kinase 1 Ribosomal protein S6 kinase alpha-1 1.0 Inhibitor of nuclear factor kappa-B kinase subunit alpha P19419 UniProt 1.0 1.0 Rap guanine nucleotide exchange factor 3 1.0 PIP3(16:0/16:0) P15056 UniProt 1.0 C10H12N5O6P Cyclic AMP 329.05252 HMDB01201 HMDB Regulation of glutamate and Dopamine release in the brain SubPathway Coronary Artery Vasodilation in the heart SubPathway 1.0 Q00653 UniProt C00212 KEGG Compound C00575 KEGG Compound Q05513 UniProt GO:0005829 GENE ONTOLOGY 2.7.11.11 false 2.7.11.11 Cyclic AMP-responsive element-binding protein 1 → Cyclic AMP-responsive element-binding protein 1 + Phosphate LEFT_TO_RIGHT 1.0 1.0 24767909 ChemSpider Guanosine triphosphate Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Guanosine diphosphate Phosphate 1.0 1.0 Nuclear factor NF-kappa-B p105 subunit P01112 UniProt O4P Phosphate 94.95342 Mitogen-activated protein kinase kinase kinase 4 Bcl2 antagonist of cell death SubPathwayInput O15530 UniProt Inhibitor of nuclear factor kappa-B kinase subunit beta 1.0 5851 ChemSpider Rho guanine nucleotide exchange factor 7 6830 PubChem-compound Guanine nucleotide-binding protein alpha-beta-gamma C10H15N5O11P2 Guanosine diphosphate 443.02432 2.7.11.13 false 2.7.11.13 Ribosomal protein S6 kinase alpha-1 → Phosphate + Ribosomal protein S6 kinase alpha-1 LEFT_TO_RIGHT HMDB10032 HMDB 2.7.11.1 false 2.7.11.1 Bcl2 antagonist of cell death → Bcl2 antagonist of cell death + Phosphate LEFT_TO_RIGHT Reaction2110 false Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type → Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type LEFT_TO_RIGHT 1.0 Partitioning defective 6 homolog alpha Reaction2119 true NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit → NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit LEFT_TO_RIGHT Q9Y6R4 UniProt 2.7.11.10 false 2.7.11.10 NF-kappa-B inhibitor alpha → NF-kappa-B inhibitor alpha + Phosphate LEFT_TO_RIGHT 2.7.11.1 false 2.7.11.1 PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + Phosphate + RAC-alpha serine/threonine-protein kinase LEFT_TO_RIGHT 2.7.11.1 false 2.7.11.1 Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta → Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta + Phosphate LEFT_TO_RIGHT Apoptosis SubPathway Adenosine Reaction2113 false 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0) → 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0) LEFT_TO_RIGHT Reaction2114 true PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase LEFT_TO_RIGHT O95398 UniProt Guanine nucleotide-binding protein gamma-beta P36507 UniProt TransportCatalysis162 ACTIVATION C10H16N5O14P3 Guanosine triphosphate 522.99066 Serine/threonine-protein kinase PAK 1 Guanosine triphosphate Q9NPB6 UniProt Mitogen-activated protein kinase 1 Cyclic AMP-responsive element-binding protein 1 Cytosol 1.0 1.0 SMILES [O-]P([O-])([O-])=O 1.0 1.0 GO:0005886 GENE ONTOLOGY HMDB10147 HMDB 1.0 2.7.11.11 false 2.7.11.11 Cyclic AMP → Cyclic AMP + cAMP-dependent protein kinase catalytic subunit beta LEFT_TO_RIGHT PIP3(16:0/16:0) C00009 KEGG Compound Cyclic AMP-responsive element-binding protein 1 1.0 Phosphatidylinositols BioCyc Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 53480223 PubChem-compound P52564 UniProt Mitogen-activated protein kinase 11 1.0 Dual specificity mitogen-activated protein kinase kinase 2 Adenosine P22694 UniProt SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 P63211 UniProt CHEBI:18367 ChEBI 1032 ChemSpider P16220 UniProt Inhibitor of nuclear factor kappa-B kinase subunit beta GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc PIP3(16:0/16:0) P25963 UniProt RAC-alpha serine/threonine-protein kinase HMDB01429 HMDB Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY 1.0 C41H82O22P4 PIP3(16:0/16:0) 1050.4248 1.0 Protein kinase C zeta type 60961 PubChem-compound CHEBI:17489 ChEBI Mitogen-activated protein kinase kinase kinase 4 PIP2(16:0/16:0) P60953 UniProt CAMP BioCyc Dual specificity mitogen-activated protein kinase kinase 2 Dual specificity mitogen-activated protein kinase kinase 7 Transcription factor AP-1 1.0 Adenosine receptor A2a Extracellular Space Reaction2042 false Adenosine receptor A2a + Guanosine triphosphate → Adenosine receptor A2a + Guanine nucleotide-binding protein alpha + Guanine nucleotide-binding protein gamma-beta + Guanosine diphosphate LEFT_TO_RIGHT GTPase HRas CHEBI:15996 ChEBI Q14155 UniProt Rho guanine nucleotide exchange factor 7 Nuclear factor NF-kappa-B p100 subunit P31749 UniProt GO:0005615 GENE ONTOLOGY Guanine nucleotide-binding protein G(T) subunit gamma-T1 60-92-4 CAS 1.0 Ras-related protein Rap-1A Guanosine diphosphate Q92934 UniProt Guanine nucleotide-binding protein G(s) subunit alpha isoforms short BiologicalState23 1.0 ReactionCatalysis1959 ACTIVATION CL:0000000 CELL TYPE ONTOLOGY Mitogen-activated protein kinase 1 Cyclic AMP-dependent transcription factor ATF-2 CPD-8587 BioCyc Adenosine receptor A2a C00035 KEGG Compound ReactionCatalysis1962 ACTIVATION 1.0 ReactionCatalysis1961 ACTIVATION ReactionCatalysis1964 ACTIVATION 1.0 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform ReactionCatalysis1963 ACTIVATION Protein kinase C zeta type ReactionCatalysis1845 ACTIVATION Ribosomal protein S6 kinase alpha-1 ReactionCatalysis1965 ACTIVATION 2.7.12.2 false 2.7.12.2 Mitogen-activated protein kinase 1 → Mitogen-activated protein kinase 1 + Phosphate LEFT_TO_RIGHT Intracellular Signalling Through Adenosine Receptor A2a and Adenosine ReactionCatalysis1960 ACTIVATION 1.0 SubPathwayInteraction665 SubPathwayReaction SubPathway665Reaction Cell division control protein 42 homolog P05412 UniProt Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Phosphate C00044 KEGG Compound Serine/threonine-protein kinase B-raf P15336 UniProt NF-kappa-B inhibitor alpha 24768024 ChemSpider Q9Y4G8 UniProt 1.0 Reaction2056 false Serine/threonine-protein kinase B-raf → Serine/threonine-protein kinase B-raf LEFT_TO_RIGHT Reaction2054 false Dual specificity mitogen-activated protein kinase kinase 2 → Dual specificity mitogen-activated protein kinase kinase 2 + Phosphate LEFT_TO_RIGHT GTPase HRas ReactionCatalysis1975 ACTIVATION ReactionCatalysis1974 ACTIVATION RAC-alpha serine/threonine-protein kinase P63092 UniProt Mitogen-activated protein kinase 8 ReactionCatalysis1977 ACTIVATION Reaction2050 false Cyclic AMP + Guanosine triphosphate + Rap guanine nucleotide exchange factor 3 + Ras-related protein Rap-1A → Guanosine diphosphate + Ras-related protein Rap-1A LEFT_TO_RIGHT ReactionCatalysis1979 ACTIVATION ReactionCatalysis1978 ACTIVATION Serine/threonine-protein kinase B-raf 1.0 cAMP-dependent protein kinase catalytic subunit beta Cell 1.0 PW000445 PathWhiz Rap guanine nucleotide exchange factor 2 Mitogen-activated protein kinase kinase kinase 1 Nuclear factor NF-kappa-B p100 subunit Ras-related protein Rap-1A 1.0 Bcl2 antagonist of cell death NF-kappa-B inhibitor alpha ETS domain-containing protein Elk-1 Dual specificity mitogen-activated protein kinase kinase 6 2.7.11.25 false 2.7.11.25 Dual specificity mitogen-activated protein kinase kinase 7 → Dual specificity mitogen-activated protein kinase kinase 7 + Phosphate LEFT_TO_RIGHT ReactionCatalysis1984 ACTIVATION ReactionCatalysis1983 ACTIVATION 2.7.11.25 false 2.7.11.25 Mitogen-activated protein kinase kinase kinase 1 → Mitogen-activated protein kinase kinase kinase 1 + Phosphate LEFT_TO_RIGHT ReactionCatalysis1986 ACTIVATION ReactionCatalysis1985 ACTIVATION Reaction2085 true Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4 → Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4 LEFT_TO_RIGHT ReactionCatalysis1988 ACTIVATION ReactionCatalysis1987 ACTIVATION 2.7.11.11 false 2.7.11.11 Rho guanine nucleotide exchange factor 7 → Rho guanine nucleotide exchange factor 7 with phosphate LEFT_TO_RIGHT SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 1.0 Reaction2084 false Cell division control protein 42 homolog with GDP + Guanosine triphosphate → Cell division control protein 42 homolog with GTP + Guanosine diphosphate LEFT_TO_RIGHT O14733 UniProt SMP00320 SMPDB C41H81O19P3 PIP2(16:0/16:0) 970.4585 ReactionCatalysis1980 ACTIVATION ReactionCatalysis1982 ACTIVATION ReactionCatalysis1981 ACTIVATION 1.0 BiologicalState14 C00626 KEGG Compound P19838 UniProt Nuclear factor NF-kappa-B p105 subunit Reaction2082 false PIP2(16:0/16:0) → PIP3(16:0/16:0) LEFT_TO_RIGHT Mitogen-activated protein kinase kinase kinase 1 8977 PubChem-compound Reaction2080 false GTPase HRas with GDP + Guanosine triphosphate → GTPase HRas with GTP + Guanosine diphosphate LEFT_TO_RIGHT 58-61-7 CAS 2.7.11.24 false 2.7.11.24 ETS domain-containing protein Elk-1 → ETS domain-containing protein Elk-1 + Phosphate LEFT_TO_RIGHT Reaction2079 true Cyclic AMP + Rap guanine nucleotide exchange factor 2 → Rap guanine nucleotide exchange factor 2 with cAMP LEFT_TO_RIGHT 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Inhibitor of nuclear factor kappa-B kinase subunit alpha 9606 TAXONOMY Q13233 UniProt HMDB00058 HMDB CHEBI:16335 ChEBI Dual specificity mitogen-activated protein kinase kinase 6 2.0 P62873 UniProt 1.0 HMDB00050 HMDB 8630 ChemSpider 3-phosphoinositide-dependent protein kinase 1 ReactionCatalysis1920 ACTIVATION P45983 UniProt 1.0 Dual specificity mitogen-activated protein kinase kinase 6 ReactionCatalysis1923 ACTIVATION 1.0 Q15418 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(O)(O)=O)[C@@H](OP(O)(O)=O)C1O)OC(=O)CCCCCCCCCCCCCCC ADENOSINE BioCyc BiologicalState2 Cell Membrane Adenosine receptor A2a Transport200 false Adenosine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT 14265-44-2 CAS ETS domain-containing protein Elk-1 6569 ChemSpider ReactionCatalysis1926 ACTIVATION Rho guanine nucleotide exchange factor 7 O15111 UniProt ReactionCatalysis1927 ACTIVATION CHEBI:17552 ChEBI Inhibitor of nuclear factor kappa-B kinase subunit alpha 1.0 HMDB01273 HMDB GTP BioCyc Phosphate 1.0 ReactionCatalysis1930 ACTIVATION 1.0 Transport205 false Nuclear factor NF-kappa-B p105 subunit (→), Nuclear factor NF-kappa-B p100 subunit (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT 1.0 Serine/threonine-protein kinase PAK 1 SubPathwayInteraction657 SubPathwayReaction SubPathway657Reaction SubPathwayInteraction658 SubPathway658Reaction SubPathwayReaction ReactionCatalysis1816 ACTIVATION SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 cAMP-dependent protein kinase catalytic subunit beta Cell division control protein 42 homolog 1.0 P29274 UniProt 1.0 P42336 UniProt Mitogen-activated protein kinase 1 Rap guanine nucleotide exchange factor 2 54923 ChemSpider 1.0 Q15759 UniProt 86-01-1 CAS Partitioning defective 6 homolog alpha Nucleus Rap guanine nucleotide exchange factor 2 1.0 1061 PubChem-compound 6076 PubChem-compound 1.0 Mitogen-activated protein kinase 8 Nuclear factor NF-kappa-B p100 subunit Transcription factor AP-1 1.0 1.0 146-91-8 CAS ReactionCatalysis1957 ACTIVATION ReactionCatalysis1956 ACTIVATION O14920 UniProt 3-phosphoinositide-dependent protein kinase 1 1.0 SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(OP(O)(O)=O)C(OP(O)(O)=O)[C@@H](OP(O)(O)=O)C1O)OC(=O)CCCCCCCCCCCCCCC Adenylate cyclase type 2 Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Bcl2 antagonist of cell death Adenosine receptor A2a Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p100 subunit Adenosine receptor A2a Adenosine receptor A2a Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Adenylate cyclase type 2 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit beta Cyclic AMP-responsive element-binding protein 1 Cyclic AMP-responsive element-binding protein 1 Rap guanine nucleotide exchange factor 3 Ras-related protein Rap-1A Ras-related protein Rap-1A Rap guanine nucleotide exchange factor 3 Dual specificity mitogen- activated protein kinase kinase 2 Dual specificity mitogen- activated protein kinase kinase 2 Ras-related protein Rap-1A Serine/threonine- protein kinase B-raf Serine/threonine- protein kinase B-raf Dual specificity mitogen- activated protein kinase kinase 2 Dual specificity mitogen- activated protein kinase kinase 2 Mitogen- activated protein kinase 1 Mitogen- activated protein kinase 1 ETS domain- containing protein Elk-1 ETS domain- containing protein Elk-1 Rap guanine nucleotide exchange factor 2 Rap guanine nucleotide exchange factor 2 GTPase HRas GTPase HRas Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform GTPase HRas Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 7 Cell division control protein 42 homolog Cell division control protein 42 homolog Mitogen- activated protein kinase kinase kinase 4 Mitogen- activated protein kinase kinase kinase 4 Cell division control protein 42 homolog Mitogen- activated protein kinase kinase kinase 1 Mitogen- activated protein kinase kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 7 Dual specificity mitogen- activated protein kinase kinase 7 Mitogen- activated protein kinase 8 Mitogen- activated protein kinase 8 Transcription factor AP-1 Transcription factor AP-1 Cell division control protein 42 homolog Serine/threonine- protein kinase PAK 1 Serine/threonine- protein kinase PAK 1 Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 11 Mitogen- activated protein kinase 11 Cyclic AMP-dependent transcription factor ATF-2 Cyclic AMP-dependent transcription factor ATF-2 Partitioning defective 6 homolog alpha Protein kinase C zeta type Cell division control protein 42 homolog Partitioning defective 6 homolog alpha Protein kinase C zeta type Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-1 Bcl2 antagonist of cell death 3- phosphoinositide- dependent protein kinase 1 3- phosphoinositide- dependent protein kinase 1 RAC-alpha serine/threonine- protein kinase RAC-alpha serine/threonine- protein kinase RAC-alpha serine/threonine- protein kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B inhibitor alpha NF-kappa-B inhibitor alpha NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p100 subunit Cyclic AMP Adenosine Adenosine GTP GDP Adenosine triphosphate PP i Cyclic AMP P i GTP GDP P i P i P i GTP GDP PIP2(16:0/16:0) PIP3(16:0/16:0) GTP GDP P i P i P i P i P i P i P i PIP3(16:0/16:0) P i P i PIP3(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) P i P i P i GDP GDP GTP GTP GTP GTP GDP Magnesium Magnesium Magnesium Zinc Zinc Magnesium Magnesium Cyclic AMP Guanosine diphosphate Guanosine triphosphate Guanosine triphosphate Phosphate Guanosine diphosphate Guanosine triphosphate Magnesium Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Guanosine triphosphate Regulation of glutamate and Dopamine release in the brain Coronary Artery Vasodilation in the heart Apoptosis Regulatory Subunit Regulatory Subunit Regulatory Subunit Regulatory Subunit Transcription Transcription Transcription Transcription Inhibition Transcription Nucleus Activation Activation Activation Activation Extracellular Space Intracellular Space
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1.0 P62834 UniProt Dual specificity mitogen-activated protein kinase kinase 7 1.0 cAMP-dependent protein kinase catalytic subunit beta Q13153 UniProt Cyclic AMP-dependent transcription factor ATF-2 Rap guanine nucleotide exchange factor 3 Cyclic AMP SubPathwayInput P28482 UniProt 2.7.12.2 false 2.7.12.2 Mitogen-activated protein kinase 8 → Mitogen-activated protein kinase 8 + Phosphate LEFT_TO_RIGHT 2.7.11.24 false 2.7.11.24 Transcription factor AP-1 → Phosphate + Transcription factor AP-1 LEFT_TO_RIGHT Mitogen-activated protein kinase 11 2.7.11.24 false 2.7.11.24 Cyclic AMP-dependent transcription factor ATF-2 → Cyclic AMP-dependent transcription factor ATF-2 + Phosphate LEFT_TO_RIGHT Reaction2109 false PIP3(16:0/16:0) → PIP3(16:0/16:0) LEFT_TO_RIGHT C10H13N5O4 Adenosine 267.09674 2.7.11.1 false 2.7.11.1 Dual specificity mitogen-activated protein kinase kinase 6 → Dual specificity mitogen-activated protein kinase kinase 6 + Phosphate LEFT_TO_RIGHT Inhibitor of nuclear factor kappa-B kinase subunit beta 2.7.12.2 false 2.7.12.2 Mitogen-activated protein kinase 11 → Mitogen-activated protein kinase 11 + Phosphate LEFT_TO_RIGHT Reaction2104 false Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1 → Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1 LEFT_TO_RIGHT 1.0 1.0 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Mitogen-activated protein kinase 8 3-phosphoinositide-dependent protein kinase 1 Ribosomal protein S6 kinase alpha-1 1.0 Inhibitor of nuclear factor kappa-B kinase subunit alpha P19419 UniProt 1.0 1.0 Rap guanine nucleotide exchange factor 3 1.0 PIP3(16:0/16:0) P15056 UniProt 1.0 C10H12N5O6P Cyclic AMP 329.05252 HMDB01201 HMDB Regulation of glutamate and Dopamine release in the brain SubPathway Coronary Artery Vasodilation in the heart SubPathway 1.0 Q00653 UniProt C00212 KEGG Compound C00575 KEGG Compound Q05513 UniProt GO:0005829 GENE ONTOLOGY 2.7.11.11 false 2.7.11.11 Cyclic AMP-responsive element-binding protein 1 → Cyclic AMP-responsive element-binding protein 1 + Phosphate LEFT_TO_RIGHT 1.0 1.0 24767909 ChemSpider Guanosine triphosphate Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Guanosine diphosphate Phosphate 1.0 1.0 Nuclear factor NF-kappa-B p105 subunit P01112 UniProt O4P Phosphate 94.95342 Mitogen-activated protein kinase kinase kinase 4 Bcl2 antagonist of cell death SubPathwayInput O15530 UniProt Inhibitor of nuclear factor kappa-B kinase subunit beta 1.0 5851 ChemSpider Rho guanine nucleotide exchange factor 7 6830 PubChem-compound Guanine nucleotide-binding protein alpha-beta-gamma C10H15N5O11P2 Guanosine diphosphate 443.02432 2.7.11.13 false 2.7.11.13 Ribosomal protein S6 kinase alpha-1 → Phosphate + Ribosomal protein S6 kinase alpha-1 LEFT_TO_RIGHT HMDB10032 HMDB 2.7.11.1 false 2.7.11.1 Bcl2 antagonist of cell death → Bcl2 antagonist of cell death + Phosphate LEFT_TO_RIGHT Reaction2110 false Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type → Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type LEFT_TO_RIGHT 1.0 Partitioning defective 6 homolog alpha Reaction2119 true NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit → NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit LEFT_TO_RIGHT Q9Y6R4 UniProt 2.7.11.10 false 2.7.11.10 NF-kappa-B inhibitor alpha → NF-kappa-B inhibitor alpha + Phosphate LEFT_TO_RIGHT 2.7.11.1 false 2.7.11.1 PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + Phosphate + RAC-alpha serine/threonine-protein kinase LEFT_TO_RIGHT 2.7.11.1 false 2.7.11.1 Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta → Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta + Phosphate LEFT_TO_RIGHT Apoptosis SubPathway Adenosine Reaction2113 false 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0) → 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0) LEFT_TO_RIGHT Reaction2114 true PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase LEFT_TO_RIGHT O95398 UniProt Guanine nucleotide-binding protein gamma-beta P36507 UniProt TransportCatalysis162 ACTIVATION C10H16N5O14P3 Guanosine triphosphate 522.99066 Serine/threonine-protein kinase PAK 1 Guanosine triphosphate Q9NPB6 UniProt Mitogen-activated protein kinase 1 Cyclic AMP-responsive element-binding protein 1 Cytosol 1.0 1.0 SMILES [O-]P([O-])([O-])=O 1.0 1.0 GO:0005886 GENE ONTOLOGY HMDB10147 HMDB 1.0 2.7.11.11 false 2.7.11.11 Cyclic AMP → Cyclic AMP + cAMP-dependent protein kinase catalytic subunit beta LEFT_TO_RIGHT PIP3(16:0/16:0) C00009 KEGG Compound Cyclic AMP-responsive element-binding protein 1 1.0 Phosphatidylinositols BioCyc Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 53480223 PubChem-compound P52564 UniProt Mitogen-activated protein kinase 11 1.0 Dual specificity mitogen-activated protein kinase kinase 2 Adenosine P22694 UniProt SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 P63211 UniProt CHEBI:18367 ChEBI 1032 ChemSpider P16220 UniProt Inhibitor of nuclear factor kappa-B kinase subunit beta GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc PIP3(16:0/16:0) P25963 UniProt RAC-alpha serine/threonine-protein kinase HMDB01429 HMDB Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY 1.0 C41H82O22P4 PIP3(16:0/16:0) 1050.4248 1.0 Protein kinase C zeta type 60961 PubChem-compound CHEBI:17489 ChEBI Mitogen-activated protein kinase kinase kinase 4 PIP2(16:0/16:0) P60953 UniProt CAMP BioCyc Dual specificity mitogen-activated protein kinase kinase 2 Dual specificity mitogen-activated protein kinase kinase 7 Transcription factor AP-1 1.0 Adenosine receptor A2a Extracellular Space Reaction2042 false Adenosine receptor A2a + Guanosine triphosphate → Adenosine receptor A2a + Guanine nucleotide-binding protein alpha + Guanine nucleotide-binding protein gamma-beta + Guanosine diphosphate LEFT_TO_RIGHT GTPase HRas CHEBI:15996 ChEBI Q14155 UniProt Rho guanine nucleotide exchange factor 7 Nuclear factor NF-kappa-B p100 subunit P31749 UniProt GO:0005615 GENE ONTOLOGY Guanine nucleotide-binding protein G(T) subunit gamma-T1 60-92-4 CAS 1.0 Ras-related protein Rap-1A Guanosine diphosphate Q92934 UniProt Guanine nucleotide-binding protein G(s) subunit alpha isoforms short BiologicalState23 Homo sapiens, Cell, Nucleus 1.0 ReactionCatalysis1959 ACTIVATION CL:0000000 CELL TYPE ONTOLOGY Mitogen-activated protein kinase 1 Cyclic AMP-dependent transcription factor ATF-2 CPD-8587 BioCyc Adenosine receptor A2a C00035 KEGG Compound ReactionCatalysis1962 ACTIVATION 1.0 ReactionCatalysis1961 ACTIVATION ReactionCatalysis1964 ACTIVATION 1.0 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform ReactionCatalysis1963 ACTIVATION Protein kinase C zeta type ReactionCatalysis1845 ACTIVATION Ribosomal protein S6 kinase alpha-1 ReactionCatalysis1965 ACTIVATION 2.7.12.2 false 2.7.12.2 Mitogen-activated protein kinase 1 → Mitogen-activated protein kinase 1 + Phosphate LEFT_TO_RIGHT Intracellular Signalling Through Adenosine Receptor A2a and Adenosine ReactionCatalysis1960 ACTIVATION 1.0 SubPathwayInteraction665 SubPathwayReaction SubPathway665Reaction Cell division control protein 42 homolog P05412 UniProt Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Phosphate C00044 KEGG Compound Serine/threonine-protein kinase B-raf P15336 UniProt NF-kappa-B inhibitor alpha 24768024 ChemSpider Q9Y4G8 UniProt 1.0 Reaction2056 false Serine/threonine-protein kinase B-raf → Serine/threonine-protein kinase B-raf LEFT_TO_RIGHT Reaction2054 false Dual specificity mitogen-activated protein kinase kinase 2 → Dual specificity mitogen-activated protein kinase kinase 2 + Phosphate LEFT_TO_RIGHT GTPase HRas ReactionCatalysis1975 ACTIVATION ReactionCatalysis1974 ACTIVATION RAC-alpha serine/threonine-protein kinase P63092 UniProt Mitogen-activated protein kinase 8 ReactionCatalysis1977 ACTIVATION Reaction2050 false Cyclic AMP + Guanosine triphosphate + Rap guanine nucleotide exchange factor 3 + Ras-related protein Rap-1A → Guanosine diphosphate + Ras-related protein Rap-1A LEFT_TO_RIGHT ReactionCatalysis1979 ACTIVATION ReactionCatalysis1978 ACTIVATION Serine/threonine-protein kinase B-raf 1.0 cAMP-dependent protein kinase catalytic subunit beta Cell 1.0 PW000445 PathWhiz Rap guanine nucleotide exchange factor 2 Mitogen-activated protein kinase kinase kinase 1 Nuclear factor NF-kappa-B p100 subunit Ras-related protein Rap-1A 1.0 Bcl2 antagonist of cell death NF-kappa-B inhibitor alpha ETS domain-containing protein Elk-1 Dual specificity mitogen-activated protein kinase kinase 6 2.7.11.25 false 2.7.11.25 Dual specificity mitogen-activated protein kinase kinase 7 → Dual specificity mitogen-activated protein kinase kinase 7 + Phosphate LEFT_TO_RIGHT ReactionCatalysis1984 ACTIVATION ReactionCatalysis1983 ACTIVATION 2.7.11.25 false 2.7.11.25 Mitogen-activated protein kinase kinase kinase 1 → Mitogen-activated protein kinase kinase kinase 1 + Phosphate LEFT_TO_RIGHT ReactionCatalysis1986 ACTIVATION ReactionCatalysis1985 ACTIVATION Reaction2085 true Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4 → Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4 LEFT_TO_RIGHT ReactionCatalysis1988 ACTIVATION ReactionCatalysis1987 ACTIVATION 2.7.11.11 false 2.7.11.11 Rho guanine nucleotide exchange factor 7 → Rho guanine nucleotide exchange factor 7 with phosphate LEFT_TO_RIGHT SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 1.0 Reaction2084 false Cell division control protein 42 homolog with GDP + Guanosine triphosphate → Cell division control protein 42 homolog with GTP + Guanosine diphosphate LEFT_TO_RIGHT O14733 UniProt http://identifiers.org/smpdb/SMP00320 SMPDB C41H81O19P3 PIP2(16:0/16:0) 970.4585 ReactionCatalysis1980 ACTIVATION ReactionCatalysis1982 ACTIVATION ReactionCatalysis1981 ACTIVATION 1.0 BiologicalState14 Homo sapiens, Cell Membrane C00626 KEGG Compound P19838 UniProt Nuclear factor NF-kappa-B p105 subunit Reaction2082 false PIP2(16:0/16:0) → PIP3(16:0/16:0) LEFT_TO_RIGHT Mitogen-activated protein kinase kinase kinase 1 8977 PubChem-compound Reaction2080 false GTPase HRas with GDP + Guanosine triphosphate → GTPase HRas with GTP + Guanosine diphosphate LEFT_TO_RIGHT 58-61-7 CAS 2.7.11.24 false 2.7.11.24 ETS domain-containing protein Elk-1 → ETS domain-containing protein Elk-1 + Phosphate LEFT_TO_RIGHT Reaction2079 true Cyclic AMP + Rap guanine nucleotide exchange factor 2 → Rap guanine nucleotide exchange factor 2 with cAMP LEFT_TO_RIGHT 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Inhibitor of nuclear factor kappa-B kinase subunit alpha 9606 TAXONOMY Q13233 UniProt HMDB00058 HMDB CHEBI:16335 ChEBI Dual specificity mitogen-activated protein kinase kinase 6 2.0 P62873 UniProt 1.0 HMDB00050 HMDB 8630 ChemSpider 3-phosphoinositide-dependent protein kinase 1 ReactionCatalysis1920 ACTIVATION P45983 UniProt 1.0 Dual specificity mitogen-activated protein kinase kinase 6 ReactionCatalysis1923 ACTIVATION 1.0 Q15418 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(O)(O)=O)[C@@H](OP(O)(O)=O)C1O)OC(=O)CCCCCCCCCCCCCCC ADENOSINE BioCyc BiologicalState2 Homo sapiens, Cell, Cytosol Cell Membrane Adenosine receptor A2a Transport200 false Adenosine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT 14265-44-2 CAS ETS domain-containing protein Elk-1 6569 ChemSpider ReactionCatalysis1926 ACTIVATION Rho guanine nucleotide exchange factor 7 O15111 UniProt ReactionCatalysis1927 ACTIVATION CHEBI:17552 ChEBI Inhibitor of nuclear factor kappa-B kinase subunit alpha 1.0 HMDB01273 HMDB GTP BioCyc Phosphate 1.0 ReactionCatalysis1930 ACTIVATION 1.0 Transport205 false Nuclear factor NF-kappa-B p105 subunit (→), Nuclear factor NF-kappa-B p100 subunit (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT 1.0 Serine/threonine-protein kinase PAK 1 SubPathwayInteraction657 SubPathwayReaction SubPathway657Reaction SubPathwayInteraction658 SubPathway658Reaction SubPathwayReaction ReactionCatalysis1816 ACTIVATION SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 cAMP-dependent protein kinase catalytic subunit beta Cell division control protein 42 homolog 1.0 P29274 UniProt 1.0 P42336 UniProt Mitogen-activated protein kinase 1 Rap guanine nucleotide exchange factor 2 54923 ChemSpider 1.0 Q15759 UniProt 86-01-1 CAS Partitioning defective 6 homolog alpha Nucleus Rap guanine nucleotide exchange factor 2 1.0 1061 PubChem-compound 6076 PubChem-compound 1.0 Mitogen-activated protein kinase 8 Nuclear factor NF-kappa-B p100 subunit Transcription factor AP-1 1.0 1.0 146-91-8 CAS ReactionCatalysis1957 ACTIVATION ReactionCatalysis1956 ACTIVATION O14920 UniProt 3-phosphoinositide-dependent protein kinase 1 1.0 SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(OP(O)(O)=O)C(OP(O)(O)=O)[C@@H](OP(O)(O)=O)C1O)OC(=O)CCCCCCCCCCCCCCC ADCY2 GNG12 GNAS GNB1 BAD ADORA2A NFKB1 NFKB1 NFKB2 NFKB2 ADORA2A ADORA2A GNG12 GNB1 GNAS GNAS GNG12 GNB1 ADCY2 GNAS PRKACB PRKACB CREB1 CREB1 RAPGEF3 RAP1A RAP1A RAPGEF3 MAP2K2 MAP2K2 RAP1A BRAF BRAF MAP2K2 MAP2K2 MAPK1 MAPK1 ELK1 ELK1 RAPGEF2 RAPGEF2 HRAS HRAS PIK3CA HRAS PIK3CA ARHGEF7 ARHGEF7 CDC42 CDC42 MAP3K4 MAP3K4 CDC42 MAP3K1 MAP3K1 MAP2K7 MAP2K7 MAPK8 MAPK8 JUN JUN CDC42 PAK1 PAK1 MAP2K6 MAP2K6 MAPK11 MAPK11 ATF2 ATF2 PARD6A PRKCZ CDC42 PARD6A PRKCZ RPS6KA1 RPS6KA1 BAD PDPK1 PDPK1 AKT1 AKT1 AKT1 CHUK IKBKB CHUK IKBKB NFKBIA NFKBIA NFKBIA