PathWhiz

Pathway Description

Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

Homo sapiens

Protein Pathway

Adenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells. The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates down stream effectors that lead to a specific cellular response. This occurs though activation of the MAPK/ERK signaling cascade.

References

Intracellular Signalling Through Adenosine Receptor A2b and Adenosine References

Feoktistov I, Goldstein AE, Biaggioni I: Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Mol Pharmacol. 1999 Apr;55(4):726-34.

Pubmed: 10101031

Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine
		Adenosine triphosphate
		cAMP
		Guanosine diphosphate
		Guanosine triphosphate
		Magnesium
		Phosphate
		PIP2(16:0/16:0)
		PIP3(16:0/16:0)
		Pyrophosphate
		Zinc

Visualize Protein Data

		3-phosphoinositide-dependent protein kinase 1
		Adenosine receptor A2b
		Adenylate cyclase type 2
		Bcl2-associated agonist of cell death
		cAMP-dependent protein kinase catalytic subunit beta
		Cell division control protein 42 homolog
		Cyclic AMP-dependent transcription factor ATF-2
		Cyclic AMP-responsive element-binding protein 1
		Dual specificity mitogen-activated protein kinase kinase 2
		Dual specificity mitogen-activated protein kinase kinase 6
		Dual specificity mitogen-activated protein kinase kinase 7
		ETS domain-containing protein Elk-1
		GTPase HRas
		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
		Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
		Gβ
		Inhibitor of nuclear factor kappa-B kinase subunit alpha
		Inhibitor of nuclear factor kappa-B kinase subunit beta
		Mitogen-activated protein kinase 1
		Mitogen-activated protein kinase 11
		Mitogen-activated protein kinase 8
		Mitogen-activated protein kinase kinase kinase 1
		Mitogen-activated protein kinase kinase kinase 4
		NF-kappa-B inhibitor alpha
		Nuclear factor NF-kappa-B p100 subunit
		Nuclear factor NF-kappa-B p105 subunit
		Partitioning defective 6 homolog alpha
		Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
		Protein kinase C zeta type
		RAC-alpha serine/threonine-protein kinase
		Rap guanine nucleotide exchange factor 2
		Rap guanine nucleotide exchange factor 3
		Ras-related protein Rap-1A
		Rho guanine nucleotide exchange factor 7
		Ribosomal protein S6 kinase alpha-1
		Serine/threonine-protein kinase B-raf
		Serine/threonine-protein kinase PAK 1
		Transcription factor AP-1

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