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Pathway Description
Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
Homo sapiens
Protein Pathway
The follicle-stimulating hormone receptor (FSHR) is a transmembrane G protein-coupled receptor located in the ovary, testis, and uterus. As its name suggests, the receptor is activated by follicle-stimulating hormone (FSH) and plays an important role in the regulation of reproduction. In the ovaries, FSHRs present on granulosa cells initiate follicular development. In the testis, FSHRs present on Sertoli cells are essential for spermatogenesis. The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone References
Simoni M, Gromoll J, Nieschlag E: The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr Rev. 1997 Dec;18(6):739-73. doi: 10.1210/edrv.18.6.0320.
Pubmed: 9408742
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
Asatiani K, Gromoll J, Eckardstein SV, Zitzmann M, Nieschlag E, Simoni M: Distribution and function of FSH receptor genetic variants in normal men. Andrologia. 2002 Jun;34(3):172-6.
Pubmed: 12059813
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