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Pathway Description
Intracellular Signalling Through Histamine H2 Receptor and Histamine
Homo sapiens
Signaling Pathway
Histamine is an organic nitrogenous compound that is involved in local immune responses and it is a neurotransmitter for brain. Histamine can mediate various actions by interacting with histamine receptors (H1, H2, H3 and H4). The H2 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Intracellular Signalling Through Histamine H2 Receptor and Histamine References
Elenkov IJ, Webster E, Papanicolaou DA, Fleisher TA, Chrousos GP, Wilder RL: Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors. J Immunol. 1998 Sep 1;161(5):2586-93.
Pubmed: 9725260
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
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