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Thymidylate synthase Ribonucleoside- diphosphate reductase large subunit Ribonucleoside- diphosphate reductase subunit M2 Ribonucleoside- diphosphate reductase large subunit Ribonucleoside- diphosphate reductase subunit M2 B CTP synthase 1 Equilibrative nucleoside transporter 1 Sodium/nucleoside cotransporter 1 Solute carrier family 28 member 3 5'(3')- deoxyribonucleotidase, cytosolic type Deoxycytidine kinase Deoxycytidylate deaminase UMP-CMP kinase Nucleoside diphosphate kinase A Difluorodeoxyuridine monophosphate Gemcitabine diphosphate Gemcitabine triphosphate Gemcitabine Gemcitabine Gemcitabine Monophosphate ADP ATP ATP ADP H2O NH3 ATP ADP ATP ADP Fe3+ Fe3+ Magnesium Zinc Magnesium Magnesium Incorporation into DNA and RNA
TYMS RRM1 RRM2 RRM1 RRM2B CTPS1 SLC29A1 SLC28A1 SLC28A3 NT5C DCK DCTD CMPK1 NME1 Difluorodeoxyuridine monophosphate Gemcitabine diphosphate Gemcitabine triphosphate Gemcitabine Gemcitabine Gemcitabine Monophosphate Adenosine diphosphate Adenosine triphosphate Adenosine triphosphate Adenosine diphosphate Water Ammonia Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Incorporation into DNA and RNA
TYMS RRM1 RRM2 RRM1 RRM2B CTPS1 SLC29A1 SLC28A1 SLC28A3 NT5C DCK DCTD CMPK1 NME1 Difluor GD GcbTP Gemcitb Gemcitb GcbMP ADP ATP ATP ADP H2O NH3 ATP ADP ATP ADP Fe3+ Fe3+ Mg2+ Zinc Mg2+ Mg2+ I i D a
TYMS RRM1 RRM2 RRM1 RRM2B CTPS1 SLC29A1 SLC28A1 SLC28A3 NT5C DCK DCTD CMPK1 NME1 Difluor GD GcbTP Gemcitb Gemcitb GcbMP ADP ATP ATP ADP H2O NH3 ATP ADP ATP ADP I i D a