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CHEBI:16015 ChEBI HMDB00134 HMDB Mitochondrial pyruvate carrier 1 439161 PubChem-compound 1.0 96860 ChemSpider 1.0 6-phosphofructokinase, liver type Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial CHEBI:30797 ChEBI 439153 PubChem-compound 1.0 1.0 50 ChemSpider C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 HMDB00148 HMDB D-Ribulose 5-phosphate 1.0 OXALACETIC_ACID BioCyc HMDB01473 HMDB 4.0 1.0 HMDB00595 HMDB HMDB01201 HMDB 5743 ChemSpider CHEBI:16238 ChEBI P09622 UniProt 5746 ChemSpider HCO3 BioCyc HMDB01206 HMDB CHEBI:15380 ChEBI 5742 ChemSpider NADH C25H40N7O19P3S Succinyl-CoA 867.1312 439184 PubChem-compound D-Ribose 5-phosphate O95336 UniProt CHEBI:16474 ChEBI Glucose-6-phosphate 1-dehydrogenase 1.0 Transport139 false L-Glutamine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O 97-67-6 CAS HMDB00122 HMDB HMDB00124 HMDB C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 D-Sedoheptulose 7-phosphate 2646-35-7 CAS FAD 1.0 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 1.0 CHEBI:30769 ChEBI Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial 439167 PubChem-compound 1.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 138-08-9 CAS SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O HMDB01423 HMDB 1161 ChemSpider C00231 KEGG Compound C00236 KEGG Compound 1.0 1.0 SUC BioCyc Reaction390 false L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE Monocarboxylate transporter 1 7664-38-2 CAS 6.0 1.0 C00009 KEGG Compound C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O C00006 KEGG Compound P29401 UniProt Hydrogen Ion CHEBI:18009 ChEBI C00001 KEGG Compound P15259 UniProt Fructose 6-phosphate Succinate dehydrogenase cytochrome b560 subunit, mitochondrial 439190 PubChem-compound P52209 UniProt C00005 KEGG Compound C00004 KEGG Compound C00003 KEGG Compound NADPH C00002 KEGG Compound 60.0 Coenzyme A HMDB01429 HMDB C6H11O9P 6-Phosphonoglucono-D-lactone 258.01407 C11378 KEGG Compound C59H90O4 Coenzyme Q10 862.6839 HMDB01401 HMDB 388411 ChemSpider C7H15O10P D-Sedoheptulose 7-phosphate 290.04028 1.0 107689 PubChem-compound P53985 UniProt C00011 KEGG Compound C00010 KEGG Compound P49247 UniProt FRUCTOSE-6P BioCyc C00016 KEGG Compound C00014 KEGG Compound CHEBI:17363 ChEBI Transketolase CHEBI:17138 ChEBI H Hydrogen Ion 1.007825 Phosphate Neutral amino acid transporter B(0) C00022 KEGG Compound 56-65-5 CAS C01352 KEGG Compound 53-84-9 CAS C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound CHEBI:26078 ChEBI O14521 UniProt L-Glutamic acid NADP CHEBI:48928 ChEBI 4.0 P06733 UniProt 769 PubChem-compound 1.4.1.3 false 1.4.1.3 L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid LEFT_TO_RIGHT CL:0000000 CELL TYPE ONTOLOGY SMILES O[C@H](COP(O)(O)=O)[C@@H](O)C=O C00031 KEGG Compound C00279 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00036 KEGG Compound CHEBI:18276 ChEBI C00035 KEGG Compound SMILES OC(=O)CCC(O)=O 1.0 C00282 KEGG Compound C00281 KEGG Compound P50213 UniProt 1.0 Transaldolase 2.7.1.11 false 2.7.1.11 Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate LEFT_TO_RIGHT 1.0 P06744 UniProt D-Erythrose 4-phosphate C00044 KEGG Compound C00042 KEGG Compound L-Glutamine 648 ChemSpider 1.0 3.5.1.2 false 3.5.1.2 L-Glutamine + Water → Ammonia + L-Glutamic acid LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE C00288 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 604-98-8 CAS 1.0 HMDB00538 HMDB P51553 UniProt SMILES OC(=O)C(=C)OP(O)(O)=O Reaction812 false D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH REVERSIBLE C3H7O7P 3-Phosphoglyceric acid 185.99294 FUM BioCyc SMILES OC(=O)CC(=O)C(O)=O CHEBI:4170 ChEBI CHEBI:18012 ChEBI 6-phosphogluconolactonase Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Q99798 UniProt Glucose-6-phosphate 1-dehydrogenase 1.0 Pyruvic acid 1.0 P21912 UniProt 1.0 24.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 Phosphoric acid DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 6-phosphofructokinase, liver type P30613 UniProt 1.0 SMILES COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)C)C(O)=C1OC C00064 KEGG Compound NAD SMILES CC(=O)C(O)=O Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial 663 ChemSpider C00074 KEGG Compound Mitochondrial pyruvate carrier 1 SMILES O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O 6.4.1.1 false 6.4.1.1 Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT 3-Phosphoglyceric acid 962 PubChem-compound 1.0 724 PubChem-compound Transaldolase CO2 Carbon dioxide 43.98983 C00080 KEGG Compound C00085 KEGG Compound C01172 KEGG Compound 729 PubChem-compound Q9Y5U8 UniProt BiologicalState4 BiologicalState2 Adenosine diphosphate 14265-44-2 CAS Glucose-6-phosphate isomerase PYRUVATE BioCyc QH2 BioCyc C5H11O8P D-Ribulose 5-phosphate 230.01915 1.0 C00092 KEGG Compound Transketolase C00091 KEGG Compound G3P BioCyc Glucose-6-phosphate isomerase 1.0 CHEBI:4167 ChEBI Isocitric acid 2.0 L-Glutamine 1.0 Succinic acid XYLULOSE-5-PHOSPHATE BioCyc Coenzyme Q10 CHEBI:18050 ChEBI 1.0 FADH2 BioCyc 393165 ChemSpider NADH BioCyc C5H11O8P Xylulose 5-phosphate 230.01915 1.0 P17858 UniProt 970 PubChem-compound Acetyl-CoA O75390 UniProt Citrate synthase, mitochondrial CHO3 Hydrogen carbonate 60.99257 820-11-1 CAS SMILES [H][H] 30572 ChemSpider 17215925 ChemSpider 446013 PubChem-compound CHEBI:15721 ChEBI L-Malic acid 1.0 6-phosphogluconate dehydrogenase, decarboxylating SMILES OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O Glyceraldehyde-3-phosphate dehydrogenase 21883788 PubChem-compound Guanosine triphosphate H3N Ammonia 17.026548 1.0 HMDB00807 HMDB Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial 5961 PubChem-compound Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 643-13-0 CAS 1981-49-3 CAS 1.0 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 51 PubChem-compound FADH SMILES OC([O-])=O CHEBI:46245 ChEBI Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Neutral amino acid transporter B(0) Isocitrate dehydrogenase [NADP] cytoplasmic Oxoglutarate dehydrogenase complex Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 274 ChemSpider O4P Phosphate 94.95342 6830 PubChem-compound CHEBI:15946 ChEBI TransportCatalysis228 ACTIVATION TransportCatalysis227 ACTIVATION P40925 UniProt NADPH BioCyc Carbon dioxide 217 ChemSpider 58-68-4 CAS SMILES [O-]P([O-])([O-])=O 6-phosphogluconolactonase C6H13O9P Fructose 6-phosphate 260.02972 CHEBI:30915 ChEBI Q96HY7 UniProt 1.0 C6H12O6 D-Glucose 180.06339 L-Glutamine Warburg Effect ReactionCatalysis4 ACTIVATION GO:0005759 GENE ONTOLOGY GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Q96I99 UniProt 1.0 C4H4O4 Fumaric acid 116.010956 Pyruvate kinase PKM P14618 UniProt CHEBI:15741 ChEBI Oxoglutaric acid Fumarate hydratase, mitochondrial Malate dehydrogenase, cytoplasmic SMILES O=C=O SubPathwayControl886 SubPathway886Control InhibitorySubPathwayControl 1.0 1110 PubChem-compound Ribose-5-phosphate isomerase 5958 PubChem-compound C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound P21399 UniProt CHEBI:15996 ChEBI PW000630 PathWhiz L-lactate dehydrogenase A chain SMILES OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O Alpha-enolase 60.0 GO:0005737 GENE ONTOLOGY 1.0 C6H8O7 Citric acid 192.02701 HMDB01068 HMDB Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial L-lactate dehydrogenase A chain SMILES OCC1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]1O 1.0 82615 ChemSpider SMILES COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O 5682 ChemSpider 1.2.4.2 false 1.2.4.2 Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA LEFT_TO_RIGHT CHEBI:52742 ChEBI 2.3.3.1 false 2.3.3.1 Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A LEFT_TO_RIGHT Mitochondrial Matrix Reaction593 false Guanosine diphosphate + Phosphate + Succinyl-CoA ↔ Coenzyme A + Guanosine triphosphate + Succinic acid REVERSIBLE D-Glucose 1.2.4.1 false 1.2.4.1 Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH LEFT_TO_RIGHT 2.0 D-SEDOHEPTULOSE-7-P BioCyc CO-A BioCyc HMDB01072 HMDB Monocarboxylate transporter 1 222656 PubChem-compound 5675 ChemSpider 72-89-9 CAS 1078 ChemSpider Phosphoglycerate mutase 2 HMDB03498 HMDB Fructose-bisphosphate aldolase B ReactionCatalysis658 ACTIVATION ReactionCatalysis659 ACTIVATION 2.7.1.40 false 2.7.1.40 Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid REVERSIBLE Cell Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial ReactionCatalysis692 ACTIVATION Citrate synthase, mitochondrial 6557 ChemSpider 643975 PubChem-compound HMDB00193 HMDB Beta-D-Glucose 6-phosphate 127-17-3 CAS HMDB00190 HMDB CHEBI:17719 ChEBI D-6-P-GLUCONO-DELTA-LACTONE BioCyc Water 1.1.1.27 false 1.1.1.27 L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid REVERSIBLE C5H9NO4 L-Glutamic acid 147.05316 HMDB01058 HMDB 33032 PubChem-compound Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 1.0 HMDB02142 HMDB GLC-6-P BioCyc C5H11O8P D-Ribose 5-phosphate 230.01915 ReactionCatalysis678 ACTIVATION 9606 TAXONOMY 1333-74-0 CAS CHEBI:17544 ChEBI P08559 UniProt 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES OC(COP(O)(O)=O)C(O)=O HMDB02111 HMDB HMDB01022 HMDB Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 110-15-6 CAS Phosphoglycerate kinase 1 1.0 CHEBI:15377 ChEBI Fumarate hydratase, mitochondrial CHEBI:15378 ChEBI SMILES [H+] Glucose-6-phosphate isomerase Isocitrate dehydrogenase 6569 ChemSpider HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O CHEBI:17552 ChEBI HMDB01273 HMDB Pyruvate carboxylase, mitochondrial CHEBI:422 ChEBI CHEBI:30744 ChEBI Isocitrate dehydrogenase [NADP] cytoplasmic Dihydrolipoyl dehydrogenase, mitochondrial HMDB01487 HMDB 5793 PubChem-compound HMDB00156 HMDB L-Glutamine HMDB01248 HMDB SMILES OC(COP(O)(O)=O)C=O P05062 UniProt 1198 PubChem-compound 1.0 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Glucose → Adenosine diphosphate + Glucose 6-phosphate LEFT_TO_RIGHT 1.0 FAD BioCyc 3-METHYLBENZYLSUCCINYL-COA BioCyc 1.1.1.41 false 1.1.1.41 Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid LEFT_TO_RIGHT 86-01-1 CAS P53597 UniProt 1.0 1.0 109096 ChemSpider Mitochondrial citrate transport protein CHEBI:15351 ChEBI Solute carrier family 2, facilitated glucose transporter member 2 SMILES O[C@H]1[C@H](O)[C@@H](COP(O)(O)=O)OC(=O)[C@@H]1O 85-61-0 CAS HMDB00254 HMDB 6022 PubChem-compound Q9UI32 UniProt C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider C00311 KEGG Compound CHEBI:16134 ChEBI HMDB01341 HMDB 439278 PubChem-compound Phosphoglycerate mutase 2 110-17-8 CAS ReactionCatalysis702 ACTIVATION ReactionCatalysis700 ACTIVATION Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Pyruvate kinase PKLR SubPathwayInhibition 2641-81-8 CAS HMDB01112 HMDB 1.0 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial ATP BioCyc HMDB00263 HMDB 2.7.2.3 false 2.7.2.3 Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate LEFT_TO_RIGHT ReactionCatalysis936 ACTIVATION 1.1.1.49 false 1.1.1.49 Beta-D-Glucose 6-phosphate + NADP ↔ 6-Phosphonoglucono-D-lactone + Hydrogen Ion + NADPH REVERSIBLE 1.1.1.42 false 1.1.1.42 Isocitric acid + NADP → Carbon dioxide + NADPH + Oxoglutaric acid LEFT_TO_RIGHT Reaction1246 false 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid REVERSIBLE HMDB01321 HMDB 388330 ChemSpider 2280-44-6 CAS ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc HMDB59597 HMDB 1.1.1.44 false 1.1.1.44 6-Phosphogluconic acid + NADP → Carbon dioxide + D-Ribulose 5-phosphate + NADPH LEFT_TO_RIGHT 1.0 5281915 PubChem-compound ReactionCatalysis960 ACTIVATION HMDB00243 HMDB C27H35N9O15P2 FADH 787.1728 Carbon dioxide 709 ChemSpider 704 ChemSpider 945 ChemSpider C00345 KEGG Compound 1010 ChemSpider C10H15N5O11P2 Guanosine diphosphate 443.02432 O75874 UniProt 488-69-7 CAS CHEBI:30887 ChEBI ReactionCatalysis958 ACTIVATION ReactionCatalysis713 ACTIVATION ReactionCatalysis714 ACTIVATION ReactionCatalysis953 ACTIVATION C00117 KEGG Compound 388313 ChemSpider 1.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 HMDB01304 HMDB 1.0 1.0 C5H10N2O3 L-Glutamine 146.06914 HMDB01548 HMDB CPD-2961 BioCyc C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 HMDB00217 HMDB 388559 ChemSpider C00111 KEGG Compound Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Cytosol Alpha-enolase C00597 KEGG Compound C00354 KEGG Compound O43837 UniProt Glyceraldehyde-3-phosphate dehydrogenase Transport72 false Citric acid (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT 1.0 HMDB00208 HMDB Transport279 false D-Glucose (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Fructose 1,6-bisphosphate 5.3.1.9 false 5.3.1.9 Fructose 6-phosphate ↔ Glucose 6-phosphate REVERSIBLE 5.3.1.9 false 5.3.1.9 Beta-D-Glucose 6-phosphate ↔ Glucose 6-phosphate REVERSIBLE HMDB00221 HMDB HMDB00223 HMDB 1.0 Transport281 false L-Glutamine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT HMDB01316 HMDB 1.0 559059 ChemSpider C00122 KEGG Compound SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1 122357 PubChem-compound 4.0 Transport280 false L-Lactic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 921-62-0 CAS 2.0 NADH SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 CHEBI:18367 ChEBI 1032 ChemSpider 1910-41-4 CAS 1031 ChemSpider 2.2.1.1 false 2.2.1.1 D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate ↔ D-Ribose 5-phosphate + Xylulose 5-phosphate REVERSIBLE 5.3.1.6 false 5.3.1.6 D-Ribulose 5-phosphate ↔ D-Ribose 5-phosphate REVERSIBLE 2.2.1.2 false 2.2.1.2 D-Erythrose 4-phosphate + Fructose 6-phosphate ↔ D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate REVERSIBLE Pyruvic acid C27H33N9O15P2 FAD 785.1571 388538 ChemSpider C21H28N7O14P2 NAD 664.11694 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Extracellular Space NAD(P) BioCyc Pyruvate dehydrogenase E1 component subunit beta, mitochondrial C00149 KEGG Compound 388307 ChemSpider P52789 UniProt Pyruvate carboxylase, mitochondrial C01236 KEGG Compound 62713 ChemSpider Q6LAP8 UniProt Fumaric acid C00390 KEGG Compound 1.0 Ribose-5-phosphate isomerase Pyruvate carboxylase, mitochondrial 56275-39-9 CAS C00158 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 328-50-7 CAS L-Lactic acid Transketolase D-Glucose L-Lactic acid 4.0 P07954 UniProt 1.0 4445197 ChemSpider 303-98-0 CAS SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O 762 ChemSpider PHOSPHO-ENOL-PYRUVATE BioCyc Pyruvate kinase isozymes R/L Succinyl-CoA 10197150 ChemSpider 668 PubChem-compound Ammonia Hexokinase-2 7732-18-5 CAS Aconitate hydratase, mitochondrial 591-59-3 CAS Cytoplasmic aconitate hydratase 22833559 PubChem-compound AMMONIA BioCyc SMILES N 56-86-0 CAS 585-18-2 CAS Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial HMDB00868 HMDB Glutamate dehydrogenase 1, mitochondrial 1.0 NAD HMDB00641 HMDB C00186 KEGG Compound 305 ChemSpider 445557 PubChem-compound C3H7O7P 2-Phospho-D-glyceric acid 185.99294 CHEBI:17050 ChEBI SMILES OCC(=O)COP(O)(O)=O HMDB01967 HMDB Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial P11168 UniProt 5800 ChemSpider RIBULOSE-5P BioCyc C00199 KEGG Compound 979 ChemSpider QH2 Water H3O4P Phosphoric acid 97.9769 SMILES N[C@@H](CCC(O)=O)C(O)=O Isocitrate dehydrogenase [NADP] cytoplasmic 4.0 146-14-5 CAS CHEBI:44897 ChEBI 58-64-0 CAS Glutaminase liver isoform, mitochondrial GTP BioCyc 1.0 RIBOSE-5P BioCyc P11177 UniProt SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O C3H6O3 L-Lactic acid 90.03169 HMDB00618 HMDB P04406 UniProt Phosphoglycerate kinase 1 444493 PubChem-compound 56-73-5 CAS 2-PG BioCyc SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 1.0 22833512 PubChem-compound ACETYL-COA BioCyc H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O Hydrogen carbonate NAD BioCyc 2.0 SMP00654 SMPDB 1.0 Glyceraldehyde-3-phosphate dehydrogenase Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Glutamate dehydrogenase 1, mitochondrial 749 ChemSpider 71-52-3 CAS Glutamate dehydrogenase 1, mitochondrial SMILES OC(=O)\C=C\C(O)=O Q99643 UniProt 980 ChemSpider 146-91-8 CAS C4H6O5 L-Malic acid 134.02153 Succinate dehydrogenase 2-Phospho-D-glyceric acid 1.0 6-phosphofructokinase, liver type C4H4O5 Oxalacetic acid 132.00587 Succinyl-CoA ligase Adenosine triphosphate Cytoplasmic aconitate hydratase 1.0 2.0 1.0 SMILES O CIT BioCyc 58838673 PubChem-compound P11498 UniProt C19H28O4 QH2 320.19876 1004 PubChem-compound 1005 PubChem-compound 1.0 TransportCatalysis6 ACTIVATION Pyruvate kinase PKM Pyruvate kinase isozymes R/L 328-42-7 CAS Aconitate hydratase, mitochondrial 2.0 SMILES O[C@@H](CC(O)=O)C(O)=O C6H13O10P 6-Phosphogluconic acid 276.02463 1.0 CHEBI:15846 ChEBI P00367 UniProt CHEBI:16938 ChEBI ADP BioCyc 6-Phosphogluconic acid C3H4O3 Pyruvic acid 88.016045 Tyrosine kinase regulation InhibitorySubPathway ReactionCatalysis38 ACTIVATION 2.0 6-Phosphonoglucono-D-lactone 1.0 53-59-8 CAS C6H8O7 Isocitric acid 192.02701 1038 PubChem-compound GO:0005829 GENE ONTOLOGY C5H6O5 Oxoglutaric acid 146.02153 CHEBI:16905 ChEBI HMDB00902 HMDB 393487 ChemSpider Citric acid CHEBI:16908 ChEBI Pyruvate dehydrogenase complex Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 77-92-9 CAS ReactionCatalysis43 ACTIVATION 6-phosphogluconate dehydrogenase, decarboxylating 1.0 C21H30N7O17P3 NADPH 745.0911 L-LACTATE BioCyc C21H29N7O17P3 NADP 744.08325 Pyruvate kinase PKM SubPathwayInhibitor TransportCatalysis101 ACTIVATION Hexokinase-2 P37837 UniProt Solute carrier family 2, facilitated glucose transporter member 2 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Mitochondrial citrate transport protein 683 PubChem-compound Phosphoenolpyruvic acid 3.1.1.31 false 3.1.1.31 6-Phosphonoglucono-D-lactone + Water → 6-Phosphogluconic acid + Hydrogen LEFT_TO_RIGHT SMILES OC(=O)CCC(=O)C(O)=O 1.0 6-phosphogluconate dehydrogenase, decarboxylating 124-38-9 CAS Guanosine diphosphate P00558 UniProt ReactionCatalysis69 ACTIVATION CHEBI:17835 ChEBI Fructose-bisphosphate aldolase B GLC BioCyc 1.0 ReactionCatalysis62 ACTIVATION 4.2.1.3 false 4.2.1.3 Citric acid → Isocitric acid LEFT_TO_RIGHT ReactionCatalysis67 ACTIVATION ReactionCatalysis68 ACTIVATION SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc Hydrogen GLT BioCyc 7664-41-7 CAS 1.0 57-04-5 CAS 69507 PubChem-compound P31040 UniProt H2 Hydrogen 2.01565 53-57-6 CAS 1.0 ReactionCatalysis75 ACTIVATION C4H9O7P D-Erythrose 4-phosphate 200.00859 4.0 ReactionCatalysis78 ACTIVATION 4444052 ChemSpider ReactionCatalysis79 ACTIVATION 222 PubChem-compound Hydrogen Ion SMILES OP(O)(O)=O 1.0 ReactionCatalysis70 ACTIVATION 5280344 PubChem-compound C4H6O4 Succinic acid 118.02661 P00338 UniProt 60802-29-1 CAS 320-77-4 CAS threo-d(s)-iso-citrate BioCyc ERYTHROSE-4P BioCyc Glucose-6-phosphate 1-dehydrogenase ReactionCatalysis1315 ACTIVATION C3H5O6P Phosphoenolpyruvic acid 167.98238 Adenosine triphosphate GO:0005615 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES OC(C(CC(O)=O)C(O)=O)C(O)=O HMDB03391 HMDB 1.0 SMILES C[C@H](O)C(O)=O 4151-19-3 CAS D-Glyceraldehyde 3-phosphate Malate dehydrogenase, cytoplasmic SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc HMDB00094 HMDB Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 19782904 PubChem-compound Dihydroxyacetone phosphate CHEBI:1146900 ChEBI Oxalacetic acid 17216052 ChemSpider 1.3.5.1 false 1.3.5.1 Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2 REVERSIBLE C6H13O9P Glucose 6-phosphate 260.02972 2.0 Fumarate hydratase, mitochondrial P11413 UniProt CHEBI:17877 ChEBI 2.0 HMDB01197 HMDB C21H36N7O16P3S Coenzyme A 767.11523 Adenosine diphosphate SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O Isocitric acid Cytoplasm 4.2.1.11 false 4.2.1.11 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water REVERSIBLE 91493 PubChem-compound 439427 PubChem-compound 1.0 CHEBI:15422 ChEBI 5589 ChemSpider 1.0 SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 1.0 1.0 TransportCatalysis36 ACTIVATION CHEBI:48153 ChEBI 79-33-4 CAS 439452 PubChem-compound 1.0 FRUCTOSE-16-DIPHOSPHATE BioCyc P36957 UniProt CHEBI:16526 ChEBI 8977 PubChem-compound CHEBI:16761 ChEBI 4.2.1.2 false 4.2.1.2 L-Malic acid ↔ Fumaric acid + Water REVERSIBLE 1.0 1.0 Glucose 6-phosphate 1.0 HMDB00051 HMDB Oxoglutaric acid C00631 KEGG Compound 8630 ChemSpider 5893 PubChem-compound CHEBI:16332 ChEBI P10515 UniProt Citrate synthase, mitochondrial CHEBI:32816 ChEBI ReactionCatalysis349 ACTIVATION Glutaminase liver isoform, mitochondrial ReactionCatalysis342 ACTIVATION Xylulose 5-phosphate CHEBI:16108 ChEBI 5886 PubChem-compound 60.0 Glyceric acid 1,3-biphosphate SMILES OC[C@@H](OP(O)(O)=O)C(O)=O 280 PubChem-compound HMDB01127 HMDB SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 SMILES N[C@@H](CCC(N)=O)C(O)=O HMDB01362 HMDB ReactionCatalysis2237 ACTIVATION ReactionCatalysis2239 ACTIVATION Citric acid 193317 ChemSpider Q15758 UniProt GAP BioCyc 1060 PubChem-compound 1061 PubChem-compound C00661 KEGG Compound Transaldolase ReactionCatalysis2240 ACTIVATION ReactionCatalysis2242 ACTIVATION UBIQUINONE-10 BioCyc 4300-28-1 CAS ReactionCatalysis2241 ACTIVATION Pyruvate kinase PKM Pyruvate kinase isozymes R/L Solute carrier family 2, facilitated glucose transporter member 2 Mitochondrial pyruvate carrier 1 Monocarboxylate transporter 1 Neutral amino acid transporter B(0) Mitochondrial citrate transport protein Hexokinase-2 Glucose-6- phosphate isomerase 6- phosphofructokinase, liver type Fructose- bisphosphate aldolase B Glyceraldehyde- 3-phosphate dehydrogenase Phosphoglycerate kinase 1 Phosphoglycerate mutase 2 Alpha-enolase Pyruvate carboxylase, mitochondrial Pyruvate dehydrogenase complex Citrate synthase, mitochondrial L-lactate dehydrogenase A-like 6A Aconitate hydratase, mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Oxoglutarate dehydrogenase complex Succinyl-CoA ligase Succinate dehydrogenase Fumarate hydratase, mitochondrial