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Pathway Description
Fatty Acid Oxidation
Escherichia coli
Metabolic Pathway
Fatty acid oxidation is also known as beta-oxidation. The fatty acid oxidation pathway converts fatty acids into acetyl-CoA under both anaerobic and aerobic conditions. Enzymes in this pathway can process short and long chain fatty acids, both starting the conversion of acyl-CoA to enoyl-CoA. The pathway continues in a cycle, each turn removing two carbon atoms from the input acyl-CoA to produce acetyl-CoA and NADH. Fatty acids are an important source of energy because they can be reduced due to their anhydrous properties. In addition, fatty acid oxidation yields more energy when compared to carbohydrates.
References
Fatty Acid Oxidation References
Campbell JW, Morgan-Kiss RM, Cronan JE Jr: A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway. Mol Microbiol. 2003 Feb;47(3):793-805.
Pubmed: 12535077
Clark D: Regulation of fatty acid degradation in Escherichia coli: analysis by operon fusion. J Bacteriol. 1981 Nov;148(2):521-6.
Pubmed: 6271734
Morgan-Kiss RM, Cronan JE: The Escherichia coli fadK (ydiD) gene encodes an anerobically regulated short chain acyl-CoA synthetase. J Biol Chem. 2004 Sep 3;279(36):37324-33. doi: 10.1074/jbc.M405233200. Epub 2004 Jun 22.
Pubmed: 15213221
Doi H, Hoshino Y, Nakase K, Usuda Y: Reduction of hydrogen peroxide stress derived from fatty acid beta-oxidation improves fatty acid utilization in Escherichia coli. Appl Microbiol Biotechnol. 2014 Jan;98(2):629-39. doi: 10.1007/s00253-013-5327-6. Epub 2013 Oct 30.
Pubmed: 24169950
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