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4.2.1.17 false 4.2.1.17 (3S)-3-hydroxyacyl-CoA + NAD → Hydrogen Ion + NADH + a 3-oxoacyl-CoA  LEFT_TO_RIGHT 2.3.1.16 false 2.3.1.16 Coenzyme A + a 3-oxoacyl-CoA  → Acetyl-CoA + a 2,3,4-saturated fatty acyl CoA  LEFT_TO_RIGHT 4.2.1.17 false 4.2.1.17 a cis-3-enoyl-CoA  → a trans-2-enoyl-CoA  LEFT_TO_RIGHT 4.2.1.17 false 4.2.1.17 a trans-2-enoyl-CoA  → (3S)-3-hydroxyacyl-CoA + Water LEFT_TO_RIGHT 6.2.1.3 false 6.2.1.3 Adenosine triphosphate + Coenzyme A + a 2,3,4- saturated fatty acid → Adenosine monophosphate + Pyrophosphate + a 2,3,4-saturated fatty acyl CoA  LEFT_TO_RIGHT 1.0 a 2,3,4-saturated fatty acyl CoA  Reaction2905 false Hydrogen Ion + a 2,3,4-saturated fatty acyl CoA  + an oxidized electron-transfer flavoprotein  → Reduced electron-transfer flavoprotein + a trans-2-enoyl-CoA  LEFT_TO_RIGHT a 2,3,4-saturated fatty acyl CoA  C23H38N7O17P3S Acetyl-CoA 809.1258 Long-chain-fatty-acid--CoA ligase 937 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O HMDB00250 HMDB 1.0 5682 ChemSpider Reduced electron-transfer flavoprotein SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI Fatty acid oxidation complex subunit alpha_ NADH AMP BioCyc Water 439153 PubChem-compound SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate a 3-oxoacyl-CoA  SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 1.0 SMP00781 SMPDB 14000-31-8 CAS FadJ component of anaerobic fatty acid oxidation complex a cis-3-enoyl-CoA  CHEBI:16027 ChEBI a trans-2-enoyl-CoA  CO-A BioCyc NAD ATP BioCyc 72-89-9 CAS Coenzyme A 3-ketoacyl-CoA thiolase 1.0 C21H36N7O16P3S Coenzyme A 767.11523 1.0 Short-chain-fatty-acid--CoA ligase 6816 PubChem-compound 559142 ChemSpider 1.0 HMDB00538 HMDB CHEBI:15846 ChEBI CHEBI:15422 ChEBI (3S)-3-hydroxyacyl-CoA 6557 ChemSpider HMDB01206 HMDB 1.0 P69451 UniProt 5742 ChemSpider 1038 PubChem-compound SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N Fatty acid oxidation complex subunit alpha 7732-18-5 CAS 388299 ChemSpider 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB59597 HMDB Adenosine monophosphate 1.0 HMDB00902 HMDB 1.0 CHEBI:16908 ChEBI 5858 ChemSpider C10H16N5O13P3 Adenosine triphosphate 506.99576 a trans-2-enoyl-CoA  1.0 3-ketoacyl-CoA thiolase_ Acetyl-CoA 1.0 2,3-dehydroadipyl-CoA hydratase 1.0 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Long-chain-fatty-acid--CoA ligase PPI BioCyc a cis-3-enoyl-CoA  a 3-oxoacyl-CoA  962 PubChem-compound 1.0 HMDB01423 HMDB Hydrogen Ion P76082 UniProt 392413 ChemSpider 2.0 CHEBI:5086 ChEBI 5893 PubChem-compound Adenosine triphosphate HMDB02111 HMDB 58-68-4 CAS C00080 KEGG Compound Reduced electron-transfer flavoprotein 1.0 CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] C00001 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O CHEBI:18361 ChEBI Fatty acid oxidation complex subunit alpha_ C00004 KEGG Compound C00003 KEGG Compound C00002 KEGG Compound 1.0 ReactionCatalysis2868 ACTIVATION Fatty acid oxidation complex subunit alpha ReactionCatalysis2869 ACTIVATION a 2,3,4- saturated fatty acid 1.0 an oxidized electron-transfer flavoprotein  fatty acid oxidation HMDB01487 HMDB 644102 PubChem-compound a 2,3,4- saturated fatty acid 444493 PubChem-compound C21H28N7O14P2 NAD 664.11694 6083 PubChem-compound (3S)-3-hydroxyacyl-CoA P21151 UniProt C00010 KEGG Compound acetyl-CoA C-acyltransferase 3-ketoacyl-CoA thiolase_ 3-ketoacyl-CoA thiolase C00013 KEGG Compound Short-chain-fatty-acid--CoA ligase O7P2 Pyrophosphate 173.91193 ReactionCatalysis2874 ACTIVATION B7L9A7 UniProt an oxidized electron-transfer flavoprotein  ACETYL-COA BioCyc C21H29N7O14P2 NADH 665.12476 H2O Water 18.010565 5957 PubChem-compound 2,3-dehydroadipyl-CoA hydratase PW000758 PathWhiz P76503 UniProt 1.0 ReactionCatalysis2871 ACTIVATION NADH BioCyc ReactionCatalysis2870 ACTIVATION ReactionCatalysis2873 ACTIVATION P77399 UniProt ReactionCatalysis2872 ACTIVATION NAD BioCyc HMDB00045 HMDB H Hydrogen Ion 1.007825 56-65-5 CAS C00020 KEGG Compound 53-84-9 CAS CHEBI:15351 ChEBI C00024 KEGG Compound 85-61-0 CAS P38135 UniProt Fatty acid oxidation complex subunit alpha 2,3- dehydroadipyl- CoA hydratase 2,3- dehydroadipyl- CoA hydratase 3-ketoacyl-CoA thiolase_ 3-ketoacyl-CoA thiolase CoA ATP AMP PP i H + H 2 O NAD NADH H + CoA Acetyl-CoA a 2,3,4- saturated fatty acid a 2,3,4-saturated fatty acyl CoA an oxidized electron- transfer flavoprotein Reduced electron- transfer flavoprotein a trans-2- enoyl-CoA a cis-3-enoyl-CoA (3S)-3- hydroxyacyl- CoA a 3-oxoacyl-CoA a 2,3,4-saturated fatty acyl CoA Long-chain- fatty-acid-- CoA ligase Short-chain- fatty-acid-- CoA ligase Fatty acid oxidation complex subunit alpha_
4.2.1.17 false 4.2.1.17 (3S)-3-hydroxyacyl-CoA + NAD → Hydrogen Ion + NADH + a 3-oxoacyl-CoA  LEFT_TO_RIGHT 2.3.1.16 false 2.3.1.16 Coenzyme A + a 3-oxoacyl-CoA  → Acetyl-CoA + a 2,3,4-saturated fatty acyl CoA  LEFT_TO_RIGHT 4.2.1.17 false 4.2.1.17 a cis-3-enoyl-CoA  → a trans-2-enoyl-CoA  LEFT_TO_RIGHT 4.2.1.17 false 4.2.1.17 a trans-2-enoyl-CoA  → (3S)-3-hydroxyacyl-CoA + Water LEFT_TO_RIGHT 6.2.1.3 false 6.2.1.3 Adenosine triphosphate + Coenzyme A + a 2,3,4- saturated fatty acid → Adenosine monophosphate + Pyrophosphate + a 2,3,4-saturated fatty acyl CoA  LEFT_TO_RIGHT 1.0 a 2,3,4-saturated fatty acyl CoA  Reaction2905 false Hydrogen Ion + a 2,3,4-saturated fatty acyl CoA  + an oxidized electron-transfer flavoprotein  → Reduced electron-transfer flavoprotein + a trans-2-enoyl-CoA  LEFT_TO_RIGHT a 2,3,4-saturated fatty acyl CoA  C23H38N7O17P3S Acetyl-CoA 809.1258 Long-chain-fatty-acid--CoA ligase 937 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O HMDB00250 HMDB 1.0 5682 ChemSpider Reduced electron-transfer flavoprotein SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI Fatty acid oxidation complex subunit alpha_ NADH AMP BioCyc Water 439153 PubChem-compound SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate a 3-oxoacyl-CoA  SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 1.0 http://identifiers.org/smpdb/SMP00781 SMPDB 14000-31-8 CAS FadJ component of anaerobic fatty acid oxidation complex a cis-3-enoyl-CoA  CHEBI:16027 ChEBI a trans-2-enoyl-CoA  CO-A BioCyc NAD ATP BioCyc 72-89-9 CAS Coenzyme A 3-ketoacyl-CoA thiolase 1.0 C21H36N7O16P3S Coenzyme A 767.11523 1.0 Short-chain-fatty-acid--CoA ligase 6816 PubChem-compound 559142 ChemSpider 1.0 HMDB00538 HMDB CHEBI:15846 ChEBI CHEBI:15422 ChEBI (3S)-3-hydroxyacyl-CoA 6557 ChemSpider HMDB01206 HMDB 1.0 P69451 UniProt 5742 ChemSpider 1038 PubChem-compound SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N Fatty acid oxidation complex subunit alpha 7732-18-5 CAS 388299 ChemSpider 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB59597 HMDB Adenosine monophosphate 1.0 HMDB00902 HMDB 1.0 CHEBI:16908 ChEBI 5858 ChemSpider C10H16N5O13P3 Adenosine triphosphate 506.99576 a trans-2-enoyl-CoA  1.0 3-ketoacyl-CoA thiolase_ Acetyl-CoA 1.0 2,3-dehydroadipyl-CoA hydratase 1.0 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Long-chain-fatty-acid--CoA ligase PPI BioCyc a cis-3-enoyl-CoA  a 3-oxoacyl-CoA  962 PubChem-compound 1.0 HMDB01423 HMDB Hydrogen Ion P76082 UniProt 392413 ChemSpider 2.0 CHEBI:5086 ChEBI 5893 PubChem-compound Adenosine triphosphate HMDB02111 HMDB 58-68-4 CAS C00080 KEGG Compound Reduced electron-transfer flavoprotein 1.0 CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] C00001 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O CHEBI:18361 ChEBI Fatty acid oxidation complex subunit alpha_ C00004 KEGG Compound C00003 KEGG Compound C00002 KEGG Compound 1.0 ReactionCatalysis2868 ACTIVATION Fatty acid oxidation complex subunit alpha ReactionCatalysis2869 ACTIVATION a 2,3,4- saturated fatty acid 1.0 an oxidized electron-transfer flavoprotein  fatty acid oxidation HMDB01487 HMDB 644102 PubChem-compound a 2,3,4- saturated fatty acid 444493 PubChem-compound C21H28N7O14P2 NAD 664.11694 6083 PubChem-compound (3S)-3-hydroxyacyl-CoA P21151 UniProt C00010 KEGG Compound acetyl-CoA C-acyltransferase 3-ketoacyl-CoA thiolase_ 3-ketoacyl-CoA thiolase C00013 KEGG Compound Short-chain-fatty-acid--CoA ligase O7P2 Pyrophosphate 173.91193 ReactionCatalysis2874 ACTIVATION B7L9A7 UniProt an oxidized electron-transfer flavoprotein  ACETYL-COA BioCyc C21H29N7O14P2 NADH 665.12476 H2O Water 18.010565 5957 PubChem-compound 2,3-dehydroadipyl-CoA hydratase PW000758 PathWhiz P76503 UniProt 1.0 ReactionCatalysis2871 ACTIVATION NADH BioCyc ReactionCatalysis2870 ACTIVATION ReactionCatalysis2873 ACTIVATION P77399 UniProt ReactionCatalysis2872 ACTIVATION NAD BioCyc HMDB00045 HMDB H Hydrogen Ion 1.007825 56-65-5 CAS C00020 KEGG Compound 53-84-9 CAS CHEBI:15351 ChEBI C00024 KEGG Compound 85-61-0 CAS P38135 UniProt fadB paaF paaF fadI fadA Coenzyme A Adenosine triphosphate Adenosine monophosphate Pyrophosphate Hydrogen Ion Water NAD NADH Hydrogen Ion Coenzyme A Acetyl-CoA a 2,3,4- saturated fatty acid a 2,3,4-saturated fatty acyl CoA an oxidized electron- transfer flavoprotein Reduced electron- transfer flavoprotein a trans-2- enoyl-CoA a cis-3-enoyl-CoA (3S)-3- hydroxyacyl- CoA a 3-oxoacyl-CoA a 2,3,4-saturated fatty acyl CoA fadD fadK fadJ