Loading Pathway...
TransportCatalysis360 ACTIVATION 6022 PubChem-compound Phenylalanine Biosynthesis SubPathway 923 PubChem-compound Tyrosine Biosynthesis SubPathway ReactionCatalysis5480 ACTIVATION L-Serine 937 ChemSpider ReactionCoupledTransportCatalysis171 ACTIVATION Chorismate SubPathwayOutput HMDB0012199 HMDB 29936 PubChem-compound P15047 UniProt 439153 PubChem-compound SMILES O TransportCatalysis359 ACTIVATION TransportCatalysis358 ACTIVATION TransportCatalysis357 ACTIVATION C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate isochorismate CHEBI:17115 ChEBI CHEBI:16027 ChEBI Tryptophan Metabolism SubPathway HMDB0000538 HMDB Protein tonB SMILES [Na+] Ferrienterobactin receptor Biopolymer transport protein exbD ATP BioCyc Ferric enterobactin transport system permease protein fepG 1.0 Enterochelin esterase 5.4.4.2 false 5.4.4.2 Chorismate → isochorismate LEFT_TO_RIGHT 3.0 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Reaction2453 false Water + isochorismate → (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + Pyruvic acid LEFT_TO_RIGHT 1.0 CHEBI:5572 ChEBI 1.0 1.0 1.0 2,3-Dihydroxybenzoic acid Water 559142 ChemSpider 1.0 CHEBI:15846 ChEBI ADP BioCyc 4'-phosphopantetheinyl transferase entD C3H4O3 Pyruvic acid 88.016045 1.3.1.28 false 1.3.1.28 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD → 2,3-Dihydroxybenzoic acid + Hydrogen Ion + NADH LEFT_TO_RIGHT C10H8O6 isochorismate 224.03319 Ferrienterobactin-binding periplasmic protein CHEBI:15941 ChEBI 5742 ChemSpider NADH 1038 PubChem-compound SMILES [Fe++] Isochorismatase SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O GO:0005829 GENE ONTOLOGY Adenosine monophosphate SMP0000783 SMPDB 2.0 Ferric-Hydroxamate-Complexes BioCyc Serine/threonine transporter sstT P05825 UniProt CHEBI:16908 ChEBI 5858 ChemSpider 5736 ChemSpider CHEBI:17455 ChEBI Ferrienterobactin-binding periplasmic protein Isochorismate synthase entC P0AEJ2 UniProt 440956 PubChem-compound Outer membrane protein tolC 25244759 PubChem-compound CHEBI:17333 ChEBI SER BioCyc 1010 ChemSpider GO:0070258 GENE ONTOLOGY 27815 ChemSpider SubPathwayInteraction79822 SubPathwayReaction SubPathway79822Reaction 6.0 PPI BioCyc 3.0 CHEBI:29780 ChEBI SubPathwayInteraction79828 SubPathwayReaction SubPathway79828Reaction SubPathwayInteraction79826 SubPathway79826Reaction SubPathwayReaction Ferric enterobactin (2,3-Dihydroxybenzoyl)adenylic acid Hydrogen Ion Ferric enterobactin 1.0 27284 PubChem-compound Cytosol 2,3-Dihydroxybenzoylserine 1.0 1.0 Adenosine triphosphate 2.0 Ferric enterobactin transport system permease protein fepG 58-68-4 CAS Fe3+ SMILES OC(=O)C1=C([O-])C(O)=CC=C1 Hydrogen Ion Enterobactin exporter entS HMDB0000692 HMDB C00008 KEGG Compound SMILES OC1=CC=CC(C(=O)NC2COC(=O)C(COC(=O)C(COC2=O)NC(=O)C2=CC=CC(O)=C2O)NC(=O)C2=CC=CC(O)=C2O)=C1O ferric enterobactin ABC transporter P11454 UniProt Hydrogen Ion C00001 KEGG Compound P24077 UniProt C01330 KEGG Compound 1.0 CHEBI:18361 ChEBI C00004 KEGG Compound Inner Membrane C00003 KEGG Compound C00002 KEGG Compound 1031 ChemSpider enterobactin synthase 4'-phosphopantetheinyl transferase entD ferric enterobactin outer membrane transport complex C04171 KEGG Compound EntS-TolC Enterobactin Efflux Transport System HMDB0000588 HMDB Biopolymer transport protein exbB Reaction5520 false Ferric enterobactin + 3 Water → 3 2,3-Dihydroxybenzoylserine + Fe3+ + 3 Hydrogen Ion LEFT_TO_RIGHT SMILES [Fe].OC1OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC1N=C(O)C1=C(O)C(O)=CC=C1 PW000760 PathWhiz 1.0 P10378 UniProt C21H28N7O14P2 NAD 664.11694 3.0 C00251 KEGG Compound HMDB0000902 HMDB 5951 PubChem-compound Extracellular Space 1.0 C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 C21H29N7O14P2 NADH 665.12476 1.0 5957 PubChem-compound ReactionCoupledTransport137 false Adenosine triphosphate + Ferric enterobactin + Water ? Adenosine diphosphate + Ferric enterobactin + Hydrogen Ion GO:0005620 GENE ONTOLOGY ReactionCatalysis5221 ACTIVATION 562 TAXONOMY Pyruvic acid H Hydrogen Ion 1.007825 CPD-10134 BioCyc C17H18N5O10P (2,3-Dihydroxybenzoyl)adenylic acid 483.07913 2.0 C10H11NO6 2,3-Dihydroxybenzoylserine 241.05864 C00022 KEGG Compound 56-65-5 CAS Ferric enterobactin C00020 KEGG Compound 53-84-9 CAS 1.0 SMILES N[C@@H](CO)C(O)=O HMDB0000243 HMDB GO:0005615 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY 3.0 CHEBI:29101 ChEBI SMILES [H][C@]1(O)C(=CC=C[C@]1([H])OC(=C)C([O-])=O)C([O-])=O 3.0 C30H33FeN3O15 Ferric enterobactin 731.1261 Adenosine triphosphate Fe Fe2+ 55.93494 P19925 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 1.0 1.0 Chorismate SubPathwayOutput 899 ChemSpider 5682 ChemSpider P23878 UniProt SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc P23876 UniProt Water P23877 UniProt Enterobactin exporter entS 1.0 P02930 UniProt HMDB0000250 HMDB 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS HMDB0001341 HMDB 1.0 1.0 Reaction3390 false Ferric enterobactin → Fe2+ + enterobactin LEFT_TO_RIGHT P13039 UniProt C10H10O6 Chorismate 226.04774 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ReactionCatalysis3358 ACTIVATION 1.0 1.0 Biopolymer transport protein exbB Enterobactin synthase component E enterobactin Cytoplasm 11542 ChemSpider 6.3.2.14 false 6.3.2.14 3 2,3-Dihydroxybenzoic acid + 6 Adenosine triphosphate + 3 L-Serine → 6 Adenosine monophosphate + 3 Hydrogen Ion + 6 Pyrophosphate + enterobactin LEFT_TO_RIGHT 17341-25-2 CAS Water 1.0 SMP0000826 SMPDB CHEBI:15422 ChEBI ReactionCatalysis2392 ACTIVATION ReactionCatalysis2391 ACTIVATION Escherichia coli 1.0 7732-18-5 CAS 388299 ChemSpider isochorismate SMP0000827 SMPDB Chorismate 61-19-8 CAS HMDB0001487 HMDB 617-12-9 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 440201 PubChem-compound 127-17-3 CAS Enterobactin synthase component F Transport415 false enterobactin (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Extracellular Space LEFT_TO_RIGHT Transport414 false enterobactin (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT ReactionCatalysis2393 ACTIVATION (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate Transport417 false Ferric enterobactin (→) Transport: Escherichia coli, Extracellular Space to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT CHEBI:29033 ChEBI Transport416 false L-Serine (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT SMILES OC1C=CC=C(C1O)C(O)=O CHEBI:29034 ChEBI Fe Fe3+ 55.93494 NAD SMP0000835 SMPDB C10H16N5O13P3 Adenosine triphosphate 506.99576 HMDB0012943 HMDB 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Fe2+ C00065 KEGG Compound CHEBI:18026 ChEBI 1.0 CHEBI:16761 ChEBI HMDB0000045 HMDB SMILES CC(=O)C(O)=O CHEBI:28855 ChEBI P0AGE5 UniProt 6.0 962 PubChem-compound CPD-9517 BioCyc P0ABU7 UniProt 2,3-Dihydroxybenzoic acid enterobactin 6.3.2.14 false 6.3.2.14 2,3-Dihydroxybenzoic acid + Adenosine triphosphate ↔ (2,3-Dihydroxybenzoyl)adenylic acid + Pyrophosphate REVERSIBLE 5800 ChemSpider Protein tonB Sodium P0ADI4 UniProt 1.0 5893 PubChem-compound C00080 KEGG Compound Periplasmic Space Enterochelin esterase Biopolymer transport protein exbD Ferrienterobactin receptor (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate SMILES [Fe+3] 3.0 HMDB0002111 HMDB CHEBI:32816 ChEBI L-Serine 1.0 PW000815 PathWhiz Serine/threonine transporter sstT CHEBI:15377 ChEBI C7H8O4 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 156.04225 Sodium CHEBI:15378 ChEBI SMILES [H+] SMILES [H][C@@](CO)(NC(=O)C1=C(O)C(O)=CC=C1)C(O)=O PYRUVATE BioCyc SMILES [H][C@]1(COP(O)(=O)OC(=O)C2=C(O)C(O)=CC=C2)O[C@@]([H])(N2C=NC3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 56-45-1 CAS 20074-52-6 CAS C00885 KEGG Compound P0AEL6 UniProt PW000807 PathWhiz 1.0 Isochorismatase L-Serine P0ABV2 UniProt C3H7NO3 L-Serine 105.042595 6.0 PW000806 PathWhiz HMDB0000187 HMDB enterobactin 644102 PubChem-compound 6083 PubChem-compound 1.0 Ferric enterobactin transport ATP-binding protein fepC Enterobactin synthase component E Ferric enterobactin transport system permease protein fepD C14819 KEGG Compound Isochorismate synthase entC H2O Water 18.010565 C14818 KEGG Compound Outer membrane protein tolC NADH BioCyc Ferric enterobactin transport ATP-binding protein fepC 1.0 NAD BioCyc C7H5O4 2,3-Dihydroxybenzoic acid 153.01933 15438-31-0 CAS Isochorismatase 1060 PubChem-compound C30H27N3O15 enterobactin 669.1442 Ferric enterobactin Na Sodium 22.989769 HMDB0059597 HMDB 25394 ChemSpider Enterobactin synthase component F 12039 PubChem-compound 1.0 Ferric enterobactin transport system permease protein fepD P02929 UniProt Adenosine diphosphate enterobactin 1.0 Biosynthesis of Siderophore Group Nonribosomal Peptides Enterobactin exporter entS Enterobactin exporter entS Outer membrane protein tolC Serine/threonine transporter sstT Protein tonB Biopolymer transport protein exbB Biopolymer transport protein exbD Ferrienterobactin receptor Isochorismate synthase entC Isochorismatase 4'- phosphopantetheinyl transferase entD Enterobactin synthase component F Enterobactin synthase component E Isochorismatase Enterochelin esterase 2,3-dihydro- 2,3- dihydroxybenzoate dehydrogenase Isochorismatase Chorismate enterobactin enterobactin enterobactin L-Serine L-Serine Na + Na + Ferric enterobactin Ferric enterobactin isochorismate ATP L-Serine 2,3- Dihydroxybenzoic acid AMP enterobactin PP i H + Ferric enterobactin Fe2+ enterobactin ATP (2,3- Dihydroxybenzoyl)adenylic acid PP i H 2 O 2,3- Dihydroxybenzoylserine Fe3+ H + (2S,3S)-2,3- dihydroxy- 2,3- dihydrobenzoate NAD NADH H + H 2 O Pyruvic acid ATP H 2 O ADP H + enterobactin Ferric enterobactin transport system permease protein fepG Ferric enterobactin transport system permease protein fepD Ferrienterobactin- binding periplasmic protein Phenylalanine Biosynthesis Tryptophan Metabolism Tyrosine Biosynthesis Ferric enterobactin transport ATP-binding protein fepC
TransportCatalysis360 ACTIVATION 6022 PubChem-compound Phenylalanine Biosynthesis SubPathway 923 PubChem-compound Tyrosine Biosynthesis SubPathway ReactionCatalysis5480 ACTIVATION L-Serine 937 ChemSpider ReactionCoupledTransportCatalysis171 ACTIVATION Chorismate SubPathwayOutput HMDB0012199 HMDB 29936 PubChem-compound P15047 UniProt 439153 PubChem-compound SMILES O TransportCatalysis359 ACTIVATION TransportCatalysis358 ACTIVATION TransportCatalysis357 ACTIVATION C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate isochorismate CHEBI:17115 ChEBI CHEBI:16027 ChEBI Tryptophan Metabolism SubPathway HMDB0000538 HMDB Protein tonB SMILES [Na+] Ferrienterobactin receptor Biopolymer transport protein exbD ATP BioCyc Ferric enterobactin transport system permease protein fepG 1.0 Enterochelin esterase 5.4.4.2 false 5.4.4.2 Chorismate → isochorismate LEFT_TO_RIGHT 3.0 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Reaction2453 false Water + isochorismate → (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + Pyruvic acid LEFT_TO_RIGHT 1.0 CHEBI:5572 ChEBI 1.0 1.0 1.0 2,3-Dihydroxybenzoic acid Water 559142 ChemSpider 1.0 CHEBI:15846 ChEBI ADP BioCyc 4'-phosphopantetheinyl transferase entD C3H4O3 Pyruvic acid 88.016045 1.3.1.28 false 1.3.1.28 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD → 2,3-Dihydroxybenzoic acid + Hydrogen Ion + NADH LEFT_TO_RIGHT C10H8O6 isochorismate 224.03319 Ferrienterobactin-binding periplasmic protein CHEBI:15941 ChEBI 5742 ChemSpider NADH 1038 PubChem-compound SMILES [Fe++] Isochorismatase SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O GO:0005829 GENE ONTOLOGY Adenosine monophosphate SMP0000783 SMPDB 2.0 Ferric-Hydroxamate-Complexes BioCyc Serine/threonine transporter sstT P05825 UniProt CHEBI:16908 ChEBI 5858 ChemSpider 5736 ChemSpider CHEBI:17455 ChEBI Ferrienterobactin-binding periplasmic protein Isochorismate synthase entC P0AEJ2 UniProt 440956 PubChem-compound Outer membrane protein tolC 25244759 PubChem-compound CHEBI:17333 ChEBI SER BioCyc 1010 ChemSpider GO:0070258 GENE ONTOLOGY 27815 ChemSpider SubPathwayInteraction79822 SubPathwayReaction SubPathway79822Reaction 6.0 PPI BioCyc 3.0 CHEBI:29780 ChEBI SubPathwayInteraction79828 SubPathwayReaction SubPathway79828Reaction SubPathwayInteraction79826 SubPathway79826Reaction SubPathwayReaction Ferric enterobactin (2,3-Dihydroxybenzoyl)adenylic acid Hydrogen Ion Ferric enterobactin 1.0 27284 PubChem-compound Cytosol 2,3-Dihydroxybenzoylserine 1.0 1.0 Adenosine triphosphate 2.0 Ferric enterobactin transport system permease protein fepG 58-68-4 CAS Fe3+ SMILES OC(=O)C1=C([O-])C(O)=CC=C1 Hydrogen Ion Enterobactin exporter entS HMDB0000692 HMDB C00008 KEGG Compound SMILES OC1=CC=CC(C(=O)NC2COC(=O)C(COC(=O)C(COC2=O)NC(=O)C2=CC=CC(O)=C2O)NC(=O)C2=CC=CC(O)=C2O)=C1O ferric enterobactin ABC transporter P11454 UniProt Hydrogen Ion C00001 KEGG Compound P24077 UniProt C01330 KEGG Compound 1.0 CHEBI:18361 ChEBI C00004 KEGG Compound Inner Membrane C00003 KEGG Compound C00002 KEGG Compound 1031 ChemSpider enterobactin synthase 4'-phosphopantetheinyl transferase entD ferric enterobactin outer membrane transport complex C04171 KEGG Compound EntS-TolC Enterobactin Efflux Transport System HMDB0000588 HMDB Biopolymer transport protein exbB Reaction5520 false Ferric enterobactin + 3 Water → 3 2,3-Dihydroxybenzoylserine + Fe3+ + 3 Hydrogen Ion LEFT_TO_RIGHT SMILES [Fe].OC1OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC1N=C(O)C1=C(O)C(O)=CC=C1 PW000760 PathWhiz 1.0 P10378 UniProt C21H28N7O14P2 NAD 664.11694 3.0 C00251 KEGG Compound HMDB0000902 HMDB 5951 PubChem-compound Extracellular Space 1.0 C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 C21H29N7O14P2 NADH 665.12476 1.0 5957 PubChem-compound ReactionCoupledTransport137 false Adenosine triphosphate + Ferric enterobactin + Water ? Adenosine diphosphate + Ferric enterobactin + Hydrogen Ion GO:0005620 GENE ONTOLOGY ReactionCatalysis5221 ACTIVATION 562 TAXONOMY Pyruvic acid H Hydrogen Ion 1.007825 CPD-10134 BioCyc C17H18N5O10P (2,3-Dihydroxybenzoyl)adenylic acid 483.07913 2.0 C10H11NO6 2,3-Dihydroxybenzoylserine 241.05864 C00022 KEGG Compound 56-65-5 CAS Ferric enterobactin C00020 KEGG Compound 53-84-9 CAS 1.0 SMILES N[C@@H](CO)C(O)=O HMDB0000243 HMDB GO:0005615 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY 3.0 CHEBI:29101 ChEBI SMILES [H][C@]1(O)C(=CC=C[C@]1([H])OC(=C)C([O-])=O)C([O-])=O 3.0 C30H33FeN3O15 Ferric enterobactin 731.1261 Adenosine triphosphate Fe Fe2+ 55.93494 P19925 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 1.0 1.0 Chorismate SubPathwayOutput 899 ChemSpider 5682 ChemSpider P23878 UniProt SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc P23876 UniProt Water P23877 UniProt Enterobactin exporter entS 1.0 P02930 UniProt HMDB0000250 HMDB 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS HMDB0001341 HMDB 1.0 1.0 Reaction3390 false Ferric enterobactin → Fe2+ + enterobactin LEFT_TO_RIGHT P13039 UniProt C10H10O6 Chorismate 226.04774 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ReactionCatalysis3358 ACTIVATION 1.0 1.0 Biopolymer transport protein exbB Enterobactin synthase component E enterobactin Cytoplasm 11542 ChemSpider 6.3.2.14 false 6.3.2.14 3 2,3-Dihydroxybenzoic acid + 6 Adenosine triphosphate + 3 L-Serine → 6 Adenosine monophosphate + 3 Hydrogen Ion + 6 Pyrophosphate + enterobactin LEFT_TO_RIGHT 17341-25-2 CAS Water 1.0 SMP0000826 SMPDB CHEBI:15422 ChEBI ReactionCatalysis2392 ACTIVATION ReactionCatalysis2391 ACTIVATION Escherichia coli 1.0 7732-18-5 CAS 388299 ChemSpider isochorismate SMP0000827 SMPDB Chorismate 61-19-8 CAS HMDB0001487 HMDB 617-12-9 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 440201 PubChem-compound 127-17-3 CAS Enterobactin synthase component F Transport415 false enterobactin (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Extracellular Space LEFT_TO_RIGHT Transport414 false enterobactin (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT ReactionCatalysis2393 ACTIVATION (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate Transport417 false Ferric enterobactin (→) Transport: Escherichia coli, Extracellular Space to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT CHEBI:29033 ChEBI Transport416 false L-Serine (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT SMILES OC1C=CC=C(C1O)C(O)=O CHEBI:29034 ChEBI Fe Fe3+ 55.93494 NAD SMP0000835 SMPDB C10H16N5O13P3 Adenosine triphosphate 506.99576 HMDB0012943 HMDB 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Fe2+ C00065 KEGG Compound CHEBI:18026 ChEBI 1.0 CHEBI:16761 ChEBI HMDB0000045 HMDB SMILES CC(=O)C(O)=O CHEBI:28855 ChEBI P0AGE5 UniProt 6.0 962 PubChem-compound CPD-9517 BioCyc P0ABU7 UniProt 2,3-Dihydroxybenzoic acid enterobactin 6.3.2.14 false 6.3.2.14 2,3-Dihydroxybenzoic acid + Adenosine triphosphate ↔ (2,3-Dihydroxybenzoyl)adenylic acid + Pyrophosphate REVERSIBLE 5800 ChemSpider Protein tonB Sodium P0ADI4 UniProt 1.0 5893 PubChem-compound C00080 KEGG Compound Periplasmic Space Enterochelin esterase Biopolymer transport protein exbD Ferrienterobactin receptor (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate SMILES [Fe+3] 3.0 HMDB0002111 HMDB CHEBI:32816 ChEBI L-Serine 1.0 PW000815 PathWhiz Serine/threonine transporter sstT CHEBI:15377 ChEBI C7H8O4 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 156.04225 Sodium CHEBI:15378 ChEBI SMILES [H+] SMILES [H][C@@](CO)(NC(=O)C1=C(O)C(O)=CC=C1)C(O)=O PYRUVATE BioCyc SMILES [H][C@]1(COP(O)(=O)OC(=O)C2=C(O)C(O)=CC=C2)O[C@@]([H])(N2C=NC3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 56-45-1 CAS 20074-52-6 CAS C00885 KEGG Compound P0AEL6 UniProt PW000807 PathWhiz 1.0 Isochorismatase L-Serine P0ABV2 UniProt C3H7NO3 L-Serine 105.042595 6.0 PW000806 PathWhiz HMDB0000187 HMDB enterobactin 644102 PubChem-compound 6083 PubChem-compound 1.0 Ferric enterobactin transport ATP-binding protein fepC Enterobactin synthase component E Ferric enterobactin transport system permease protein fepD C14819 KEGG Compound Isochorismate synthase entC H2O Water 18.010565 C14818 KEGG Compound Outer membrane protein tolC NADH BioCyc Ferric enterobactin transport ATP-binding protein fepC 1.0 NAD BioCyc C7H5O4 2,3-Dihydroxybenzoic acid 153.01933 15438-31-0 CAS Isochorismatase 1060 PubChem-compound C30H27N3O15 enterobactin 669.1442 Ferric enterobactin Na Sodium 22.989769 HMDB0059597 HMDB 25394 ChemSpider Enterobactin synthase component F 12039 PubChem-compound 1.0 Ferric enterobactin transport system permease protein fepD P02929 UniProt Adenosine diphosphate enterobactin 1.0 Biosynthesis of Siderophore Group Nonribosomal Peptides entS entS tolC sstT tonB exbB exbD fepA entC entB entD entF entE entB fes entA entB Chorismate enterobactin enterobactin enterobactin L-Serine L-Serine Sodium Sodium Ferric enterobactin Ferric enterobactin isochorismate Adenosine triphosphate L-Serine 2,3- Dihydroxybenzoic acid Adenosine monophosphate enterobactin Pyrophosphate Hydrogen Ion Ferric enterobactin Fe2+ enterobactin Adenosine triphosphate (2,3- Dihydroxybenzoyl)adenylic acid Pyrophosphate Water 2,3- Dihydroxybenzoylserine Fe3+ Hydrogen Ion (2S,3S)-2,3- dihydroxy- 2,3- dihydrobenzoate NAD NADH Hydrogen Ion Water Pyruvic acid Adenosine triphosphate Water Adenosine diphosphate Hydrogen Ion enterobactin fepG fepD fepB Phenylalanine Biosynthesis Tryptophan Metabolism Tyrosine Biosynthesis fepC