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TransportCatalysis360 ACTIVATION 6022 PubChem-compound SMP00826 SMPDB 923 PubChem-compound ReactionCatalysis5480 ACTIVATION 937 ChemSpider L-Serine HMDB00250 HMDB SMP00827 SMPDB ReactionCoupledTransportCatalysis171 ACTIVATION HMDB01341 HMDB NADH 29936 PubChem-compound P15047 UniProt 439153 PubChem-compound SMILES O TransportCatalysis359 ACTIVATION TransportCatalysis358 ACTIVATION TransportCatalysis357 ACTIVATION C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate 1.0 isochorismate SMP00835 SMPDB CHEBI:17115 ChEBI CHEBI:16027 ChEBI NAD Protein tonB SMILES [Na+] Ferrienterobactin receptor Biopolymer transport protein exbD ATP BioCyc Ferric enterobactin transport system permease protein fepG 1.0 Enterochelin esterase 5.4.4.2 false 5.4.4.2 Chorismate → isochorismate LEFT_TO_RIGHT 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase 3.0 Reaction2453 false Water + isochorismate → (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + Pyruvic acid LEFT_TO_RIGHT 1.0 CHEBI:5572 ChEBI 1.0 Pyruvic acid 559142 ChemSpider CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 4'-phosphopantetheinyl transferase entD 1.3.1.28 false 1.3.1.28 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD → 2,3-Dihydroxybenzoic acid + Hydrogen Ion + NADH LEFT_TO_RIGHT C10H8O6 isochorismate 224.03319 CHEBI:15941 ChEBI (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate Ferrienterobactin-binding periplasmic protein 5742 ChemSpider 1038 PubChem-compound SMILES [Fe++] Isochorismatase SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O GO:0005829 GENE ONTOLOGY HMDB59597 HMDB Adenosine monophosphate HMDB00902 HMDB 2.0 Ferric-Hydroxamate-Complexes BioCyc Serine/threonine transporter sstT CHEBI:16908 ChEBI P05825 UniProt HMDB00243 HMDB 5858 ChemSpider 5736 ChemSpider CHEBI:17455 ChEBI Ferrienterobactin-binding periplasmic protein Isochorismate synthase entC P0AEJ2 UniProt 440956 PubChem-compound Outer membrane protein tolC 25244759 PubChem-compound tyrosine biosynthesis SubPathway CHEBI:17333 ChEBI 1010 ChemSpider SER BioCyc phenylalanine biosynthesis SubPathway GO:0070258 GENE ONTOLOGY tryptophan metabolism SubPathway 27815 ChemSpider 6.0 PPI BioCyc 3.0 CHEBI:29780 ChEBI BiologicalState109 Ferric enterobactin (2,3-Dihydroxybenzoyl)adenylic acid Hydrogen Ion Biosynthesis of siderophore group nonribosomal peptides Ferric enterobactin 1.0 27284 PubChem-compound Cytosol 2,3-Dihydroxybenzoylserine 1.0 HMDB00692 HMDB Adenosine triphosphate 58-68-4 CAS 2.0 Ferric enterobactin transport system permease protein fepG Fe3+ SMILES OC(=O)C1=C([O-])C(O)=CC=C1 Hydrogen Ion Enterobactin exporter entS C00008 KEGG Compound SMILES OC1=CC=CC(C(=O)NC2COC(=O)C(COC(=O)C(COC2=O)NC(=O)C2=CC=CC(O)=C2O)NC(=O)C2=CC=CC(O)=C2O)=C1O ferric enterobactin ABC transporter HMDB00588 HMDB P11454 UniProt C00001 KEGG Compound P24077 UniProt C01330 KEGG Compound CHEBI:18361 ChEBI C00004 KEGG Compound C00003 KEGG Compound Inner Membrane 1031 ChemSpider C00002 KEGG Compound enterobactin synthase 4'-phosphopantetheinyl transferase entD ferric enterobactin outer membrane transport complex C04171 KEGG Compound EntS-TolC Enterobactin Efflux Transport System Biopolymer transport protein exbB Reaction5520 false Ferric enterobactin + 3 Water → 3 2,3-Dihydroxybenzoylserine + Fe3+ + 3 Hydrogen Ion LEFT_TO_RIGHT SMILES [Fe].OC1OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC1N=C(O)C1=C(O)C(O)=CC=C1 PW000760 PathWhiz C21H28N7O14P2 NAD 664.11694 P10378 UniProt 3.0 C00251 KEGG Compound 5951 PubChem-compound Extracellular Space 1.0 C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound ReactionCoupledTransport137 false Adenosine triphosphate + Ferric enterobactin + Water ? Adenosine diphosphate + Ferric enterobactin + Hydrogen Ion GO:0005620 GENE ONTOLOGY ReactionCatalysis5221 ACTIVATION 562 TAXONOMY H Hydrogen Ion 1.007825 CPD-10134 BioCyc C17H18N5O10P (2,3-Dihydroxybenzoyl)adenylic acid 483.07913 2.0 C00022 KEGG Compound C10H11NO6 2,3-Dihydroxybenzoylserine 241.05864 56-65-5 CAS Ferric enterobactin 53-84-9 CAS C00020 KEGG Compound 1.0 SMILES N[C@@H](CO)C(O)=O GO:0005615 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 3.0 CHEBI:29101 ChEBI SMILES [H][C@]1(O)C(=CC=C[C@]1([H])OC(=C)C([O-])=O)C([O-])=O 3.0 1.0 C30H33FeN3O15 Ferric enterobactin 731.1261 Adenosine triphosphate Fe Fe2+ 55.93494 P19925 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 1.0 899 ChemSpider 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O P23878 UniProt Water AMP BioCyc P23876 UniProt P23877 UniProt Enterobactin exporter entS 1.0 SMP00783 SMPDB P02930 UniProt 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS 1.0 1.0 1.0 Reaction3390 false Ferric enterobactin → Fe2+ + enterobactin LEFT_TO_RIGHT P13039 UniProt C10H10O6 Chorismate 226.04774 HMDB12199 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ReactionCatalysis3358 ACTIVATION 1.0 1.0 Biopolymer transport protein exbB Enterobactin synthase component E enterobactin HMDB00538 HMDB 11542 ChemSpider 6.3.2.14 false 6.3.2.14 3 2,3-Dihydroxybenzoic acid + 6 Adenosine triphosphate + 3 L-Serine → 6 Adenosine monophosphate + 3 Hydrogen Ion + 6 Pyrophosphate + enterobactin LEFT_TO_RIGHT 17341-25-2 CAS Water 1.0 CHEBI:15422 ChEBI ReactionCatalysis2392 ACTIVATION ReactionCatalysis2391 ACTIVATION 1.0 7732-18-5 CAS 1.0 388299 ChemSpider Chorismate 61-19-8 CAS 617-12-9 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 440201 PubChem-compound 127-17-3 CAS Enterobactin synthase component F Transport415 false enterobactin (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Extracellular Space LEFT_TO_RIGHT ReactionCatalysis2393 ACTIVATION Transport414 false enterobactin (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT Transport417 false Ferric enterobactin (→) Transport: Escherichia coli, Extracellular Space to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT CHEBI:29033 ChEBI Transport416 false L-Serine (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT SMILES OC1C=CC=C(C1O)C(O)=O CHEBI:29034 ChEBI Fe Fe3+ 55.93494 C10H16N5O13P3 Adenosine triphosphate 506.99576 Fe2+ C00065 KEGG Compound 1.0 CHEBI:18026 ChEBI 1.0 CHEBI:16761 ChEBI SMILES CC(=O)C(O)=O CHEBI:28855 ChEBI P0AGE5 UniProt 6.0 962 PubChem-compound CPD-9517 BioCyc P0ABU7 UniProt 2,3-Dihydroxybenzoic acid enterobactin 6.3.2.14 false 6.3.2.14 2,3-Dihydroxybenzoic acid + Adenosine triphosphate ↔ (2,3-Dihydroxybenzoyl)adenylic acid + Pyrophosphate REVERSIBLE 5800 ChemSpider SubPathwayInteraction1367 SubPathway1367Reaction SubPathwayReaction SubPathwayInteraction1366 SubPathway1366Reaction SubPathwayReaction Protein tonB Sodium P0ADI4 UniProt 1.0 5893 PubChem-compound SubPathwayInteraction1365 SubPathwayReaction SubPathway1365Reaction HMDB02111 HMDB C00080 KEGG Compound Periplasmic Space Enterochelin esterase Biopolymer transport protein exbD Ferrienterobactin receptor SMILES [Fe+3] CHEBI:32816 ChEBI 3.0 L-Serine 1.0 PW000815 PathWhiz CHEBI:15377 ChEBI C7H8O4 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 156.04225 Serine/threonine transporter sstT Sodium CHEBI:15378 ChEBI SMILES [H+] SMILES [H][C@@](CO)(NC(=O)C1=C(O)C(O)=CC=C1)C(O)=O PYRUVATE BioCyc SMILES [H][C@]1(COP(O)(=O)OC(=O)C2=C(O)C(O)=CC=C2)O[C@@]([H])(N2C=NC3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 56-45-1 CAS 20074-52-6 CAS C00885 KEGG Compound P0AEL6 UniProt HMDB00187 HMDB 1.0 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase PW000807 PathWhiz 1.0 Isochorismatase L-Serine P0ABV2 UniProt C3H7NO3 L-Serine 105.042595 6.0 PW000806 PathWhiz HMDB01487 HMDB enterobactin 644102 PubChem-compound 6083 PubChem-compound 1.0 Ferric enterobactin transport ATP-binding protein fepC Enterobactin synthase component E Ferric enterobactin transport system permease protein fepD C14819 KEGG Compound Isochorismate synthase entC H2O Water 18.010565 C14818 KEGG Compound Outer membrane protein tolC HMDB12943 HMDB NADH BioCyc Ferric enterobactin transport ATP-binding protein fepC NAD BioCyc 1060 PubChem-compound C7H5O4 2,3-Dihydroxybenzoic acid 153.01933 HMDB00045 HMDB 15438-31-0 CAS C30H27N3O15 enterobactin 669.1442 Ferric enterobactin Na Sodium 22.989769 25394 ChemSpider Enterobactin synthase component F 12039 PubChem-compound 1.0 Ferric enterobactin transport system permease protein fepD P02929 UniProt Adenosine diphosphate enterobactin 1.0 Enterobactin exporter entS Enterobactin exporter entS Outer membrane protein tolC Serine/threonine transporter sstT Protein tonB Biopolymer transport protein exbB Biopolymer transport protein exbD Ferrienterobactin receptor Isochorismate synthase entC Isochorismatase 2,3-dihydro- 2,3- dihydroxybenzoate dehydrogenase Isochorismatase 4'- phosphopantetheinyl transferase entD Enterobactin synthase component F Enterobactin synthase component E Isochorismatase Enterochelin esterase enterobactin enterobactin enterobactin L-Serine L-Serine Na + Na + Ferric enterobactin Ferric enterobactin Chorismate isochorismate H 2 O Pyruvic acid (2S,3S)-2,3- dihydroxy- 2,3- dihydrobenzoate NAD 2,3- Dihydroxybenzoic acid NADH H + ATP L-Serine AMP enterobactin PP i H + Ferric enterobactin Fe2+ enterobactin ATP (2,3- Dihydroxybenzoyl)adenylic acid PP i H 2 O 2,3- Dihydroxybenzoylserine Fe3+ H + ATP H 2 O ADP H + enterobactin Ferric enterobactin transport system permease protein fepG Ferric enterobactin transport system permease protein fepD Ferrienterobactin- binding periplasmic protein tyrosine biosynthesis tryptophan metabolism phenylalanine biosynthesis Ferric enterobactin transport ATP-binding protein fepC
TransportCatalysis360 ACTIVATION 6022 PubChem-compound http://identifiers.org/smpdb/SMP00826 SMPDB 923 PubChem-compound ReactionCatalysis5480 ACTIVATION 937 ChemSpider L-Serine HMDB00250 HMDB http://identifiers.org/smpdb/SMP00827 SMPDB ReactionCoupledTransportCatalysis171 ACTIVATION HMDB01341 HMDB NADH 29936 PubChem-compound P15047 UniProt 439153 PubChem-compound SMILES O TransportCatalysis359 ACTIVATION TransportCatalysis358 ACTIVATION TransportCatalysis357 ACTIVATION C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate 1.0 isochorismate http://identifiers.org/smpdb/SMP00835 SMPDB CHEBI:17115 ChEBI CHEBI:16027 ChEBI NAD Protein tonB SMILES [Na+] Ferrienterobactin receptor Biopolymer transport protein exbD ATP BioCyc Ferric enterobactin transport system permease protein fepG 1.0 Enterochelin esterase 5.4.4.2 false 5.4.4.2 Chorismate → isochorismate LEFT_TO_RIGHT 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase 3.0 Reaction2453 false Water + isochorismate → (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + Pyruvic acid LEFT_TO_RIGHT 1.0 CHEBI:5572 ChEBI 1.0 Pyruvic acid 559142 ChemSpider CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 4'-phosphopantetheinyl transferase entD 1.3.1.28 false 1.3.1.28 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD → 2,3-Dihydroxybenzoic acid + Hydrogen Ion + NADH LEFT_TO_RIGHT C10H8O6 isochorismate 224.03319 CHEBI:15941 ChEBI (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate Ferrienterobactin-binding periplasmic protein 5742 ChemSpider 1038 PubChem-compound SMILES [Fe++] Isochorismatase SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O GO:0005829 GENE ONTOLOGY HMDB59597 HMDB Adenosine monophosphate HMDB00902 HMDB 2.0 Ferric-Hydroxamate-Complexes BioCyc Serine/threonine transporter sstT CHEBI:16908 ChEBI P05825 UniProt HMDB00243 HMDB 5858 ChemSpider 5736 ChemSpider CHEBI:17455 ChEBI Ferrienterobactin-binding periplasmic protein Isochorismate synthase entC P0AEJ2 UniProt 440956 PubChem-compound Outer membrane protein tolC 25244759 PubChem-compound CHEBI:17333 ChEBI 1010 ChemSpider SER BioCyc GO:0070258 GENE ONTOLOGY 27815 ChemSpider 6.0 PPI BioCyc 3.0 CHEBI:29780 ChEBI BiologicalState109 Escherichia coli, Inner Membrane Ferric enterobactin (2,3-Dihydroxybenzoyl)adenylic acid Hydrogen Ion Biosynthesis of siderophore group nonribosomal peptides Ferric enterobactin 1.0 27284 PubChem-compound Cytosol 2,3-Dihydroxybenzoylserine 1.0 HMDB00692 HMDB Adenosine triphosphate 58-68-4 CAS 2.0 Ferric enterobactin transport system permease protein fepG Fe3+ SMILES OC(=O)C1=C([O-])C(O)=CC=C1 Hydrogen Ion Enterobactin exporter entS C00008 KEGG Compound SMILES OC1=CC=CC(C(=O)NC2COC(=O)C(COC(=O)C(COC2=O)NC(=O)C2=CC=CC(O)=C2O)NC(=O)C2=CC=CC(O)=C2O)=C1O ferric enterobactin ABC transporter HMDB00588 HMDB P11454 UniProt C00001 KEGG Compound P24077 UniProt C01330 KEGG Compound CHEBI:18361 ChEBI C00004 KEGG Compound C00003 KEGG Compound Inner Membrane 1031 ChemSpider C00002 KEGG Compound enterobactin synthase 4'-phosphopantetheinyl transferase entD ferric enterobactin outer membrane transport complex C04171 KEGG Compound EntS-TolC Enterobactin Efflux Transport System Biopolymer transport protein exbB Reaction5520 false Ferric enterobactin + 3 Water → 3 2,3-Dihydroxybenzoylserine + Fe3+ + 3 Hydrogen Ion LEFT_TO_RIGHT SMILES [Fe].OC1OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC(N=C(O)C2=C(O)C(O)=CC=C2)C(O)OCC1N=C(O)C1=C(O)C(O)=CC=C1 PW000760 PathWhiz C21H28N7O14P2 NAD 664.11694 P10378 UniProt 3.0 C00251 KEGG Compound 5951 PubChem-compound Extracellular Space 1.0 C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound ReactionCoupledTransport137 false Adenosine triphosphate + Ferric enterobactin + Water ? Adenosine diphosphate + Ferric enterobactin + Hydrogen Ion GO:0005620 GENE ONTOLOGY ReactionCatalysis5221 ACTIVATION 562 TAXONOMY H Hydrogen Ion 1.007825 CPD-10134 BioCyc C17H18N5O10P (2,3-Dihydroxybenzoyl)adenylic acid 483.07913 2.0 C00022 KEGG Compound C10H11NO6 2,3-Dihydroxybenzoylserine 241.05864 56-65-5 CAS Ferric enterobactin 53-84-9 CAS C00020 KEGG Compound 1.0 SMILES N[C@@H](CO)C(O)=O GO:0005615 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 3.0 CHEBI:29101 ChEBI SMILES [H][C@]1(O)C(=CC=C[C@]1([H])OC(=C)C([O-])=O)C([O-])=O 3.0 1.0 C30H33FeN3O15 Ferric enterobactin 731.1261 Adenosine triphosphate Fe Fe2+ 55.93494 P19925 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 1.0 899 ChemSpider 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O P23878 UniProt Water AMP BioCyc P23876 UniProt P23877 UniProt Enterobactin exporter entS 1.0 http://identifiers.org/smpdb/SMP00783 SMPDB P02930 UniProt 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS 1.0 tyrosine biosynthesis SubPathway 1.0 phenylalanine biosynthesis SubPathway 1.0 Reaction3390 false Ferric enterobactin → Fe2+ + enterobactin LEFT_TO_RIGHT P13039 UniProt C10H10O6 Chorismate 226.04774 HMDB12199 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ReactionCatalysis3358 ACTIVATION 1.0 1.0 Biopolymer transport protein exbB Enterobactin synthase component E enterobactin HMDB00538 HMDB 11542 ChemSpider 6.3.2.14 false 6.3.2.14 3 2,3-Dihydroxybenzoic acid + 6 Adenosine triphosphate + 3 L-Serine → 6 Adenosine monophosphate + 3 Hydrogen Ion + 6 Pyrophosphate + enterobactin LEFT_TO_RIGHT 17341-25-2 CAS Water 1.0 CHEBI:15422 ChEBI tryptophan metabolism SubPathway ReactionCatalysis2392 ACTIVATION ReactionCatalysis2391 ACTIVATION 1.0 7732-18-5 CAS 1.0 388299 ChemSpider Chorismate 61-19-8 CAS 617-12-9 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 440201 PubChem-compound 127-17-3 CAS Enterobactin synthase component F Transport415 false enterobactin (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Extracellular Space LEFT_TO_RIGHT ReactionCatalysis2393 ACTIVATION Transport414 false enterobactin (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT Transport417 false Ferric enterobactin (→) Transport: Escherichia coli, Extracellular Space to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT CHEBI:29033 ChEBI Transport416 false L-Serine (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT SMILES OC1C=CC=C(C1O)C(O)=O CHEBI:29034 ChEBI Fe Fe3+ 55.93494 C10H16N5O13P3 Adenosine triphosphate 506.99576 Fe2+ C00065 KEGG Compound 1.0 CHEBI:18026 ChEBI 1.0 CHEBI:16761 ChEBI SMILES CC(=O)C(O)=O CHEBI:28855 ChEBI P0AGE5 UniProt 6.0 962 PubChem-compound CPD-9517 BioCyc P0ABU7 UniProt 2,3-Dihydroxybenzoic acid enterobactin 6.3.2.14 false 6.3.2.14 2,3-Dihydroxybenzoic acid + Adenosine triphosphate ↔ (2,3-Dihydroxybenzoyl)adenylic acid + Pyrophosphate REVERSIBLE 5800 ChemSpider SubPathwayInteraction1367 SubPathway1367Reaction SubPathwayReaction SubPathwayInteraction1366 SubPathway1366Reaction SubPathwayReaction Protein tonB Sodium P0ADI4 UniProt 1.0 5893 PubChem-compound SubPathwayInteraction1365 SubPathwayReaction SubPathway1365Reaction HMDB02111 HMDB C00080 KEGG Compound Periplasmic Space Enterochelin esterase Biopolymer transport protein exbD Ferrienterobactin receptor SMILES [Fe+3] CHEBI:32816 ChEBI 3.0 L-Serine 1.0 PW000815 PathWhiz CHEBI:15377 ChEBI C7H8O4 (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 156.04225 Serine/threonine transporter sstT Sodium CHEBI:15378 ChEBI SMILES [H+] SMILES [H][C@@](CO)(NC(=O)C1=C(O)C(O)=CC=C1)C(O)=O PYRUVATE BioCyc SMILES [H][C@]1(COP(O)(=O)OC(=O)C2=C(O)C(O)=CC=C2)O[C@@]([H])(N2C=NC3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 56-45-1 CAS 20074-52-6 CAS C00885 KEGG Compound P0AEL6 UniProt HMDB00187 HMDB 1.0 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase PW000807 PathWhiz 1.0 Isochorismatase L-Serine P0ABV2 UniProt C3H7NO3 L-Serine 105.042595 6.0 PW000806 PathWhiz HMDB01487 HMDB enterobactin 644102 PubChem-compound 6083 PubChem-compound 1.0 Ferric enterobactin transport ATP-binding protein fepC Enterobactin synthase component E Ferric enterobactin transport system permease protein fepD C14819 KEGG Compound Isochorismate synthase entC H2O Water 18.010565 C14818 KEGG Compound Outer membrane protein tolC HMDB12943 HMDB NADH BioCyc Ferric enterobactin transport ATP-binding protein fepC NAD BioCyc 1060 PubChem-compound C7H5O4 2,3-Dihydroxybenzoic acid 153.01933 HMDB00045 HMDB 15438-31-0 CAS C30H27N3O15 enterobactin 669.1442 Ferric enterobactin Na Sodium 22.989769 25394 ChemSpider Enterobactin synthase component F 12039 PubChem-compound 1.0 Ferric enterobactin transport system permease protein fepD P02929 UniProt Adenosine diphosphate enterobactin 1.0 entS entS tolC sstT tonB exbB exbD fepA entC entB entA entB entD entF entE entB fes enterobactin enterobactin enterobactin L-Serine L-Serine Sodium Sodium Ferric enterobactin Ferric enterobactin Chorismate isochorismate Water Pyruvic acid (2S,3S)-2,3- dihydroxy- 2,3- dihydrobenzoate NAD 2,3- Dihydroxybenzoic acid NADH Hydrogen Ion Adenosine triphosphate L-Serine Adenosine monophosphate enterobactin Pyrophosphate Hydrogen Ion Ferric enterobactin Fe2+ enterobactin Adenosine triphosphate (2,3- Dihydroxybenzoyl)adenylic acid Pyrophosphate Water 2,3- Dihydroxybenzoylserine Fe3+ Hydrogen Ion Adenosine triphosphate Water Adenosine diphosphate Hydrogen Ion enterobactin fepG fepD fepB tyrosine biosynthesis tryptophan metabolism phenylalanine biosynthesis fepC