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Pathway Description
Lysine Degradation
Escherichia coli
Metabolic Pathway
Lysine is an essential amino acid used in protein synthesis. Lysine can be transported into the cell by probable cadaverine (also known as lysine antiporter). Once inside the cell, lysine is decarboxylated by lysine decarboxylase to cadaverine. Cadaverine can then exit the cell via the same type of transporter as lysine (probable cadaverine). Alternatively, lysine can be produced during lysine biosynthesis (from aspartic acid) inside the cell and used in the same pathway.
References
Lysine Degradation References
Foster JW: Escherichia coli acid resistance: tales of an amateur acidophile. Nat Rev Microbiol. 2004 Nov;2(11):898-907. doi: 10.1038/nrmicro1021.
Pubmed: 15494746
Moreau PL: The lysine decarboxylase CadA protects Escherichia coli starved of phosphate against fermentation acids. J Bacteriol. 2007 Mar;189(6):2249-61. doi: 10.1128/JB.01306-06. Epub 2007 Jan 5.
Pubmed: 17209032
Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE. Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition. American Society for Microbiology, Washington, D.C., 1996.
Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS: Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate. Nat Commun. 2018 Nov 29;9(1):5071. doi: 10.1038/s41467-018-07563-6.
Pubmed: 30498244
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from PW000772
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