PathWhiz

Pathway Description

Lysine Degradation

Escherichia coli

Metabolic Pathway

Lysine is an essential amino acid used in protein synthesis. Lysine can be transported into the cell by probable cadaverine (also known as lysine antiporter). Once inside the cell, lysine is decarboxylated by lysine decarboxylase to cadaverine. Cadaverine can then exit the cell via the same type of transporter as lysine (probable cadaverine). Alternatively, lysine can be produced during lysine biosynthesis (from aspartic acid) inside the cell and used in the same pathway.

References

Lysine Degradation References

Foster JW: Escherichia coli acid resistance: tales of an amateur acidophile. Nat Rev Microbiol. 2004 Nov;2(11):898-907. doi: 10.1038/nrmicro1021.

Pubmed: 15494746

Moreau PL: The lysine decarboxylase CadA protects Escherichia coli starved of phosphate against fermentation acids. J Bacteriol. 2007 Mar;189(6):2249-61. doi: 10.1128/JB.01306-06. Epub 2007 Jan 5.

Pubmed: 17209032

Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE. Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition. American Society for Microbiology, Washington, D.C., 1996.

Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS: Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate. Nat Commun. 2018 Nov 29;9(1):5071. doi: 10.1038/s41467-018-07563-6.

Pubmed: 30498244

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW000772

Highlighted elements will appear in red.

Highlight Compounds

	Cadaverine
	Carbon dioxide
	Hydrogen Ion
	L-Lysine

Highlight Proteins

	Lysine decarboxylase, constitutive
	Lysine decarboxylase, inducible
	Probable cadaverine/lysine antiporter

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