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6022 PubChem-compound Fumarate hydratase class I, anaerobic C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider Aconitate hydratase 1 lipoamide dehydrogenase CHEBI:30797 ChEBI 439153 PubChem-compound 110-17-8 CAS 1.0 HMDB0000094 HMDB Reaction2588 false Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT 4.2.1.3 false 4.2.1.3 Citric acid → Water + cis-Aconitic acid LEFT_TO_RIGHT 50 ChemSpider HMDB0003364 HMDB CHEBI:16389 ChEBI P0AC33 UniProt P33940 UniProt NAD 1.0 1.0 OXALACETIC_ACID BioCyc succinate dehydrogenase, FeS subunit succinate:quinone oxidoreductase, FAD binding protein Fumarate hydratase class I, anaerobic ATP BioCyc CHEBI:17594 ChEBI 1.0 succinate dehydrogenase fumarate reductase, membrane anchor subunit succinate dehydrogenase P0AC44 UniProt 1.0 CHEBI:15380 ChEBI C00451 KEGG Compound 5742 ChemSpider NADH C25H40N7O19P3S Succinyl-CoA 867.1312 2.0 CHEBI:16474 ChEBI P0AC41 UniProt 97-67-6 CAS 2.0 945 ChemSpider 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS CHEBI:30769 ChEBI 1.1.1.42 false 1.1.1.42 D-threo-Isocitric acid + NADP → Carbon dioxide + NADPH + Oxoglutaric acid LEFT_TO_RIGHT Reaction2590 false Water + cis-Aconitic acid → D-threo-Isocitric acid LEFT_TO_RIGHT 1.0 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 C00472 KEGG Compound Cytosol 1.0 Adenosine triphosphate SUC BioCyc Quinone 24.0 C00009 KEGG Compound 4307 ChemSpider C00008 KEGG Compound C00006 KEGG Compound SubPathwayInteraction83267 SubPathway83267Reaction SubPathwayReaction CHEBI:18009 ChEBI Hydrogen Ion SubPathwayInteraction83265 SubPathwayReaction SubPathway83265Reaction C00001 KEGG Compound C00122 KEGG Compound C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider 1.0 C00002 KEGG Compound Aspartate Metabolism SubPathway Glycolysis and Pyruvate Dehydrogenase SubPathway SubPathwayInteraction83273 SubPathwayReaction SubPathway83273Reaction Coenzyme A C21H28N7O14P2 NAD 664.11694 TCA Cycle 447920 PubChem-compound C00011 KEGG Compound C00010 KEGG Compound HMDB0000902 HMDB Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1.0 2-oxoglutarate dehydrogenase E1 component NAD(P) BioCyc 562 TAXONOMY H Hydrogen Ion 1.007825 C00149 KEGG Compound 388307 ChemSpider Ornithine Metabolism SubPathway 56-65-5 CAS 53-84-9 CAS C00026 KEGG Compound C00024 KEGG Compound 1.0 1.0 SMP0000802 SMPDB C6H6O2 Hydroquinone 110.03678 SMP0000809 SMPDB SMP0000807 SMPDB C00158 KEGG Compound Succinyl-CoA ligase [ADP-forming] subunit alpha C00036 KEGG Compound C00399 KEGG Compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0002434 HMDB HMDB0000134 HMDB 6.0 HMDB0000254 HMDB Water SMILES OC(=O)CCC(O)=O Oxalacetic acid SubPathwayOutput SMILES OC(=O)C\C(=C\C(O)=O)C(O)=O HMDB0001341 HMDB SMP0000813 SMPDB C00042 KEGG Compound Malate:quinone oxidoreductase 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 764 ChemSpider SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O 604-98-8 CAS 1.0 10197150 ChemSpider 785 PubChem-compound Malate dehydrogenase FUM BioCyc SMILES OC(=O)CC(=O)C(O)=O P69054 UniProt 7732-18-5 CAS SMILES COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC CHEBI:18012 ChEBI Succinyl-CoA ligase [ADP-forming] subunit beta HMDB0001487 HMDB HMDB0000156 HMDB Fumarate hydratase class I, aerobic Aconitate hydratase 2 SMILES O[C@H]([C@H](CC(O)=O)C(O)=O)C(O)=O C6H4O2 Quinone 108.021126 NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 Hydroquinone 305 ChemSpider Aconitate hydratase 1 lipoamide dehydrogenase ReactionCatalysis2606 ACTIVATION Fumarate hydratase class I, aerobic 962 PubChem-compound 1.0 2.0 6061-97-8 CAS 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate Ubiquinone-1 C00080 KEGG Compound Oxoglutaric acid succinate:quinone oxidoreductase, FAD binding protein succinate dehydrogenase, FeS subunit HMDB0002111 HMDB HMDB0001022 HMDB 14265-44-2 CAS 2.0 58-64-0 CAS 585-84-2 CAS C00091 KEGG Compound succinate dehydrogenase fumarate reductase, membrane anchor subunit succinate dehydrogenase P61889 UniProt 444493 PubChem-compound 2.0 22833512 PubChem-compound ACETYL-COA BioCyc H2O Water 18.010565 HMDB0000072 HMDB 1.0 NADH BioCyc HMDB0002012 HMDB NAD BioCyc HMDB0059597 HMDB Carbon dioxide CIS-ACONITATE BioCyc 970 PubChem-compound P0ABH7 UniProt Fumarate hydratase class II SMILES OC(=O)\C=C\C(O)=O L-Malic acid P0A836 UniProt C4H6O5 L-Malic acid 134.02153 1.0 17215925 ChemSpider C4H4O5 Oxalacetic acid 132.00587 Succinic acid NADH cis-Aconitic acid 21883788 PubChem-compound SMILES O C6H8O7 D-threo-Isocitric acid 192.02701 CIT BioCyc Acetyl-CoA SubPathwayOutput HMDB0000538 HMDB P14407 UniProt 1.0 HMDB0001874 HMDB 1.0 6816 PubChem-compound 328-42-7 CAS 4477081 ChemSpider 51 PubChem-compound P0A9P0 UniProt SMILES O[C@@H](CC(O)=O)C(O)=O CHEBI:15846 ChEBI ADP BioCyc 53-59-8 CAS 1038 PubChem-compound D-threo-Isocitric acid GO:0005829 GENE ONTOLOGY ReactionCatalysis2558 ACTIVATION ReactionCatalysis2559 ACTIVATION 274 ChemSpider 4.0 P36683 UniProt C5H6O5 Oxoglutaric acid 146.02153 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2-oxoglutarate dehydrogenase E1 component CHEBI:16908 ChEBI 1.0 Isocitrate dehydrogenase [NADP] O4P Phosphate 94.95342 Oxalacetic acid C14H18O4 Ubiquinone-1 250.12051 Ubiquinol-1 NADPH 4650 PubChem-compound 77-92-9 CAS 558863 ChemSpider Succinyl-CoA ligase [ADP-forming] subunit alpha NADP C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis2561 ACTIVATION ReactionCatalysis2560 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis2562 ACTIVATION ReactionCatalysis2564 ACTIVATION NADPH BioCyc PW000787 PathWhiz 643757 PubChem-compound Fumaric acid PW000785 PathWhiz HMDB0000208 HMDB 236-TRICHLOROHYDROQUINONE BioCyc ReactionCatalysis2607 ACTIVATION L-Malic acid 58-68-4 CAS HMDB0001423 HMDB ReactionCatalysis2613 ACTIVATION ReactionCatalysis2612 ACTIVATION SMILES [O-]P([O-])([O-])=O HMDB0000217 HMDB SMILES OC(=O)CCC(=O)C(O)=O 2-oxoglutarate dehydrogenase PW000779 PathWhiz 124-38-9 CAS CHEBI:30915 ChEBI Citrate synthase monomer 1.0 2.0 HMDB0001429 HMDB 1.0 SMILES COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB succinyl-CoA synthetase Succinyl-CoA ligase [ADP-forming] subunit beta HMDB0000223 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Fumaric acid C4H4O4 Fumaric acid 116.010956 succinate:quinone oxidoreductase ReactionCatalysis2620 ACTIVATION 53-57-6 CAS CHEBI:15741 ChEBI 1.0 1.2.4.2 false 1.2.4.2 Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + NADH + Succinyl-CoA LEFT_TO_RIGHT SMILES O=C=O 1110 PubChem-compound P0AFG3 UniProt 2.0 P25516 UniProt C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound HMDB0001206 HMDB 2.0 CHEBI:151 ChEBI C4H6O4 Succinic acid 118.02661 C6H6O6 cis-Aconitic acid 174.01643 Citric acid Adenosine diphosphate P0AFG6 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 12.0 C6H8O7 Citric acid 192.02701 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 19782904 PubChem-compound 5682 ChemSpider CHEBI:1146900 ChEBI 5318532 PubChem-compound 1.1.1.37 false 1.1.1.37 L-Malic acid + NAD → Hydrogen Ion + NADH + Oxalacetic acid LEFT_TO_RIGHT 4.2.1.2 false 4.2.1.2 Fumaric acid + Water → L-Malic acid LEFT_TO_RIGHT 1.0 6.2.1.5 false 6.2.1.5 Adenosine diphosphate + Phosphate + Succinyl-CoA → Adenosine triphosphate + Coenzyme A + Succinic acid LEFT_TO_RIGHT Reaction2619 false Succinic acid + Ubiquinone-1 → Fumaric acid + Ubiquinol-1 LEFT_TO_RIGHT CO-A BioCyc 222656 PubChem-compound 5675 ChemSpider 1078 ChemSpider 72-89-9 CAS Fumarate hydratase class II Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 malate dehydrogenase CHEBI:15422 ChEBI 6557 ChemSpider Escherichia coli SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 1.0 CHEBI:16509 ChEBI Water PW000791 PathWhiz 4489 ChemSpider 1.0 CHEBI:16526 ChEBI 1.0 1.0 CPD-8130 BioCyc CHEBI:16761 ChEBI 1.0 P0AGE9 UniProt 123-31-9 CAS Succinic acid SubPathwayOutput 1.0 Reaction2630 false L-Malic acid + Quinone → Hydroquinone + Oxalacetic acid LEFT_TO_RIGHT 2-KETOGLUTARATE BioCyc 392413 ChemSpider 1.0 C14H20O4 Ubiquinol-1 252.13615 P05042 UniProt 5893 PubChem-compound 1.0 110-15-6 CAS SMILES O=C1C=CC(=O)C=C1 CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] P08200 UniProt Succinyl-CoA Citrate hydro-lyase (cis-aconitate-forming) Citrate hydro-lyase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound citrate dehydrogenase citrate synthase 1.0 SMILES OC1=CC=C(O)C=C1 280 PubChem-compound CHEBI:30744 ChEBI CHEBI:32805 ChEBI fumarase hydratase 2.0 4462 PubChem-compound C00417 KEGG Compound Malate:quinone oxidoreductase Citrate synthase monomer C00530 KEGG Compound Malate dehydrogenase 1.0 727-81-1 CAS Isocitrate dehydrogenase [NADP] Citric acid 193317 ChemSpider ReactionCatalysis2593 ACTIVATION 3-METHYLBENZYLSUCCINYL-COA BioCyc 1.0 1061 PubChem-compound 1.0 CPD-1941 BioCyc P07014 UniProt HMDB0001967 HMDB 106-51-4 CAS Aconitate hydratase 2 CHEBI:15351 ChEBI 85-61-0 CAS Aconitate hydratase 1 Isocitrate dehydrogenase [NADP] 2-oxoglutarate dehydrogenase E1 component Dihydrolipoyllysine- residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex lipoamide dehydrogenase Succinyl-CoA ligase [ADP-forming] subunit alpha Succinyl-CoA ligase [ADP-forming] subunit beta Malate:quinone oxidoreductase succinate:quinone oxidoreductase, FAD binding protein succinate dehydrogenase, FeS subunit succinate dehydrogenase succinate dehydrogenase fumarate reductase, membrane anchor subunit Citrate synthase monomer Malate dehydrogenase Fumarate hydratase class I, aerobic Fumarate hydratase class I, anaerobic Fumarate hydratase class II Oxalacetic acid Acetyl-CoA Succinic acid Citric acid H 2 O cis-Aconitic acid H 2 O D-threo- Isocitric acid NADP CO 2 NADPH Oxoglutaric acid NAD CoA NADH CO 2 Succinyl-CoA ADP P i ATP CoA L-Malic acid Quinone Hydroquinone Ubiquinone-1 Ubiquinol-1 Fumaric acid H 2 O CoA H + NAD NADH H + H 2 O 4Fe-4S FAD ferroheme b 2Fe-2S 3Fe-4S iron-sulfur cluster Aconitate hydratase 1 Aspartate Metabolism Glycolysis and Pyruvate Dehydrogenase Ornithine Metabolism Aconitate hydratase 2 Aconitate hydratase 2
6022 PubChem-compound Fumarate hydratase class I, anaerobic C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider Aconitate hydratase 1 lipoamide dehydrogenase CHEBI:30797 ChEBI 439153 PubChem-compound 110-17-8 CAS 1.0 HMDB0000094 HMDB Reaction2588 false Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT 4.2.1.3 false 4.2.1.3 Citric acid → Water + cis-Aconitic acid LEFT_TO_RIGHT 50 ChemSpider HMDB0003364 HMDB CHEBI:16389 ChEBI P0AC33 UniProt P33940 UniProt NAD 1.0 1.0 OXALACETIC_ACID BioCyc succinate dehydrogenase, FeS subunit succinate:quinone oxidoreductase, FAD binding protein Fumarate hydratase class I, anaerobic ATP BioCyc CHEBI:17594 ChEBI 1.0 succinate dehydrogenase fumarate reductase, membrane anchor subunit succinate dehydrogenase P0AC44 UniProt 1.0 CHEBI:15380 ChEBI C00451 KEGG Compound 5742 ChemSpider NADH C25H40N7O19P3S Succinyl-CoA 867.1312 2.0 CHEBI:16474 ChEBI P0AC41 UniProt 97-67-6 CAS 2.0 945 ChemSpider 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS CHEBI:30769 ChEBI 1.1.1.42 false 1.1.1.42 D-threo-Isocitric acid + NADP → Carbon dioxide + NADPH + Oxoglutaric acid LEFT_TO_RIGHT Reaction2590 false Water + cis-Aconitic acid → D-threo-Isocitric acid LEFT_TO_RIGHT 1.0 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 C00472 KEGG Compound Cytosol 1.0 Adenosine triphosphate SUC BioCyc Quinone 24.0 C00009 KEGG Compound 4307 ChemSpider C00008 KEGG Compound C00006 KEGG Compound SubPathwayInteraction83267 SubPathway83267Reaction SubPathwayReaction CHEBI:18009 ChEBI Hydrogen Ion SubPathwayInteraction83265 SubPathwayReaction SubPathway83265Reaction C00001 KEGG Compound C00122 KEGG Compound C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider 1.0 C00002 KEGG Compound Aspartate Metabolism SubPathway Glycolysis and Pyruvate Dehydrogenase SubPathway SubPathwayInteraction83273 SubPathwayReaction SubPathway83273Reaction Coenzyme A C21H28N7O14P2 NAD 664.11694 TCA Cycle 447920 PubChem-compound C00011 KEGG Compound C00010 KEGG Compound HMDB0000902 HMDB Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1.0 2-oxoglutarate dehydrogenase E1 component NAD(P) BioCyc 562 TAXONOMY H Hydrogen Ion 1.007825 C00149 KEGG Compound 388307 ChemSpider Ornithine Metabolism SubPathway 56-65-5 CAS 53-84-9 CAS C00026 KEGG Compound C00024 KEGG Compound 1.0 1.0 SMP0000802 SMPDB C6H6O2 Hydroquinone 110.03678 SMP0000809 SMPDB SMP0000807 SMPDB C00158 KEGG Compound Succinyl-CoA ligase [ADP-forming] subunit alpha C00036 KEGG Compound C00399 KEGG Compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0002434 HMDB HMDB0000134 HMDB 6.0 HMDB0000254 HMDB Water SMILES OC(=O)CCC(O)=O Oxalacetic acid SubPathwayOutput SMILES OC(=O)C\C(=C\C(O)=O)C(O)=O HMDB0001341 HMDB SMP0000813 SMPDB C00042 KEGG Compound Malate:quinone oxidoreductase 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 764 ChemSpider SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O 604-98-8 CAS 1.0 10197150 ChemSpider 785 PubChem-compound Malate dehydrogenase FUM BioCyc SMILES OC(=O)CC(=O)C(O)=O P69054 UniProt 7732-18-5 CAS SMILES COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC CHEBI:18012 ChEBI Succinyl-CoA ligase [ADP-forming] subunit beta HMDB0001487 HMDB HMDB0000156 HMDB Fumarate hydratase class I, aerobic Aconitate hydratase 2 SMILES O[C@H]([C@H](CC(O)=O)C(O)=O)C(O)=O C6H4O2 Quinone 108.021126 NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 Hydroquinone 305 ChemSpider Aconitate hydratase 1 lipoamide dehydrogenase ReactionCatalysis2606 ACTIVATION Fumarate hydratase class I, aerobic 962 PubChem-compound 1.0 2.0 6061-97-8 CAS 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate Ubiquinone-1 C00080 KEGG Compound Oxoglutaric acid succinate:quinone oxidoreductase, FAD binding protein succinate dehydrogenase, FeS subunit HMDB0002111 HMDB HMDB0001022 HMDB 14265-44-2 CAS 2.0 58-64-0 CAS 585-84-2 CAS C00091 KEGG Compound succinate dehydrogenase fumarate reductase, membrane anchor subunit succinate dehydrogenase P61889 UniProt 444493 PubChem-compound 2.0 22833512 PubChem-compound ACETYL-COA BioCyc H2O Water 18.010565 HMDB0000072 HMDB 1.0 NADH BioCyc HMDB0002012 HMDB NAD BioCyc HMDB0059597 HMDB Carbon dioxide CIS-ACONITATE BioCyc 970 PubChem-compound P0ABH7 UniProt Fumarate hydratase class II SMILES OC(=O)\C=C\C(O)=O L-Malic acid P0A836 UniProt C4H6O5 L-Malic acid 134.02153 1.0 17215925 ChemSpider C4H4O5 Oxalacetic acid 132.00587 Succinic acid NADH cis-Aconitic acid 21883788 PubChem-compound SMILES O C6H8O7 D-threo-Isocitric acid 192.02701 CIT BioCyc Acetyl-CoA SubPathwayOutput HMDB0000538 HMDB P14407 UniProt 1.0 HMDB0001874 HMDB 1.0 6816 PubChem-compound 328-42-7 CAS 4477081 ChemSpider 51 PubChem-compound P0A9P0 UniProt SMILES O[C@@H](CC(O)=O)C(O)=O CHEBI:15846 ChEBI ADP BioCyc 53-59-8 CAS 1038 PubChem-compound D-threo-Isocitric acid GO:0005829 GENE ONTOLOGY ReactionCatalysis2558 ACTIVATION ReactionCatalysis2559 ACTIVATION 274 ChemSpider 4.0 P36683 UniProt C5H6O5 Oxoglutaric acid 146.02153 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2-oxoglutarate dehydrogenase E1 component CHEBI:16908 ChEBI 1.0 Isocitrate dehydrogenase [NADP] O4P Phosphate 94.95342 Oxalacetic acid C14H18O4 Ubiquinone-1 250.12051 Ubiquinol-1 NADPH 4650 PubChem-compound 77-92-9 CAS 558863 ChemSpider Succinyl-CoA ligase [ADP-forming] subunit alpha NADP C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis2561 ACTIVATION ReactionCatalysis2560 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis2562 ACTIVATION ReactionCatalysis2564 ACTIVATION NADPH BioCyc PW000787 PathWhiz 643757 PubChem-compound Fumaric acid PW000785 PathWhiz HMDB0000208 HMDB 236-TRICHLOROHYDROQUINONE BioCyc ReactionCatalysis2607 ACTIVATION L-Malic acid 58-68-4 CAS HMDB0001423 HMDB ReactionCatalysis2613 ACTIVATION ReactionCatalysis2612 ACTIVATION SMILES [O-]P([O-])([O-])=O HMDB0000217 HMDB SMILES OC(=O)CCC(=O)C(O)=O 2-oxoglutarate dehydrogenase PW000779 PathWhiz 124-38-9 CAS CHEBI:30915 ChEBI Citrate synthase monomer 1.0 2.0 HMDB0001429 HMDB 1.0 SMILES COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB succinyl-CoA synthetase Succinyl-CoA ligase [ADP-forming] subunit beta HMDB0000223 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Fumaric acid C4H4O4 Fumaric acid 116.010956 succinate:quinone oxidoreductase ReactionCatalysis2620 ACTIVATION 53-57-6 CAS CHEBI:15741 ChEBI 1.0 1.2.4.2 false 1.2.4.2 Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + NADH + Succinyl-CoA LEFT_TO_RIGHT SMILES O=C=O 1110 PubChem-compound P0AFG3 UniProt 2.0 P25516 UniProt C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound HMDB0001206 HMDB 2.0 CHEBI:151 ChEBI C4H6O4 Succinic acid 118.02661 C6H6O6 cis-Aconitic acid 174.01643 Citric acid Adenosine diphosphate P0AFG6 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 12.0 C6H8O7 Citric acid 192.02701 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 19782904 PubChem-compound 5682 ChemSpider CHEBI:1146900 ChEBI 5318532 PubChem-compound 1.1.1.37 false 1.1.1.37 L-Malic acid + NAD → Hydrogen Ion + NADH + Oxalacetic acid LEFT_TO_RIGHT 4.2.1.2 false 4.2.1.2 Fumaric acid + Water → L-Malic acid LEFT_TO_RIGHT 1.0 6.2.1.5 false 6.2.1.5 Adenosine diphosphate + Phosphate + Succinyl-CoA → Adenosine triphosphate + Coenzyme A + Succinic acid LEFT_TO_RIGHT Reaction2619 false Succinic acid + Ubiquinone-1 → Fumaric acid + Ubiquinol-1 LEFT_TO_RIGHT CO-A BioCyc 222656 PubChem-compound 5675 ChemSpider 1078 ChemSpider 72-89-9 CAS Fumarate hydratase class II Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 malate dehydrogenase CHEBI:15422 ChEBI 6557 ChemSpider Escherichia coli SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 1.0 CHEBI:16509 ChEBI Water PW000791 PathWhiz 4489 ChemSpider 1.0 CHEBI:16526 ChEBI 1.0 1.0 CPD-8130 BioCyc CHEBI:16761 ChEBI 1.0 P0AGE9 UniProt 123-31-9 CAS Succinic acid SubPathwayOutput 1.0 Reaction2630 false L-Malic acid + Quinone → Hydroquinone + Oxalacetic acid LEFT_TO_RIGHT 2-KETOGLUTARATE BioCyc 392413 ChemSpider 1.0 C14H20O4 Ubiquinol-1 252.13615 P05042 UniProt 5893 PubChem-compound 1.0 110-15-6 CAS SMILES O=C1C=CC(=O)C=C1 CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] P08200 UniProt Succinyl-CoA Citrate hydro-lyase (cis-aconitate-forming) Citrate hydro-lyase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound citrate dehydrogenase citrate synthase 1.0 SMILES OC1=CC=C(O)C=C1 280 PubChem-compound CHEBI:30744 ChEBI CHEBI:32805 ChEBI fumarase hydratase 2.0 4462 PubChem-compound C00417 KEGG Compound Malate:quinone oxidoreductase Citrate synthase monomer C00530 KEGG Compound Malate dehydrogenase 1.0 727-81-1 CAS Isocitrate dehydrogenase [NADP] Citric acid 193317 ChemSpider ReactionCatalysis2593 ACTIVATION 3-METHYLBENZYLSUCCINYL-COA BioCyc 1.0 1061 PubChem-compound 1.0 CPD-1941 BioCyc P07014 UniProt HMDB0001967 HMDB 106-51-4 CAS Aconitate hydratase 2 CHEBI:15351 ChEBI 85-61-0 CAS