Loading Pathway...
Serine Biosynthesis and Metabolism SubPathway 6022 PubChem-compound 2.0 Phosphocarrier protein HPr C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider ReactionCoupledTransportCatalysis172 ACTIVATION Glucose-specific phosphotransferase enzyme IIA component 439278 PubChem-compound 439153 PubChem-compound ReactionCatalysis5121 ACTIVATION 1.0 58238 ChemSpider Phosphoenolpyruvate synthase C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 CHEBI:16027 ChEBI 6251 PubChem-compound NAD Pyruvate kinase I ATP BioCyc PTS system glucose-specific EIICB component 1.0 1.2.4.1 false 1.2.4.1 Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH LEFT_TO_RIGHT 1.0 HMDB0003498 HMDB P0AA04 UniProt C00579 KEGG Compound 1.0 Glyceraldehyde-3-phosphate dehydrogenase A Fucose and Rhamnose Degradation SubPathway 6-phosphofructokinase II 2.0 CHEBI:15380 ChEBI Fructose-1,6-bisphosphatase class 1 Fructose-bisphosphate aldolase class 1 5742 ChemSpider NADH 6-phosphofructokinase I C25H40N7O19P3S Succinyl-CoA 867.1312 Fructose 1,6-bisphosphate 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1.0 ReactionCatalysis5143 ACTIVATION ReactionCatalysis5144 ACTIVATION P0AD61 UniProt Lipopolysaccharide Biosynthesis SubPathway mannitol-1-phosphate 5-dehydrogenase 5858 ChemSpider C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 Adenosine monophosphate HMDB0003391 HMDB 709 ChemSpider 1.0 P0A9B2 UniProt C00221 KEGG Compound Acetyl-CoA 704 ChemSpider Fructose-1,6-bisphosphatase class 2 1010 ChemSpider CHEBI:17694 ChEBI SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 488-69-7 CAS 15806-48-1 CAS 4.0 138-08-9 CAS C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 2.0 Glyceraldehyde 3-phosphate dehydrogenase 1046 ChemSpider SMP0000846 SMPDB Hydrogen Ion C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Enolase Cytosol Uncharacterized protein yggF C00236 KEGG Compound 1.0 C00597 KEGG Compound glucose PTS permease Adenosine triphosphate C00354 KEGG Compound CHEBI:16298 ChEBI Glucose-6-phosphate isomerase Fructose 1,6-bisphosphate Fructose-1,6-bisphosphatase class 1 Phosphoenolpyruvic acid C00009 KEGG Compound 1.0 C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Hydrogen Ion 3-Phosphoglyceric acid C00001 KEGG Compound Fructose 6-phosphate SubPathwayInput C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider Phosphocarrier protein HPr SMP0000851 SMPDB Glycolysis and Pyruvate Dehydrogenase 388411 ChemSpider 388538 ChemSpider C21H28N7O14P2 NAD 664.11694 388536 ChemSpider TCA Cycle SubPathway Adenosine triphosphate C00011 KEGG Compound C00010 KEGG Compound HMDB0000902 HMDB FRUCTOSE-6P BioCyc phosphoenolpyruvate synthetase 2.7.1.69 false 2.7.1.69 Beta-D-Glucose + HPr - phosphorylated → Beta-D-Glucose 6-phosphate + HPr LEFT_TO_RIGHT 562 TAXONOMY S-ACETYLDIHYDROLIPOAMIDE BioCyc CHEBI:17138 ChEBI Pyruvic acid H Hydrogen Ion 1.007825 D-Glyceraldehyde 3-phosphate 388307 ChemSpider C6H14O6 Mannitol 182.07904 C00022 KEGG Compound Unknown 56-65-5 CAS Glyceric acid 1,3-biphosphate fructose-1,6-bisphosphatase 53-84-9 CAS C00020 KEGG Compound Pyruvate kinase II SMILES NC(=O)CCCC[C@H](CCS)SC(=O)CCC(O)=O Fructose-bisphosphate aldolase class 2 1.0 Unknown 62713 ChemSpider C00024 KEGG Compound P0A796 UniProt 2.0 Phosphoglycerate kinase P0A799 UniProt C00392 KEGG Compound P21829 UniProt 2,3-bisphosphoglycerate-independent phosphoglycerate mutase SMP0000802 SMPDB SMP0000807 SMPDB 1.0 Unknown SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Water AMP BioCyc 492-61-5 CAS PTS system glucose-specific EIICB component HMDB0001341 HMDB SubPathwayInteraction83464 SubPathway83464Reaction SubPathwayReaction 648 ChemSpider C01136 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 HMDB0001112 HMDB 643 ChemSpider 604-98-8 CAS PHOSPHO-ENOL-PYRUVATE BioCyc P0A858 UniProt Mannitol 1-phosphate 24.0 HMDB0000263 HMDB SMILES OC(=O)C(=C)OP(O)(O)=O HMDB0001473 HMDB 64689 PubChem-compound MANNITOL-1P BioCyc 663 PubChem-compound CPD0-341 BioCyc C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound 7732-18-5 CAS 1.0 SMP0000829 SMPDB P0A991 UniProt 591-59-3 CAS HMDB0001487 HMDB 61-19-8 CAS SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 triosephosphate isomerase 1.0 Triosephosphate isomerase P06999 UniProt NAD SubPathwayInteraction83484 SubPathway83484Reaction SubPathwayReaction C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 4.0 1.0 445557 PubChem-compound P0A6T1 UniProt P0A993 UniProt 2-Phospho-D-glyceric acid SMILES CC(=O)C(O)=O HMDB0000045 HMDB 663 ChemSpider C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI Dihydrolipoamide SMILES OCC(=O)COP(O)(O)=O C8H17NOS2 Dihydrolipoamide 207.07515 3-Phosphoglyceric acid SubPathwayInput 962 PubChem-compound Beta-D-Glucose 724 PubChem-compound 5800 ChemSpider CO2 Carbon dioxide 43.98983 C01169 KEGG Compound C00080 KEGG Compound 4.0 C00085 KEGG Compound Pyruvate kinase I C01172 KEGG Compound 729 PubChem-compound HMDB0002111 HMDB HMDB0001022 HMDB 4.0 CHEBI:44897 ChEBI 14265-44-2 CAS PYRUVATE BioCyc 58-64-0 CAS SubPathwayInteraction83303 SubPathway83303Reaction SubPathwayReaction C00091 KEGG Compound PW000809 PathWhiz G3P BioCyc 4.0 ReactionCatalysis2902 ACTIVATION HMDB0001270 HMDB 2.0 1.0 444493 PubChem-compound 1.0 6083 PubChem-compound Fructose-bisphosphate aldolase class 1 2-PG BioCyc 1.0 Glucose-specific phosphotransferase enzyme IIA component ACETYL-COA BioCyc 60.0 H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 393165 ChemSpider NADH BioCyc P06959 UniProt NAD BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex HMDB0059597 HMDB P37689 UniProt Carbon dioxide 1.0 SubPathwayInteraction83449 SubPathwayReaction SubPathway83449Reaction HMDB0001058 HMDB SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O SMILES CC(=O)SC(CCS)CCCCC(N)=O Enolase 980 ChemSpider CHEBI:15903 ChEBI P0A6P9 UniProt 820-11-1 CAS HMDB0001177 HMDB 2-Phospho-D-glyceric acid 1.1.1.17 false 1.1.1.17 Fructose 6-phosphate + Hydrogen Ion + NADH ↔ Mannitol 1-phosphate + NAD REVERSIBLE 1.0 Glyceraldehyde-3-phosphate dehydrogenase A 6015 ChemSpider NADH 1.0 enolase 1.0 SMILES O pyruvate kinase Acetyl-CoA SubPathwayInput C6H12O6 Beta-D-Glucose 180.06339 C10H14N5O7P Adenosine monophosphate 347.06308 Glucose-6-phosphate isomerase CHEBI:16807 ChEBI P62707 UniProt C6H13O9P Beta-D-glucose 6-phosphate 260.02972 2.3.1.12 false 2.3.1.12 Acetyl-CoA + Dihydrolipoamide ↔ Coenzyme A + S-Acetyldihydrolipoamide REVERSIBLE Reaction5173 false Dihydrolipoamide + Succinyl-CoA → (S)-Succinyldihydrolipoamide + Coenzyme A LEFT_TO_RIGHT HMDB0000538 HMDB 1005 PubChem-compound 643-13-0 CAS 1.0 1981-49-3 CAS Dihydroxyacetone phosphate 1.0 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Water Pyruvic acid CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 ReactionCatalysis2542 ACTIVATION fructose bisphosphate aldolase 1.0 1038 PubChem-compound Pyruvate kinase II GO:0005829 GENE ONTOLOGY Phosphatase ybhA HMDB0001526 HMDB 274 ChemSpider CHEBI:16905 ChEBI CHEBI:16908 ChEBI 1.0 PTS system mannitol-specific EIICBA component PW000831 PathWhiz O4P Phosphate 94.95342 GO:0070258 GENE ONTOLOGY 1.0 HMDB0001530 HMDB fructose 1,6-bisphosphatase 2 CHEBI:15946 ChEBI Phosphoglycerate kinase PW000826 PathWhiz PW000785 PathWhiz P00550 UniProt 1.0 mannitol PTS permease 683 PubChem-compound 58-68-4 CAS 10.0 HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O C6H13O9P Fructose 6-phosphate 260.02972 124-38-9 CAS PW000779 PathWhiz CHEBI:17835 ChEBI 5.3.1.1 false 5.3.1.1 D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate REVERSIBLE DIHYDROLIPOAMIDE BioCyc HMDB0001429 HMDB 1.0 130418 PubChem-compound P69783 UniProt Inner Membrane Mannitol 1-phosphate ReactionCatalysis2622 ACTIVATION ReactionCatalysis2621 ACTIVATION P69786 UniProt C10H19NO2S2 S-Acetyldihydrolipoamide 249.08572 ReactionCatalysis2624 ACTIVATION C6H15O9P Mannitol 1-phosphate 262.04538 ReactionCatalysis2623 ACTIVATION ReactionCatalysis2626 ACTIVATION ReactionCatalysis2625 ACTIVATION S-Acetyldihydrolipoamide ReactionCatalysis2628 ACTIVATION ReactionCatalysis2627 ACTIVATION 115387 ChemSpider 57-04-5 CAS 69507 PubChem-compound Beta-D-glucose 6-phosphate 1.0 2.0 Mannitol ReactionCatalysis2629 ACTIVATION SMILES O=C=O ReactionCatalysis2633 ACTIVATION ReactionCatalysis2632 ACTIVATION ReactionCatalysis2634 ACTIVATION Fructose 6-phosphate C21H29N7O14P2 NADH 665.12476 1.0 5957 PubChem-compound HMDB0001206 HMDB Triosephosphate isomerase 1.0 ReactionCatalysis2631 ACTIVATION Beta-D-Glucose 6-phosphate ReactionCatalysis2630 ACTIVATION 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 6-phosphofructokinase II 6-phosphofructokinase I phosphoglycerate mutase 6-phosphofructokinase-1 Adenosine diphosphate HMDB0000243 HMDB C3H5O6P Phosphoenolpyruvic acid 167.98238 HMDB0000124 HMDB C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase GO:0005737 GENE ONTOLOGY D-Glyceraldehyde 3-phosphate Phosphoenolpyruvic acid 2.0 1.0 CHEBI:16899 ChEBI SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc HMDB0000807 HMDB 5682 ChemSpider Dihydroxyacetone phosphate SubPathwayOutput CHEBI:1146900 ChEBI 10.0 1.0 Fructose-1,6-bisphosphatase class 2 CO-A BioCyc SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 72-89-9 CAS Coenzyme A Fructose-1,6-bisphosphatase 1 C21H36N7O16P3S Coenzyme A 767.11523 SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O 1.0 1.0 Cytoplasm 439425 PubChem-compound 439427 PubChem-compound CHEBI:15422 ChEBI 6557 ChemSpider Escherichia coli SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 2.0 388299 ChemSpider Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex 1.0 P21599 UniProt P23538 UniProt 2.7.9.2 false 2.7.9.2 Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid + Water LEFT_TO_RIGHT Hydrogen Ion 127-17-3 CAS 1.0 CHEBI:17719 ChEBI 2.7.1.40 false 2.7.1.40 Adenosine diphosphate + Hydrogen Ion + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid LEFT_TO_RIGHT Water FRUCTOSE-16-DIPHOSPHATE BioCyc 2.7.1.69 false 2.7.1.69 HPr - phosphorylated + Mannitol → HPr + Mannitol 1-phosphate LEFT_TO_RIGHT mannitol-1-phosphate 5-dehydrogenase Reaction2638 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 1.0 4.2.1.11 false 4.2.1.11 2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Water LEFT_TO_RIGHT CHEBI:16526 ChEBI SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 1.0 1.0 CHEBI:16761 ChEBI 2.7.2.3 false 2.7.2.3 Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate LEFT_TO_RIGHT Reaction2637 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE 1.0 1.2.1.12 false 1.2.1.12 D-Glyceraldehyde 3-phosphate + NAD + Phosphate → Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 6-phosphate + Phosphate → Fructose 1,6-bisphosphate + Water LEFT_TO_RIGHT Reaction2633 false Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate + Hydrogen Ion LEFT_TO_RIGHT 5.3.1.9 false 5.3.1.9 Beta-D-glucose 6-phosphate → Fructose 6-phosphate LEFT_TO_RIGHT 1.0 Unknown Unknown 392413 ChemSpider SMILES OC(COP(O)(O)=O)C(O)=O 69-65-8 CAS Phosphatase ybhA P0A9C9 UniProt C00631 KEGG Compound 5893 PubChem-compound 1.0 Pyruvate dehydrogenase complex CHEBI:32816 ChEBI 1.0 CHEBI:15377 ChEBI C12H21NO4S2 (S)-Succinyldihydrolipoamide 307.0912 CHEBI:15378 ChEBI SMILES [H+] C00644 KEGG Compound Phosphoenolpyruvate synthase Succinyl-CoA CHEBI:16108 ChEBI SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 60.0 Glyceric acid 1,3-biphosphate CHEBI:17432 ChEBI Unknown Phosphate 1.0 SMILES OC[C@@H](OP(O)(O)=O)C(O)=O Phosphate 1.0 HMDB0000985 HMDB 280 PubChem-compound SMILES OC(=N)CCCCC(S)CCS 1.0 2.0 PTS system mannitol-specific EIICBA component (S)-Succinyldihydrolipoamide P09424 UniProt 2.0 SMILES OC(COP(O)(O)=O)C=O 1076 PubChem-compound Fructose-bisphosphate aldolase class 2 P21437 UniProt 3-METHYLBENZYLSUCCINYL-COA BioCyc 1060 PubChem-compound GAP BioCyc 1061 PubChem-compound ReactionCoupledTransportCatalysis205 ACTIVATION HMDB0000516 HMDB C00661 KEGG Compound HMDB0001967 HMDB Uncharacterized protein yggF CHEBI:15351 ChEBI 3884-47-7 CAS HMDB0000765 HMDB 85-61-0 CAS P0AB71 UniProt Glucose-6- phosphate isomerase 6- phosphofructokinase I 6- phosphofructokinase II Phosphoglycerate kinase 2,3- bisphosphoglycerate- dependent phosphoglycerate mutase Enolase Pyruvate kinase I Pyruvate kinase II Unknown Unknown Unknown Unknown Triosephosphate isomerase mannitol-1- phosphate 5-dehydrogenase Dihydrolipoyllysine- residue acetyltransferase component of pyruvate dehydrogenase complex Dihydrolipoyllysine- residue acetyltransferase component of pyruvate dehydrogenase complex 2,3- bisphosphoglycerate- independent phosphoglycerate mutase Phosphoenolpyruvate synthase Fructose- bisphosphate aldolase class 1 Fructose- bisphosphate aldolase class 2 Fructose-1,6- bisphosphatase class 2 Uncharacterized protein yggF Fructose-1,6- bisphosphatase class 1 Phosphatase ybhA Glyceraldehyde- 3-phosphate dehydrogenase A Phosphocarrier protein HPr Phosphocarrier protein HPr PTS system glucose- specific EIICB component Glucose- specific phosphotransferase enzyme IIA component Phosphocarrier protein HPr Phosphocarrier protein HPr PTS system mannitol- specific EIICBA component Fructose 6-phosphate Dihydroxyacetone phosphate 3- Phosphoglyceric acid Acetyl-CoA Beta-D-glucose 6-phosphate ATP Fructose 1,6- bisphosphate ADP H + Glyceric acid 1,3-biphosphate ADP ATP 2-Phospho-D- glyceric acid Phosphoenolpyruvic acid H 2 O ADP H + ATP Pyruvic acid CoA NAD CO 2 NADH D- Glyceraldehyde 3-phosphate NADH H + NAD Mannitol 1-phosphate Dihydrolipoamide CoA S- Acetyldihydrolipoamide Succinyl-CoA CoA (S)- Succinyldihydrolipoamide AMP P i H + ATP H 2 O P i H 2 O NAD P i NADH H + Beta-D-Glucose 6-phosphate Beta-D-Glucose 6-phosphate Mannitol Lipopolysaccharide Biosynthesis Fucose and Rhamnose Degradation Serine Biosynthesis and Metabolism TCA Cycle
Serine Biosynthesis and Metabolism SubPathway 6022 PubChem-compound 2.0 Phosphocarrier protein HPr C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider ReactionCoupledTransportCatalysis172 ACTIVATION Glucose-specific phosphotransferase enzyme IIA component 439278 PubChem-compound 439153 PubChem-compound ReactionCatalysis5121 ACTIVATION 1.0 58238 ChemSpider Phosphoenolpyruvate synthase C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 CHEBI:16027 ChEBI 6251 PubChem-compound NAD Pyruvate kinase I ATP BioCyc PTS system glucose-specific EIICB component 1.0 1.2.4.1 false 1.2.4.1 Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH LEFT_TO_RIGHT 1.0 HMDB0003498 HMDB P0AA04 UniProt C00579 KEGG Compound 1.0 Glyceraldehyde-3-phosphate dehydrogenase A Fucose and Rhamnose Degradation SubPathway 6-phosphofructokinase II 2.0 CHEBI:15380 ChEBI Fructose-1,6-bisphosphatase class 1 Fructose-bisphosphate aldolase class 1 5742 ChemSpider NADH 6-phosphofructokinase I C25H40N7O19P3S Succinyl-CoA 867.1312 Fructose 1,6-bisphosphate 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1.0 ReactionCatalysis5143 ACTIVATION ReactionCatalysis5144 ACTIVATION P0AD61 UniProt Lipopolysaccharide Biosynthesis SubPathway mannitol-1-phosphate 5-dehydrogenase 5858 ChemSpider C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 Adenosine monophosphate HMDB0003391 HMDB 709 ChemSpider 1.0 P0A9B2 UniProt C00221 KEGG Compound Acetyl-CoA 704 ChemSpider Fructose-1,6-bisphosphatase class 2 1010 ChemSpider CHEBI:17694 ChEBI SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 488-69-7 CAS 15806-48-1 CAS 4.0 138-08-9 CAS C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 2.0 Glyceraldehyde 3-phosphate dehydrogenase 1046 ChemSpider SMP0000846 SMPDB Hydrogen Ion C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Enolase Cytosol Uncharacterized protein yggF C00236 KEGG Compound 1.0 C00597 KEGG Compound glucose PTS permease Adenosine triphosphate C00354 KEGG Compound CHEBI:16298 ChEBI Glucose-6-phosphate isomerase Fructose 1,6-bisphosphate Fructose-1,6-bisphosphatase class 1 Phosphoenolpyruvic acid C00009 KEGG Compound 1.0 C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Hydrogen Ion 3-Phosphoglyceric acid C00001 KEGG Compound Fructose 6-phosphate SubPathwayInput C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider Phosphocarrier protein HPr SMP0000851 SMPDB Glycolysis and Pyruvate Dehydrogenase 388411 ChemSpider 388538 ChemSpider C21H28N7O14P2 NAD 664.11694 388536 ChemSpider TCA Cycle SubPathway Adenosine triphosphate C00011 KEGG Compound C00010 KEGG Compound HMDB0000902 HMDB FRUCTOSE-6P BioCyc phosphoenolpyruvate synthetase 2.7.1.69 false 2.7.1.69 Beta-D-Glucose + HPr - phosphorylated → Beta-D-Glucose 6-phosphate + HPr LEFT_TO_RIGHT 562 TAXONOMY S-ACETYLDIHYDROLIPOAMIDE BioCyc CHEBI:17138 ChEBI Pyruvic acid H Hydrogen Ion 1.007825 D-Glyceraldehyde 3-phosphate 388307 ChemSpider C6H14O6 Mannitol 182.07904 C00022 KEGG Compound Unknown 56-65-5 CAS Glyceric acid 1,3-biphosphate fructose-1,6-bisphosphatase 53-84-9 CAS C00020 KEGG Compound Pyruvate kinase II SMILES NC(=O)CCCC[C@H](CCS)SC(=O)CCC(O)=O Fructose-bisphosphate aldolase class 2 1.0 Unknown 62713 ChemSpider C00024 KEGG Compound P0A796 UniProt 2.0 Phosphoglycerate kinase P0A799 UniProt C00392 KEGG Compound P21829 UniProt 2,3-bisphosphoglycerate-independent phosphoglycerate mutase SMP0000802 SMPDB SMP0000807 SMPDB 1.0 Unknown SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Water AMP BioCyc 492-61-5 CAS PTS system glucose-specific EIICB component HMDB0001341 HMDB SubPathwayInteraction83464 SubPathway83464Reaction SubPathwayReaction 648 ChemSpider C01136 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 HMDB0001112 HMDB 643 ChemSpider 604-98-8 CAS PHOSPHO-ENOL-PYRUVATE BioCyc P0A858 UniProt Mannitol 1-phosphate 24.0 HMDB0000263 HMDB SMILES OC(=O)C(=C)OP(O)(O)=O HMDB0001473 HMDB 64689 PubChem-compound MANNITOL-1P BioCyc 663 PubChem-compound CPD0-341 BioCyc C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound 7732-18-5 CAS 1.0 SMP0000829 SMPDB P0A991 UniProt 591-59-3 CAS HMDB0001487 HMDB 61-19-8 CAS SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 triosephosphate isomerase 1.0 Triosephosphate isomerase P06999 UniProt NAD SubPathwayInteraction83484 SubPathway83484Reaction SubPathwayReaction C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 4.0 1.0 445557 PubChem-compound P0A6T1 UniProt P0A993 UniProt 2-Phospho-D-glyceric acid SMILES CC(=O)C(O)=O HMDB0000045 HMDB 663 ChemSpider C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI Dihydrolipoamide SMILES OCC(=O)COP(O)(O)=O C8H17NOS2 Dihydrolipoamide 207.07515 3-Phosphoglyceric acid SubPathwayInput 962 PubChem-compound Beta-D-Glucose 724 PubChem-compound 5800 ChemSpider CO2 Carbon dioxide 43.98983 C01169 KEGG Compound C00080 KEGG Compound 4.0 C00085 KEGG Compound Pyruvate kinase I C01172 KEGG Compound 729 PubChem-compound HMDB0002111 HMDB HMDB0001022 HMDB 4.0 CHEBI:44897 ChEBI 14265-44-2 CAS PYRUVATE BioCyc 58-64-0 CAS SubPathwayInteraction83303 SubPathway83303Reaction SubPathwayReaction C00091 KEGG Compound PW000809 PathWhiz G3P BioCyc 4.0 ReactionCatalysis2902 ACTIVATION HMDB0001270 HMDB 2.0 1.0 444493 PubChem-compound 1.0 6083 PubChem-compound Fructose-bisphosphate aldolase class 1 2-PG BioCyc 1.0 Glucose-specific phosphotransferase enzyme IIA component ACETYL-COA BioCyc 60.0 H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 393165 ChemSpider NADH BioCyc P06959 UniProt NAD BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex HMDB0059597 HMDB P37689 UniProt Carbon dioxide 1.0 SubPathwayInteraction83449 SubPathwayReaction SubPathway83449Reaction HMDB0001058 HMDB SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O SMILES CC(=O)SC(CCS)CCCCC(N)=O Enolase 980 ChemSpider CHEBI:15903 ChEBI P0A6P9 UniProt 820-11-1 CAS HMDB0001177 HMDB 2-Phospho-D-glyceric acid 1.1.1.17 false 1.1.1.17 Fructose 6-phosphate + Hydrogen Ion + NADH ↔ Mannitol 1-phosphate + NAD REVERSIBLE 1.0 Glyceraldehyde-3-phosphate dehydrogenase A 6015 ChemSpider NADH 1.0 enolase 1.0 SMILES O pyruvate kinase Acetyl-CoA SubPathwayInput C6H12O6 Beta-D-Glucose 180.06339 C10H14N5O7P Adenosine monophosphate 347.06308 Glucose-6-phosphate isomerase CHEBI:16807 ChEBI P62707 UniProt C6H13O9P Beta-D-glucose 6-phosphate 260.02972 2.3.1.12 false 2.3.1.12 Acetyl-CoA + Dihydrolipoamide ↔ Coenzyme A + S-Acetyldihydrolipoamide REVERSIBLE Reaction5173 false Dihydrolipoamide + Succinyl-CoA → (S)-Succinyldihydrolipoamide + Coenzyme A LEFT_TO_RIGHT HMDB0000538 HMDB 1005 PubChem-compound 643-13-0 CAS 1.0 1981-49-3 CAS Dihydroxyacetone phosphate 1.0 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Water Pyruvic acid CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 ReactionCatalysis2542 ACTIVATION fructose bisphosphate aldolase 1.0 1038 PubChem-compound Pyruvate kinase II GO:0005829 GENE ONTOLOGY Phosphatase ybhA HMDB0001526 HMDB 274 ChemSpider CHEBI:16905 ChEBI CHEBI:16908 ChEBI 1.0 PTS system mannitol-specific EIICBA component PW000831 PathWhiz O4P Phosphate 94.95342 GO:0070258 GENE ONTOLOGY 1.0 HMDB0001530 HMDB fructose 1,6-bisphosphatase 2 CHEBI:15946 ChEBI Phosphoglycerate kinase PW000826 PathWhiz PW000785 PathWhiz P00550 UniProt 1.0 mannitol PTS permease 683 PubChem-compound 58-68-4 CAS 10.0 HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O C6H13O9P Fructose 6-phosphate 260.02972 124-38-9 CAS PW000779 PathWhiz CHEBI:17835 ChEBI 5.3.1.1 false 5.3.1.1 D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate REVERSIBLE DIHYDROLIPOAMIDE BioCyc HMDB0001429 HMDB 1.0 130418 PubChem-compound P69783 UniProt Inner Membrane Mannitol 1-phosphate ReactionCatalysis2622 ACTIVATION ReactionCatalysis2621 ACTIVATION P69786 UniProt C10H19NO2S2 S-Acetyldihydrolipoamide 249.08572 ReactionCatalysis2624 ACTIVATION C6H15O9P Mannitol 1-phosphate 262.04538 ReactionCatalysis2623 ACTIVATION ReactionCatalysis2626 ACTIVATION ReactionCatalysis2625 ACTIVATION S-Acetyldihydrolipoamide ReactionCatalysis2628 ACTIVATION ReactionCatalysis2627 ACTIVATION 115387 ChemSpider 57-04-5 CAS 69507 PubChem-compound Beta-D-glucose 6-phosphate 1.0 2.0 Mannitol ReactionCatalysis2629 ACTIVATION SMILES O=C=O ReactionCatalysis2633 ACTIVATION ReactionCatalysis2632 ACTIVATION ReactionCatalysis2634 ACTIVATION Fructose 6-phosphate C21H29N7O14P2 NADH 665.12476 1.0 5957 PubChem-compound HMDB0001206 HMDB Triosephosphate isomerase 1.0 ReactionCatalysis2631 ACTIVATION Beta-D-Glucose 6-phosphate ReactionCatalysis2630 ACTIVATION 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 6-phosphofructokinase II 6-phosphofructokinase I phosphoglycerate mutase 6-phosphofructokinase-1 Adenosine diphosphate HMDB0000243 HMDB C3H5O6P Phosphoenolpyruvic acid 167.98238 HMDB0000124 HMDB C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase GO:0005737 GENE ONTOLOGY D-Glyceraldehyde 3-phosphate Phosphoenolpyruvic acid 2.0 1.0 CHEBI:16899 ChEBI SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc HMDB0000807 HMDB 5682 ChemSpider Dihydroxyacetone phosphate SubPathwayOutput CHEBI:1146900 ChEBI 10.0 1.0 Fructose-1,6-bisphosphatase class 2 CO-A BioCyc SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 72-89-9 CAS Coenzyme A Fructose-1,6-bisphosphatase 1 C21H36N7O16P3S Coenzyme A 767.11523 SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O 1.0 1.0 Cytoplasm 439425 PubChem-compound 439427 PubChem-compound CHEBI:15422 ChEBI 6557 ChemSpider Escherichia coli SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 2.0 388299 ChemSpider Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex 1.0 P21599 UniProt P23538 UniProt 2.7.9.2 false 2.7.9.2 Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid + Water LEFT_TO_RIGHT Hydrogen Ion 127-17-3 CAS 1.0 CHEBI:17719 ChEBI 2.7.1.40 false 2.7.1.40 Adenosine diphosphate + Hydrogen Ion + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid LEFT_TO_RIGHT Water FRUCTOSE-16-DIPHOSPHATE BioCyc 2.7.1.69 false 2.7.1.69 HPr - phosphorylated + Mannitol → HPr + Mannitol 1-phosphate LEFT_TO_RIGHT mannitol-1-phosphate 5-dehydrogenase Reaction2638 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 1.0 4.2.1.11 false 4.2.1.11 2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Water LEFT_TO_RIGHT CHEBI:16526 ChEBI SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 1.0 1.0 CHEBI:16761 ChEBI 2.7.2.3 false 2.7.2.3 Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate LEFT_TO_RIGHT Reaction2637 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE 1.0 1.2.1.12 false 1.2.1.12 D-Glyceraldehyde 3-phosphate + NAD + Phosphate → Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 6-phosphate + Phosphate → Fructose 1,6-bisphosphate + Water LEFT_TO_RIGHT Reaction2633 false Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate + Hydrogen Ion LEFT_TO_RIGHT 5.3.1.9 false 5.3.1.9 Beta-D-glucose 6-phosphate → Fructose 6-phosphate LEFT_TO_RIGHT 1.0 Unknown Unknown 392413 ChemSpider SMILES OC(COP(O)(O)=O)C(O)=O 69-65-8 CAS Phosphatase ybhA P0A9C9 UniProt C00631 KEGG Compound 5893 PubChem-compound 1.0 Pyruvate dehydrogenase complex CHEBI:32816 ChEBI 1.0 CHEBI:15377 ChEBI C12H21NO4S2 (S)-Succinyldihydrolipoamide 307.0912 CHEBI:15378 ChEBI SMILES [H+] C00644 KEGG Compound Phosphoenolpyruvate synthase Succinyl-CoA CHEBI:16108 ChEBI SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 60.0 Glyceric acid 1,3-biphosphate CHEBI:17432 ChEBI Unknown Phosphate 1.0 SMILES OC[C@@H](OP(O)(O)=O)C(O)=O Phosphate 1.0 HMDB0000985 HMDB 280 PubChem-compound SMILES OC(=N)CCCCC(S)CCS 1.0 2.0 PTS system mannitol-specific EIICBA component (S)-Succinyldihydrolipoamide P09424 UniProt 2.0 SMILES OC(COP(O)(O)=O)C=O 1076 PubChem-compound Fructose-bisphosphate aldolase class 2 P21437 UniProt 3-METHYLBENZYLSUCCINYL-COA BioCyc 1060 PubChem-compound GAP BioCyc 1061 PubChem-compound ReactionCoupledTransportCatalysis205 ACTIVATION HMDB0000516 HMDB C00661 KEGG Compound HMDB0001967 HMDB Uncharacterized protein yggF CHEBI:15351 ChEBI 3884-47-7 CAS HMDB0000765 HMDB 85-61-0 CAS P0AB71 UniProt