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6022 PubChem-compound 2.0 Phosphocarrier protein HPr C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider ReactionCoupledTransportCatalysis172 ACTIVATION SubPathwayInteraction1560 SubPathwayReaction SubPathway1560Reaction HMDB01341 HMDB Glucose-specific phosphotransferase enzyme IIA component 439278 PubChem-compound 439153 PubChem-compound ReactionCatalysis5121 ACTIVATION 1.0 58238 ChemSpider HMDB01112 HMDB C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 CHEBI:16027 ChEBI 6251 PubChem-compound NAD Pyruvate kinase I ATP BioCyc HMDB00263 HMDB PTS system glucose-specific EIICB component HMDB01473 HMDB 1.0 1.2.4.1 false 1.2.4.1 Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH LEFT_TO_RIGHT 1.0 P0AA04 UniProt C00579 KEGG Compound 1.0 Glyceraldehyde-3-phosphate dehydrogenase A HMDB01206 HMDB Fructose-1,6-bisphosphatase class 1 6-phosphofructokinase II 2.0 CHEBI:15380 ChEBI 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Fructose-bisphosphate aldolase class 1 5742 ChemSpider 6-phosphofructokinase I C25H40N7O19P3S Succinyl-CoA 867.1312 Fructose 1,6-bisphosphate 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1.0 HMDB59597 HMDB ReactionCatalysis5143 ACTIVATION ReactionCatalysis5144 ACTIVATION P0AD61 UniProt mannitol-1-phosphate 5-dehydrogenase 5858 ChemSpider HMDB00243 HMDB HMDB00124 HMDB C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 P0A9B2 UniProt 709 ChemSpider 1.0 C00221 KEGG Compound Acetyl-CoA 704 ChemSpider Fructose-1,6-bisphosphatase class 2 1010 ChemSpider CHEBI:17694 ChEBI SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 488-69-7 CAS 15806-48-1 CAS 4.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 138-08-9 CAS BiologicalState109 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 2.0 1.0 HMDB01423 HMDB 1046 ChemSpider Hydrogen Ion C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Uncharacterized protein yggF Enolase C00236 KEGG Compound C00597 KEGG Compound glucose PTS permease C00354 KEGG Compound Adenosine triphosphate CHEBI:16298 ChEBI Glucose-6-phosphate isomerase C00009 KEGG Compound 1.0 C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O C00001 KEGG Compound 3-Phosphoglyceric acid CHEBI:18367 ChEBI C00004 KEGG Compound serine biosynthesis and metabolism SubPathway 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 1031 ChemSpider Phosphocarrier protein HPr HMDB01429 HMDB 2.0 388411 ChemSpider 388538 ChemSpider C21H28N7O14P2 NAD 664.11694 HMDB01526 HMDB 388536 ChemSpider C00011 KEGG Compound C00010 KEGG Compound FRUCTOSE-6P BioCyc SubPathwayInteraction1661 SubPathwayReaction SubPathway1661Reaction 2.7.1.69 false 2.7.1.69 Beta-D-Glucose + HPr - phosphorylated → Beta-D-Glucose 6-phosphate + HPr LEFT_TO_RIGHT 562 TAXONOMY S-ACETYLDIHYDROLIPOAMIDE BioCyc CHEBI:17138 ChEBI H Hydrogen Ion 1.007825 HMDB01530 HMDB D-Glyceraldehyde 3-phosphate lipopolysaccharide biosynthesis SubPathway 388307 ChemSpider C6H14O6 Mannitol 182.07904 C00022 KEGG Compound Unknown 56-65-5 CAS Glyceric acid 1,3-biphosphate 53-84-9 CAS C00020 KEGG Compound Pyruvate kinase II Fructose-bisphosphate aldolase class 2 SMILES NC(=O)CCCC[C@H](CCS)SC(=O)CCC(O)=O 1.0 Unknown 62713 ChemSpider C00024 KEGG Compound P0A796 UniProt Phosphoglycerate kinase P0A799 UniProt 2.0 C00392 KEGG Compound Phosphatase ybhA P21829 UniProt Phosphoenolpyruvate synthase SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Unknown Water AMP BioCyc 492-61-5 CAS PTS system glucose-specific EIICB component 648 ChemSpider C01136 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 643 ChemSpider 604-98-8 CAS PHOSPHO-ENOL-PYRUVATE BioCyc P0A858 UniProt HMDB00538 HMDB Mannitol 1-phosphate 24.0 SMILES OC(=O)C(=C)OP(O)(O)=O 64689 PubChem-compound MANNITOL-1P BioCyc 663 PubChem-compound CPD0-341 BioCyc C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound 7732-18-5 CAS 1.0 P0A991 UniProt 591-59-3 CAS 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O 1.0 triosephosphate isomerase Triosephosphate isomerase P06999 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc HMDB00765 HMDB DIHYDROXY-ACETONE-PHOSPHATE BioCyc 4.0 1.0 445557 PubChem-compound P0A6T1 UniProt P0A993 UniProt 2-Phospho-D-glyceric acid SMILES CC(=O)C(O)=O 663 ChemSpider C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI Dihydrolipoamide SMILES OCC(=O)COP(O)(O)=O HMDB01967 HMDB HMDB00516 HMDB C8H17NOS2 Dihydrolipoamide 207.07515 962 PubChem-compound Beta-D-Glucose 724 PubChem-compound 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate C01169 KEGG Compound C00080 KEGG Compound 4.0 C00085 KEGG Compound Pyruvate kinase I C01172 KEGG Compound 729 PubChem-compound 14265-44-2 CAS CHEBI:44897 ChEBI PYRUVATE BioCyc HMDB00985 HMDB 58-64-0 CAS Glyceraldehyde-3-phosphate dehydrogenase A Fructose-1,6-bisphosphatase class 1 C00091 KEGG Compound PW000809 PathWhiz G3P BioCyc Fructose-bisphosphate aldolase class 1 ReactionCatalysis2902 ACTIVATION 2.0 1.0 444493 PubChem-compound 6083 PubChem-compound 2-PG BioCyc 1.0 Glucose-specific phosphotransferase enzyme IIA component ACETYL-COA BioCyc 60.0 H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O Fructose-1,6-bisphosphatase class 2 393165 ChemSpider NADH BioCyc P06959 UniProt NAD BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex P37689 UniProt Carbon dioxide SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O SMILES CC(=O)SC(CCS)CCCCC(N)=O Uncharacterized protein yggF Enolase 980 ChemSpider CHEBI:15903 ChEBI P0A6P9 UniProt 820-11-1 CAS 1.1.1.17 false 1.1.1.17 Fructose 6-phosphate + Hydrogen Ion + NADH ↔ Mannitol 1-phosphate + NAD REVERSIBLE 6015 ChemSpider SMP00829 SMPDB 2.0 NADH phosphoenolpyruvate synthetase enolase SMILES O 4.0 pyruvate kinase C10H14N5O7P Adenosine monophosphate 347.06308 C6H12O6 Beta-D-Glucose 180.06339 Glucose-6-phosphate isomerase CHEBI:16807 ChEBI HMDB00807 HMDB P62707 UniProt C6H13O9P Beta-D-glucose 6-phosphate 260.02972 2.3.1.12 false 2.3.1.12 Acetyl-CoA + Dihydrolipoamide ↔ Coenzyme A + S-Acetyldihydrolipoamide REVERSIBLE Reaction5173 false Dihydrolipoamide + Succinyl-CoA → (S)-Succinyldihydrolipoamide + Coenzyme A LEFT_TO_RIGHT 1005 PubChem-compound 643-13-0 CAS 1.0 1981-49-3 CAS Dihydroxyacetone phosphate 1.0 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Pyruvic acid CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 4.0 ReactionCatalysis2542 ACTIVATION SMP00846 SMPDB 1.0 1038 PubChem-compound Pyruvate kinase II Fructose-bisphosphate aldolase class 2 Adenosine monophosphate 274 ChemSpider CHEBI:16905 ChEBI HMDB00902 HMDB CHEBI:16908 ChEBI 1.0 PTS system mannitol-specific EIICBA component PW000831 PathWhiz O4P Phosphate 94.95342 GO:0070258 GENE ONTOLOGY CHEBI:15946 ChEBI SMP00851 SMPDB Phosphoglycerate kinase PW000826 PathWhiz PW000785 PathWhiz P00550 UniProt 1.0 mannitol PTS permease 683 PubChem-compound 58-68-4 CAS SMILES [O-]P([O-])([O-])=O C6H13O9P Fructose 6-phosphate 260.02972 124-38-9 CAS PW000779 PathWhiz CHEBI:17835 ChEBI 5.3.1.1 false 5.3.1.1 D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate REVERSIBLE DIHYDROLIPOAMIDE BioCyc 130418 PubChem-compound P69783 UniProt Inner Membrane ReactionCatalysis2622 ACTIVATION Mannitol 1-phosphate ReactionCatalysis2621 ACTIVATION P69786 UniProt C10H19NO2S2 S-Acetyldihydrolipoamide 249.08572 ReactionCatalysis2624 ACTIVATION ReactionCatalysis2623 ACTIVATION C6H15O9P Mannitol 1-phosphate 262.04538 ReactionCatalysis2626 ACTIVATION ReactionCatalysis2625 ACTIVATION ReactionCatalysis2628 ACTIVATION S-Acetyldihydrolipoamide ReactionCatalysis2627 ACTIVATION 115387 ChemSpider 57-04-5 CAS 69507 PubChem-compound Beta-D-glucose 6-phosphate SMP00802 SMPDB glycolysis and pyruvate dehydrogenase Mannitol ReactionCatalysis2629 ACTIVATION SMILES O=C=O SMP00807 SMPDB ReactionCatalysis2633 ACTIVATION ReactionCatalysis2632 ACTIVATION ReactionCatalysis2634 ACTIVATION Fructose 6-phosphate C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound Triosephosphate isomerase ReactionCatalysis2631 ACTIVATION Beta-D-Glucose 6-phosphate ReactionCatalysis2630 ACTIVATION 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 6-phosphofructokinase II 6-phosphofructokinase I phosphoglycerate mutase 6-phosphofructokinase-1 Adenosine diphosphate Glyceraldehyde 3-phosphate dehydrogenase C3H5O6P Phosphoenolpyruvic acid 167.98238 fructose bisphosphate aldolase fructose-1,6-bisphosphatase C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase HMDB03391 HMDB fructose 1,6-bisphosphatase 2 Fructose-1,6-bisphosphatase 1 Phosphoenolpyruvic acid 1.0 CHEBI:16899 ChEBI CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 10.0 5682 ChemSpider CHEBI:1146900 ChEBI CO-A BioCyc SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 72-89-9 CAS HMDB03498 HMDB Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O 1.0 1.0 439425 PubChem-compound 439427 PubChem-compound CHEBI:15422 ChEBI 6557 ChemSpider SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex P23538 UniProt 2.7.9.2 false 2.7.9.2 Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid + Water LEFT_TO_RIGHT P21599 UniProt TCA cycle SubPathway 127-17-3 CAS 1.0 fucose and rhamnose degradation SubPathway CHEBI:17719 ChEBI 2.7.1.40 false 2.7.1.40 Adenosine diphosphate + Hydrogen Ion + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid LEFT_TO_RIGHT HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc SubPathwayInteraction1518 SubPathwayReaction SubPathway1518Reaction 2.7.1.69 false 2.7.1.69 HPr - phosphorylated + Mannitol → HPr + Mannitol 1-phosphate LEFT_TO_RIGHT SubPathwayInteraction1519 SubPathway1519Reaction SubPathwayReaction mannitol-1-phosphate 5-dehydrogenase Reaction2638 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 1.0 4.2.1.11 false 4.2.1.11 2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Water LEFT_TO_RIGHT CHEBI:16526 ChEBI SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 1.0 1.0 CHEBI:16761 ChEBI HMDB01177 HMDB 2.7.2.3 false 2.7.2.3 Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate LEFT_TO_RIGHT Reaction2637 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE 1.2.1.12 false 1.2.1.12 D-Glyceraldehyde 3-phosphate + NAD + Phosphate → Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 6-phosphate + Phosphate → Fructose 1,6-bisphosphate + Water LEFT_TO_RIGHT Reaction2633 false Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate + Hydrogen Ion LEFT_TO_RIGHT 5.3.1.9 false 5.3.1.9 Beta-D-glucose 6-phosphate → Fructose 6-phosphate LEFT_TO_RIGHT Unknown Unknown 392413 ChemSpider SMILES OC(COP(O)(O)=O)C(O)=O 69-65-8 CAS Phosphatase ybhA P0A9C9 UniProt C00631 KEGG Compound 1.0 5893 PubChem-compound HMDB02111 HMDB HMDB01022 HMDB 1.0 Pyruvate dehydrogenase complex CHEBI:32816 ChEBI CHEBI:15377 ChEBI C12H21NO4S2 (S)-Succinyldihydrolipoamide 307.0912 CHEBI:15378 ChEBI SMILES [H+] C00644 KEGG Compound Phosphoenolpyruvate synthase Succinyl-CoA CHEBI:16108 ChEBI HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 60.0 CHEBI:17432 ChEBI Unknown SMILES OC[C@@H](OP(O)(O)=O)C(O)=O 1.0 280 PubChem-compound SMILES OC(=N)CCCCC(S)CCS 1.0 2.0 HMDB01487 HMDB PTS system mannitol-specific EIICBA component (S)-Succinyldihydrolipoamide P09424 UniProt 2.0 SMILES OC(COP(O)(O)=O)C=O 1076 PubChem-compound 10.0 P21437 UniProt 3-METHYLBENZYLSUCCINYL-COA BioCyc 2.0 GAP BioCyc HMDB00045 HMDB 1060 PubChem-compound 1061 PubChem-compound ReactionCoupledTransportCatalysis205 ACTIVATION C00661 KEGG Compound CHEBI:15351 ChEBI 3884-47-7 CAS 85-61-0 CAS P0AB71 UniProt Glucose-6- phosphate isomerase Fructose-1,6- bisphosphatase class 2 Fructose-1,6- bisphosphatase class 1 Uncharacterized protein yggF Phosphatase ybhA 6- phosphofructokinase I 6- phosphofructokinase II Glyceraldehyde- 3-phosphate dehydrogenase A Phosphoglycerate kinase 2,3- bisphosphoglycerate- independent phosphoglycerate mutase 2,3- bisphosphoglycerate- dependent phosphoglycerate mutase Enolase Phosphoenolpyruvate synthase Pyruvate kinase I Pyruvate kinase II Unknown Unknown Unknown Unknown Fructose- bisphosphate aldolase class 1 Fructose- bisphosphate aldolase class 2 Triosephosphate isomerase mannitol-1- phosphate 5-dehydrogenase Dihydrolipoyllysine- residue acetyltransferase component of pyruvate dehydrogenase complex Dihydrolipoyllysine- residue acetyltransferase component of pyruvate dehydrogenase complex Phosphocarrier protein HPr Phosphocarrier protein HPr PTS system glucose- specific EIICB component Glucose- specific phosphotransferase enzyme IIA component Phosphocarrier protein HPr Phosphocarrier protein HPr PTS system mannitol- specific EIICBA component Beta-D-glucose 6-phosphate Fructose 6-phosphate P i Fructose 1,6- bisphosphate H 2 O ATP Fructose 1,6- bisphosphate ADP H + D- Glyceraldehyde 3-phosphate NAD P i Glyceric acid 1,3-biphosphate NADH H + ADP ATP 3- Phosphoglyceric acid 2-Phospho-D- glyceric acid 2-Phospho-D- glyceric acid Phosphoenolpyruvic acid H 2 O AMP P i H + ATP H 2 O Pyruvic acid ADP H + ATP Pyruvic acid CoA NAD Acetyl-CoA CO 2 NADH D- Glyceraldehyde 3-phosphate Dihydroxyacetone phosphate D- Glyceraldehyde 3-phosphate NADH H + NAD Mannitol 1-phosphate Dihydrolipoamide CoA S- Acetyldihydrolipoamide Succinyl-CoA CoA (S)- Succinyldihydrolipoamide Beta-D-Glucose 6-phosphate Beta-D-Glucose 6-phosphate Mannitol fucose and rhamnose degradation lipopolysaccharide biosynthesis serine biosynthesis and metabolism TCA cycle
6022 PubChem-compound 2.0 Phosphocarrier protein HPr C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider ReactionCoupledTransportCatalysis172 ACTIVATION SubPathwayInteraction1560 SubPathwayReaction SubPathway1560Reaction HMDB01341 HMDB Glucose-specific phosphotransferase enzyme IIA component 439278 PubChem-compound 439153 PubChem-compound ReactionCatalysis5121 ACTIVATION 1.0 58238 ChemSpider HMDB01112 HMDB C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 CHEBI:16027 ChEBI 6251 PubChem-compound NAD Pyruvate kinase I ATP BioCyc HMDB00263 HMDB PTS system glucose-specific EIICB component HMDB01473 HMDB 1.0 1.2.4.1 false 1.2.4.1 Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH LEFT_TO_RIGHT 1.0 P0AA04 UniProt C00579 KEGG Compound 1.0 Glyceraldehyde-3-phosphate dehydrogenase A HMDB01206 HMDB Fructose-1,6-bisphosphatase class 1 6-phosphofructokinase II 2.0 CHEBI:15380 ChEBI 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Fructose-bisphosphate aldolase class 1 5742 ChemSpider 6-phosphofructokinase I C25H40N7O19P3S Succinyl-CoA 867.1312 Fructose 1,6-bisphosphate 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1.0 HMDB59597 HMDB ReactionCatalysis5143 ACTIVATION ReactionCatalysis5144 ACTIVATION P0AD61 UniProt mannitol-1-phosphate 5-dehydrogenase 5858 ChemSpider HMDB00243 HMDB HMDB00124 HMDB C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 P0A9B2 UniProt 709 ChemSpider 1.0 C00221 KEGG Compound Acetyl-CoA 704 ChemSpider Fructose-1,6-bisphosphatase class 2 1010 ChemSpider CHEBI:17694 ChEBI SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 488-69-7 CAS 15806-48-1 CAS 4.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 138-08-9 CAS BiologicalState109 Escherichia coli, Inner Membrane SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 2.0 1.0 HMDB01423 HMDB 1046 ChemSpider Hydrogen Ion C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Uncharacterized protein yggF Enolase C00236 KEGG Compound C00597 KEGG Compound glucose PTS permease C00354 KEGG Compound Adenosine triphosphate CHEBI:16298 ChEBI Glucose-6-phosphate isomerase C00009 KEGG Compound 1.0 C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O C00001 KEGG Compound 3-Phosphoglyceric acid CHEBI:18367 ChEBI C00004 KEGG Compound 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 1031 ChemSpider Phosphocarrier protein HPr HMDB01429 HMDB 2.0 388411 ChemSpider 388538 ChemSpider C21H28N7O14P2 NAD 664.11694 HMDB01526 HMDB 388536 ChemSpider C00011 KEGG Compound C00010 KEGG Compound FRUCTOSE-6P BioCyc SubPathwayInteraction1661 SubPathwayReaction SubPathway1661Reaction 2.7.1.69 false 2.7.1.69 Beta-D-Glucose + HPr - phosphorylated → Beta-D-Glucose 6-phosphate + HPr LEFT_TO_RIGHT 562 TAXONOMY S-ACETYLDIHYDROLIPOAMIDE BioCyc CHEBI:17138 ChEBI H Hydrogen Ion 1.007825 HMDB01530 HMDB D-Glyceraldehyde 3-phosphate 388307 ChemSpider C6H14O6 Mannitol 182.07904 C00022 KEGG Compound Unknown 56-65-5 CAS Glyceric acid 1,3-biphosphate 53-84-9 CAS C00020 KEGG Compound Pyruvate kinase II Fructose-bisphosphate aldolase class 2 SMILES NC(=O)CCCC[C@H](CCS)SC(=O)CCC(O)=O 1.0 Unknown 62713 ChemSpider C00024 KEGG Compound P0A796 UniProt Phosphoglycerate kinase P0A799 UniProt 2.0 C00392 KEGG Compound Phosphatase ybhA P21829 UniProt Phosphoenolpyruvate synthase SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Unknown Water AMP BioCyc 492-61-5 CAS PTS system glucose-specific EIICB component 648 ChemSpider C01136 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 643 ChemSpider 604-98-8 CAS PHOSPHO-ENOL-PYRUVATE BioCyc P0A858 UniProt HMDB00538 HMDB Mannitol 1-phosphate 24.0 SMILES OC(=O)C(=C)OP(O)(O)=O 64689 PubChem-compound MANNITOL-1P BioCyc 663 PubChem-compound CPD0-341 BioCyc C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound 7732-18-5 CAS 1.0 P0A991 UniProt 591-59-3 CAS 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O 1.0 triosephosphate isomerase Triosephosphate isomerase P06999 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc HMDB00765 HMDB DIHYDROXY-ACETONE-PHOSPHATE BioCyc 4.0 1.0 445557 PubChem-compound P0A6T1 UniProt P0A993 UniProt 2-Phospho-D-glyceric acid SMILES CC(=O)C(O)=O 663 ChemSpider C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI Dihydrolipoamide SMILES OCC(=O)COP(O)(O)=O HMDB01967 HMDB HMDB00516 HMDB C8H17NOS2 Dihydrolipoamide 207.07515 962 PubChem-compound Beta-D-Glucose 724 PubChem-compound 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate C01169 KEGG Compound C00080 KEGG Compound 4.0 C00085 KEGG Compound Pyruvate kinase I C01172 KEGG Compound 729 PubChem-compound 14265-44-2 CAS CHEBI:44897 ChEBI PYRUVATE BioCyc HMDB00985 HMDB 58-64-0 CAS Glyceraldehyde-3-phosphate dehydrogenase A Fructose-1,6-bisphosphatase class 1 C00091 KEGG Compound PW000809 PathWhiz G3P BioCyc Fructose-bisphosphate aldolase class 1 ReactionCatalysis2902 ACTIVATION 2.0 1.0 444493 PubChem-compound 6083 PubChem-compound 2-PG BioCyc 1.0 Glucose-specific phosphotransferase enzyme IIA component ACETYL-COA BioCyc 60.0 H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O Fructose-1,6-bisphosphatase class 2 393165 ChemSpider NADH BioCyc P06959 UniProt NAD BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex P37689 UniProt Carbon dioxide SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O SMILES CC(=O)SC(CCS)CCCCC(N)=O Uncharacterized protein yggF Enolase 980 ChemSpider CHEBI:15903 ChEBI P0A6P9 UniProt 820-11-1 CAS 1.1.1.17 false 1.1.1.17 Fructose 6-phosphate + Hydrogen Ion + NADH ↔ Mannitol 1-phosphate + NAD REVERSIBLE 6015 ChemSpider http://identifiers.org/smpdb/SMP00829 SMPDB 2.0 NADH phosphoenolpyruvate synthetase enolase SMILES O 4.0 pyruvate kinase C10H14N5O7P Adenosine monophosphate 347.06308 C6H12O6 Beta-D-Glucose 180.06339 Glucose-6-phosphate isomerase CHEBI:16807 ChEBI HMDB00807 HMDB P62707 UniProt C6H13O9P Beta-D-glucose 6-phosphate 260.02972 2.3.1.12 false 2.3.1.12 Acetyl-CoA + Dihydrolipoamide ↔ Coenzyme A + S-Acetyldihydrolipoamide REVERSIBLE Reaction5173 false Dihydrolipoamide + Succinyl-CoA → (S)-Succinyldihydrolipoamide + Coenzyme A LEFT_TO_RIGHT 1005 PubChem-compound 643-13-0 CAS 1.0 1981-49-3 CAS Dihydroxyacetone phosphate 1.0 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Pyruvic acid CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 4.0 ReactionCatalysis2542 ACTIVATION http://identifiers.org/smpdb/SMP00846 SMPDB 1.0 1038 PubChem-compound Pyruvate kinase II Fructose-bisphosphate aldolase class 2 Adenosine monophosphate 274 ChemSpider CHEBI:16905 ChEBI HMDB00902 HMDB CHEBI:16908 ChEBI 1.0 PTS system mannitol-specific EIICBA component PW000831 PathWhiz O4P Phosphate 94.95342 GO:0070258 GENE ONTOLOGY TCA cycle SubPathway CHEBI:15946 ChEBI http://identifiers.org/smpdb/SMP00851 SMPDB Phosphoglycerate kinase PW000826 PathWhiz PW000785 PathWhiz P00550 UniProt 1.0 mannitol PTS permease 683 PubChem-compound 58-68-4 CAS SMILES [O-]P([O-])([O-])=O C6H13O9P Fructose 6-phosphate 260.02972 124-38-9 CAS PW000779 PathWhiz lipopolysaccharide biosynthesis SubPathway CHEBI:17835 ChEBI 5.3.1.1 false 5.3.1.1 D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate REVERSIBLE DIHYDROLIPOAMIDE BioCyc 130418 PubChem-compound P69783 UniProt Inner Membrane ReactionCatalysis2622 ACTIVATION Mannitol 1-phosphate ReactionCatalysis2621 ACTIVATION P69786 UniProt C10H19NO2S2 S-Acetyldihydrolipoamide 249.08572 ReactionCatalysis2624 ACTIVATION ReactionCatalysis2623 ACTIVATION C6H15O9P Mannitol 1-phosphate 262.04538 ReactionCatalysis2626 ACTIVATION ReactionCatalysis2625 ACTIVATION ReactionCatalysis2628 ACTIVATION S-Acetyldihydrolipoamide ReactionCatalysis2627 ACTIVATION 115387 ChemSpider 57-04-5 CAS 69507 PubChem-compound Beta-D-glucose 6-phosphate http://identifiers.org/smpdb/SMP00802 SMPDB glycolysis and pyruvate dehydrogenase Mannitol ReactionCatalysis2629 ACTIVATION SMILES O=C=O http://identifiers.org/smpdb/SMP00807 SMPDB ReactionCatalysis2633 ACTIVATION ReactionCatalysis2632 ACTIVATION ReactionCatalysis2634 ACTIVATION Fructose 6-phosphate C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound Triosephosphate isomerase ReactionCatalysis2631 ACTIVATION Beta-D-Glucose 6-phosphate ReactionCatalysis2630 ACTIVATION 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 6-phosphofructokinase II 6-phosphofructokinase I phosphoglycerate mutase 6-phosphofructokinase-1 Adenosine diphosphate Glyceraldehyde 3-phosphate dehydrogenase C3H5O6P Phosphoenolpyruvic acid 167.98238 fructose bisphosphate aldolase fructose-1,6-bisphosphatase C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase HMDB03391 HMDB fructose 1,6-bisphosphatase 2 Fructose-1,6-bisphosphatase 1 Phosphoenolpyruvic acid 1.0 CHEBI:16899 ChEBI CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 10.0 5682 ChemSpider CHEBI:1146900 ChEBI CO-A BioCyc serine biosynthesis and metabolism SubPathway SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 72-89-9 CAS HMDB03498 HMDB Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O 1.0 1.0 439425 PubChem-compound 439427 PubChem-compound CHEBI:15422 ChEBI 6557 ChemSpider SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex P23538 UniProt 2.7.9.2 false 2.7.9.2 Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid + Water LEFT_TO_RIGHT P21599 UniProt 127-17-3 CAS 1.0 CHEBI:17719 ChEBI 2.7.1.40 false 2.7.1.40 Adenosine diphosphate + Hydrogen Ion + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid LEFT_TO_RIGHT HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc SubPathwayInteraction1518 SubPathwayReaction SubPathway1518Reaction 2.7.1.69 false 2.7.1.69 HPr - phosphorylated + Mannitol → HPr + Mannitol 1-phosphate LEFT_TO_RIGHT SubPathwayInteraction1519 SubPathway1519Reaction SubPathwayReaction fucose and rhamnose degradation SubPathway mannitol-1-phosphate 5-dehydrogenase Reaction2638 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 1.0 4.2.1.11 false 4.2.1.11 2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Water LEFT_TO_RIGHT CHEBI:16526 ChEBI SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 1.0 1.0 CHEBI:16761 ChEBI HMDB01177 HMDB 2.7.2.3 false 2.7.2.3 Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate LEFT_TO_RIGHT Reaction2637 false 3-Phosphoglyceric acid → 2-Phospho-D-glyceric acid LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE 1.2.1.12 false 1.2.1.12 D-Glyceraldehyde 3-phosphate + NAD + Phosphate → Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 6-phosphate + Phosphate → Fructose 1,6-bisphosphate + Water LEFT_TO_RIGHT Reaction2633 false Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate + Hydrogen Ion LEFT_TO_RIGHT 5.3.1.9 false 5.3.1.9 Beta-D-glucose 6-phosphate → Fructose 6-phosphate LEFT_TO_RIGHT Unknown Unknown 392413 ChemSpider SMILES OC(COP(O)(O)=O)C(O)=O 69-65-8 CAS Phosphatase ybhA P0A9C9 UniProt C00631 KEGG Compound 1.0 5893 PubChem-compound HMDB02111 HMDB HMDB01022 HMDB 1.0 Pyruvate dehydrogenase complex CHEBI:32816 ChEBI CHEBI:15377 ChEBI C12H21NO4S2 (S)-Succinyldihydrolipoamide 307.0912 CHEBI:15378 ChEBI SMILES [H+] C00644 KEGG Compound Phosphoenolpyruvate synthase Succinyl-CoA CHEBI:16108 ChEBI HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 60.0 CHEBI:17432 ChEBI Unknown SMILES OC[C@@H](OP(O)(O)=O)C(O)=O 1.0 280 PubChem-compound SMILES OC(=N)CCCCC(S)CCS 1.0 2.0 HMDB01487 HMDB PTS system mannitol-specific EIICBA component (S)-Succinyldihydrolipoamide P09424 UniProt 2.0 SMILES OC(COP(O)(O)=O)C=O 1076 PubChem-compound 10.0 P21437 UniProt 3-METHYLBENZYLSUCCINYL-COA BioCyc 2.0 GAP BioCyc HMDB00045 HMDB 1060 PubChem-compound 1061 PubChem-compound ReactionCoupledTransportCatalysis205 ACTIVATION C00661 KEGG Compound CHEBI:15351 ChEBI 3884-47-7 CAS 85-61-0 CAS P0AB71 UniProt