Loading Pathway...
CHEBI:16015 ChEBI Glutamate/aspartate transport system permease protein gltK SubPathwayInteraction84386 SubPathwayReaction SubPathway84386Reaction 6022 PubChem-compound 923 PubChem-compound 937 ChemSpider CHEBI:16134 ChEBI direct_interaction P69910 UniProt 110-17-8 CAS 50 ChemSpider 1.0 Glutamate decarboxylase alpha 1.0 Pyrimidine Metabolism SubPathway P0AC38 UniProt OXALACETIC_ACID BioCyc Glutamate/aspartate periplasmic-binding protein ATP BioCyc H4N Ammonium 18.034374 1.0 P69908 UniProt SubPathwayInteraction84393 SubPathway84393Reaction SubPathwayReaction Transport369 false L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 1.0 5746 ChemSpider 5745 ChemSpider Transport371 false Hydrogen Ion (→), L-Glutamic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 5742 ChemSpider L-ASPARTATE BioCyc Glutamate/aspartate transport system permease protein gltJ CHEBI:16474 ChEBI Glutamate decarboxylase beta Aerobic C4-dicarboxylate transport protein Proton glutamate symport protein 945 ChemSpider Glutamine synthetase 1010 ChemSpider Glutamate/aspartate transport ATP-binding protein gltL 23724570 PubChem-compound 1.0 5105-96-4 CAS Ammonium 1.0 ReactionCoupledTransportCatalysis136 ACTIVATION 1.0 C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion Cytosol SUC BioCyc Glutamine transport ATP-binding protein glnQ CHEBI:49260 ChEBI C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI P0ABN5 UniProt Hydrogen Ion C00001 KEGG Compound C00122 KEGG Compound C01330 KEGG Compound ReactionCoupledTransportCatalysis141 ACTIVATION P0A6W0 UniProt C00005 KEGG Compound Glutamate/aspartate transport ATP-binding protein gltL CPD-9000 BioCyc C00489 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider NADPH 1.0 C00002 KEGG Compound C5H8O4 Glutaric acid 132.04225 ReactionCoupledTransport107 false Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate LEFT_TO_RIGHT Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB ReactionCoupledTransport102 false Adenosine triphosphate + L-Glutamic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT Glutamate synthase [NADPH] large chain Glutaric acid 44367445 PubChem-compound 110-94-1 CAS TCA Cycle SubPathway C01342 KEGG Compound C00011 KEGG Compound glutaminase 1 C00014 KEGG Compound NAD(P) BioCyc glutaminase 2 L-Glutamate Metabolism 562 TAXONOMY P0ABP1 UniProt H Hydrogen Ion 1.007825 P09832 UniProt P0ABP4 UniProt P09831 UniProt L-Glutamine 56-65-5 CAS Glutamate/aspartate periplasmic-binding protein L-Glutamic acid 1.0 C00026 KEGG Compound C00025 KEGG Compound ReactionCatalysis5119 ACTIVATION 1.0 CHEBI:29101 ChEBI NADP Glutamine transport system permease protein glnP SMP0000802 SMPDB P0AAG3 UniProt 899 ChemSpider C00036 KEGG Compound 328-50-7 CAS HMDB0000134 HMDB HMDB0000254 HMDB Water SMILES OC(=O)CCC(O)=O 2.0 Oxalacetic acid C15767 KEGG Compound HMDB0001341 HMDB P0AFR2 UniProt SMP0000811 SMPDB C00042 KEGG Compound C00049 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Anaerobic C4-dicarboxylate transporter dcuA HMDB0000148 HMDB 1.0 17341-25-2 CAS 2.0 10197150 ChemSpider P0AEQ3 UniProt P0AEQ6 UniProt FUM BioCyc SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS CHEBI:18012 ChEBI Aspartate ammonia-lyase Glutamine transport system permease protein glnP Aspartate aminotransferase AMMONIA BioCyc SMILES N 56-86-0 CAS P0AER3 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 P0AER5 UniProt CHEBI:17053 ChEBI 1.0 P0AER8 UniProt C00064 KEGG Compound Sodium/glutamate symport carrier protein Glutamate/aspartate transport system permease protein gltK L-Glutamic acid SMP0000959 SMPDB Glutamate/aspartate transport system permease protein gltJ 962 PubChem-compound 5800 ChemSpider glutamine ABC transporter 4.0 Sodium CO2 Carbon dioxide 43.98983 SMILES N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O C00080 KEGG Compound Periplasmic Space Oxoglutaric acid TransportCatalysis317 ACTIVATION TransportCatalysis315 ACTIVATION HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O 14265-44-2 CAS 58-64-0 CAS HMDB0012161 HMDB Putative sulfate transporter ychM 723 ChemSpider Glutamine transport ATP-binding protein glnQ L-Aspartic acid 1.0 Transport448 false Fumaric acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT C4H7NO4 L-Aspartic acid 133.0375 Transport447 false Fumaric acid (→), Succinic acid (←) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT Transport446 false Fumaric acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 743 PubChem-compound Fumaric acid 22833512 PubChem-compound L-Aspartic acid CHEBI:18050 ChEBI H2O Water 18.010565 Proton glutamate symport protein ReactionCoupledTransport411 false Adenosine triphosphate + L-Glutamine + Water ? Adenosine triphosphate + Hydrogen Ion + L-Glutamine + Phosphate Aerobic C4-dicarboxylate transport protein HMDB0000191 HMDB Ammonium Na Sodium 22.989769 HMDB0041827 HMDB HMDB0059597 HMDB L-Glutamic acid Carbon dioxide 56-84-8 CAS 21865667 ChemSpider 1.0 1.0 970 PubChem-compound SMILES OC(=O)\C=C\C(O)=O P0A830 UniProt 1.0 Adenosine diphosphate Reaction5146 false Hydrogen Ion + L-Glutamic acid → 4-(Glutamylamino) butanoate + Carbon dioxide LEFT_TO_RIGHT 1.0 30572 ChemSpider 17215925 ChemSpider C4H4O5 Oxalacetic acid 132.00587 L-Glutamine aspartate ammonia-lyase dicarboxylate transporter ReactionCatalysis2659 ACTIVATION ReactionCatalysis2658 ACTIVATION 21883788 PubChem-compound SMILES O H3N Ammonia 17.026548 HMDB0000538 HMDB SMILES [Na+] 1.0 5961 PubChem-compound 1.0 HMDB0000661 HMDB 328-42-7 CAS 51 PubChem-compound Succinic acid ReactionCatalysis2660 ACTIVATION ADP BioCyc ReactionCatalysis2662 ACTIVATION ReactionCatalysis2661 ACTIVATION P00370 UniProt 53-59-8 CAS 1038 PubChem-compound glutamate / aspartate ABC transporter glutamate decarboxylase GO:0005829 GENE ONTOLOGY Ammonia 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 NADP-specific glutamate dehydrogenase 1.0 Aspartate aminotransferase O4P Phosphate 94.95342 Glutamine synthetase Glutamate synthase [NADPH] small chain NADPH GO:0070258 GENE ONTOLOGY NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000942 PathWhiz NADPH BioCyc Fumaric acid HMDB0000208 HMDB 218 ChemSpider 217 ChemSpider L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB 1.0 CHEBI:30915 ChEBI 124-38-9 CAS PW000779 PathWhiz Hydrogen Ion 2.0 HMDB0001429 HMDB 4-(Glutamylamino) butanoate Inner Membrane aspartate transaminase SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB HMDB0000223 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O HMDB0000588 HMDB Fumaric acid 1.0 GLN BioCyc GLT BioCyc 7664-41-7 CAS C4H4O4 Fumaric acid 116.010956 Anaerobic C4-dicarboxylate transporter dcuA 53-57-6 CAS TransportCatalysis385 ACTIVATION Glutamate decarboxylase alpha 1.0 TransportCatalysis384 ACTIVATION TransportCatalysis383 ACTIVATION CHEBI:15741 ChEBI 1.0 Oxoglutaric acid SubPathwayInput 1.0 Glutamate synthase [NADPH] large chain SMILES O=C=O Glutamate synthase [NADPH] small chain CHEBI:28938 ChEBI 222 PubChem-compound 1110 PubChem-compound Interaction1024 Glutaric acid inhibits glutamate decarboxylase Sodium/glutamate symport carrier protein Aspartate ammonia-lyase 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 Glutamate decarboxylase beta glutamate synthase Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O glutaminase Glutamine-binding periplasmic protein Adenosine triphosphate CPD-8587 BioCyc Putative sulfate transporter ychM CHEBI:17859 ChEBI Phosphate P37902 UniProt 1.0 5675 ChemSpider 1078 ChemSpider Adenosine diphosphate 14798-03-9 CAS Water CHEBI:15422 ChEBI C9H16N2O5 4-(Glutamylamino) butanoate 232.10593 Escherichia coli Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB 1.0 1.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] P10346 UniProt 1.0 CHEBI:16526 ChEBI glutaminase 1 glutaminase 2 1.0 CHEBI:16761 ChEBI P21345 UniProt Succinic acid PW000789 PathWhiz 3.5.1.2 false 3.5.1.2 L-Glutamine + Water → Ammonia + L-Glutamic acid LEFT_TO_RIGHT 2-KETOGLUTARATE BioCyc P0A9C5 UniProt 1.0 110-15-6 CAS 1.0 Reaction2669 false Hydrogen Ion + L-Glutamine + NADPH + Oxoglutaric acid → 2 L-Glutamic acid + NADP LEFT_TO_RIGHT Reaction2667 false L-Glutamic acid + Oxalacetic acid → L-Aspartic acid + Oxoglutaric acid LEFT_TO_RIGHT Reaction2668 false L-Aspartic acid → Ammonium + Fumaric acid LEFT_TO_RIGHT Reaction2665 false Adenosine triphosphate + Ammonium + L-Glutamic acid → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate LEFT_TO_RIGHT Reaction2666 false Ammonium + Hydrogen Ion + NADPH + Oxoglutaric acid → L-Glutamic acid + NADP + Water LEFT_TO_RIGHT P77454 UniProt CHEBI:15377 ChEBI Sodium NADP-specific glutamate dehydrogenase CHEBI:15378 ChEBI SMILES [H+] Glutamine-binding periplasmic protein SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound Phosphate 1.0 1.0 280 PubChem-compound CHEBI:30744 ChEBI 2.0 L-Glutamine SubPathwayInput 16741146 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 1.0 1061 PubChem-compound ReactionCoupledTransportCatalysis448 ACTIVATION Hydrogen Ion HMDB0001967 HMDB SMILES OC(=O)CCCC(O)=O 1.0 HMDB0000641 HMDB 1.0 P00509 UniProt 1.0 ReactionCatalysis2481 ACTIVATION Glutamate decarboxylase beta Glutamate decarboxylase alpha Sodium/glutamate symport carrier protein Proton glutamate symport protein Aerobic C4- dicarboxylate transport protein Putative sulfate transporter ychM Anaerobic C4- dicarboxylate transporter dcuC Anaerobic C4- dicarboxylate transporter dcuA Anaerobic C4- dicarboxylate transporter dcuB glutaminase 2 glutaminase 1 NADP-specific glutamate dehydrogenase Aspartate ammonia-lyase Glutamate synthase [NADPH] large chain Glutamate synthase [NADPH] small chain Glutamine synthetase Aspartate aminotransferase Glutamine transport ATP-binding protein glnQ Glutamine transport system permease protein glnP Glutamine- binding periplasmic protein Glutamate/aspartate transport ATP-binding protein gltL Glutamate/aspartate transport system permease protein gltK Glutamate/aspartate transport system permease protein gltJ Glutamate/aspartate periplasmic- binding protein Glutamine transport ATP-binding protein glnQ Glutamine transport system permease protein glnP Glutamine- binding periplasmic protein Glutaric acid Oxoglutaric acid L-Glutamine L-Glutamic acid L-Glutamic acid Na + Na + H + H + L-Glutamic acid Fumaric acid Fumaric acid H + H + Fumaric acid Fumaric acid Succinic acid Succinic acid L-Glutamine H 2 O NH 3 NADPH Ammonium H + H 2 O NADP L-Aspartic acid Ammonium H + CO 2 4- (Glutamylamino) butanoate L-Glutamine Oxoglutaric acid NADPH H + NADP ATP Ammonium H + ADP P i Oxalacetic acid Oxoglutaric acid L-Glutamine ATP H 2 O ADP P i H + ATP H 2 O ADP P i H + L-Glutamic acid ATP H 2 O L-Glutamine ATP H + P i TCA Cycle Pyrimidine Metabolism
CHEBI:16015 ChEBI Glutamate/aspartate transport system permease protein gltK SubPathwayInteraction84386 SubPathwayReaction SubPathway84386Reaction 6022 PubChem-compound 923 PubChem-compound 937 ChemSpider CHEBI:16134 ChEBI direct_interaction P69910 UniProt 110-17-8 CAS 50 ChemSpider 1.0 Glutamate decarboxylase alpha 1.0 Pyrimidine Metabolism SubPathway P0AC38 UniProt OXALACETIC_ACID BioCyc Glutamate/aspartate periplasmic-binding protein ATP BioCyc H4N Ammonium 18.034374 1.0 P69908 UniProt SubPathwayInteraction84393 SubPathway84393Reaction SubPathwayReaction Transport369 false L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 1.0 5746 ChemSpider 5745 ChemSpider Transport371 false Hydrogen Ion (→), L-Glutamic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 5742 ChemSpider L-ASPARTATE BioCyc Glutamate/aspartate transport system permease protein gltJ CHEBI:16474 ChEBI Glutamate decarboxylase beta Aerobic C4-dicarboxylate transport protein Proton glutamate symport protein 945 ChemSpider Glutamine synthetase 1010 ChemSpider Glutamate/aspartate transport ATP-binding protein gltL 23724570 PubChem-compound 1.0 5105-96-4 CAS Ammonium 1.0 ReactionCoupledTransportCatalysis136 ACTIVATION 1.0 C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion Cytosol SUC BioCyc Glutamine transport ATP-binding protein glnQ CHEBI:49260 ChEBI C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI P0ABN5 UniProt Hydrogen Ion C00001 KEGG Compound C00122 KEGG Compound C01330 KEGG Compound ReactionCoupledTransportCatalysis141 ACTIVATION P0A6W0 UniProt C00005 KEGG Compound Glutamate/aspartate transport ATP-binding protein gltL CPD-9000 BioCyc C00489 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider NADPH 1.0 C00002 KEGG Compound C5H8O4 Glutaric acid 132.04225 ReactionCoupledTransport107 false Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate LEFT_TO_RIGHT Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB ReactionCoupledTransport102 false Adenosine triphosphate + L-Glutamic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT Glutamate synthase [NADPH] large chain Glutaric acid 44367445 PubChem-compound 110-94-1 CAS TCA Cycle SubPathway C01342 KEGG Compound C00011 KEGG Compound glutaminase 1 C00014 KEGG Compound NAD(P) BioCyc glutaminase 2 L-Glutamate Metabolism 562 TAXONOMY P0ABP1 UniProt H Hydrogen Ion 1.007825 P09832 UniProt P0ABP4 UniProt P09831 UniProt L-Glutamine 56-65-5 CAS Glutamate/aspartate periplasmic-binding protein L-Glutamic acid 1.0 C00026 KEGG Compound C00025 KEGG Compound ReactionCatalysis5119 ACTIVATION 1.0 CHEBI:29101 ChEBI NADP Glutamine transport system permease protein glnP SMP0000802 SMPDB P0AAG3 UniProt 899 ChemSpider C00036 KEGG Compound 328-50-7 CAS HMDB0000134 HMDB HMDB0000254 HMDB Water SMILES OC(=O)CCC(O)=O 2.0 Oxalacetic acid C15767 KEGG Compound HMDB0001341 HMDB P0AFR2 UniProt SMP0000811 SMPDB C00042 KEGG Compound C00049 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Anaerobic C4-dicarboxylate transporter dcuA HMDB0000148 HMDB 1.0 17341-25-2 CAS 2.0 10197150 ChemSpider P0AEQ3 UniProt P0AEQ6 UniProt FUM BioCyc SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS CHEBI:18012 ChEBI Aspartate ammonia-lyase Glutamine transport system permease protein glnP Aspartate aminotransferase AMMONIA BioCyc SMILES N 56-86-0 CAS P0AER3 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 P0AER5 UniProt CHEBI:17053 ChEBI 1.0 P0AER8 UniProt C00064 KEGG Compound Sodium/glutamate symport carrier protein Glutamate/aspartate transport system permease protein gltK L-Glutamic acid SMP0000959 SMPDB Glutamate/aspartate transport system permease protein gltJ 962 PubChem-compound 5800 ChemSpider glutamine ABC transporter 4.0 Sodium CO2 Carbon dioxide 43.98983 SMILES N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O C00080 KEGG Compound Periplasmic Space Oxoglutaric acid TransportCatalysis317 ACTIVATION TransportCatalysis315 ACTIVATION HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O 14265-44-2 CAS 58-64-0 CAS HMDB0012161 HMDB Putative sulfate transporter ychM 723 ChemSpider Glutamine transport ATP-binding protein glnQ L-Aspartic acid 1.0 Transport448 false Fumaric acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT C4H7NO4 L-Aspartic acid 133.0375 Transport447 false Fumaric acid (→), Succinic acid (←) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT Transport446 false Fumaric acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 743 PubChem-compound Fumaric acid 22833512 PubChem-compound L-Aspartic acid CHEBI:18050 ChEBI H2O Water 18.010565 Proton glutamate symport protein ReactionCoupledTransport411 false Adenosine triphosphate + L-Glutamine + Water ? Adenosine triphosphate + Hydrogen Ion + L-Glutamine + Phosphate Aerobic C4-dicarboxylate transport protein HMDB0000191 HMDB Ammonium Na Sodium 22.989769 HMDB0041827 HMDB HMDB0059597 HMDB L-Glutamic acid Carbon dioxide 56-84-8 CAS 21865667 ChemSpider 1.0 1.0 970 PubChem-compound SMILES OC(=O)\C=C\C(O)=O P0A830 UniProt 1.0 Adenosine diphosphate Reaction5146 false Hydrogen Ion + L-Glutamic acid → 4-(Glutamylamino) butanoate + Carbon dioxide LEFT_TO_RIGHT 1.0 30572 ChemSpider 17215925 ChemSpider C4H4O5 Oxalacetic acid 132.00587 L-Glutamine aspartate ammonia-lyase dicarboxylate transporter ReactionCatalysis2659 ACTIVATION ReactionCatalysis2658 ACTIVATION 21883788 PubChem-compound SMILES O H3N Ammonia 17.026548 HMDB0000538 HMDB SMILES [Na+] 1.0 5961 PubChem-compound 1.0 HMDB0000661 HMDB 328-42-7 CAS 51 PubChem-compound Succinic acid ReactionCatalysis2660 ACTIVATION ADP BioCyc ReactionCatalysis2662 ACTIVATION ReactionCatalysis2661 ACTIVATION P00370 UniProt 53-59-8 CAS 1038 PubChem-compound glutamate / aspartate ABC transporter glutamate decarboxylase GO:0005829 GENE ONTOLOGY Ammonia 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 NADP-specific glutamate dehydrogenase 1.0 Aspartate aminotransferase O4P Phosphate 94.95342 Glutamine synthetase Glutamate synthase [NADPH] small chain NADPH GO:0070258 GENE ONTOLOGY NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000942 PathWhiz NADPH BioCyc Fumaric acid HMDB0000208 HMDB 218 ChemSpider 217 ChemSpider L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB 1.0 CHEBI:30915 ChEBI 124-38-9 CAS PW000779 PathWhiz Hydrogen Ion 2.0 HMDB0001429 HMDB 4-(Glutamylamino) butanoate Inner Membrane aspartate transaminase SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB HMDB0000223 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O HMDB0000588 HMDB Fumaric acid 1.0 GLN BioCyc GLT BioCyc 7664-41-7 CAS C4H4O4 Fumaric acid 116.010956 Anaerobic C4-dicarboxylate transporter dcuA 53-57-6 CAS TransportCatalysis385 ACTIVATION Glutamate decarboxylase alpha 1.0 TransportCatalysis384 ACTIVATION TransportCatalysis383 ACTIVATION CHEBI:15741 ChEBI 1.0 Oxoglutaric acid SubPathwayInput 1.0 Glutamate synthase [NADPH] large chain SMILES O=C=O Glutamate synthase [NADPH] small chain CHEBI:28938 ChEBI 222 PubChem-compound 1110 PubChem-compound Interaction1024 Glutaric acid inhibits glutamate decarboxylase Sodium/glutamate symport carrier protein Aspartate ammonia-lyase 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 Glutamate decarboxylase beta glutamate synthase Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O glutaminase Glutamine-binding periplasmic protein Adenosine triphosphate CPD-8587 BioCyc Putative sulfate transporter ychM CHEBI:17859 ChEBI Phosphate P37902 UniProt 1.0 5675 ChemSpider 1078 ChemSpider Adenosine diphosphate 14798-03-9 CAS Water CHEBI:15422 ChEBI C9H16N2O5 4-(Glutamylamino) butanoate 232.10593 Escherichia coli Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB 1.0 1.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] P10346 UniProt 1.0 CHEBI:16526 ChEBI glutaminase 1 glutaminase 2 1.0 CHEBI:16761 ChEBI P21345 UniProt Succinic acid PW000789 PathWhiz 3.5.1.2 false 3.5.1.2 L-Glutamine + Water → Ammonia + L-Glutamic acid LEFT_TO_RIGHT 2-KETOGLUTARATE BioCyc P0A9C5 UniProt 1.0 110-15-6 CAS 1.0 Reaction2669 false Hydrogen Ion + L-Glutamine + NADPH + Oxoglutaric acid → 2 L-Glutamic acid + NADP LEFT_TO_RIGHT Reaction2667 false L-Glutamic acid + Oxalacetic acid → L-Aspartic acid + Oxoglutaric acid LEFT_TO_RIGHT Reaction2668 false L-Aspartic acid → Ammonium + Fumaric acid LEFT_TO_RIGHT Reaction2665 false Adenosine triphosphate + Ammonium + L-Glutamic acid → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate LEFT_TO_RIGHT Reaction2666 false Ammonium + Hydrogen Ion + NADPH + Oxoglutaric acid → L-Glutamic acid + NADP + Water LEFT_TO_RIGHT P77454 UniProt CHEBI:15377 ChEBI Sodium NADP-specific glutamate dehydrogenase CHEBI:15378 ChEBI SMILES [H+] Glutamine-binding periplasmic protein SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound Phosphate 1.0 1.0 280 PubChem-compound CHEBI:30744 ChEBI 2.0 L-Glutamine SubPathwayInput 16741146 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 1.0 1061 PubChem-compound ReactionCoupledTransportCatalysis448 ACTIVATION Hydrogen Ion HMDB0001967 HMDB SMILES OC(=O)CCCC(O)=O 1.0 HMDB0000641 HMDB 1.0 P00509 UniProt 1.0 ReactionCatalysis2481 ACTIVATION gadB gadA gltS gltP dctA ychM dcuC dcuA dcuB glsB glsA gdhA aspA gltB gltD glnA aspC glnQ glnP glnH gltL gltK gltJ gltI glnQ glnP glnH Glutaric acid Oxoglutaric acid L-Glutamine L-Glutamic acid L-Glutamic acid Sodium Sodium Hydrogen Ion Hydrogen Ion L-Glutamic acid Fumaric acid Fumaric acid Hydrogen Ion Hydrogen Ion Fumaric acid Fumaric acid Succinic acid Succinic acid L-Glutamine Water Ammonia NADPH Ammonium Hydrogen Ion Water NADP L-Aspartic acid Ammonium Hydrogen Ion Carbon dioxide 4- (Glutamylamino) butanoate L-Glutamine Oxoglutaric acid NADPH Hydrogen Ion NADP Adenosine triphosphate Ammonium Hydrogen Ion Adenosine diphosphate Phosphate Oxalacetic acid Oxoglutaric acid L-Glutamine Adenosine triphosphate Water Adenosine diphosphate Phosphate Hydrogen Ion Adenosine triphosphate Water Adenosine diphosphate Phosphate Hydrogen Ion L-Glutamic acid Adenosine triphosphate Water L-Glutamine Adenosine triphosphate Hydrogen Ion Phosphate TCA Cycle Pyrimidine Metabolism