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CHEBI:16015 ChEBI 1.0 C00437 KEGG Compound 6022 PubChem-compound 7722-84-1 CAS 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 HMDB0001180 HMDB 1.0 439161 PubChem-compound 937 ChemSpider Succinic acid semialdehyde C00555 KEGG Compound Succinate-semialdehyde dehydrogenase [NADP+] 4-AMINO-BUTYRALDEHYDE BioCyc P04391 UniProt HMDB0003125 HMDB 1.0 439153 PubChem-compound 110-17-8 CAS 1.0 CHEBI:58763 ChEBI 50 ChemSpider 1.0 388369 ChemSpider C00327 KEGG Compound 4-Aminobutyraldehyde Agmatinase CHEBI:16027 ChEBI NAD 1.0 ATP BioCyc 389690 ChemSpider Citrulline H4N Ammonium 18.034374 CHEBI:16265 ChEBI Reaction2694 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT 1.0 1.2.1.79 false 1.2.1.79 NADP + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADPH + Succinic acid LEFT_TO_RIGHT 1.2.1.16 false 1.2.1.16 NAD + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADH + Succinic acid LEFT_TO_RIGHT SMILES NCCCCNC(=O)CC[C@H](N)C(O)=O 1.2.1.19 false 1.2.1.19 4-Aminobutyraldehyde + NAD + Water → Hydrogen Ion + NADH + gamma-Aminobutyric acid LEFT_TO_RIGHT 2.6.1.19 false 2.6.1.19 Oxoglutaric acid + gamma-Aminobutyric acid → L-Glutamic acid + Succinic acid semialdehyde LEFT_TO_RIGHT 4.0 559142 ChemSpider P23908 UniProt 1.0 1.0 HMDB0001199 HMDB 1.0 5746 ChemSpider HCO3 BioCyc 5745 ChemSpider HMDB0001080 HMDB CHEBI:15380 ChEBI Carbamoyl-phosphate synthase small chain 5742 ChemSpider Argininosuccinate synthase C25H40N7O19P3S Succinyl-CoA 867.1312 L-ASPARTATE BioCyc C00334 KEGG Compound 1143 ChemSpider CHEBI:16474 ChEBI 952 ChemSpider Acetylglutamate kinase Carbamoyl-phosphate synthase large chain Arginine N-succinyltransferase Gamma-glutamylputrescine oxidoreductase 192878 PubChem-compound P18335 UniProt UREA BioCyc 5858 ChemSpider ARG BioCyc C9H16N2O5 N2-Succinyl-L-ornithine 232.10593 L-CITRULLINE BioCyc Acetyl-CoA CHEBI:16240 ChEBI 16950 PubChem-compound Aldehyde dehydrogenase-like protein yneI 1010 ChemSpider Biodegradative arginine decarboxylase SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS AGMATHINE BioCyc PPI BioCyc SMILES NCCCCN HMDB0001096 HMDB 23724570 PubChem-compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O Gamma-glutamyl-gamma-aminobutyrate hydrolase 1.0 5105-96-4 CAS 1.0 Ammonium CHEBI:17148 ChEBI 1.0 Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 CH4NO5P Carbamoyl phosphate 140.98271 Putrescine aminotransferase C00232 KEGG Compound 1.0 Cytosol Adenosine triphosphate SUC BioCyc Acetylornithine/succinyldiaminopimelate aminotransferase 1.0 CHEBI:49260 ChEBI 2.0 ReactionCatalysis144515 ACTIVATION C00009 KEGG Compound C00008 KEGG Compound 110-60-1 CAS C00007 KEGG Compound C00006 KEGG Compound 1.0 P0AE37 UniProt CHEBI:18009 ChEBI Hydrogen Ion C00001 KEGG Compound C00122 KEGG Compound C05932 KEGG Compound N-Acetylornithine CHEBI:18361 ChEBI CPD-9000 BioCyc C00005 KEGG Compound CHEBI:18367 ChEBI C00004 KEGG Compound N-Acetylglutamic acid 1032 ChemSpider SMILES NCCC[C@H](NC(=O)CCC(O)=O)C(O)=O C00003 KEGG Compound NADPH C00002 KEGG Compound 6205-08-9 CAS N-succinylglutamate 5-semialdehyde dehydrogenase Succinylglutamate desuccinylase N-succinylarginine dihydrolase 2.0 C6H13N3O3 Citrulline 175.09569 372-75-8 CAS C03406 KEGG Compound C21H28N7O14P2 NAD 664.11694 44367445 PubChem-compound 1.0 TCA Cycle SubPathway C00011 KEGG Compound C01342 KEGG Compound 4-aminobutyrate aminotransferase_ C00010 KEGG Compound HMDB0000902 HMDB 1.0 HMDB0000904 HMDB C4H9NO 4-Aminobutyraldehyde 87.06841 C00013 KEGG Compound C00134 KEGG Compound Q86WD1 UniProt NAD(P) BioCyc 1.0 Arginine Metabolism 2.0 HMDB0006456 HMDB 562 TAXONOMY 1.0 H Hydrogen Ion 1.007825 SMILES OC(=O)CCC(=O)N[C@@H](CCC=O)C(O)=O 388307 ChemSpider C4H6O3 Succinic acid semialdehyde 102.03169 1.0 L-Glutamine 4-aminobutyrate aminotransferase 56-65-5 CAS Carbamoyl phosphate C00020 KEGG Compound C03415 KEGG Compound 53-84-9 CAS C00027 KEGG Compound L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound ACET BioCyc 1.0 NADP 1.0 PUTRESCINE BioCyc SMP0000802 SMPDB 769 PubChem-compound 1.0 C00033 KEGG Compound 9367 ChemSpider HMDB0012230 HMDB 1.0 328-50-7 CAS HMDB0000134 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000254 HMDB Water AMP BioCyc SMILES OC(=O)CCC(O)=O Hydrogen peroxide C01250 KEGG Compound HYDROGEN-PEROXIDE BioCyc P50457 UniProt HMDB0000250 HMDB C15767 KEGG Compound SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB SMP0000812 SMPDB N-Acetyl-L-glutamate 5-semialdehyde N-Acetyl-L-glutamyl 5-phosphate C00042 KEGG Compound Acetylornithine deacetylase C00049 KEGG Compound C00169 KEGG Compound C00288 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 NAD+-dependent succinate semialdehyde dehydrogenase 763 ChemSpider CREB3L2-PPARgamma 1.0 604-98-8 CAS HMDB0000148 HMDB Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase CH4N2O Urea 60.032364 10197150 ChemSpider 784 PubChem-compound 1.0 C7H11NO5 N-Acetylglutamic acid 189.06372 4390-05-0 CAS FUM BioCyc SMILES CC(O)=O C7H14N2O3 N-Acetylornithine 174.10045 7732-18-5 CAS CHEBI:18012 ChEBI C00179 KEGG Compound CHEBI:16199 ChEBI 61-19-8 CAS SMILES N[C@@H](CCCNC(N)=N)C(O)=O HMDB0001487 HMDB SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 Argininosuccinate lyase SMILES N[C@@H](CCCNC(=N)N[C@@H](CC(O)=O)C(O)=O)C(O)=O C00062 KEGG Compound Gamma-aminobutyraldehyde dehydrogenase 56-86-0 CAS 590-55-6 CAS Succinylornithine transaminase 2.0 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 CHEBI:17053 ChEBI 1.0 C00064 KEGG Compound 2387-71-5 CAS HMDB0001377 HMDB HMDB0000045 HMDB HMDB0001138 HMDB HMDB0001259 HMDB 4-(Glutamylamino) butanoate Agmatine HMDB0000042 HMDB 3.0 962 PubChem-compound 5800 ChemSpider Agmatine C00077 KEGG Compound CO2 Carbon dioxide 43.98983 SMILES N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O Phosphate C00080 KEGG Compound SMILES O=O C7H11NO4 N-Acetyl-L-glutamate 5-semialdehyde 173.0688 Oxoglutaric acid 15383-57-0 CAS SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0002111 HMDB HMDB0000052 HMDB HMDB0000294 HMDB HMDB0001022 HMDB 14265-44-2 CAS 58-64-0 CAS HMDB0012161 HMDB C00086 KEGG Compound Putrescine C00091 KEGG Compound L-Aspartic acid γ-glutamyl-γ-aminobutyrate hydrolase C4H7NO4 L-Aspartic acid 133.0375 C15699 KEGG Compound 644102 PubChem-compound 444493 PubChem-compound 306-60-5 CAS 6083 PubChem-compound 1.0 C7H12NO8P N-Acetyl-L-glutamyl 5-phosphate 269.03006 N-Acetyl-L-glutamate 5-semialdehyde Biodegradative arginine decarboxylase Carbamoyl phosphate 22833512 PubChem-compound Aldehyde dehydrogenase-like protein yneI ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 4-AMINO-BUTYRATE BioCyc HMDB0000191 HMDB NADH BioCyc Arginine N-succinyltransferase Gamma-glutamylputrescine oxidoreductase P28629 UniProt 1.0 SMILES NCCCC(O)=O NAD BioCyc P06960 UniProt Ornithine carbamoyltransferase chain F 977 PubChem-compound HMDB0059597 HMDB HMDB0041827 HMDB Carbon dioxide 56-84-8 CAS SMILES NC(CCC(=O)NCCCC=O)C([O-])=O 21865667 ChemSpider 749 ChemSpider SMILES [O-]C(=O)CC[C@H](NC(=O)CCC([O-])=O)C([O-])=O 71-52-3 CAS SMILES NC(=[NH2+])NCCC[C@H](NC(=O)CCC([O-])=O)C([O-])=O 1.0 SMILES OC(=O)\C=C\C(O)=O HMDB0003357 HMDB Hydrogen carbonate CHEBI:58241 ChEBI 1.0 CHO3 Hydrogen carbonate 60.99257 30572 ChemSpider 17215925 ChemSpider CHEBI:12575 ChEBI C2H4O2 Acetic acid 60.02113 P78061 UniProt SMILES CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O argininosuccinate synthase P60651 UniProt Succinic acid NADH 13074-21-0 CAS 64-19-7 CAS N-acetyl-gamma-glutamyl-phosphate reductase 21883788 PubChem-compound SMILES O 13837702 ChemSpider SMILES OO C10H18N4O6 Argininosuccinic acid 290.12262 57-13-6 CAS C6H14N4O2 L-Arginine 174.11168 Acetylornithine/succinyldiaminopimelate aminotransferase Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 Succinic acid semialdehyde 119 PubChem-compound 6992098 PubChem-compound 118 PubChem-compound HMDB0000538 HMDB ornithine carbamoyltransferase C10H17N4O5 N2-succinyl-L-arginine 273.12045 C9H10NO7 N2-succinylglutamate 244.04738 C9H15N2O4 4-(γ-glutamylamino)butanal 215.10373 1.0 5961 PubChem-compound 1.0 C04133 KEGG Compound ReactionCatalysis2668 ACTIVATION CHEBI:61508 ChEBI P25526 UniProt 6816 PubChem-compound P22256 UniProt 51 PubChem-compound ReactionCatalysis2669 ACTIVATION SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc 1.0 CHEBI:15729 ChEBI ReactionCatalysis2664 ACTIVATION ReactionCatalysis2663 ACTIVATION 53-59-8 CAS 1.0 acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase 440848 PubChem-compound acetylornithine deacetylase carbamoyl phosphate synthetase 1038 PubChem-compound Argininosuccinic acid acetylglutamate kinase ReactionCatalysis2677 ACTIVATION N-acetylglutamate synthase ReactionCatalysis2676 ACTIVATION GO:0005829 GENE ONTOLOGY ReactionCatalysis2679 ACTIVATION ReactionCatalysis2678 ACTIVATION L-Arginine Adenosine monophosphate 274 ChemSpider 1.0 C5H6O5 Oxoglutaric acid 146.02153 272 ChemSpider ReactionCatalysis2671 ACTIVATION ReactionCatalysis2670 ACTIVATION ReactionCatalysis2673 ACTIVATION N-Acetyl-L-glutamyl 5-phosphate ReactionCatalysis2672 ACTIVATION ReactionCatalysis2675 ACTIVATION ReactionCatalysis2674 ACTIVATION CHEBI:16908 ChEBI 70-26-8 CAS O4P Phosphate 94.95342 Ornithine carbamoyltransferase chain I GLUTAMINE-PUTRESCINE LIGASE NADPH 6026 ChemSpider C5H14N4 Agmatine 130.12184 Acetic acid arginine decarboxylase ReactionCatalysis2687 ACTIVATION Ornithine 2.0 succinylarginine dihydrolase HMDB0001414 HMDB NADP SMILES NC(N)=O succinylornithine transaminase ReactionCatalysis2680 ACTIVATION C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis2682 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis2681 ACTIVATION ReactionCatalysis2684 ACTIVATION ReactionCatalysis2683 ACTIVATION ReactionCatalysis2686 ACTIVATION C5H12N2O2 Ornithine 132.08987 ReactionCatalysis2685 ACTIVATION P0A6E4 UniProt P11447 UniProt NADPH BioCyc P11446 UniProt Gamma-glutamylputrescine synthetase Ornithine carbamoyltransferase chain F gamma-Aminobutyric acid HMDB0000208 HMDB CPD-6641 BioCyc 218 ChemSpider GAMMA-GLUTAMYL-PUTRESCINE BioCyc agmatinase 58-68-4 CAS C4H9NO2 gamma-Aminobutyric acid 103.06333 L-Glutamic acid HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O HMDB0000214 HMDB SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB Oxygen 692-29-5 CAS CHEBI:30915 ChEBI 124-38-9 CAS PW000779 PathWhiz succinate-semialdehyde dehydrogenase (NADP+) CHEBI:16865 ChEBI ACETYL-GLU BioCyc HMDB0001429 HMDB SMILES NCCCCNC(N)=N 4-(Glutamylamino) butanoate Urea SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0001432 HMDB HMDB0000221 HMDB SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Fumaric acid 1.0 GLN BioCyc GLT BioCyc C4H4O4 Fumaric acid 116.010956 P0A6F1 UniProt CREB3L2-PPARgamma 53-57-6 CAS 1.0 CHEBI:15741 ChEBI 1.0 2.0 1.0 4.0 4-(γ-glutamylamino)butanal 1112 PubChem-compound SMILES O=C=O 127370 PubChem-compound CHEBI:28938 ChEBI N2-succinyl-L-arginine 1110 PubChem-compound 12.0 N2-succinylglutamate HMDB0000112 HMDB 116 ChemSpider HMDB0000595 HMDB O7P2 Pyrophosphate 173.91193 115 ChemSpider C21H29N7O14P2 NADH 665.12476 6082 ChemSpider SMILES CC(=O)N[C@@H](CCC=O)C(O)=O HMDB0001206 HMDB 5957 PubChem-compound 1188-37-0 CAS gamma-Aminobutyric acid C4H6O4 Succinic acid 118.02661 Carbamoyl-phosphate synthase small chain Ornithine carbamoyltransferase chain I Argininosuccinate synthase Acetylglutamate kinase Carbamoyl-phosphate synthase large chain Adenosine diphosphate ReactionCatalysis2645 ACTIVATION C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O 16059 ChemSpider ReactionCatalysis2642 ACTIVATION 899816-95-6 CAS 2.0 1.0 SMILES NCCCC=O 1.0 SUCC-S-ALD BioCyc SMILES N[C@@H](CCCNC(N)=O)C(O)=O CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 2.0 CHEBI:15682 ChEBI 5682 ChemSpider CHEBI:1146900 ChEBI SMILES OC(=O)CCC=O SubPathwayInteraction85074 SubPathway85074Reaction SubPathwayReaction 14000-31-8 CAS CHEBI:16543 ChEBI CPD-822 BioCyc 10.0 CARBAMOYL-P BioCyc CO-A BioCyc Putrescine aminotransferase 1.0 Gamma-glutamyl-gamma-aminobutyrate hydrolase 5675 ChemSpider 72-89-9 CAS 1078 ChemSpider 199 PubChem-compound 1.0 Ornithine P37906 UniProt Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 SMILES NC(=O)OP(O)(O)=O 14798-03-9 CAS 1080 ChemSpider 1.0 HMDB0006488 HMDB Putrescine 1.0 P76038 UniProt C4H12N2 Putrescine 88.10005 CHEBI:15422 ChEBI 6557 ChemSpider Reaction2649 false Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Argininosuccinic acid + Pyrophosphate LEFT_TO_RIGHT CHEBI:16878 ChEBI P0A6C8 UniProt C9H16N2O5 4-(Glutamylamino) butanoate 232.10593 Escherichia coli N-succinylglutamate 5-semialdehyde dehydrogenase SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N N-succinylarginine dihydrolase 388299 ChemSpider Succinylglutamate desuccinylase 2.0 1.0 O2 Oxygen 31.98983 1.0 CHEBI:27657 ChEBI 28782 PubChem-compound 2.0 P76149 UniProt 6.0 C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound 20148392 ChemSpider C00624 KEGG Compound SMILES [NH4+] P77581 UniProt 4-aminobutyrate aminotransferase_ 1.0 CHEBI:16526 ChEBI 1.0 1.0 PW000790 PathWhiz 1.0 CHEBI:16761 ChEBI 7782-44-7 CAS 2.0 P23883 UniProt Succinic acid SubPathwayInput 113025 ChemSpider 1.0 N-ALPHA-ACETYLORNITHINE BioCyc CHEBI:15366 ChEBI CHEBI:17544 ChEBI 4-aminobutyrate aminotransferase 2-KETOGLUTARATE BioCyc 392413 ChemSpider 2.0 SMILES CC(=O)NC(CCC(O)=O)C(O)=O SMILES CC(=O)N[C@@H](CCCN)C(O)=O 1.0 1.0 N2-Succinyl-L-ornithine 1.0 5893 PubChem-compound 2.0 1176 PubChem-compound 110-15-6 CAS γ-aminobutyraldehyde dehydrogenase 439232 PubChem-compound 4-aminobutyrate aminotransferase 171 ChemSpider CHEBI:15377 ChEBI 278 PubChem-compound CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] CHEBI:16467 ChEBI CHEBI:16349 ChEBI N-ACETYL-GLUTAMYL-P BioCyc Succinyl-CoA 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 3.0 5886 PubChem-compound CHEBI:17431 ChEBI C9H13NO6 N2-Succinyl-L-glutamic acid 5-semialdehyde 231.07428 CHEBI:17672 ChEBI 1045 PubChem-compound Phosphate P00968 UniProt 1.0 1.0 280 PubChem-compound 4.3.2.1 false 4.3.2.1 Argininosuccinic acid → Fumaric acid + L-Arginine LEFT_TO_RIGHT 2.0 N2-Succinyl-L-glutamic acid 5-semialdehyde 167387 ChemSpider CHEBI:17769 ChEBI 56-12-2 CAS Reaction154145 false Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH ? N-Acetyl-L-glutamate 5-semialdehyde + NADP + Phosphate 16741146 PubChem-compound Acetylornithine deacetylase 389220 ChemSpider 185 PubChem-compound Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase SMILES N[C@@H](CCC(N)=O)C(O)=O Agmatinase 20841830 PubChem-compound 4.1.1.19 false 4.1.1.19 Hydrogen Ion + L-Arginine → Agmatine + Carbon dioxide LEFT_TO_RIGHT 3.5.3.11 false 3.5.3.11 Agmatine + Water → Putrescine + Urea LEFT_TO_RIGHT Succinylornithine transaminase 1.2.1.71 false 1.2.1.71 N2-Succinyl-L-glutamic acid 5-semialdehyde + NAD + Water → N2-succinylglutamate + 2 Hydrogen Ion + NADH LEFT_TO_RIGHT 2.0 3.5.1.96 false 3.5.1.96 N2-succinylglutamate + Water → L-Glutamic acid + Succinic acid LEFT_TO_RIGHT 2.6.1.81 false 2.6.1.81 N2-Succinyl-L-ornithine + Oxoglutaric acid → L-Glutamic acid + N2-Succinyl-L-glutamic acid 5-semialdehyde LEFT_TO_RIGHT 1.0 2.6.1.82 false 2.6.1.82 Oxoglutaric acid + Putrescine → 4-Aminobutyraldehyde + L-Glutamic acid LEFT_TO_RIGHT 194 ChemSpider 3-METHYLBENZYLSUCCINYL-COA BioCyc 1.2.1.5 false 1.2.1.5 4-(γ-glutamylamino)butanal + NADP + Water → 4-(Glutamylamino) butanoate + 2 Hydrogen Ion + NADPH LEFT_TO_RIGHT 3.5.1.94 false 3.5.1.94 4-(Glutamylamino) butanoate + Water → L-Glutamic acid + gamma-Aminobutyric acid LEFT_TO_RIGHT 6.3.1.11 false 6.3.1.11 Adenosine triphosphate + L-Glutamic acid + Putrescine → Adenosine diphosphate + Gamma-glutamyl-L-putrescine + Hydrogen Ion + Phosphate LEFT_TO_RIGHT Succinate-semialdehyde dehydrogenase [NADP+] 2.0 CHEBI:27574 ChEBI 1.4.3.- false 1.4.3.- Gamma-glutamyl-L-putrescine + Oxygen + Water → 4-(γ-glutamylamino)butanal + Ammonium + Hydrogen peroxide LEFT_TO_RIGHT P77674 UniProt 1061 PubChem-compound 74-79-3 CAS 1.0 HMDB0001967 HMDB HMDB0000517 HMDB CHEBI:15351 ChEBI Gamma-aminobutyraldehyde dehydrogenase Argininosuccinate lyase Gamma-glutamylputrescine synthetase N-acetyl-gamma-glutamyl-phosphate reductase 440236 PubChem-compound 176 PubChem-compound Citrulline C9H19N3O3 Gamma-glutamyl-L-putrescine 217.14264 Reaction2670 false Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetylglutamic acid LEFT_TO_RIGHT Gamma-glutamyl-L-putrescine 2.7.2.8 false 2.7.2.8 Adenosine triphosphate + N-Acetylglutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate LEFT_TO_RIGHT HMDB0000641 HMDB 2.0 4.0 P42588 UniProt P76216 UniProt 85-61-0 CAS CHEBI:16319 ChEBI N2-SUCCINYLORNITHINE BioCyc P76217 UniProt 2.3.1.109 false 2.3.1.109 L-Arginine + Succinyl-CoA → N2-succinyl-L-arginine + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT L-ORNITHINE BioCyc 3.5.3.23 false 3.5.3.23 N2-succinyl-L-arginine + 2 Hydrogen Ion + 2 Water → 2 Ammonium + Carbon dioxide + N2-Succinyl-L-ornithine LEFT_TO_RIGHT P76215 UniProt 2.1.3.3 false 2.1.3.3 Carbamoyl phosphate + Ornithine → Citrulline + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 180 ChemSpider 6.3.5.5 false 6.3.5.5 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + 2 Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT CHEBI:48005 ChEBI 2.6.1.11 false 2.6.1.11 L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT CREB3L2- PPARgamma Acetylglutamate kinase Acetylornithine/succinyldiaminopimelate aminotransferase Carbamoyl- phosphate synthase large chain Carbamoyl- phosphate synthase small chain Argininosuccinate synthase Argininosuccinate lyase Arginine N- succinyltransferase N- succinylarginine dihydrolase Succinylornithine transaminase N- succinylglutamate 5-semialdehyde dehydrogenase Succinylglutamate desuccinylase Gamma- glutamylputrescine synthetase Gamma- glutamylputrescine oxidoreductase Gamma- glutamyl- gamma- aminobutyraldehyde dehydrogenase Putrescine aminotransferase Gamma- aminobutyraldehyde dehydrogenase 4-aminobutyrate aminotransferase_ 4-aminobutyrate aminotransferase Aldehyde dehydrogenase- like protein yneI Acetylornithine deacetylase Biodegradative arginine decarboxylase N-acetyl- gamma- glutamyl- phosphate reductase Ornithine carbamoyltransferase chain F Ornithine carbamoyltransferase chain I Agmatinase Gamma- glutamyl- gamma- aminobutyrate hydrolase Succinate- semialdehyde dehydrogenase [NADP+] Succinic acid Succinic acid L-Glutamic acid Acetyl-CoA CoA H + N- Acetylglutamic acid ATP ADP N-Acetyl-L- glutamyl 5-phosphate N-Acetyl-L- glutamate 5-semialdehyde L-Glutamic acid Oxoglutaric acid N- Acetylornithine HCO 3 - H 2 O L-Glutamine ATP ADP P i L-Glutamic acid H + Carbamoyl phosphate ATP Citrulline L-Aspartic acid PP i AMP Argininosuccinic acid Fumaric acid L-Arginine Succinyl-CoA CoA H + N2-succinyl- L-arginine H 2 O H + CO 2 Ammonium N2-Succinyl- L-ornithine Oxoglutaric acid L-Glutamic acid N2-Succinyl- L-glutamic acid 5-semialdehyde H 2 O NAD H + NADH N2- succinylglutamate H 2 O L-Glutamic acid Putrescine ATP L-Glutamic acid P i ADP H + Gamma- glutamyl-L- putrescine O 2 H 2 O 4-(γ- glutamylamino)butanal Ammonium H 2 O 2 H 2 O NADP 4- (Glutamylamino) butanoate H + NADPH Oxoglutaric acid L-Glutamic acid 4- Aminobutyraldehyde H 2 O NAD H + NADH gamma- Aminobutyric acid Oxoglutaric acid Succinic acid semialdehyde L-Glutamic acid NAD H 2 O H + NADH H 2 O Ornithine Acetic acid H + Agmatine CO 2 NADPH H + NADP P i P i H + H 2 O Urea H 2 O L-Glutamic acid H 2 O NADP NADPH H + TCA Cycle TCA Cycle
CHEBI:16015 ChEBI 1.0 C00437 KEGG Compound 6022 PubChem-compound 7722-84-1 CAS 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 HMDB0001180 HMDB 1.0 439161 PubChem-compound 937 ChemSpider Succinic acid semialdehyde C00555 KEGG Compound Succinate-semialdehyde dehydrogenase [NADP+] 4-AMINO-BUTYRALDEHYDE BioCyc P04391 UniProt HMDB0003125 HMDB 1.0 439153 PubChem-compound 110-17-8 CAS 1.0 CHEBI:58763 ChEBI 50 ChemSpider 1.0 388369 ChemSpider C00327 KEGG Compound 4-Aminobutyraldehyde Agmatinase CHEBI:16027 ChEBI NAD 1.0 ATP BioCyc 389690 ChemSpider Citrulline H4N Ammonium 18.034374 CHEBI:16265 ChEBI Reaction2694 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT 1.0 1.2.1.79 false 1.2.1.79 NADP + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADPH + Succinic acid LEFT_TO_RIGHT 1.2.1.16 false 1.2.1.16 NAD + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADH + Succinic acid LEFT_TO_RIGHT SMILES NCCCCNC(=O)CC[C@H](N)C(O)=O