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CREB3L2- PPARgamma Acetylglutamate kinase Acetylornithine/succinyldiaminopimelate aminotransferase Carbamoyl- phosphate synthase large chain Carbamoyl- phosphate synthase small chain Argininosuccinate synthase Argininosuccinate lyase Arginine N- succinyltransferase N- succinylarginine dihydrolase Succinylornithine transaminase N- succinylglutamate 5-semialdehyde dehydrogenase Succinylglutamate desuccinylase Gamma- glutamylputrescine synthetase Gamma- glutamylputrescine oxidoreductase Gamma- glutamyl- gamma- aminobutyraldehyde dehydrogenase Putrescine aminotransferase Gamma- aminobutyraldehyde dehydrogenase 4-aminobutyrate aminotransferase_ 4-aminobutyrate aminotransferase Aldehyde dehydrogenase- like protein yneI Acetylornithine deacetylase Biodegradative arginine decarboxylase N-acetyl- gamma- glutamyl- phosphate reductase Ornithine carbamoyltransferase chain F Ornithine carbamoyltransferase chain I Agmatinase Gamma- glutamyl- gamma- aminobutyrate hydrolase Succinate- semialdehyde dehydrogenase [NADP+] Succinic acid Succinic acid L-Glutamic acid Acetyl-CoA CoA H + N- Acetylglutamic acid ATP ADP N-Acetyl-L- glutamyl 5-phosphate N-Acetyl-L- glutamate 5-semialdehyde L-Glutamic acid Oxoglutaric acid N- Acetylornithine HCO 3 - H 2 O L-Glutamine ATP ADP P i L-Glutamic acid H + Carbamoyl phosphate ATP Citrulline L-Aspartic acid PP i AMP Argininosuccinic acid Fumaric acid L-Arginine Succinyl-CoA CoA H + N2-succinyl- L-arginine H 2 O H + CO 2 Ammonium N2-Succinyl- L-ornithine Oxoglutaric acid L-Glutamic acid N2-Succinyl- L-glutamic acid 5-semialdehyde H 2 O NAD H + NADH N2- succinylglutamate H 2 O L-Glutamic acid Putrescine ATP L-Glutamic acid P i ADP H + γ-glutamyl-L- putrescine O 2 H 2 O 4-(γ- glutamylamino)butanal Ammonium H 2 O 2 H 2 O NADP 4- (Glutamylamino) butanoate H + NADPH Oxoglutaric acid L-Glutamic acid 4- Aminobutyraldehyde H 2 O NAD H + NADH γ-Aminobutyric acid Oxoglutaric acid Succinic acid semialdehyde L-Glutamic acid NAD H 2 O H + NADH H 2 O Ornithine Acetic acid H + Agmatine CO 2 NADPH H + NADP P i P i H + H 2 O Urea H 2 O L-Glutamic acid H 2 O NADP NADPH H + TCA Cycle TCA Cycle