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CHEBI:16015 ChEBI HMDB00254 HMDB C00437 KEGG Compound 6022 PubChem-compound 7722-84-1 CAS 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 1.0 937 ChemSpider Succinic acid semialdehyde C00555 KEGG Compound Succinate-semialdehyde dehydrogenase [NADP+] HMDB01341 HMDB 4-AMINO-BUTYRALDEHYDE BioCyc 1.0 439153 PubChem-compound 50 ChemSpider 1.0 388369 ChemSpider 4-Aminobutyraldehyde HMDB00148 HMDB NAD ATP BioCyc H4N Ammonium 18.034374 CHEBI:16265 ChEBI Reaction2694 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT 4.1.1.17 false 4.1.1.17 Hydrogen Ion + Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 1.0 HMDB12230 HMDB 1.2.1.79 false 1.2.1.79 NADP + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADPH + Succinic acid LEFT_TO_RIGHT 1.2.1.16 false 1.2.1.16 NAD + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADH + Succinic acid LEFT_TO_RIGHT SMILES NCCCCNC(=O)CC[C@H](N)C(O)=O 1.2.1.19 false 1.2.1.19 4-Aminobutyraldehyde + NAD + Water → Gamma-Aminobutyric acid + Hydrogen Ion + NADH LEFT_TO_RIGHT 2.6.1.19 false 2.6.1.19 Gamma-Aminobutyric acid + Oxoglutaric acid → L-Glutamic acid + Succinic acid semialdehyde LEFT_TO_RIGHT P23908 UniProt HMDB00112 HMDB 1.0 HMDB01206 HMDB 5742 ChemSpider C00334 KEGG Compound CHEBI:16474 ChEBI 952 ChemSpider Acetylglutamate kinase Gamma-glutamylputrescine oxidoreductase 192878 PubChem-compound HMDB59597 HMDB P18335 UniProt Acetyl-CoA CHEBI:16240 ChEBI Aldehyde dehydrogenase-like protein yneI 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS HMDB41827 HMDB SMILES NCCCCN 23724570 PubChem-compound 1.0 5105-96-4 CAS HMDB01423 HMDB 2.0 CHEBI:17148 ChEBI Ammonium HMDB00214 HMDB Hydrogen Ion HMDB00217 HMDB Putrescine aminotransferase C00232 KEGG Compound glycolysis and pyruvate dehydrogenase SubPathway Adenosine triphosphate SUC BioCyc TCA cycle SubPathway Acetylornithine/succinyldiaminopimelate aminotransferase CHEBI:49260 ChEBI Gamma-glutamyl-gamma-aminobutyrate hydrolase HMDB00208 HMDB HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound 110-60-1 CAS C00007 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound N-Acetylornithine SubPathwayInteraction1652 SubPathway1652Reaction SubPathwayReaction SubPathwayInteraction1654 SubPathwayReaction SubPathway1654Reaction C00005 KEGG Compound CPD-9000 BioCyc CHEBI:18367 ChEBI C00004 KEGG Compound N-Acetylglutamic acid 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 6205-08-9 CAS HMDB01429 HMDB C21H28N7O14P2 NAD 664.11694 1.0 C01342 KEGG Compound 4-aminobutyrate aminotransferase_ C00011 KEGG Compound C00010 KEGG Compound C4H9NO 4-Aminobutyraldehyde 87.06841 C00134 KEGG Compound 4.0 Q86WD1 UniProt NAD(P) BioCyc 1.0 H Hydrogen Ion 1.007825 HMDB01414 HMDB C4H6O3 Succinic acid semialdehyde 102.03169 1.0 4-aminobutyrate aminotransferase 56-65-5 CAS 53-84-9 CAS C00027 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound ACET BioCyc 1.0 1.0 PUTRESCINE BioCyc 1.0 C00033 KEGG Compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Water Hydrogen peroxide SMILES OC(=O)CCC(O)=O C01250 KEGG Compound HYDROGEN-PEROXIDE BioCyc P50457 UniProt P24169 UniProt C15767 KEGG Compound Ornithine decarboxylase, inducible N-Acetyl-L-glutamyl 5-phosphate C00042 KEGG Compound Acetylornithine deacetylase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ornithine decarboxylase NAD+-dependent succinate semialdehyde dehydrogenase 763 ChemSpider CREB3L2-PPARgamma Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase succinate-semialdehyde dehydrogenase (NADP+) HMDB00538 HMDB 784 PubChem-compound C7H11NO5 N-Acetylglutamic acid 189.06372 4390-05-0 CAS SMILES CC(O)=O C7H14N2O3 N-Acetylornithine 174.10045 7732-18-5 CAS N-acetyl-gamma-glutamyl-phosphate reductase Gamma-aminobutyraldehyde dehydrogenase 56-86-0 CAS 2.0 2.0 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 1.0 Succinate-semialdehyde dehydrogenase [NADP+] HMDB01967 HMDB 962 PubChem-compound 5800 ChemSpider C00077 KEGG Compound CO2 Carbon dioxide 43.98983 SMILES N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O Phosphate C00080 KEGG Compound SMILES O=O C7H11NO4 N-Acetyl-L-glutamate 5-semialdehyde 173.0688 Oxoglutaric acid 15383-57-0 CAS SMILES N[C@@H](CCC(O)=O)C(O)=O 14265-44-2 CAS 58-64-0 CAS C15699 KEGG Compound 444493 PubChem-compound C7H12NO8P N-Acetyl-L-glutamyl 5-phosphate 269.03006 N-Acetyl-L-glutamate 5-semialdehyde 22833512 PubChem-compound Aldehyde dehydrogenase-like protein yneI ACETYL-COA BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 4-AMINO-BUTYRATE BioCyc NADH BioCyc Gamma-glutamylputrescine oxidoreductase SMILES NCCCC(O)=O NAD BioCyc SMILES CC(=O)N[C@@H](CCC(O)=O)C(O)=O 977 PubChem-compound Carbon dioxide SMILES NC(CCC(=O)NCCCC=O)C([O-])=O 21865667 ChemSpider 30572 ChemSpider 17215925 ChemSpider CHEBI:12575 ChEBI C2H4O2 Acetic acid 60.02113 P78061 UniProt SMILES CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O Succinic acid NADH 13074-21-0 CAS 64-19-7 CAS 13837702 ChemSpider SMILES O SMILES OO Acetylornithine/succinyldiaminopimelate aminotransferase 119 PubChem-compound 118 PubChem-compound C7H11NO5 N-acetylglutamate semialdehyde 189.06372 C9H15N2O4 4-(γ-glutamylamino)butanal 215.10373 HMDB06488 HMDB ReactionCatalysis2665 ACTIVATION 1.0 C04133 KEGG Compound ReactionCatalysis2668 ACTIVATION CHEBI:61508 ChEBI P25526 UniProt 6816 PubChem-compound P22256 UniProt 51 PubChem-compound CHEBI:15846 ChEBI ADP BioCyc 1.0 CHEBI:15729 ChEBI ReactionCatalysis2664 ACTIVATION ReactionCatalysis2663 ACTIVATION 53-59-8 CAS 1.0 acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase acetylornithine deacetylase 1038 PubChem-compound HMDB06456 HMDB acetylglutamate kinase N-acetylglutamate synthase ReactionCatalysis2679 ACTIVATION ReactionCatalysis2678 ACTIVATION 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 HMDB00902 HMDB CHEBI:16908 ChEBI 70-26-8 CAS O4P Phosphate 94.95342 GLUTAMINE-PUTRESCINE LIGASE γ-glutamyl-γ-aminobutyrate hydrolase NADPH 6026 ChemSpider Acetic acid ReactionCatalysis2688 ACTIVATION ReactionCatalysis2687 ACTIVATION Ornithine NADP C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis2680 ACTIVATION ReactionCatalysis2682 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis2681 ACTIVATION ReactionCatalysis2684 ACTIVATION ReactionCatalysis2683 ACTIVATION ReactionCatalysis2686 ACTIVATION C5H12N2O2 Ornithine 132.08987 ReactionCatalysis2685 ACTIVATION NADPH BioCyc P11446 UniProt 6857435 PubChem-compound Gamma-glutamylputrescine synthetase PW000785 PathWhiz CPD-6641 BioCyc GAMMA-GLUTAMYL-PUTRESCINE BioCyc 218 ChemSpider 58-68-4 CAS C4H9NO2 Gamma-Aminobutyric acid 103.06333 L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O Oxygen 692-29-5 CAS CHEBI:30915 ChEBI 124-38-9 CAS PW000779 PathWhiz CHEBI:16865 ChEBI ACETYL-GLU BioCyc 4-(Glutamylamino) butanoate SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 1.0 GLT BioCyc CREB3L2-PPARgamma 53-57-6 CAS SMP00802 SMPDB CHEBI:15741 ChEBI 4-(γ-glutamylamino)butanal 1112 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI N-acetylglutamate semialdehyde 12.0 1110 PubChem-compound SMP00807 SMPDB 116 ChemSpider 115 ChemSpider C21H29N7O14P2 NADH 665.12476 SMILES CC(=O)N[C@@H](CCC=O)C(O)=O 5957 PubChem-compound HMDB01080 HMDB 1188-37-0 CAS Gamma-Aminobutyric acid C4H6O4 Succinic acid 118.02661 SMP00813 SMPDB Acetylglutamate kinase Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 2.0 HMDB03125 HMDB SMILES NCCCC=O 1.0 SUCC-S-ALD BioCyc CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider CHEBI:1146900 ChEBI SMILES OC(=O)CCC=O CHEBI:16543 ChEBI ornithine metabolism CO-A BioCyc Putrescine aminotransferase Gamma-glutamyl-gamma-aminobutyrate hydrolase 5675 ChemSpider 72-89-9 CAS 1078 ChemSpider P37906 UniProt Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 14798-03-9 CAS 1080 ChemSpider Putrescine 1.0 P76038 UniProt C4H12N2 Putrescine 88.10005 CHEBI:15422 ChEBI 6557 ChemSpider CHEBI:16878 ChEBI P0A6C8 UniProt C9H16N2O5 4-(Glutamylamino) butanoate 232.10593 SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 2.0 O2 Oxygen 31.98983 1.0 2.0 1.0 P76149 UniProt 6.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 20148392 ChemSpider C00624 KEGG Compound SMILES [NH4+] PW000791 PathWhiz HMDB03357 HMDB 4-aminobutyrate aminotransferase_ 1.0 CHEBI:16526 ChEBI 1.0 1.0 CHEBI:16761 ChEBI 7782-44-7 CAS P23883 UniProt N-ALPHA-ACETYLORNITHINE BioCyc CHEBI:15366 ChEBI 4-aminobutyrate aminotransferase 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O SMILES CC(=O)N[C@@H](CCCN)C(O)=O 1.0 1.0 5893 PubChem-compound 2.0 HMDB02111 HMDB 110-15-6 CAS γ-aminobutyraldehyde dehydrogenase HMDB12161 HMDB 439232 PubChem-compound 4-aminobutyrate aminotransferase 171 ChemSpider CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] N-ACETYL-GLUTAMYL-P BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1045 PubChem-compound 1.0 1.0 280 PubChem-compound HMDB01487 HMDB 167387 ChemSpider CHEBI:17769 ChEBI 56-12-2 CAS Ornithine decarboxylase, inducible 16741146 PubChem-compound Acetylornithine deacetylase 389220 ChemSpider 185 PubChem-compound Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 20841830 PubChem-compound 1.0 2.6.1.82 false 2.6.1.82 Oxoglutaric acid + Putrescine → 4-Aminobutyraldehyde + L-Glutamic acid LEFT_TO_RIGHT 1.2.1.5 false 1.2.1.5 4-(γ-glutamylamino)butanal + NADP + Water → 4-(Glutamylamino) butanoate + 2 Hydrogen Ion + NADPH LEFT_TO_RIGHT 3.5.1.94 false 3.5.1.94 4-(Glutamylamino) butanoate + Water → Gamma-Aminobutyric acid + L-Glutamic acid LEFT_TO_RIGHT 6.3.1.11 false 6.3.1.11 Adenosine triphosphate + L-Glutamic acid + Putrescine → Adenosine diphosphate + Gamma-glutamyl-L-putrescine + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 1.4.3.- false 1.4.3.- Gamma-glutamyl-L-putrescine + Oxygen + Water → 4-(γ-glutamylamino)butanal + Ammonium + Hydrogen peroxide LEFT_TO_RIGHT 2.0 P77674 UniProt HMDB01377 HMDB 1061 PubChem-compound HMDB01138 HMDB 1.0 HMDB01259 HMDB CHEBI:15351 ChEBI Gamma-aminobutyraldehyde dehydrogenase HMDB00042 HMDB N-acetyl-gamma-glutamyl-phosphate reductase Gamma-glutamylputrescine synthetase 440236 PubChem-compound 176 PubChem-compound 1.2.1.38 false 1.2.1.38 Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH → N-acetylglutamate semialdehyde + NADP + Phosphate LEFT_TO_RIGHT C9H19N3O3 Gamma-glutamyl-L-putrescine 217.14264 Reaction2670 false Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetylglutamic acid LEFT_TO_RIGHT Gamma-glutamyl-L-putrescine 2.7.2.8 false 2.7.2.8 Adenosine triphosphate + N-Acetylglutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate LEFT_TO_RIGHT 4.0 P42588 UniProt 85-61-0 CAS CHEBI:16319 ChEBI L-ORNITHINE BioCyc 180 ChemSpider CHEBI:48005 ChEBI 2.6.1.11 false 2.6.1.11 L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT Unknown Acetylglutamate kinase N-acetyl- gamma- glutamyl- phosphate reductase Acetylornithine/succinyldiaminopimelate aminotransferase Gamma- glutamylputrescine synthetase Gamma- glutamylputrescine oxidoreductase Gamma- glutamyl- gamma- aminobutyraldehyde dehydrogenase Gamma- glutamyl- gamma- aminobutyrate hydrolase Putrescine aminotransferase Gamma- aminobutyraldehyde dehydrogenase 4-aminobutyrate aminotransferase_ 4-aminobutyrate aminotransferase Succinate- semialdehyde dehydrogenase [NADP+] Aldehyde dehydrogenase- like protein yneI Acetylornithine deacetylase Ornithine decarboxylase, inducible L-Glutamic acid Acetyl-CoA CoA H + N- Acetylglutamic acid ATP ADP N-Acetyl-L- glutamyl 5-phosphate NADPH H + N- acetylglutamate semialdehyde P i NADP N-Acetyl-L- glutamate 5-semialdehyde L-Glutamic acid Oxoglutaric acid N- Acetylornithine Putrescine ATP L-Glutamic acid P i ADP H + Gamma- glutamyl-L- putrescine O 2 H 2 O 4-(γ- glutamylamino)butanal Ammonium H 2 O 2 H 2 O NADP 4- (Glutamylamino) butanoate H + NADPH H 2 O L-Glutamic acid Gamma- Aminobutyric acid Oxoglutaric acid L-Glutamic acid 4- Aminobutyraldehyde H 2 O NAD H + NADH Gamma- Aminobutyric acid Oxoglutaric acid Succinic acid semialdehyde L-Glutamic acid H 2 O NADP NADPH H + Succinic acid NAD H 2 O H + NADH Succinic acid H 2 O Ornithine Acetic acid H + Putrescine CO 2 TCA cycle glycolysis and pyruvate dehydrogenase
CHEBI:16015 ChEBI HMDB00254 HMDB C00437 KEGG Compound 6022 PubChem-compound 7722-84-1 CAS 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 1.0 937 ChemSpider Succinic acid semialdehyde C00555 KEGG Compound Succinate-semialdehyde dehydrogenase [NADP+] HMDB01341 HMDB 4-AMINO-BUTYRALDEHYDE BioCyc 1.0 439153 PubChem-compound 50 ChemSpider 1.0 388369 ChemSpider 4-Aminobutyraldehyde HMDB00148 HMDB NAD ATP BioCyc H4N Ammonium 18.034374 CHEBI:16265 ChEBI Reaction2694 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT 4.1.1.17 false 4.1.1.17 Hydrogen Ion + Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 1.0 HMDB12230 HMDB 1.2.1.79 false 1.2.1.79 NADP + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADPH + Succinic acid LEFT_TO_RIGHT 1.2.1.16 false 1.2.1.16 NAD + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADH + Succinic acid LEFT_TO_RIGHT SMILES NCCCCNC(=O)CC[C@H](N)C(O)=O 1.2.1.19 false 1.2.1.19 4-Aminobutyraldehyde + NAD + Water → Gamma-Aminobutyric acid + Hydrogen Ion + NADH LEFT_TO_RIGHT 2.6.1.19 false 2.6.1.19 Gamma-Aminobutyric acid + Oxoglutaric acid → L-Glutamic acid + Succinic acid semialdehyde LEFT_TO_RIGHT P23908 UniProt HMDB00112 HMDB 1.0 HMDB01206 HMDB 5742 ChemSpider C00334 KEGG Compound CHEBI:16474 ChEBI 952 ChemSpider Acetylglutamate kinase Gamma-glutamylputrescine oxidoreductase 192878 PubChem-compound HMDB59597 HMDB P18335 UniProt Acetyl-CoA CHEBI:16240 ChEBI Aldehyde dehydrogenase-like protein yneI 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS HMDB41827 HMDB SMILES NCCCCN 23724570 PubChem-compound 1.0 5105-96-4 CAS HMDB01423 HMDB 2.0 CHEBI:17148 ChEBI Ammonium HMDB00214 HMDB Hydrogen Ion HMDB00217 HMDB Putrescine aminotransferase C00232 KEGG Compound Adenosine triphosphate SUC BioCyc Acetylornithine/succinyldiaminopimelate aminotransferase CHEBI:49260 ChEBI Gamma-glutamyl-gamma-aminobutyrate hydrolase HMDB00208 HMDB HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound 110-60-1 CAS C00007 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound N-Acetylornithine SubPathwayInteraction1652 SubPathway1652Reaction SubPathwayReaction SubPathwayInteraction1654 SubPathwayReaction SubPathway1654Reaction C00005 KEGG Compound CPD-9000 BioCyc CHEBI:18367 ChEBI C00004 KEGG Compound N-Acetylglutamic acid 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 6205-08-9 CAS HMDB01429 HMDB C21H28N7O14P2 NAD 664.11694 1.0 C01342 KEGG Compound 4-aminobutyrate aminotransferase_ C00011 KEGG Compound C00010 KEGG Compound C4H9NO 4-Aminobutyraldehyde 87.06841 C00134 KEGG Compound 4.0 Q86WD1 UniProt NAD(P) BioCyc 1.0 H Hydrogen Ion 1.007825 HMDB01414 HMDB C4H6O3 Succinic acid semialdehyde 102.03169 1.0 4-aminobutyrate aminotransferase 56-65-5 CAS 53-84-9 CAS C00027 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound ACET BioCyc 1.0 1.0 PUTRESCINE BioCyc 1.0 C00033 KEGG Compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Water Hydrogen peroxide SMILES OC(=O)CCC(O)=O C01250 KEGG Compound HYDROGEN-PEROXIDE BioCyc P50457 UniProt P24169 UniProt C15767 KEGG Compound Ornithine decarboxylase, inducible N-Acetyl-L-glutamyl 5-phosphate C00042 KEGG Compound Acetylornithine deacetylase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ornithine decarboxylase NAD+-dependent succinate semialdehyde dehydrogenase 763 ChemSpider CREB3L2-PPARgamma Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase succinate-semialdehyde dehydrogenase (NADP+) HMDB00538 HMDB 784 PubChem-compound C7H11NO5 N-Acetylglutamic acid 189.06372 4390-05-0 CAS SMILES CC(O)=O C7H14N2O3 N-Acetylornithine 174.10045 7732-18-5 CAS N-acetyl-gamma-glutamyl-phosphate reductase Gamma-aminobutyraldehyde dehydrogenase 56-86-0 CAS 2.0 2.0 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 1.0 Succinate-semialdehyde dehydrogenase [NADP+] HMDB01967 HMDB 962 PubChem-compound 5800 ChemSpider C00077 KEGG Compound CO2 Carbon dioxide 43.98983 SMILES N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O Phosphate C00080 KEGG Compound SMILES O=O C7H11NO4 N-Acetyl-L-glutamate 5-semialdehyde 173.0688 Oxoglutaric acid 15383-57-0 CAS SMILES N[C@@H](CCC(O)=O)C(O)=O 14265-44-2 CAS 58-64-0 CAS C15699 KEGG Compound 444493 PubChem-compound C7H12NO8P N-Acetyl-L-glutamyl 5-phosphate 269.03006 N-Acetyl-L-glutamate 5-semialdehyde 22833512 PubChem-compound Aldehyde dehydrogenase-like protein yneI ACETYL-COA BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 4-AMINO-BUTYRATE BioCyc NADH BioCyc Gamma-glutamylputrescine oxidoreductase SMILES NCCCC(O)=O NAD BioCyc SMILES CC(=O)N[C@@H](CCC(O)=O)C(O)=O 977 PubChem-compound Carbon dioxide SMILES NC(CCC(=O)NCCCC=O)C([O-])=O 21865667 ChemSpider 30572 ChemSpider 17215925 ChemSpider CHEBI:12575 ChEBI C2H4O2 Acetic acid 60.02113 P78061 UniProt SMILES CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O Succinic acid NADH 13074-21-0 CAS 64-19-7 CAS 13837702 ChemSpider SMILES O SMILES OO Acetylornithine/succinyldiaminopimelate aminotransferase 119 PubChem-compound 118 PubChem-compound C7H11NO5 N-acetylglutamate semialdehyde 189.06372 C9H15N2O4 4-(γ-glutamylamino)butanal 215.10373 HMDB06488 HMDB ReactionCatalysis2665 ACTIVATION 1.0 C04133 KEGG Compound ReactionCatalysis2668 ACTIVATION CHEBI:61508 ChEBI P25526 UniProt 6816 PubChem-compound P22256 UniProt 51 PubChem-compound CHEBI:15846 ChEBI ADP BioCyc 1.0 CHEBI:15729 ChEBI ReactionCatalysis2664 ACTIVATION ReactionCatalysis2663 ACTIVATION 53-59-8 CAS 1.0 acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase acetylornithine deacetylase 1038 PubChem-compound HMDB06456 HMDB acetylglutamate kinase N-acetylglutamate synthase ReactionCatalysis2679 ACTIVATION ReactionCatalysis2678 ACTIVATION 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 HMDB00902 HMDB CHEBI:16908 ChEBI 70-26-8 CAS O4P Phosphate 94.95342 GLUTAMINE-PUTRESCINE LIGASE γ-glutamyl-γ-aminobutyrate hydrolase NADPH 6026 ChemSpider Acetic acid ReactionCatalysis2688 ACTIVATION ReactionCatalysis2687 ACTIVATION Ornithine NADP TCA cycle SubPathway C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis2680 ACTIVATION ReactionCatalysis2682 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis2681 ACTIVATION ReactionCatalysis2684 ACTIVATION glycolysis and pyruvate dehydrogenase SubPathway ReactionCatalysis2683 ACTIVATION ReactionCatalysis2686 ACTIVATION C5H12N2O2 Ornithine 132.08987 ReactionCatalysis2685 ACTIVATION NADPH BioCyc P11446 UniProt 6857435 PubChem-compound Gamma-glutamylputrescine synthetase PW000785 PathWhiz CPD-6641 BioCyc GAMMA-GLUTAMYL-PUTRESCINE BioCyc 218 ChemSpider 58-68-4 CAS C4H9NO2 Gamma-Aminobutyric acid 103.06333 L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O Oxygen 692-29-5 CAS CHEBI:30915 ChEBI 124-38-9 CAS PW000779 PathWhiz CHEBI:16865 ChEBI ACETYL-GLU BioCyc 4-(Glutamylamino) butanoate SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 1.0 GLT BioCyc CREB3L2-PPARgamma 53-57-6 CAS http://identifiers.org/smpdb/SMP00802 SMPDB CHEBI:15741 ChEBI 4-(γ-glutamylamino)butanal 1112 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI N-acetylglutamate semialdehyde 12.0 1110 PubChem-compound http://identifiers.org/smpdb/SMP00807 SMPDB 116 ChemSpider 115 ChemSpider C21H29N7O14P2 NADH 665.12476 SMILES CC(=O)N[C@@H](CCC=O)C(O)=O 5957 PubChem-compound HMDB01080 HMDB 1188-37-0 CAS Gamma-Aminobutyric acid C4H6O4 Succinic acid 118.02661 http://identifiers.org/smpdb/SMP00813 SMPDB Acetylglutamate kinase Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 2.0 HMDB03125 HMDB SMILES NCCCC=O 1.0 SUCC-S-ALD BioCyc CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider CHEBI:1146900 ChEBI SMILES OC(=O)CCC=O CHEBI:16543 ChEBI ornithine metabolism CO-A BioCyc Putrescine aminotransferase Gamma-glutamyl-gamma-aminobutyrate hydrolase 5675 ChemSpider 72-89-9 CAS 1078 ChemSpider P37906 UniProt Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 14798-03-9 CAS 1080 ChemSpider Putrescine 1.0 P76038 UniProt C4H12N2 Putrescine 88.10005 CHEBI:15422 ChEBI 6557 ChemSpider CHEBI:16878 ChEBI P0A6C8 UniProt C9H16N2O5 4-(Glutamylamino) butanoate 232.10593 SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 2.0 O2 Oxygen 31.98983 1.0 2.0 1.0 P76149 UniProt 6.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 20148392 ChemSpider C00624 KEGG Compound SMILES [NH4+] PW000791 PathWhiz HMDB03357 HMDB 4-aminobutyrate aminotransferase_ 1.0 CHEBI:16526 ChEBI 1.0 1.0 CHEBI:16761 ChEBI 7782-44-7 CAS P23883 UniProt N-ALPHA-ACETYLORNITHINE BioCyc CHEBI:15366 ChEBI 4-aminobutyrate aminotransferase 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O SMILES CC(=O)N[C@@H](CCCN)C(O)=O 1.0 1.0 5893 PubChem-compound 2.0 HMDB02111 HMDB 110-15-6 CAS γ-aminobutyraldehyde dehydrogenase HMDB12161 HMDB 439232 PubChem-compound 4-aminobutyrate aminotransferase 171 ChemSpider CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] N-ACETYL-GLUTAMYL-P BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1045 PubChem-compound 1.0 1.0 280 PubChem-compound HMDB01487 HMDB 167387 ChemSpider CHEBI:17769 ChEBI 56-12-2 CAS Ornithine decarboxylase, inducible 16741146 PubChem-compound Acetylornithine deacetylase 389220 ChemSpider 185 PubChem-compound Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 20841830 PubChem-compound 1.0 2.6.1.82 false 2.6.1.82 Oxoglutaric acid + Putrescine → 4-Aminobutyraldehyde + L-Glutamic acid LEFT_TO_RIGHT 1.2.1.5 false 1.2.1.5 4-(γ-glutamylamino)butanal + NADP + Water → 4-(Glutamylamino) butanoate + 2 Hydrogen Ion + NADPH LEFT_TO_RIGHT 3.5.1.94 false 3.5.1.94 4-(Glutamylamino) butanoate + Water → Gamma-Aminobutyric acid + L-Glutamic acid LEFT_TO_RIGHT 6.3.1.11 false 6.3.1.11 Adenosine triphosphate + L-Glutamic acid + Putrescine → Adenosine diphosphate + Gamma-glutamyl-L-putrescine + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 1.4.3.- false 1.4.3.- Gamma-glutamyl-L-putrescine + Oxygen + Water → 4-(γ-glutamylamino)butanal + Ammonium + Hydrogen peroxide LEFT_TO_RIGHT 2.0 P77674 UniProt HMDB01377 HMDB 1061 PubChem-compound HMDB01138 HMDB 1.0 HMDB01259 HMDB CHEBI:15351 ChEBI Gamma-aminobutyraldehyde dehydrogenase HMDB00042 HMDB N-acetyl-gamma-glutamyl-phosphate reductase Gamma-glutamylputrescine synthetase 440236 PubChem-compound 176 PubChem-compound 1.2.1.38 false 1.2.1.38 Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH → N-acetylglutamate semialdehyde + NADP + Phosphate LEFT_TO_RIGHT C9H19N3O3 Gamma-glutamyl-L-putrescine 217.14264 Reaction2670 false Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetylglutamic acid LEFT_TO_RIGHT Gamma-glutamyl-L-putrescine 2.7.2.8 false 2.7.2.8 Adenosine triphosphate + N-Acetylglutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate LEFT_TO_RIGHT 4.0 P42588 UniProt 85-61-0 CAS CHEBI:16319 ChEBI L-ORNITHINE BioCyc 180 ChemSpider CHEBI:48005 ChEBI 2.6.1.11 false 2.6.1.11 L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT