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Pathway Description
Fatty Acid Metabolism
Escherichia coli
Metabolic Pathway
Fatty acid metabolism is also known as beta-oxidation. During beta-oxidation, acetyl-CoA is produced which can be used in the citric acid cycle. When ATP is needed, ATP may be generated by increasing fatty acid metabolism. Therefore fatty acids constitute a large energy source for organisms since it can be a source of generated ATP when needed. Fatty acid metabolism is essentially the reverse reaction of fatty acid synthesis which is essential for cellular processes since the membrane is mostly made up of fatty acids.
References
Fatty Acid Metabolism References
Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.
Garwin JL, Klages AL, Cronan JE Jr: Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli. J Biol Chem. 1980 Dec 25;255(24):11949-56.
Pubmed: 7002930
Garwin JL, Klages AL, Cronan JE Jr: Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis. J Biol Chem. 1980 Apr 25;255(8):3263-5.
Pubmed: 6988423
Gelmann EP, Cronan JE Jr: Mutant of Escherichia coli deficient in the synthesis of cis-vaccenic acid. J Bacteriol. 1972 Oct;112(1):381-7.
Pubmed: 4562402
Heath RJ, Rock CO: Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. J Biol Chem. 1995 Nov 3;270(44):26538-42.
Pubmed: 7592873
Heath RJ, Rock CO: Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli. J Biol Chem. 1996 Jan 26;271(4):1833-6.
Pubmed: 8567624
Leesong M, Henderson BS, Gillig JR, Schwab JM, Smith JL: Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Structure. 1996 Mar 15;4(3):253-64.
Pubmed: 8805534
White SW, Zheng J, Zhang YM, Rock: The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem. 2005;74:791-831. doi: 10.1146/annurev.biochem.74.082803.133524.
Pubmed: 15952903
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