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Pathway Description
Phenylalanine Biosynthesis
Escherichia coli
Metabolic Pathway
The phenylalaline biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which further be converted to prephenate by P-protein. Combined with cofactor, H+, prephenate has been further converted to phenylpyruvic acid by P-protein with generated water and carbon dioxide. Phenylalanine transaminase catalyzes phenylpyruvic acid to phenylalaline, and also convert glutamic acid to oxoglutaric acid. Phenylalaline will be further used in phenylalaline metabolism.
References
Phenylalanine Biosynthesis References
Gelfand DH, Steinberg RA: Escherichia coli mutants deficient in the aspartate and aromatic amino acid aminotransferases. J Bacteriol. 1977 Apr;130(1):429-40.
Pubmed: 15983
Wu WB, Guo XL, Zhang ML, Huang QG, Qi F, Huang JZ: Enhancement of l-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin. Biotechnol Appl Biochem. 2018 May;65(3):476-483. doi: 10.1002/bab.1605. Epub 2017 Sep 23.
Pubmed: 28872702
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