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Pathway Description
Glycine Biosynthesis
Escherichia coli
Metabolic Pathway
Glycine biosynthesis is dependent on L-serine. L-serine is enters the cell through transporters (serine / threonine:H+ symporter TdcC, serine/threonine: Na symporter , serine:H+ symporter SdaC) and then proceeds through reversible reaction with a tetrahydrofolic acid through a serine hydroxymethyltransferase enzyme in order to produce glycine, 5,10-methylene tetrahydrofolate and water. 5,10-methylene tetrahydrofolate is a major source of one-carbon units used in other metabolic pathways.
References
Glycine Biosynthesis References
Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.
Sah S, Varshney U: Impact of Mutating the Key Residues of a Bifunctional 5,10-Methylenetetrahydrofolate Dehydrogenase-Cyclohydrolase from Escherichia coli on Its Activities. Biochemistry. 2015 Jun 9;54(22):3504-13. doi: 10.1021/acs.biochem.5b00400. Epub 2015 May 28.
Pubmed: 25988590
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