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CHEBI:16015 ChEBI 30572 ChemSpider C4H4O5 Oxalacetic acid 132.00587 937 ChemSpider C00152 KEGG Compound HMDB00250 HMDB 6267 PubChem-compound C00036 KEGG Compound aspartate transaminase 328-50-7 CAS Water AMP BioCyc P0A962 UniProt SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate 50 ChemSpider P37595 UniProt 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS CHEBI:16027 ChEBI HMDB00148 HMDB SMP00833 SMPDB CHEBI:17196 ChEBI OXALACETIC_ACID BioCyc ATP BioCyc C00049 KEGG Compound 5961 PubChem-compound 56-85-9 CAS Aspartate--ammonia ligase H4N Ammonium 18.034374 Isoaspartyl peptidase 3.4.19.5 false 3.4.19.5 L-Asparagine + Water → Ammonium + L-Aspartic acid LEFT_TO_RIGHT 1.0 1.0 1.0 P00805 UniProt 4.0 328-42-7 CAS 14798-03-9 CAS 51 PubChem-compound 559142 ChemSpider HMDB00538 HMDB ReactionCatalysis2660 ACTIVATION ReactionCatalysis3357 ACTIVATION 1.0 CHEBI:15422 ChEBI 2.0 5746 ChemSpider 5745 ChemSpider HMDB00191 HMDB 5742 ChemSpider ASN BioCyc 1038 PubChem-compound SMILES OC(=O)CC(=O)C(O)=O L-asparaginase 1 7732-18-5 CAS L-ASPARTATE BioCyc 2.0 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB59597 HMDB Adenosine monophosphate 56-86-0 CAS C5H6O5 Oxoglutaric acid 146.02153 6.3.5.4 false 6.3.5.4 Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water → Adenosine monophosphate + Hydrogen Ion + L-Asparagine + L-Glutamic acid + Pyrophosphate LEFT_TO_RIGHT 6.3.1.1 false 6.3.1.1 Adenosine triphosphate + Ammonium + L-Aspartic acid → Adenosine monophosphate + Hydrogen Ion + L-Asparagine + Pyrophosphate LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 5858 ChemSpider 33032 PubChem-compound SMILES [NH4+] HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 Aspartate aminotransferase CHEBI:17053 ChEBI Oxalacetic acid C00064 KEGG Compound 945 ChemSpider 1.0 TCA cycle SubPathway 1010 ChemSpider 6031 ChemSpider HMDB41827 HMDB PPI BioCyc 4.0 4.0 962 PubChem-compound 1.0 Ammonium C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion 2-KETOGLUTARATE BioCyc Asparagine synthetase B [glutamine-hydrolyzing] L-asparaginase 2 218 ChemSpider HMDB02111 HMDB Adenosine triphosphate SubPathwayInteraction1364 SubPathway1364Reaction SubPathwayReaction P22106 UniProt C00080 KEGG Compound ReactionCatalysis2852 ACTIVATION L-Glutamic acid Isoaspartyl peptidase Oxoglutaric acid SMILES OC(=O)CCC(=O)C(O)=O PW000813 PathWhiz HMDB00208 HMDB CHEBI:30915 ChEBI PW000779 PathWhiz Reaction2667 false L-Glutamic acid + Oxalacetic acid → L-Aspartic acid + Oxoglutaric acid LEFT_TO_RIGHT C4H8N2O3 L-Asparagine 132.0535 SMILES N[C@@H](CCC(O)=O)C(O)=O ReactionCatalysis2851 ACTIVATION ReactionCatalysis2850 ACTIVATION CHEBI:15377 ChEBI HMDB00223 HMDB CHEBI:15378 ChEBI SMILES [H+] 1.0 C00001 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 2.0 CHEBI:18361 ChEBI C00002 KEGG Compound 1.0 1.0 L-Aspartic acid GLN BioCyc CHEBI:30744 ChEBI asparaginase L-asparaginase 1 C4H7NO4 L-Aspartic acid 133.0375 GLT BioCyc P00963 UniProt 1.0 SMP00802 SMPDB Aspartate--ammonia ligase 644102 PubChem-compound 6083 PubChem-compound 44367445 PubChem-compound 16741146 PubChem-compound C01342 KEGG Compound Aspartate aminotransferase CHEBI:28938 ChEBI SMILES N[C@@H](CCC(N)=O)C(O)=O C00013 KEGG Compound SMILES N[C@@H](CC(N)=O)C(O)=O O7P2 Pyrophosphate 173.91193 CHEBI:18050 ChEBI H2O Water 18.010565 L-Asparagine 5957 PubChem-compound 1.0 HMDB00045 HMDB H Hydrogen Ion 1.007825 HMDB00168 HMDB 56-84-8 CAS L-Glutamine Asparagine synthetase B [glutamine-hydrolyzing] 56-65-5 CAS L-asparaginase 2 C00020 KEGG Compound 970 PubChem-compound C00026 KEGG Compound C00025 KEGG Compound asparagine synthetase A asparagine synthetase B P00509 UniProt 70-47-3 CAS SMILES N[C@@H](CC(O)=O)C(O)=O Asparagine biosynthesis Asparagine synthetase B [glutamine- hydrolyzing] Aspartate-- ammonia ligase Asparagine synthetase B [glutamine- hydrolyzing] Aspartate aminotransferase Isoaspartyl peptidase L-asparaginase 1 L-asparaginase 2 Isoaspartyl peptidase L-asparaginase 1 L-asparaginase 2 L-Aspartic acid H 2 O ATP L-Glutamine L-Asparagine H + AMP L-Glutamic acid PP i ATP Ammonium L-Asparagine AMP PP i H + L-Glutamic acid Oxalacetic acid Oxoglutaric acid H 2 O L-Aspartic acid Ammonium H 2 O L-Aspartic acid Ammonium TCA cycle
CHEBI:16015 ChEBI 30572 ChemSpider C4H4O5 Oxalacetic acid 132.00587 937 ChemSpider C00152 KEGG Compound HMDB00250 HMDB 6267 PubChem-compound C00036 KEGG Compound aspartate transaminase 328-50-7 CAS Water AMP BioCyc P0A962 UniProt SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate 50 ChemSpider P37595 UniProt 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS CHEBI:16027 ChEBI HMDB00148 HMDB http://identifiers.org/smpdb/SMP00833 SMPDB CHEBI:17196 ChEBI OXALACETIC_ACID BioCyc ATP BioCyc C00049 KEGG Compound 5961 PubChem-compound 56-85-9 CAS Aspartate--ammonia ligase H4N Ammonium 18.034374 Isoaspartyl peptidase 3.4.19.5 false 3.4.19.5 L-Asparagine + Water → Ammonium + L-Aspartic acid LEFT_TO_RIGHT 1.0 1.0 1.0 P00805 UniProt 4.0 328-42-7 CAS 14798-03-9 CAS 51 PubChem-compound 559142 ChemSpider HMDB00538 HMDB ReactionCatalysis2660 ACTIVATION ReactionCatalysis3357 ACTIVATION 1.0 CHEBI:15422 ChEBI 2.0 5746 ChemSpider 5745 ChemSpider HMDB00191 HMDB 5742 ChemSpider ASN BioCyc 1038 PubChem-compound SMILES OC(=O)CC(=O)C(O)=O L-asparaginase 1 7732-18-5 CAS L-ASPARTATE BioCyc 2.0 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB59597 HMDB Adenosine monophosphate 56-86-0 CAS C5H6O5 Oxoglutaric acid 146.02153 6.3.5.4 false 6.3.5.4 Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water → Adenosine monophosphate + Hydrogen Ion + L-Asparagine + L-Glutamic acid + Pyrophosphate LEFT_TO_RIGHT 6.3.1.1 false 6.3.1.1 Adenosine triphosphate + Ammonium + L-Aspartic acid → Adenosine monophosphate + Hydrogen Ion + L-Asparagine + Pyrophosphate LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 5858 ChemSpider 33032 PubChem-compound SMILES [NH4+] HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 Aspartate aminotransferase CHEBI:17053 ChEBI Oxalacetic acid C00064 KEGG Compound 945 ChemSpider 1.0 1010 ChemSpider 6031 ChemSpider HMDB41827 HMDB PPI BioCyc TCA cycle SubPathway 4.0 4.0 962 PubChem-compound 1.0 Ammonium C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion 2-KETOGLUTARATE BioCyc Asparagine synthetase B [glutamine-hydrolyzing] L-asparaginase 2 218 ChemSpider HMDB02111 HMDB Adenosine triphosphate SubPathwayInteraction1364 SubPathway1364Reaction SubPathwayReaction P22106 UniProt C00080 KEGG Compound ReactionCatalysis2852 ACTIVATION L-Glutamic acid Isoaspartyl peptidase Oxoglutaric acid SMILES OC(=O)CCC(=O)C(O)=O PW000813 PathWhiz HMDB00208 HMDB CHEBI:30915 ChEBI PW000779 PathWhiz Reaction2667 false L-Glutamic acid + Oxalacetic acid → L-Aspartic acid + Oxoglutaric acid LEFT_TO_RIGHT C4H8N2O3 L-Asparagine 132.0535 SMILES N[C@@H](CCC(O)=O)C(O)=O ReactionCatalysis2851 ACTIVATION ReactionCatalysis2850 ACTIVATION CHEBI:15377 ChEBI HMDB00223 HMDB CHEBI:15378 ChEBI SMILES [H+] 1.0 C00001 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 2.0 CHEBI:18361 ChEBI C00002 KEGG Compound 1.0 1.0 L-Aspartic acid GLN BioCyc CHEBI:30744 ChEBI asparaginase L-asparaginase 1 C4H7NO4 L-Aspartic acid 133.0375 GLT BioCyc P00963 UniProt 1.0 http://identifiers.org/smpdb/SMP00802 SMPDB Aspartate--ammonia ligase 644102 PubChem-compound 6083 PubChem-compound 44367445 PubChem-compound 16741146 PubChem-compound C01342 KEGG Compound Aspartate aminotransferase CHEBI:28938 ChEBI SMILES N[C@@H](CCC(N)=O)C(O)=O C00013 KEGG Compound SMILES N[C@@H](CC(N)=O)C(O)=O O7P2 Pyrophosphate 173.91193 CHEBI:18050 ChEBI H2O Water 18.010565 L-Asparagine 5957 PubChem-compound 1.0 HMDB00045 HMDB H Hydrogen Ion 1.007825 HMDB00168 HMDB 56-84-8 CAS L-Glutamine Asparagine synthetase B [glutamine-hydrolyzing] 56-65-5 CAS L-asparaginase 2 C00020 KEGG Compound 970 PubChem-compound C00026 KEGG Compound C00025 KEGG Compound asparagine synthetase A asparagine synthetase B P00509 UniProt 70-47-3 CAS SMILES N[C@@H](CC(O)=O)C(O)=O Asparagine biosynthesis asnB asnA asnB aspC iaaA ansA ansB iaaA ansA ansB L-Aspartic acid Water Adenosine triphosphate L-Glutamine L-Asparagine Hydrogen Ion Adenosine monophosphate L-Glutamic acid Pyrophosphate Adenosine triphosphate Ammonium L-Asparagine Adenosine monophosphate Pyrophosphate Hydrogen Ion L-Glutamic acid Oxalacetic acid Oxoglutaric acid Water L-Aspartic acid Ammonium Water L-Aspartic acid Ammonium TCA cycle