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CHEBI:16015 ChEBI 30572 ChemSpider 17215925 ChemSpider 6022 PubChem-compound 923 PubChem-compound 937 ChemSpider HMDB00491 HMDB HMDB01341 HMDB 4.0 2.0 57 ChemSpider SMILES O Acetolactate synthase isozyme 3 small subunit ReactionCatalysis2891 ACTIVATION ReactionCatalysis2890 ACTIVATION ReactionCatalysis2893 ACTIVATION ReactionCatalysis2892 ACTIVATION 50 ChemSpider 1.0 73-32-5 CAS ReactionCatalysis2894 ACTIVATION P0AEX7 UniProt SMP00837 SMPDB HMDB00148 HMDB SMP00831 SMPDB Branched-chain-amino-acid aminotransferase SMILES [Na+] branched-chain amino-acid aminotransferase ATP BioCyc SMP00838 SMPDB 1.0 H4N Ammonium 18.034374 Acetolactate synthase isozyme 1 small subunit 1.0 51 PubChem-compound 46 ChemSpider Pyruvic acid ADP BioCyc 19796801 PubChem-compound 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 P04968 UniProt 6288 PubChem-compound Reaction2928 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Isoleucine + Oxoglutaric acid LEFT_TO_RIGHT Acetolactate synthase isozyme 1 large subunit 562-43-6 CAS Reaction2926 false (S)-2-Aceto-2-hydroxybutanoic acid + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT 53-59-8 CAS Reaction2927 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT 2.2.1.6 false 2.2.1.6 2-Ketobutyric acid + Hydrogen Ion + Pyruvic acid → (S)-2-Aceto-2-hydroxybutanoic acid + Carbon dioxide LEFT_TO_RIGHT THR BioCyc 5742 ChemSpider 1038 PubChem-compound P0ADG1 UniProt Branched-chain amino acid transport system 2 carrier protein Acetolactate synthase isozyme 2 small subunit CHEBI:16474 ChEBI GO:0005829 GENE ONTOLOGY P0ADF8 UniProt HMDB59597 HMDB dihydroxy acid dehydratase 274 ChemSpider acetohydroxy acid isomeroreductase 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 P22729 UniProt C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 HMDB00243 HMDB HMDB06900 HMDB High-affinity branched-chain amino acid transport ATP-binding protein livG HMDB00005 HMDB C00109 KEGG Compound O4P Phosphate 94.95342 NADPH 1.0 SMILES CC=C(N)C([O-])=O 1010 ChemSpider GO:0070258 GENE ONTOLOGY C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 Threonine dehydratase biosynthetic (R) 2,3-Dihydroxy-3-methylvalerate HMDB41827 HMDB 600-18-0 CAS NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 L-Isoleucine Acetolactate synthase isozyme 3 large subunit BiologicalState109 1.0 SubPathwayInteraction1528 SubPathway1528Reaction SubPathwayReaction NADPH BioCyc Ammonium CHEBI:16857 ChEBI Hydrogen Ion HMDB00217 HMDB Dihydroxy-acid dehydratase SubPathwayInteraction1521 SubPathwayReaction SubPathway1521Reaction Cytosol 218 ChemSpider 1.0 (S)-2-Aceto-2-hydroxybutanoic acid SMILES CCC(C)C(=O)C(O)=O 72-19-5 CAS L-Glutamic acid CHEBI:27512 ChEBI 1.0 SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS HMDB00208 HMDB CHEBI:30915 ChEBI Reaction5890 true 3-Methyl-2-oxovaleric acid ↔ 2-Keto-3-methyl-valerate REVERSIBLE 1.0 1.0 Hydrogen Ion L-Isoleucine HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound 2-iminobutanoate C00006 KEGG Compound HMDB00588 HMDB CHEBI:18009 ChEBI C00001 KEGG Compound 1460-34-0 CAS Acetolactate synthase isozyme 3 small subunit C01330 KEGG Compound C00005 KEGG Compound ReactionCoupledTransportCatalysis140 ACTIVATION CHEBI:18367 ChEBI 2-OXOBUTANOATE BioCyc Inner Membrane 1032 ChemSpider C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 1031 ChemSpider C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Ketol-acid reductoisomerase 6051 ChemSpider High-affinity branched-chain amino acid transport ATP-binding protein livG (2Z)-2-aminobut-2-enoate SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O ReactionCoupledTransport106 false Adenosine triphosphate + L-Isoleucine + Water → Adenosine diphosphate + Hydrogen Ion + L-Isoleucine + Phosphate LEFT_TO_RIGHT SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O HMDB01429 HMDB GLT BioCyc 53-57-6 CAS TransportCatalysis382 ACTIVATION C4H6NO2 2-iminobutanoate 100.040405 1.0 C01342 KEGG Compound C00011 KEGG Compound SMILES O=C=O CHEBI:28938 ChEBI L-Isoleucine SMILES C[C@@H](O)[C@H](N)C(O)=O NAD(P) BioCyc SMILES CC[C@H](C)[C@H](N)C(O)=O 5957 PubChem-compound GO:0005620 GENE ONTOLOGY 47 PubChem-compound 562 TAXONOMY H Hydrogen Ion 1.007825 2.0 1.0 C00022 KEGG Compound 2.0 56-65-5 CAS Acetolactate synthase isozyme 2 large subunit C06006 KEGG Compound 6067 ChemSpider 1.0 C06007 KEGG Compound C00026 KEGG Compound 440875 PubChem-compound C00025 KEGG Compound ReactionCatalysis2888 ACTIVATION branched chain amino acid ABC transporter C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES CCC(=O)C(O)=O ReactionCatalysis2889 ACTIVATION 1.0 CHEBI:29101 ChEBI 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound Adenosine triphosphate Threonine dehydratase biosynthetic 6306 PubChem-compound CPD-8587 BioCyc 899 ChemSpider Leu/Ile/Val-binding protein CHEBI:30831 ChEBI 328-50-7 CAS Water 2.0 1.0 P0AB80 UniProt 395044 ChemSpider Phosphate Dihydroxy-acid dehydratase 1.0 5675 ChemSpider ILE BioCyc High-affinity branched-chain amino acid transport ATP-binding protein livF SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Ketol-acid reductoisomerase 1.0 14798-03-9 CAS CHEBI:58739 ChEBI CHEBI:17191 ChEBI HMDB00538 HMDB threonine deaminase 17341-25-2 CAS Water CHEBI:15422 ChEBI P00892 UniProt 7732-18-5 CAS 1.0 C6H10O4 (S)-2-Aceto-2-hydroxybutanoic acid 146.0579 127-17-3 CAS 1.0 acetohydroxybutanoate synthase / acetolactate synthase acetolactate synthase / acetohydroxybutanoate synthase 3 acetohydroxybutanoate synthase / acetolactate synthase 2 56-86-0 CAS P00893 UniProt 389708 ChemSpider P00894 UniProt 6.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] P05793 UniProt High-affinity branched-chain amino acid transport ATP-binding protein livF P05791 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 6857401 PubChem-compound CHEBI:16526 ChEBI C00188 KEGG Compound P08142 UniProt 1.0 CHEBI:16761 ChEBI CHEBI:35146 ChEBI threonine biosynthesis SubPathway SMILES CC(=O)C(O)=O 1.0 CHEBI:35932 ChEBI High-affinity branched-chain amino acid transport system permease protein livH Leucine Biosynthesis SubPathway 4.0 HMDB01967 HMDB SMILES CC[C@H](C)C(=O)C([O-])=O 962 PubChem-compound C4H9NO3 L-Threonine 119.05824 2-KETOGLUTARATE BioCyc SMILES CCC(=N)C([O-])=O Acetolactate synthase isozyme 2 large subunit 5800 ChemSpider High-affinity branched-chain amino acid transport system permease protein livH 2-KETO-3-METHYL-VALERATE BioCyc CO2 Carbon dioxide 43.98983 Branched-chain-amino-acid aminotransferase HMDB00172 HMDB Sodium 1.0 C03465 KEGG Compound HMDB02111 HMDB C00080 KEGG Compound PW000818 PathWhiz Periplasmic Space Oxoglutaric acid SMILES CC[C@](O)(C(C)=O)C(O)=O 3-Methyl-2-oxovaleric acid C6H13NO2 L-Isoleucine 131.09464 P0A9S7 UniProt PW000811 PathWhiz 1.0 CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000817 PathWhiz CHEBI:15377 ChEBI P0AD99 UniProt Sodium CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS PYRUVATE BioCyc 2-Keto-3-methyl-valerate C00407 KEGG Compound High-affinity branched-chain amino acid transport system permease protein livM 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2-Ketobutyric acid Acetolactate synthase isozyme 1 large subunit 2.0 1.0 1.0 Acetolactate synthase isozyme 1 small subunit Acetolactate synthase isozyme 2 small subunit 1.0 280 PubChem-compound P22731 UniProt Branched-chain amino acid transport system 2 carrier protein C4H6O3 2-Ketobutyric acid 102.03169 P0AD96 UniProt C6H9O3 2-Keto-3-methyl-valerate 129.05518 Transport445 false L-Isoleucine (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 16741146 PubChem-compound 22833512 PubChem-compound HMDB12140 HMDB L-Isoleucine H2O Water 18.010565 1.0 1060 PubChem-compound HMDB00167 HMDB 1061 PubChem-compound Na Sodium 22.989769 Carbon dioxide L-Threonine Acetolactate synthase isozyme 3 large subunit 1.0 isoleucine biosynthesis High-affinity branched-chain amino acid transport system permease protein livM Leu/Ile/Val-binding protein Adenosine diphosphate CHEBI:27681 ChEBI 1.0 Branched-chain amino acid transport system 2 carrier protein Threonine dehydratase biosynthetic Acetolactate synthase isozyme 2 large subunit Acetolactate synthase isozyme 2 small subunit Acetolactate synthase isozyme 1 large subunit Acetolactate synthase isozyme 1 small subunit Acetolactate synthase isozyme 3 large subunit Acetolactate synthase isozyme 3 small subunit Ketol-acid reductoisomerase Dihydroxy-acid dehydratase Branched- chain-amino- acid aminotransferase High-affinity branched-chain amino acid transport ATP-binding protein livF High-affinity branched-chain amino acid transport ATP-binding protein livG High-affinity branched-chain amino acid transport system permease protein livH High-affinity branched-chain amino acid transport system permease protein livM Leu/Ile/Val- binding protein L-Isoleucine L-Isoleucine Na + Na + L-Threonine H + H 2 O (2Z)-2- aminobut-2- enoate 2- iminobutanoate H 2 O H + Ammonium 2-Ketobutyric acid H + Pyruvic acid CO 2 (S)-2-Aceto- 2- hydroxybutanoic acid NADPH H + NADP (R) 2,3- Dihydroxy-3- methylvalerate H 2 O 3-Methyl-2- oxovaleric acid L-Glutamic acid Oxoglutaric acid L-Isoleucine 2-Keto-3- methyl- valerate L-Isoleucine ATP H 2 O L-Isoleucine ADP P i H + threonine biosynthesis
CHEBI:16015 ChEBI 30572 ChemSpider 17215925 ChemSpider 6022 PubChem-compound 923 PubChem-compound 937 ChemSpider HMDB00491 HMDB HMDB01341 HMDB 4.0 2.0 57 ChemSpider SMILES O Acetolactate synthase isozyme 3 small subunit ReactionCatalysis2891 ACTIVATION ReactionCatalysis2890 ACTIVATION ReactionCatalysis2893 ACTIVATION ReactionCatalysis2892 ACTIVATION 50 ChemSpider 1.0 73-32-5 CAS ReactionCatalysis2894 ACTIVATION P0AEX7 UniProt http://identifiers.org/smpdb/SMP00837 SMPDB HMDB00148 HMDB http://identifiers.org/smpdb/SMP00831 SMPDB Branched-chain-amino-acid aminotransferase SMILES [Na+] branched-chain amino-acid aminotransferase ATP BioCyc http://identifiers.org/smpdb/SMP00838 SMPDB 1.0 H4N Ammonium 18.034374 Acetolactate synthase isozyme 1 small subunit 1.0 51 PubChem-compound 46 ChemSpider Pyruvic acid ADP BioCyc 19796801 PubChem-compound 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 P04968 UniProt 6288 PubChem-compound Reaction2928 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Isoleucine + Oxoglutaric acid LEFT_TO_RIGHT Acetolactate synthase isozyme 1 large subunit 562-43-6 CAS Reaction2926 false (S)-2-Aceto-2-hydroxybutanoic acid + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT 53-59-8 CAS Reaction2927 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT 2.2.1.6 false 2.2.1.6 2-Ketobutyric acid + Hydrogen Ion + Pyruvic acid → (S)-2-Aceto-2-hydroxybutanoic acid + Carbon dioxide LEFT_TO_RIGHT THR BioCyc 5742 ChemSpider 1038 PubChem-compound P0ADG1 UniProt Branched-chain amino acid transport system 2 carrier protein Acetolactate synthase isozyme 2 small subunit CHEBI:16474 ChEBI GO:0005829 GENE ONTOLOGY P0ADF8 UniProt HMDB59597 HMDB dihydroxy acid dehydratase 274 ChemSpider acetohydroxy acid isomeroreductase 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 P22729 UniProt C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 HMDB00243 HMDB HMDB06900 HMDB High-affinity branched-chain amino acid transport ATP-binding protein livG HMDB00005 HMDB C00109 KEGG Compound O4P Phosphate 94.95342 NADPH 1.0 SMILES CC=C(N)C([O-])=O 1010 ChemSpider GO:0070258 GENE ONTOLOGY C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 Threonine dehydratase biosynthetic (R) 2,3-Dihydroxy-3-methylvalerate HMDB41827 HMDB 600-18-0 CAS NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 L-Isoleucine Acetolactate synthase isozyme 3 large subunit BiologicalState109 Escherichia coli, Inner Membrane 1.0 SubPathwayInteraction1528 SubPathway1528Reaction SubPathwayReaction NADPH BioCyc Ammonium CHEBI:16857 ChEBI Hydrogen Ion HMDB00217 HMDB Dihydroxy-acid dehydratase SubPathwayInteraction1521 SubPathwayReaction SubPathway1521Reaction Cytosol 218 ChemSpider 1.0 (S)-2-Aceto-2-hydroxybutanoic acid SMILES CCC(C)C(=O)C(O)=O 72-19-5 CAS L-Glutamic acid CHEBI:27512 ChEBI 1.0 SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS HMDB00208 HMDB CHEBI:30915 ChEBI Reaction5890 true 3-Methyl-2-oxovaleric acid ↔ 2-Keto-3-methyl-valerate REVERSIBLE 1.0 1.0 Hydrogen Ion L-Isoleucine HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound 2-iminobutanoate C00006 KEGG Compound HMDB00588 HMDB CHEBI:18009 ChEBI C00001 KEGG Compound 1460-34-0 CAS Acetolactate synthase isozyme 3 small subunit C01330 KEGG Compound C00005 KEGG Compound ReactionCoupledTransportCatalysis140 ACTIVATION CHEBI:18367 ChEBI 2-OXOBUTANOATE BioCyc Inner Membrane 1032 ChemSpider C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 1031 ChemSpider C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Ketol-acid reductoisomerase 6051 ChemSpider High-affinity branched-chain amino acid transport ATP-binding protein livG (2Z)-2-aminobut-2-enoate SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O ReactionCoupledTransport106 false Adenosine triphosphate + L-Isoleucine + Water → Adenosine diphosphate + Hydrogen Ion + L-Isoleucine + Phosphate LEFT_TO_RIGHT SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O HMDB01429 HMDB GLT BioCyc 53-57-6 CAS TransportCatalysis382 ACTIVATION C4H6NO2 2-iminobutanoate 100.040405 1.0 C01342 KEGG Compound C00011 KEGG Compound SMILES O=C=O CHEBI:28938 ChEBI L-Isoleucine SMILES C[C@@H](O)[C@H](N)C(O)=O NAD(P) BioCyc SMILES CC[C@H](C)[C@H](N)C(O)=O 5957 PubChem-compound GO:0005620 GENE ONTOLOGY 47 PubChem-compound 562 TAXONOMY H Hydrogen Ion 1.007825 2.0 1.0 C00022 KEGG Compound 2.0 56-65-5 CAS Acetolactate synthase isozyme 2 large subunit C06006 KEGG Compound 6067 ChemSpider 1.0 C06007 KEGG Compound C00026 KEGG Compound 440875 PubChem-compound C00025 KEGG Compound ReactionCatalysis2888 ACTIVATION branched chain amino acid ABC transporter C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES CCC(=O)C(O)=O ReactionCatalysis2889 ACTIVATION 1.0 CHEBI:29101 ChEBI 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound Adenosine triphosphate Threonine dehydratase biosynthetic 6306 PubChem-compound CPD-8587 BioCyc 899 ChemSpider Leu/Ile/Val-binding protein CHEBI:30831 ChEBI 328-50-7 CAS Water 2.0 1.0 P0AB80 UniProt 395044 ChemSpider Phosphate Dihydroxy-acid dehydratase 1.0 5675 ChemSpider ILE BioCyc High-affinity branched-chain amino acid transport ATP-binding protein livF SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Ketol-acid reductoisomerase 1.0 14798-03-9 CAS CHEBI:58739 ChEBI CHEBI:17191 ChEBI HMDB00538 HMDB threonine deaminase 17341-25-2 CAS Water Leucine Biosynthesis SubPathway CHEBI:15422 ChEBI threonine biosynthesis SubPathway P00892 UniProt 7732-18-5 CAS 1.0 C6H10O4 (S)-2-Aceto-2-hydroxybutanoic acid 146.0579 127-17-3 CAS 1.0 acetohydroxybutanoate synthase / acetolactate synthase acetolactate synthase / acetohydroxybutanoate synthase 3 acetohydroxybutanoate synthase / acetolactate synthase 2 56-86-0 CAS P00893 UniProt 389708 ChemSpider P00894 UniProt 6.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] P05793 UniProt High-affinity branched-chain amino acid transport ATP-binding protein livF P05791 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 6857401 PubChem-compound CHEBI:16526 ChEBI C00188 KEGG Compound P08142 UniProt 1.0 CHEBI:16761 ChEBI CHEBI:35146 ChEBI SMILES CC(=O)C(O)=O 1.0 CHEBI:35932 ChEBI High-affinity branched-chain amino acid transport system permease protein livH 4.0 HMDB01967 HMDB SMILES CC[C@H](C)C(=O)C([O-])=O 962 PubChem-compound C4H9NO3 L-Threonine 119.05824 2-KETOGLUTARATE BioCyc SMILES CCC(=N)C([O-])=O Acetolactate synthase isozyme 2 large subunit 5800 ChemSpider High-affinity branched-chain amino acid transport system permease protein livH 2-KETO-3-METHYL-VALERATE BioCyc CO2 Carbon dioxide 43.98983 Branched-chain-amino-acid aminotransferase HMDB00172 HMDB Sodium 1.0 C03465 KEGG Compound HMDB02111 HMDB C00080 KEGG Compound PW000818 PathWhiz Periplasmic Space Oxoglutaric acid SMILES CC[C@](O)(C(C)=O)C(O)=O 3-Methyl-2-oxovaleric acid C6H13NO2 L-Isoleucine 131.09464 P0A9S7 UniProt PW000811 PathWhiz 1.0 CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000817 PathWhiz CHEBI:15377 ChEBI P0AD99 UniProt Sodium CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS PYRUVATE BioCyc 2-Keto-3-methyl-valerate C00407 KEGG Compound High-affinity branched-chain amino acid transport system permease protein livM 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2-Ketobutyric acid Acetolactate synthase isozyme 1 large subunit 2.0 1.0 1.0 Acetolactate synthase isozyme 1 small subunit Acetolactate synthase isozyme 2 small subunit 1.0 280 PubChem-compound P22731 UniProt Branched-chain amino acid transport system 2 carrier protein C4H6O3 2-Ketobutyric acid 102.03169 P0AD96 UniProt C6H9O3 2-Keto-3-methyl-valerate 129.05518 Transport445 false L-Isoleucine (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 16741146 PubChem-compound 22833512 PubChem-compound HMDB12140 HMDB L-Isoleucine H2O Water 18.010565 1.0 1060 PubChem-compound HMDB00167 HMDB 1061 PubChem-compound Na Sodium 22.989769 Carbon dioxide L-Threonine Acetolactate synthase isozyme 3 large subunit 1.0 isoleucine biosynthesis High-affinity branched-chain amino acid transport system permease protein livM Leu/Ile/Val-binding protein Adenosine diphosphate CHEBI:27681 ChEBI 1.0 brnQ ilvA ilvG ilvM ilvB ilvN ilvI ilvH ilvC ilvD ilvE livF livG livH livM livJ L-Isoleucine L-Isoleucine Sodium Sodium L-Threonine Hydrogen Ion Water (2Z)-2- aminobut-2- enoate 2- iminobutanoate Water Hydrogen Ion Ammonium 2-Ketobutyric acid Hydrogen Ion Pyruvic acid Carbon dioxide (S)-2-Aceto- 2- hydroxybutanoic acid NADPH Hydrogen Ion NADP (R) 2,3- Dihydroxy-3- methylvalerate Water 3-Methyl-2- oxovaleric acid L-Glutamic acid Oxoglutaric acid L-Isoleucine 2-Keto-3- methyl- valerate L-Isoleucine Adenosine triphosphate Water L-Isoleucine Adenosine diphosphate Phosphate Hydrogen Ion threonine biosynthesis