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HMDB00254 HMDB 6022 PubChem-compound 2553-59-5 CAS 2.0 937 ChemSpider HMDB01341 HMDB CHEBI:30797 ChEBI Reaction2580 false L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE 439153 PubChem-compound 58 ChemSpider 1.0 HMDB01112 HMDB CHEBI:16027 ChEBI C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 NAD 1.0 OXALACETIC_ACID BioCyc NAD-dependent malic enzyme ATP BioCyc HMDB00263 HMDB HMDB01473 HMDB P76558 UniProt 2.0 1.0 Glyceraldehyde-3-phosphate dehydrogenase A Fructose-1,6-bisphosphatase class 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Fructose-bisphosphate aldolase class 1 5742 ChemSpider Fructose 1,6-bisphosphate CHEBI:16474 ChEBI HMDB59597 HMDB 97-67-6 CAS HMDB00243 HMDB 5858 ChemSpider P0A9B2 UniProt 709 ChemSpider 704 ChemSpider Aerobic C4-dicarboxylate transport protein 945 ChemSpider Fructose-1,6-bisphosphatase class 2 1010 ChemSpider HMDB00362 HMDB 488-69-7 CAS 138-08-9 CAS C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 1.0 1.0 2.0 Hydrogen Ion HMDB00217 HMDB C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Enolase Uncharacterized protein yggF Cytosol C00236 KEGG Compound C00597 KEGG Compound Adenosine triphosphate C00354 KEGG Compound SUC BioCyc Glucose-6-phosphate isomerase HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound HMDB00223 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI Hydrogen Ion P0ABN5 UniProt C00001 KEGG Compound 3-Phosphoglyceric acid C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB HMDB01429 HMDB 2.0 C21H28N7O14P2 NAD 664.11694 NADP-dependent malic enzyme C00011 KEGG Compound NAD(P) BioCyc CHEBI:17138 ChEBI P0ABP1 UniProt H Hydrogen Ion 1.007825 C00149 KEGG Compound D-Glyceraldehyde 3-phosphate P0ABP4 UniProt C00022 KEGG Compound 56-65-5 CAS Glyceric acid 1,3-biphosphate 53-84-9 CAS C00020 KEGG Compound Fructose-bisphosphate aldolase class 2 Phosphoenolpyruvate carboxykinase [ATP] 1.0 2.0 Phosphoglycerate kinase P0A799 UniProt Phosphatase ybhA 1.0 P21829 UniProt Unknown Phosphoenolpyruvate synthase C00036 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc Water SMILES OC(=O)CCC(O)=O C00042 KEGG Compound 648 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Anaerobic C4-dicarboxylate transporter dcuA PHOSPHO-ENOL-PYRUVATE BioCyc P0A858 UniProt HMDB00538 HMDB SMILES OC(=O)C(=C)OP(O)(O)=O C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound SMILES OC(=O)CC(=O)C(O)=O 1.0 7732-18-5 CAS P0A991 UniProt 591-59-3 CAS malate dehydrogenase B 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 triosephosphate isomerase 1.0 malate dehydrogenase, NAD-requiring Triosephosphate isomerase fructose bisphosphate aldolase class II fructose bisphosphate aldolase class I fructose-1,6-bisphosphatase C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 445557 PubChem-compound P0A993 UniProt P0A6T1 UniProt SMILES CC(=O)C(O)=O 663 ChemSpider C00074 KEGG Compound CHEBI:17050 ChEBI 1.0 SMILES OCC(=O)COP(O)(O)=O HMDB01967 HMDB 962 PubChem-compound 724 PubChem-compound SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O 5800 ChemSpider CO2 Carbon dioxide 43.98983 1.0 6.0 Phosphate C00080 KEGG Compound PW000819 PathWhiz Periplasmic Space NAD-dependent malic enzyme 729 PubChem-compound 1.0 Transport442 false L-Malic acid (→), Succinic acid (←) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT CHEBI:44897 ChEBI 14265-44-2 CAS Transport441 false L-Malic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT PYRUVATE BioCyc 58-64-0 CAS Glyceraldehyde-3-phosphate dehydrogenase A Fructose-1,6-bisphosphatase class 1 G3P BioCyc ReactionCatalysis2901 ACTIVATION ReactionCatalysis2900 ACTIVATION Fructose-bisphosphate aldolase class 1 ReactionCatalysis2903 ACTIVATION ReactionCatalysis2902 ACTIVATION 1.0 6083 PubChem-compound ReactionCatalysis2905 ACTIVATION ReactionCatalysis2904 ACTIVATION ReactionCatalysis2906 ACTIVATION 2-PG BioCyc 22833512 PubChem-compound H2O Water 18.010565 Fructose-1,6-bisphosphatase class 2 Aerobic C4-dicarboxylate transport protein NADH BioCyc 393165 ChemSpider NAD BioCyc P37689 UniProt Carbon dioxide 970 PubChem-compound CHEBI:57634 ChEBI Gluconeogenesis from L-malic acid P0A830 UniProt L-Malic acid Enolase Uncharacterized protein yggF 980 ChemSpider C4H6O5 L-Malic acid 134.02153 P0A6P9 UniProt 820-11-1 CAS 17215925 ChemSpider C4H4O5 Oxalacetic acid 132.00587 ReactionCatalysis2897 ACTIVATION 2.0 NADH ReactionCatalysis2896 ACTIVATION ReactionCatalysis2899 ACTIVATION dicarboxylate transporter ReactionCatalysis2898 ACTIVATION phosphoenolpyruvate synthetase enolase SMILES O 4.0 C10H14N5O7P Adenosine monophosphate 347.06308 Glucose-6-phosphate isomerase ReactionCatalysis2895 ACTIVATION HMDB00807 HMDB 1005 PubChem-compound SMP00839 SMPDB P22259 UniProt 1.0 P26616 UniProt 1981-49-3 CAS Dihydroxyacetone phosphate 328-42-7 CAS 1.0 ReactionCatalysis2548 ACTIVATION C3H7O6P Dihydroxyacetone phosphate 169.99803 SMILES O[C@@H](CC(O)=O)C(O)=O Pyruvic acid CHEBI:15846 ChEBI Succinic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 59 PubChem-compound 4.0 4.1.1.49 false 4.1.1.49 Adenosine triphosphate + Oxalacetic acid → Adenosine diphosphate + Carbon dioxide + Phosphoenolpyruvic acid LEFT_TO_RIGHT 53-59-8 CAS SMP00841 SMPDB 1038 PubChem-compound Fructose-bisphosphate aldolase class 2 GO:0005829 GENE ONTOLOGY 274 ChemSpider Adenosine monophosphate HMDB00902 HMDB CHEBI:16905 ChEBI CHEBI:16908 ChEBI O4P Phosphate 94.95342 Oxalacetic acid NADPH CHEBI:58247 ChEBI 2-Phosphoglyceric acid NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000821 PathWhiz C3H7O7P 2-Phosphoglyceric acid 185.99294 Phosphoglycerate kinase NADPH BioCyc 683 PubChem-compound L-Malic acid 58-68-4 CAS SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 5.3.1.9 false 5.3.1.9 β-D-fructofuranose 6-phosphate → β-D-glucose 6-phosphate LEFT_TO_RIGHT β-D-fructofuranose 6-phosphate 4.1.2.13 false 4.1.2.13 D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate → Fructose 1,6-bisphosphate LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 1,6-bisphosphate + Water → Phosphate + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT Reaction2935 false Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH → D-Glyceraldehyde 3-phosphate + NAD + Phosphate LEFT_TO_RIGHT 5.3.1.1 false 5.3.1.1 D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate REVERSIBLE β-D-glucose 6-phosphate SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES OCC(OP(O)(O)=O)C(O)=O 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Reaction2933 false 2-Phosphoglyceric acid → 3-Phosphoglyceric acid LEFT_TO_RIGHT Reaction2934 false 3-Phosphoglyceric acid + Adenosine triphosphate → Adenosine diphosphate + Glyceric acid 1,3-biphosphate LEFT_TO_RIGHT 1.1.1.38 false 1.1.1.38 L-Malic acid + NAD → Carbon dioxide + NADH + Pyruvic acid LEFT_TO_RIGHT Reaction2932 false Phosphoenolpyruvic acid → 2-Phosphoglyceric acid + Water LEFT_TO_RIGHT 57-04-5 CAS 1.1.1.40 false 1.1.1.40 L-Malic acid + NADP → Carbon dioxide + NADPH + Pyruvic acid LEFT_TO_RIGHT Anaerobic C4-dicarboxylate transporter dcuA 53-57-6 CAS 1.0 CHEBI:15741 ChEBI TransportCatalysis380 ACTIVATION 1.0 C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 β-D-glucose 6-phosphate SMILES O=C=O 4.0 1110 PubChem-compound ReactionCatalysis2633 ACTIVATION C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound Triosephosphate isomerase GO:0005620 GENE ONTOLOGY TransportCatalysis379 ACTIVATION CHEBI:24344 ChEBI C4H6O4 Succinic acid 118.02661 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Adenosine diphosphate C3H5O6P Phosphoenolpyruvic acid 167.98238 Glyceraldehyde 3-phosphate dehydrogenase C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase Phosphoenolpyruvic acid 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 10.0 5682 ChemSpider 222656 PubChem-compound 5675 ChemSpider 1078 ChemSpider SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O 1.0 CHEBI:15422 ChEBI Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB 388299 ChemSpider P23538 UniProt 2.7.9.2 false 2.7.9.2 Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid + Water LEFT_TO_RIGHT 1.0 127-17-3 CAS galactose metabolism SubPathway HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc SubPathwayInteraction1517 SubPathway1517Reaction SubPathwayReaction NADP-dependent malic enzyme CHEBI:16526 ChEBI SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 1.0 CHEBI:16761 ChEBI 1.0 Succinic acid Phosphoenolpyruvate carboxykinase [ATP] SMILES OC(COP(O)(O)=O)C(O)=O Phosphatase ybhA P0A9C9 UniProt 5893 PubChem-compound 1.0 HMDB02111 HMDB 1.0 110-15-6 CAS CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] Phosphoenolpyruvate synthase Unknown CHEBI:16108 ChEBI HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 280 PubChem-compound CHEBI:30744 ChEBI 2.0 HMDB01487 HMDB HMDB00156 HMDB SMILES OC(COP(O)(O)=O)C=O P21437 UniProt 193317 ChemSpider 1.0 2.0 1060 PubChem-compound HMDB00045 HMDB GAP BioCyc 1061 PubChem-compound Hydrogen Ion C00661 KEGG Compound L-Malic acid 1.0 P0AB71 UniProt Aerobic C4- dicarboxylate transport protein Anaerobic C4- dicarboxylate transporter dcuC Anaerobic C4- dicarboxylate transporter dcuA Anaerobic C4- dicarboxylate transporter dcuB Unknown Phosphoenolpyruvate carboxykinase [ATP] NADP-dependent malic enzyme NAD-dependent malic enzyme Phosphoenolpyruvate synthase Enolase 2,3- bisphosphoglycerate- independent phosphoglycerate mutase Phosphoglycerate kinase Glyceraldehyde- 3-phosphate dehydrogenase A Triosephosphate isomerase Uncharacterized protein yggF Phosphatase ybhA Fructose-1,6- bisphosphatase class 2 Fructose-1,6- bisphosphatase class 1 Glucose-6- phosphate isomerase L-Malic acid L-Malic acid H + H + L-Malic acid L-Malic acid Succinic acid Succinic acid L-Malic acid NAD Oxalacetic acid NADH H + ATP ADP CO 2 Phosphoenolpyruvic acid NADP CO 2 NADPH Pyruvic acid NAD CO 2 NADH Pyruvic acid Phosphoenolpyruvic acid AMP P i H + ATP H 2 O H 2 O 2- Phosphoglyceric acid 3- Phosphoglyceric acid ATP ADP Glyceric acid 1,3-biphosphate NADH H + NAD P i D- Glyceraldehyde 3-phosphate Dihydroxyacetone phosphate Dihydroxyacetone phosphate Fructose 1,6- bisphosphate H 2 O P i β-D- fructofuranose 6-phosphate β-D-glucose 6-phosphate galactose metabolism Fructose- bisphosphate aldolase class 1 Fructose- bisphosphate aldolase class 2
HMDB00254 HMDB 6022 PubChem-compound 2553-59-5 CAS 2.0 937 ChemSpider HMDB01341 HMDB CHEBI:30797 ChEBI Reaction2580 false L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE 439153 PubChem-compound 58 ChemSpider 1.0 HMDB01112 HMDB CHEBI:16027 ChEBI C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 NAD 1.0 OXALACETIC_ACID BioCyc NAD-dependent malic enzyme ATP BioCyc HMDB00263 HMDB HMDB01473 HMDB P76558 UniProt 2.0 1.0 Glyceraldehyde-3-phosphate dehydrogenase A Fructose-1,6-bisphosphatase class 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Fructose-bisphosphate aldolase class 1 5742 ChemSpider Fructose 1,6-bisphosphate CHEBI:16474 ChEBI HMDB59597 HMDB 97-67-6 CAS HMDB00243 HMDB 5858 ChemSpider P0A9B2 UniProt 709 ChemSpider 704 ChemSpider Aerobic C4-dicarboxylate transport protein 945 ChemSpider Fructose-1,6-bisphosphatase class 2 1010 ChemSpider HMDB00362 HMDB 488-69-7 CAS 138-08-9 CAS C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 1.0 1.0 2.0 Hydrogen Ion HMDB00217 HMDB C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Enolase Uncharacterized protein yggF Cytosol C00236 KEGG Compound C00597 KEGG Compound Adenosine triphosphate C00354 KEGG Compound SUC BioCyc Glucose-6-phosphate isomerase HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound HMDB00223 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI Hydrogen Ion P0ABN5 UniProt C00001 KEGG Compound 3-Phosphoglyceric acid C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB HMDB01429 HMDB 2.0 C21H28N7O14P2 NAD 664.11694 NADP-dependent malic enzyme C00011 KEGG Compound NAD(P) BioCyc CHEBI:17138 ChEBI P0ABP1 UniProt H Hydrogen Ion 1.007825 C00149 KEGG Compound D-Glyceraldehyde 3-phosphate P0ABP4 UniProt C00022 KEGG Compound 56-65-5 CAS Glyceric acid 1,3-biphosphate 53-84-9 CAS C00020 KEGG Compound Fructose-bisphosphate aldolase class 2 Phosphoenolpyruvate carboxykinase [ATP] 1.0 2.0 Phosphoglycerate kinase P0A799 UniProt Phosphatase ybhA 1.0 P21829 UniProt Unknown Phosphoenolpyruvate synthase C00036 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc Water SMILES OC(=O)CCC(O)=O C00042 KEGG Compound 648 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Anaerobic C4-dicarboxylate transporter dcuA PHOSPHO-ENOL-PYRUVATE BioCyc P0A858 UniProt HMDB00538 HMDB SMILES OC(=O)C(=C)OP(O)(O)=O C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound SMILES OC(=O)CC(=O)C(O)=O 1.0 7732-18-5 CAS P0A991 UniProt 591-59-3 CAS malate dehydrogenase B 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 triosephosphate isomerase 1.0 malate dehydrogenase, NAD-requiring Triosephosphate isomerase fructose bisphosphate aldolase class II fructose bisphosphate aldolase class I fructose-1,6-bisphosphatase C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 445557 PubChem-compound P0A993 UniProt P0A6T1 UniProt SMILES CC(=O)C(O)=O 663 ChemSpider C00074 KEGG Compound CHEBI:17050 ChEBI 1.0 SMILES OCC(=O)COP(O)(O)=O HMDB01967 HMDB 962 PubChem-compound 724 PubChem-compound SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O 5800 ChemSpider CO2 Carbon dioxide 43.98983 1.0 6.0 Phosphate C00080 KEGG Compound PW000819 PathWhiz Periplasmic Space NAD-dependent malic enzyme 729 PubChem-compound 1.0 Transport442 false L-Malic acid (→), Succinic acid (←) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT CHEBI:44897 ChEBI 14265-44-2 CAS Transport441 false L-Malic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT PYRUVATE BioCyc 58-64-0 CAS Glyceraldehyde-3-phosphate dehydrogenase A Fructose-1,6-bisphosphatase class 1 G3P BioCyc ReactionCatalysis2901 ACTIVATION ReactionCatalysis2900 ACTIVATION Fructose-bisphosphate aldolase class 1 ReactionCatalysis2903 ACTIVATION ReactionCatalysis2902 ACTIVATION 1.0 6083 PubChem-compound ReactionCatalysis2905 ACTIVATION ReactionCatalysis2904 ACTIVATION ReactionCatalysis2906 ACTIVATION 2-PG BioCyc 22833512 PubChem-compound H2O Water 18.010565 Fructose-1,6-bisphosphatase class 2 Aerobic C4-dicarboxylate transport protein NADH BioCyc 393165 ChemSpider NAD BioCyc P37689 UniProt Carbon dioxide 970 PubChem-compound CHEBI:57634 ChEBI Gluconeogenesis from L-malic acid P0A830 UniProt L-Malic acid Enolase Uncharacterized protein yggF 980 ChemSpider C4H6O5 L-Malic acid 134.02153 P0A6P9 UniProt 820-11-1 CAS 17215925 ChemSpider C4H4O5 Oxalacetic acid 132.00587 ReactionCatalysis2897 ACTIVATION 2.0 NADH ReactionCatalysis2896 ACTIVATION ReactionCatalysis2899 ACTIVATION dicarboxylate transporter ReactionCatalysis2898 ACTIVATION phosphoenolpyruvate synthetase enolase SMILES O 4.0 C10H14N5O7P Adenosine monophosphate 347.06308 Glucose-6-phosphate isomerase ReactionCatalysis2895 ACTIVATION HMDB00807 HMDB 1005 PubChem-compound http://identifiers.org/smpdb/SMP00839 SMPDB P22259 UniProt 1.0 P26616 UniProt 1981-49-3 CAS Dihydroxyacetone phosphate 328-42-7 CAS 1.0 ReactionCatalysis2548 ACTIVATION C3H7O6P Dihydroxyacetone phosphate 169.99803 SMILES O[C@@H](CC(O)=O)C(O)=O Pyruvic acid CHEBI:15846 ChEBI Succinic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 59 PubChem-compound 4.0 4.1.1.49 false 4.1.1.49 Adenosine triphosphate + Oxalacetic acid → Adenosine diphosphate + Carbon dioxide + Phosphoenolpyruvic acid LEFT_TO_RIGHT 53-59-8 CAS http://identifiers.org/smpdb/SMP00841 SMPDB 1038 PubChem-compound Fructose-bisphosphate aldolase class 2 GO:0005829 GENE ONTOLOGY 274 ChemSpider Adenosine monophosphate HMDB00902 HMDB CHEBI:16905 ChEBI CHEBI:16908 ChEBI O4P Phosphate 94.95342 Oxalacetic acid NADPH CHEBI:58247 ChEBI 2-Phosphoglyceric acid NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000821 PathWhiz C3H7O7P 2-Phosphoglyceric acid 185.99294 Phosphoglycerate kinase NADPH BioCyc 683 PubChem-compound L-Malic acid 58-68-4 CAS SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 5.3.1.9 false 5.3.1.9 β-D-fructofuranose 6-phosphate → β-D-glucose 6-phosphate LEFT_TO_RIGHT β-D-fructofuranose 6-phosphate 4.1.2.13 false 4.1.2.13 D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate → Fructose 1,6-bisphosphate LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 1,6-bisphosphate + Water → Phosphate + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT Reaction2935 false Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH → D-Glyceraldehyde 3-phosphate + NAD + Phosphate LEFT_TO_RIGHT 5.3.1.1 false 5.3.1.1 D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate REVERSIBLE β-D-glucose 6-phosphate SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES OCC(OP(O)(O)=O)C(O)=O 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Reaction2933 false 2-Phosphoglyceric acid → 3-Phosphoglyceric acid LEFT_TO_RIGHT Reaction2934 false 3-Phosphoglyceric acid + Adenosine triphosphate → Adenosine diphosphate + Glyceric acid 1,3-biphosphate LEFT_TO_RIGHT 1.1.1.38 false 1.1.1.38 L-Malic acid + NAD → Carbon dioxide + NADH + Pyruvic acid LEFT_TO_RIGHT Reaction2932 false Phosphoenolpyruvic acid → 2-Phosphoglyceric acid + Water LEFT_TO_RIGHT 57-04-5 CAS 1.1.1.40 false 1.1.1.40 L-Malic acid + NADP → Carbon dioxide + NADPH + Pyruvic acid LEFT_TO_RIGHT Anaerobic C4-dicarboxylate transporter dcuA 53-57-6 CAS 1.0 CHEBI:15741 ChEBI TransportCatalysis380 ACTIVATION 1.0 C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 β-D-glucose 6-phosphate SMILES O=C=O 4.0 1110 PubChem-compound ReactionCatalysis2633 ACTIVATION C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound Triosephosphate isomerase GO:0005620 GENE ONTOLOGY TransportCatalysis379 ACTIVATION CHEBI:24344 ChEBI C4H6O4 Succinic acid 118.02661 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Adenosine diphosphate C3H5O6P Phosphoenolpyruvic acid 167.98238 Glyceraldehyde 3-phosphate dehydrogenase C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase Phosphoenolpyruvic acid 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 10.0 5682 ChemSpider 222656 PubChem-compound 5675 ChemSpider 1078 ChemSpider SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O 1.0 CHEBI:15422 ChEBI Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB 388299 ChemSpider P23538 UniProt 2.7.9.2 false 2.7.9.2 Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid + Water LEFT_TO_RIGHT 1.0 127-17-3 CAS HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc SubPathwayInteraction1517 SubPathway1517Reaction SubPathwayReaction NADP-dependent malic enzyme CHEBI:16526 ChEBI SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 1.0 CHEBI:16761 ChEBI 1.0 Succinic acid galactose metabolism SubPathway Phosphoenolpyruvate carboxykinase [ATP] SMILES OC(COP(O)(O)=O)C(O)=O Phosphatase ybhA P0A9C9 UniProt 5893 PubChem-compound 1.0 HMDB02111 HMDB 1.0 110-15-6 CAS CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] Phosphoenolpyruvate synthase Unknown CHEBI:16108 ChEBI HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 280 PubChem-compound CHEBI:30744 ChEBI 2.0 HMDB01487 HMDB HMDB00156 HMDB SMILES OC(COP(O)(O)=O)C=O P21437 UniProt 193317 ChemSpider 1.0 2.0 1060 PubChem-compound HMDB00045 HMDB GAP BioCyc 1061 PubChem-compound Hydrogen Ion C00661 KEGG Compound L-Malic acid 1.0 P0AB71 UniProt dctA dcuC dcuA dcuB Unknown pckA maeB sfcA ppsA eno gpmM pgk gapA tpiA yggF ybhA glpX fbp