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Pathway Description
D-Allulose Degradation
Escherichia coli
Metabolic Pathway
D-allose can be used as source of carbon for E.coli. D-allose is imported into E.coli by D-allose ABC transporter without phosphorylation. Allose-6-phosphate isomerase and allulose-6-phosphate 3-epimerase catalyze the remaining reactions resulting in D-allulose 6 phosphate and Beta-D-fructofuranose 6-phosphate respectively. Once Beta D fructofuranose 6-phosphate is synthesized, it can be used in the glycolysis and pyruvatedehydrogenase pathway.
References
D-Allulose Degradation References
Chan KK, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA: Structural basis for substrate specificity in phosphate binding (beta/alpha)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12. Biochemistry. 2008 Sep 9;47(36):9608-17. doi: 10.1021/bi800821v. Epub 2008 Aug 14.
Pubmed: 18700786
Kim C, Song S, Park C: The D-allose operon of Escherichia coli K-12. J Bacteriol. 1997 Dec;179(24):7631-7.
Pubmed: 9401019
Miller BG, Raines RT: Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Biochemistry. 2005 Aug 16;44(32):10776-83. doi: 10.1021/bi0506268.
Pubmed: 16086580
Poulsen TS, Chang YY, Hove-Jensen B: D-Allose catabolism of Escherichia coli: involvement of alsI and regulation of als regulon expression by allose and ribose. J Bacteriol. 1999 Nov;181(22):7126-30.
Pubmed: 10559180
Roos AK, Mariano S, Kowalinski E, Salmon L, Mowbray SL: D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not. J Mol Biol. 2008 Oct 10;382(3):667-79. doi: 10.1016/j.jmb.2008.06.090. Epub 2008 Jul 9.
Pubmed: 18640127
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