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Lipopolysaccharide export system protein lptC Lipopolysaccharide export system ATP-binding protein lptB outer membrane lipopolysaccharide transport and assembly complex - LptD subunit UDP-3-O-[3- hydroxymyristoyl] N- acetylglucosamine deacetylase Lipid-A- disaccharide synthase Protein gutQ 2-dehydro-3- deoxyphosphooctonate aldolase 3-deoxy-D- manno- octulosonate 8-phosphate phosphatase 3-deoxy- manno- octulosonate cytidylyltransferase 3-deoxy-D- manno- octulosonic- acid transferase Lipopolysaccharide heptosyltransferase 1 ADP-heptose-- LPS heptosyltransferase 2 Lipopolysaccharide core biosynthesis protein rfaG Lipopolysaccharide core heptose(I) kinase rfaP Lipopolysaccharide core heptosyltransferase rfaQ Lipopolysaccharide core heptose(II) kinase rfaY Lipopolysaccharide 1,6- galactosyltransferase Lipopolysaccharide 1,3- galactosyltransferase Lipopolysaccharide 1,2- glucosyltransferase Lipopolysaccharide 1,2-N- acetylglucosaminetransferase Phosphoglucosamine mutase Bifunctional protein glmU Bifunctional protein glmU UDP-3-O-[3- hydroxymyristoyl] glucosamine N- acyltransferase Lipid A biosynthesis lauroyl acyltransferase Phosphoethanolamine transferase eptB UDP- galactopyranose mutase Lipid A biosynthesis (KDO)2- (lauroyl)- lipid IVA acyltransferase Tetraacyldisaccharide 4'-kinase 3-deoxy-D- manno- octulosonic- acid transferase UDP-2,3- diacylglucosamine hydrolase Acyl-[acyl- carrier- protein]-- UDP-N- acetylglucosamine O- acyltransferase Glucosamine-- fructose-6- phosphate aminotransferase [isomerizing] Lipid A export ATP- binding/permease protein msbA Phosphocarrier protein HPr Phosphocarrier protein HPr Mannose permease IID component Mannose permease IIC component PTS system mannose- specific EIIAB component Fructose 6-phosphate D-Ribulose 5-phosphate phosphoethanolamine- Kdo2-lipid A phosphoethanolamine- Kdo2-lipid A UDP-3-O- [(3R)-3- hydroxymyristoyl]- N-acetyl-α-D- glucosamine H2O Acetic acid UDP-3-O-(3- hydroxymyristoyl)- α-D- glucosamine 2,3-bis[(3R)- 3- hydroxymyristoyl]- α-D- glucosaminyl 1-phosphate UDP-2-N,3-O- bis[(3R)-3- hydroxytetradecanoyl]- α-D- glucosamine UDP H+ lipid A disaccharide D-Arabinose 5-phosphate Phosphoenolpyruvic acid H2O Pi 3-deoxy-D- manno- octulosonate 8-phosphate H2O Pi 3-deoxy-D- manno- octulosonate Cytidine triphosphate PPi CMP-3-deoxy- α-D-manno- octulosonate lipid IVA Cytidine monophosphate H+ α-Kdo-(2→6)- lipid IVA (KDO)2-lipid A ADP-L- glycero-β-D- manno-heptose H+ ADP heptosyl- Kdo2-lipid A ADP-L- glycero-β-D- manno-heptose ADP H+ (heptosyl)2- Kdo2-lipid A Uridine diphosphate glucose UDP H+ glucosyl- (heptosyl)2- Kdo2-lipid A ATP ADP H+ glucosyl- (heptosyl)2- Kdo2-lipid A-phosphate ADP-L- glycero-β-D- manno-heptose ADP H+ glucosyl- (heptosyl)3- Kdo2-lipid A-phosphate ATP ADP H+ glucosyl- (heptosyl)3- Kdo2-lipid A-bisphosphate UDP-α-D- galactose galactosyl- glucosyl- (heptosyl)3- Kdo2-lipid A-bisphosphate UDP H+ Uridine diphosphate glucose UDP H+ galactosyl- (glucosyl)2- (heptosyl)3- Kdo2-lipid A-bisphosphate Uridine diphosphate glucose UDP H+ galactosyl- (glucosyl)3- (heptosyl)3- Kdo2-lipid A-bisphosphate ADP-L- glycero-β-D- manno-heptose H+ ADP lipid A-core Glucosamine 6-phosphate Glucosamine-1P Acetyl-CoA N-Acetyl- glucosamine 1-phosphate CoA H+ Uridine triphosphate H+ Uridine diphosphate- N- acetylglucosamine PPi H+ UDP-2-N,3-O- bis[(3R)-3- hydroxytetradecanoyl]- α-D- glucosamine a-Kdo-(2->4)- a-Kdo-(2->6)- lipid IVA (KDO)2- (lauroyl)- lipid IVA PE(12:0/10:0) 1,2-Diacyl- sn-glycerol (didodecanoyl, n-C12:0) UDP-D- Galacto-1,4- furanose ATP ADP H+ Cytidine monophosphate H+ H2O Uridine 5'- monophosphate H+ L-Glutamine L-Glutamic acid ATP H2O ADP Pi H+ lipid A-core D-Fructose (3R)-3- hydroxymyristoyl- [acp] a holo-[acyl- carrier protein] dodecanoyl- [acp] a holo-[acyl- carrier protein] myristoyl-[acp] a holo-[acyl- carrier protein] (3R)-3- hydroxymyristoyl- [acp] a holo-[acyl- carrier protein] Lipopolysaccharide export system protein lptA Lipopolysaccharide export system permease protein lptF Lipopolysaccharide export system permease protein lptG outer membrane lipopolysaccharide transport and assembly complex - LptE subunit Glycolysis and Pyruvate Dehydrogenase Pentose Phosphate Arabinose 5-phosphate isomerase
lptC lptB lptD lpxC lpxB gutQ kdsA kdsC kdsB waaA rfaC rfaF rfaG rfaP rfaQ rfaY rfaB rfaI rfaJ waaU glmM glmU glmU lpxD htrB eptB glf msbB lpxK waaA lpxH lpxA glmS msbA ptsH ptsH manZ manY manX Fructose 6-phosphate D-Ribulose 5-phosphate phosphoethanolamine- Kdo2-lipid A phosphoethanolamine- Kdo2-lipid A UDP-3-O- [(3R)-3- hydroxymyristoyl]- N-acetyl-α-D- glucosamine Water Acetic acid UDP-3-O-(3- hydroxymyristoyl)- α-D- glucosamine 2,3-bis[(3R)- 3- hydroxymyristoyl]- α-D- glucosaminyl 1-phosphate UDP-2-N,3-O- bis[(3R)-3- hydroxytetradecanoyl]- α-D- glucosamine UDP Hydrogen Ion lipid A disaccharide D-Arabinose 5-phosphate Phosphoenolpyruvic acid Water Phosphate 3-deoxy-D- manno- octulosonate 8-phosphate Water Phosphate 3-deoxy-D- manno- octulosonate Cytidine triphosphate Pyrophosphate CMP-3-deoxy- α-D-manno- octulosonate lipid IVA Cytidine monophosphate Hydrogen Ion α-Kdo-(2→6)- lipid IVA (KDO)2-lipid A ADP-L- glycero-β-D- manno-heptose Hydrogen Ion Adenosine diphosphate heptosyl- Kdo2-lipid A ADP-L- glycero-β-D- manno-heptose Adenosine diphosphate Hydrogen Ion (heptosyl)2- Kdo2-lipid A Uridine diphosphate glucose UDP Hydrogen Ion glucosyl- (heptosyl)2- Kdo2-lipid A Adenosine triphosphate Adenosine diphosphate Hydrogen Ion glucosyl- (heptosyl)2- Kdo2-lipid A-phosphate ADP-L- glycero-β-D- manno-heptose Adenosine diphosphate Hydrogen Ion glucosyl- (heptosyl)3- Kdo2-lipid A-phosphate Adenosine triphosphate Adenosine diphosphate Hydrogen Ion glucosyl- (heptosyl)3- Kdo2-lipid A-bisphosphate UDP-α-D- galactose galactosyl- glucosyl- (heptosyl)3- Kdo2-lipid A-bisphosphate UDP Hydrogen Ion Uridine diphosphate glucose UDP Hydrogen Ion galactosyl- (glucosyl)2- (heptosyl)3- Kdo2-lipid A-bisphosphate Uridine diphosphate glucose UDP Hydrogen Ion galactosyl- (glucosyl)3- (heptosyl)3- Kdo2-lipid A-bisphosphate ADP-L- glycero-β-D- manno-heptose Hydrogen Ion Adenosine diphosphate lipid A-core Glucosamine 6-phosphate Glucosamine-1P Acetyl-CoA N-Acetyl- glucosamine 1-phosphate Coenzyme A Hydrogen Ion Uridine triphosphate Hydrogen Ion Uridine diphosphate- N- acetylglucosamine Pyrophosphate Hydrogen Ion UDP-2-N,3-O- bis[(3R)-3- hydroxytetradecanoyl]- α-D- glucosamine a-Kdo-(2->4)- a-Kdo-(2->6)- lipid IVA (KDO)2- (lauroyl)- lipid IVA PE(12:0/10:0) 1,2-Diacyl- sn-glycerol (didodecanoyl, n-C12:0) UDP-D- Galacto-1,4- furanose Adenosine triphosphate Adenosine diphosphate Hydrogen Ion Cytidine monophosphate Hydrogen Ion Water Uridine 5'- monophosphate Hydrogen Ion L-Glutamine L-Glutamic acid Adenosine triphosphate Water Adenosine diphosphate Phosphate Hydrogen Ion lipid A-core D-Fructose (3R)-3- hydroxymyristoyl- [acp] a holo-[acyl- carrier protein] dodecanoyl- [acp] a holo-[acyl- carrier protein] myristoyl-[acp] a holo-[acyl- carrier protein] (3R)-3- hydroxymyristoyl- [acp] a holo-[acyl- carrier protein] lptA lptF lptG lptE Glycolysis and Pyruvate Dehydrogenase Pentose Phosphate kdsD
lptC lptB lptD lpxC lpxB gutQ kdsA kdsC kdsB waaA rfaC rfaF rfaG rfaP rfaQ rfaY rfaB rfaI rfaJ waaU glmM glmU glmU lpxD htrB eptB glf msbB lpxK waaA lpxH lpxA glmS msbA ptsH ptsH manZ manY manX Fru6P RP pKdolA pKdolA UOHNADG H2O Acoh UOHDGM Bis3RHα UNBHGM UDP H+ LADS D-a-5-p Pep H2O Pi 3DDMO8P H2O Pi 3DDMO CTP PPi CMP3mo LLIVA CMP H+ αK2LI K2LA ADP-GMH H+ ADP HKLA ADP-GMH ADP H+ H2KLA UDPG UDP H+ GH2KLA ATP ADP H+ GH2KLAP ADP-GMH ADP H+ GH3KLAP ATP ADP H+ GH3KLAB UDPaDG GGH3KLA UDP H+ UDPG UDP H+ GG2H3KL UDPG UDP H+ GG3H3KL ADP-GMH H+ ADP LAC G6P GluN-1P Ac-CoA NGluA1P CoA H+ UTP H+ UDP-GN PPi H+ UNBHGM KdoIVA K2LLI PE12 DiaGlyl UDPGALF ATP ADP H+ CMP H+ H2O U-5-P H+ Gln Glu ATP H2O ADP Pi H+ LAC Fru 33HA AHACP DA AHACP MA AHACP 33HA AHACP lptA lptF lptG lptE PW000785 PW122334 kdsD
lptC lptB lptD lpxC lpxB gutQ kdsA kdsC kdsB waaA rfaC rfaF rfaG rfaP rfaQ rfaY rfaB rfaI rfaJ waaU glmM glmU glmU lpxD htrB eptB glf msbB lpxK waaA lpxH lpxA glmS msbA ptsH ptsH manZ manY manX Fru6P RP pKdolA pKdolA UOHNADG H2O Acoh UOHDGM Bis3RHα UNBHGM UDP H+ LADS D-a-5-p Pep H2O Pi 3DDMO8P H2O Pi 3DDMO CTP Ppi CMP3mo LLIVA CMP H+ αK2LI K2LA ADP-GMH H+ ADP HKLA ADP-GMH ADP H+ H2KLA UDPG UDP H+ GH2KLA ATP ADP H+ GH2KLAP ADP-GMH ADP H+ GH3KLAP ATP ADP H+ GH3KLAB UDPaDG GGH3KLA UDP H+ UDPG UDP H+ GG2H3KL UDPG UDP H+ GG3H3KL ADP-GMH H+ ADP LAC G6P GluN-1P Ac-CoA NGluA1P CoA H+ UTP H+ UDP-GN Ppi H+ UNBHGM KdoIVA K2LLI PE12 DiaGlyl UDPGALF ATP ADP H+ CMP H+ H2O U-5-P H+ Gln Glu ATP H2O ADP Pi H+ LAC Fru 33HA AHACP DA AHACP MA AHACP 33HA AHACP lptA lptF lptG lptE PW000785 PW122334 kdsD