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388358 ChemSpider CHEBI:16015 ChEBI 388356 ChemSpider 2.0 6022 PubChem-compound Phosphocarrier protein HPr C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider HMDB00250 HMDB UDP-N-acetyl-α-D-muramate HMDB01341 HMDB Glucose-specific phosphotransferase enzyme IIA component Reaction3311 false Chitin + Water → Chitin + N-Acetyl-D-glucosamine LEFT_TO_RIGHT 3.2.1.14 false 3.2.1.14 Chitin + Water → Chitin + Chitobiose LEFT_TO_RIGHT 439153 PubChem-compound 1.3.1.98 false 1.3.1.98 Hydrogen ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate LEFT_TO_RIGHT 2.5.1.7 false 2.5.1.7 Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate LEFT_TO_RIGHT 1.1.1.336 false 1.1.1.336 2 NAD + UDP-N-acetyl-D-mannosamine + Water → 3 Hydrogen Ion + 2 NADH + UDP-N-acetyl-α-D-mannosaminuronate LEFT_TO_RIGHT 5.1.3.14 false 5.1.3.14 Uridine diphosphate-N-acetylglucosamine ↔ UDP-N-acetyl-D-mannosamine REVERSIBLE Reaction3314 false Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT 2.7.7.23 false 2.7.7.23 Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate LEFT_TO_RIGHT UDP-MANNAC BioCyc 5.4.2.10 false 5.4.2.10 Glucosamine 6-phosphate ↔ Glucosamine-1P REVERSIBLE 6133 PubChem-compound Glucosamine 6-phosphate H Hydrogen ion 1.007825 HMDB00148 HMDB 3.2.1.52 false 3.2.1.52 Chitobiose + Water → 2 N-Acetyl-D-glucosamine LEFT_TO_RIGHT ATP BioCyc CHEBI:16264 ChEBI Probable bifunctional chitinase/lysozyme Bifunctional protein glmU HMDB00263 HMDB C8H16NO9P N-Acetyl-D-Glucosamine 6-Phosphate 301.05627 H4N Ammonium 18.034374 C15H26N2O12 Chitobiose 426.14856 1.0 C17H27N3O17P2 UDP-N-acetyl-D-mannosamine 607.08154 UDP-N-acetyl-D-mannosamine 559142 ChemSpider 2.7.1.59 false 2.7.1.59 Adenosine triphosphate + N-Acetyl-D-glucosamine → Adenosine diphosphate + Hydrogen Ion + N-Acetyl-D-Glucosamine 6-Phosphate LEFT_TO_RIGHT 2.6.1.16 false 2.6.1.16 L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid REVERSIBLE HMDB01109 HMDB 3.5.99.6 false 3.5.99.6 Glucosamine 6-phosphate + Water → Ammonium + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT 3.5.1.25 false 3.5.1.25 N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate LEFT_TO_RIGHT 4.2.1.126 false 4.2.1.126 MurNAc-6-P + Water → D-Lactic acid + N-Acetylglucosamine 6-phosphate LEFT_TO_RIGHT P0AA04 UniProt D-LACTATE BioCyc 5746 ChemSpider HMDB01206 HMDB UDP-N-acetylglucosamine 2-epimerase 5742 ChemSpider 1.0 NADH Probable bifunctional chitinase/lysozyme Glucosamine-1P UDP-N-acetyl-D-mannosamine dehydrogenase N-acetylglucosamine-6-phosphate deacetylase CHEBI:16474 ChEBI UDP-N-acetyl-D-mannosamine dehydrogenase HMDB59597 HMDB 17216232 ChemSpider Glucosamine 6-phosphate MurNAc-6-P 8140645 ChemSpider 439174 PubChem-compound C00461 KEGG Compound SMILES C[C@@H](O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C([O-])=O N-acetylmuramic acid PTS permease 10326-41-7 CAS 1010 ChemSpider C01674 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2.0 HMDB41827 HMDB GLUCOSAMINE-1P BioCyc 440272 PubChem-compound PPI BioCyc P76535 UniProt SMILES C[C@@H](O[C@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@@H](O)[C@@H]1NC(C)=O)C([O-])=O BiologicalState109 138-08-9 CAS BiologicalState108 CHEBI:17029 ChEBI C6H14NO8P Glucosamine-1P 259.04572 1.0 HMDB01423 HMDB 1.0 1.0 HMDB00215 HMDB 388319 ChemSpider 1.0 C5H10N2O3 L-Glutamine 146.06914 HMDB00217 HMDB C8H16NO9P N-Acetylglucosamine 6-phosphate 301.05627 C00352 KEGG Compound Cytosol Glucosamine-6-phosphate deaminase 2.0 C00357 KEGG Compound 1.0 Chitin ReactionCatalysis3268 ACTIVATION ReactionCatalysis3269 ACTIVATION ReactionCatalysis3267 ACTIVATION HMDB01311 HMDB C00009 KEGG Compound HMDB00221 HMDB 3616-42-0 CAS C00008 KEGG Compound C00006 KEGG Compound ReactionCatalysis3271 ACTIVATION 1.0 ReactionCatalysis3272 ACTIVATION Hydrogen Ion CHEBI:18009 ChEBI C00001 KEGG Compound C11H18NO8 MurNAc 292.1038 CHEBI:18361 ChEBI C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADPH Phosphocarrier protein HPr C00002 KEGG Compound N-acetylglucosamine-6-phosphate deacetylase ReactionCatalysis3275 ACTIVATION HMDB01429 HMDB ReactionCatalysis3276 ACTIVATION ReactionCatalysis3273 ACTIVATION ReactionCatalysis3274 ACTIVATION ReactionCatalysis3279 ACTIVATION ReactionCatalysis3277 ACTIVATION C11H17NO11P MurNAc-6-P 370.05557 ReactionCatalysis3278 ACTIVATION C17H22N3O18P2 UDP-N-acetyl-α-D-mannosaminuronate 618.039 C20H26N3O19P2 UDP-N-acetyl-α-D-glucosamine-enolpyruvate 674.06525 Coenzyme A ReactionCatalysis3282 ACTIVATION C20H28N3O19P2 UDP-N-acetyl-α-D-muramate 676.0809 C21H28N7O14P2 NAD 664.11694 Chitobiose ReactionCatalysis3280 ACTIVATION ReactionCatalysis3281 ACTIVATION C01342 KEGG Compound C00010 KEGG Compound Secondary Metabolites: enterobacterial common antigen biosynthesis SubPathway C00256 KEGG Compound C6H14NO8P Glucosamine 6-phosphate 259.04572 C00013 KEGG Compound CHEBI:7125 ChEBI Glucosamine-6-phosphate deaminase UDP-N-acetylglucosamine 1-carboxyvinyltransferase C00140 KEGG Compound NAD(P) BioCyc D-GLUCOSAMINE-6-P BioCyc 1.0 1.0 562 TAXONOMY H Hydrogen Ion 1.007825 N-acetylglucosamine-6-phosphate deacetylase SubPathwayInteraction1678 SubPathwayReaction SubPathway1678Reaction L-Glutamine 56-65-5 CAS 1.0 53-84-9 CAS ReactionCoupledTransportCatalysis161 ACTIVATION ReactionCoupledTransportCatalysis160 ACTIVATION C00025 KEGG Compound C00024 KEGG Compound CHEBI:16287 ChEBI ACET BioCyc 2.7.1.69 false 2.7.1.69 HPr - phosphorylated + N-Acetyl-D-glucosamine → HPr + N-Acetyl-D-Glucosamine 6-Phosphate LEFT_TO_RIGHT 2.7.1.- false 2.7.1.- HPr - phosphorylated + MurNAc → HPr + MurNAc-6-P LEFT_TO_RIGHT UDP-N-acetyl-D-mannosamine dehydrogenase NADP 577-76-4 CAS C00033 KEGG Compound N-ACETYL-D-GLUCOSAMINE-1-P BioCyc 4.0 CHEBI:70731 ChEBI 2.0 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES [O-]P([O-])(=O)OP([O-])([O-])=O P0AF18 UniProt C00043 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PHOSPHO-ENOL-PYRUVATE BioCyc HMDB00538 HMDB UTP BioCyc SMILES OC(=O)C(=C)OP(O)(O)=O SMP00792 SMPDB 389821 ChemSpider CHEBI:70757 ChEBI 5903 ChemSpider 399508 ChemSpider SMILES CC(O)=O 7732-18-5 CAS C28H49N3O16 Chitin 683.3113 56-86-0 CAS P0A749 UniProt 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1 BioCyc NAD HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 445675 PubChem-compound 2.0 C00064 KEGG Compound 1.0 6866-69-9 CAS CHEBI:7212 ChEBI SMILES C[C@@H](O)C(O)=O N-Acetyl-D-Glucosamine 6-Phosphate C00074 KEGG Compound Bifunctional protein glmU P0A759 UniProt HMDB02817 HMDB 1.0 962 PubChem-compound UDP-N-acetyl-α-D-mannosaminuronate N-Acetyl-D-Glucosamine 6-Phosphate N-Acetyl-D-glucosamine SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O N-Acetylglucosamine 6-phosphate 5800 ChemSpider C00075 KEGG Compound P75959 UniProt C01170 KEGG Compound C00080 KEGG Compound 9965052 PubChem-compound 1746-32-3 CAS SMILES N[C@@H](CCC(O)=O)C(O)=O N-Acetyl-glucosamine 1-phosphate CHEBI:42111 ChEBI CHEBI:44897 ChEBI 14265-44-2 CAS D-Glutamine and D-Glutamate Metabolism SubPathway 58-64-0 CAS 22833609 PubChem-compound P75949 UniProt UDP-N-acetylglucosamine 2-epimerase Acetic acid 644102 PubChem-compound 444493 PubChem-compound Uridine diphosphate-N-acetylglucosamine SubPathwayInteraction1384 SubPathwayReaction SubPathway1384Reaction Glucose-specific phosphotransferase enzyme IIA component 22833512 PubChem-compound SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 Ammonium 6.0 NADH BioCyc SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O NAD BioCyc N-acetylmuramic acid 6-phosphate etherase MurNAc 102029-88-9 CAS 1.0 CHEBI:57634 ChEBI 1.0 CHEBI:58721 ChEBI SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OP(O)(O)=O 980 ChemSpider Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] UDP-N-acetylglucosamine 1-carboxyvinyltransferase 30572 ChemSpider 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 64-19-7 CAS SMILES O Acetyl-CoA 21252321 PubChem-compound 1.0 N-acetylmuramic acid 6-phosphate etherase 1005 PubChem-compound 1.0 5961 PubChem-compound D-fructose-6-phosphate aminotransferase P27829 UniProt C3H6O3 D-Lactic acid 90.03169 528-04-1 CAS P0ACC7 UniProt 6816 PubChem-compound CHEBI:15846 ChEBI ADP BioCyc P27828 UniProt 1.0 ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS BioCyc N-ACETYL-D-GLUCOSAMINE-6-P BioCyc 53-59-8 CAS 1038 PubChem-compound C04256 KEGG Compound GO:0005829 GENE ONTOLOGY UDP-N-acetylglucosamine 2-epimerase HMDB00902 HMDB 1.0 PW000959 PathWhiz 393240 ChemSpider CHITOBIOSE BioCyc CHEBI:16908 ChEBI UDP-N-acetylenolpyruvoylglucosamine reductase 55423 ChemSpider N-Acetyl-D-glucosamine 2.0 CHEBI:15713 ChEBI SMP00975 SMPDB Pyrophosphate O4P Phosphate 94.95342 GO:0070258 GENE ONTOLOGY Hydrogen ion C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 C8H15NO6 N-Acetyl-D-glucosamine 221.08994 1.0 NADPH BioCyc Phosphoenolpyruvic acid SMP00905 SMPDB 218 ChemSpider 1.0 58-68-4 CAS C9H15N2O15P3 Uridine triphosphate 483.96854 L-Glutamic acid SMILES [O-]P([O-])([O-])=O 1398-61-4 CAS UDP-N-acetylenolpyruvoylglucosamine reductase Amino sugar and nucleotide sugar metabolism I 1.0 C17H27N3O17P2 Uridine diphosphate-N-acetylglucosamine 607.08154 PTS system N-acetylglucosamine-specific EIICBA component β-D-fructofuranose 6-phosphate 1.0 P69783 UniProt Inner Membrane SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O C8H16NO9P N-Acetyl-glucosamine 1-phosphate 301.05627 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc PW000769 PathWhiz GLT BioCyc 1.0 53-57-6 CAS 1.0 UDP-N-acetyl-α-D-glucosamine-enolpyruvate PW000886 PathWhiz 1.0 P77272 UniProt C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase CHEBI:28938 ChEBI Uridine diphosphate-N-acetylglucosamine O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 1.0 CHEBI:68483 ChEBI 5957 PubChem-compound CHEBI:15873 ChEBI P13656 UniProt 440996 PubChem-compound C3H5O6P Phosphoenolpyruvic acid 167.98238 Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 2.0 Beta-hexosaminidase P09323 UniProt N-acetyl-D-glucosamine kinase HMDB03362 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc HMDB01062 HMDB SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 2.0 5682 ChemSpider CHEBI:1146900 ChEBI 14000-31-8 CAS CO-A BioCyc PTS system N-acetylmuramic acid-specific EIIBC component 5675 ChemSpider N-acetyl-D-glucosamine kinase 72-89-9 CAS N-acetylglucosamine PTS permease 1.0 1.0 C21H36N7O16P3S Coenzyme A 767.11523 Adenosine diphosphate 1.0 14798-03-9 CAS Uridine triphosphate P31120 UniProt CHEBI:15784 ChEBI 1.0 CHEBI:15422 ChEBI 6557 ChemSpider P08373 UniProt Phosphoglucosamine mutase SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider β-D-fructofuranose 6-phosphate 1.0 3.0 Beta-hexosaminidase 439217 PubChem-compound 439219 PubChem-compound Water C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] N-acetylmuramic acid 6-phosphate etherase UDP-N-ACETYL-D-GLUCOSAMINE BioCyc SMILES CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O SMILES CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(O)=O)[C@@H]1O CHEBI:16761 ChEBI CHEBI:506227 ChEBI PTS system N-acetylglucosamine-specific EIICBA component SMILES CC(=O)N[C@@H]1[C@H](O)[C@@H](O)[C@H](CO)OC1OP(O)(=O)OP(O)(=O)OC[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)N1C=CC(=O)NC1=O UDP-N-acetyl-D-mannosamine 1.0 CHEBI:15366 ChEBI SMILES CC(OC1C(O)C(CO)OC(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)C1NC(C)=O)C([O-])=O SMILES CC(=O)NC1C(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)OC(CO)C(O)C1OC(=C)C([O-])=O 389248 ChemSpider SMILES CC(=O)NC1C(O)C(O)C(OC1OP([O-])(=O)OP([O-])(=O)OCC1OC(C(O)C1O)N1C=CC(=O)NC1=O)C([O-])=O 1.0 392413 ChemSpider HMDB00290 HMDB PTS system N-acetylmuramic acid-specific EIIBC component Phosphoglucosamine mutase 53481607 PubChem-compound SMILES CC(=O)NC1[C@H](O)OC(CO)[C@@H](COC[C@@H]2OC(CO)[C@@H](COC[C@@H]3OC(CO)[C@@H](O)[C@H](O)C3NC(C)=O)[C@H](O)C2NC(C)=O)[C@@H]1O 5893 PubChem-compound HMDB02111 HMDB 1.0 171 ChemSpider D-Lactic acid CHEBI:15377 ChEBI glucosamine-6-phosphate deaminase CHEBI:15378 ChEBI SMILES [H+] SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound Phosphate 1.0 61503 PubChem-compound HMDB01487 HMDB HMDB01367 HMDB 16741146 PubChem-compound SMILES CC(=O)N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O SMILES N[C@@H](CCC(N)=O)C(O)=O SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OP(O)(O)=O 1.0 1.0 MurNAc-6-P P17169 UniProt 1.0 HMDB13112 HMDB HMDB03556 HMDB 63-39-8 CAS 1061 PubChem-compound SMILES [H+] CHEBI:15351 ChEBI HMDB00042 HMDB HMDB01254 HMDB 3.0 HMDB00285 HMDB 176 PubChem-compound 1.0 1.0 85-61-0 CAS 7512-17-6 CAS N-acetylmuramic acid 6-phosphate etherase N- acetylglucosamine- 6-phosphate deacetylase Glucosamine- 6-phosphate deaminase Glucosamine-- fructose-6- phosphate aminotransferase [isomerizing] N-acetyl-D- glucosamine kinase Beta- hexosaminidase Probable bifunctional chitinase/lysozyme Probable bifunctional chitinase/lysozyme Phosphoglucosamine mutase Bifunctional protein glmU Bifunctional protein glmU UDP-N- acetylglucosamine 2-epimerase UDP-N-acetyl- D-mannosamine dehydrogenase UDP-N- acetylglucosamine 1- carboxyvinyltransferase UDP-N- acetylenolpyruvoylglucosamine reductase Phosphocarrier protein HPr Phosphocarrier protein HPr Glucose- specific phosphotransferase enzyme IIA component PTS system N-acetylmuramic acid-specific EIIBC component Phosphocarrier protein HPr Phosphocarrier protein HPr PTS system N- acetylglucosamine- specific EIICBA component MurNAc-6-P H 2 O D-Lactic acid N- Acetylglucosamine 6-phosphate N-Acetyl-D- Glucosamine 6-Phosphate H 2 O Acetic acid Glucosamine 6-phosphate H 2 O Ammonium β-D- fructofuranose 6-phosphate L-Glutamine L-Glutamic acid N-Acetyl-D- glucosamine ATP ADP H + H 2 O Chitobiose Chitin H 2 O Chitin Chitin H 2 O Chitin Glucosamine-1P Acetyl-CoA N-Acetyl- glucosamine 1-phosphate CoA H + Uridine triphosphate H + Uridine diphosphate- N- acetylglucosamine PP i UDP-N-acetyl- D-mannosamine NAD H 2 O UDP-N-acetyl- α-D- mannosaminuronate NADH H + Phosphoenolpyruvic acid P i UDP-N-acetyl- α-D- glucosamine- enolpyruvate NADPH Hydrogen ion NADP UDP-N-acetyl- α-D-muramate MurNAc N-Acetyl-D- glucosamine D-Glutamine and D-Glutamate Metabolism Secondary Metabolites: enterobacterial common antigen biosynthesis
388358 ChemSpider CHEBI:16015 ChEBI 388356 ChemSpider 2.0 6022 PubChem-compound Phosphocarrier protein HPr C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider HMDB00250 HMDB UDP-N-acetyl-α-D-muramate HMDB01341 HMDB Glucose-specific phosphotransferase enzyme IIA component Reaction3311 false Chitin + Water → Chitin + N-Acetyl-D-glucosamine LEFT_TO_RIGHT 3.2.1.14 false 3.2.1.14 Chitin + Water → Chitin + Chitobiose LEFT_TO_RIGHT 439153 PubChem-compound 1.3.1.98 false 1.3.1.98 Hydrogen ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate LEFT_TO_RIGHT 2.5.1.7 false 2.5.1.7 Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate LEFT_TO_RIGHT 1.1.1.336 false 1.1.1.336 2 NAD + UDP-N-acetyl-D-mannosamine + Water → 3 Hydrogen Ion + 2 NADH + UDP-N-acetyl-α-D-mannosaminuronate LEFT_TO_RIGHT 5.1.3.14 false 5.1.3.14 Uridine diphosphate-N-acetylglucosamine ↔ UDP-N-acetyl-D-mannosamine REVERSIBLE Reaction3314 false Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT 2.7.7.23 false 2.7.7.23 Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate LEFT_TO_RIGHT UDP-MANNAC BioCyc 5.4.2.10 false 5.4.2.10 Glucosamine 6-phosphate ↔ Glucosamine-1P REVERSIBLE 6133 PubChem-compound Glucosamine 6-phosphate H Hydrogen ion 1.007825 HMDB00148 HMDB 3.2.1.52 false 3.2.1.52 Chitobiose + Water → 2 N-Acetyl-D-glucosamine LEFT_TO_RIGHT ATP BioCyc CHEBI:16264 ChEBI Probable bifunctional chitinase/lysozyme Bifunctional protein glmU HMDB00263 HMDB C8H16NO9P N-Acetyl-D-Glucosamine 6-Phosphate 301.05627 H4N Ammonium 18.034374 C15H26N2O12 Chitobiose 426.14856 1.0 C17H27N3O17P2 UDP-N-acetyl-D-mannosamine 607.08154 UDP-N-acetyl-D-mannosamine 559142 ChemSpider 2.7.1.59 false 2.7.1.59 Adenosine triphosphate + N-Acetyl-D-glucosamine → Adenosine diphosphate + Hydrogen Ion + N-Acetyl-D-Glucosamine 6-Phosphate LEFT_TO_RIGHT 2.6.1.16 false 2.6.1.16 L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid REVERSIBLE HMDB01109 HMDB 3.5.99.6 false 3.5.99.6 Glucosamine 6-phosphate + Water → Ammonium + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT 3.5.1.25 false 3.5.1.25 N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate LEFT_TO_RIGHT 4.2.1.126 false 4.2.1.126 MurNAc-6-P + Water → D-Lactic acid + N-Acetylglucosamine 6-phosphate LEFT_TO_RIGHT P0AA04 UniProt D-LACTATE BioCyc 5746 ChemSpider HMDB01206 HMDB UDP-N-acetylglucosamine 2-epimerase 5742 ChemSpider 1.0 NADH Probable bifunctional chitinase/lysozyme Glucosamine-1P UDP-N-acetyl-D-mannosamine dehydrogenase N-acetylglucosamine-6-phosphate deacetylase CHEBI:16474 ChEBI UDP-N-acetyl-D-mannosamine dehydrogenase HMDB59597 HMDB 17216232 ChemSpider Glucosamine 6-phosphate MurNAc-6-P 8140645 ChemSpider 439174 PubChem-compound C00461 KEGG Compound SMILES C[C@@H](O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C([O-])=O N-acetylmuramic acid PTS permease 10326-41-7 CAS 1010 ChemSpider C01674 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2.0 HMDB41827 HMDB GLUCOSAMINE-1P BioCyc 440272 PubChem-compound PPI BioCyc P76535 UniProt SMILES C[C@@H](O[C@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@@H](O)[C@@H]1NC(C)=O)C([O-])=O BiologicalState109 Escherichia coli, Inner Membrane 138-08-9 CAS BiologicalState108 Escherichia coli, Cytosol CHEBI:17029 ChEBI C6H14NO8P Glucosamine-1P 259.04572 1.0 HMDB01423 HMDB 1.0 1.0 HMDB00215 HMDB 388319 ChemSpider 1.0 C5H10N2O3 L-Glutamine 146.06914 HMDB00217 HMDB C8H16NO9P N-Acetylglucosamine 6-phosphate 301.05627 C00352 KEGG Compound Cytosol Glucosamine-6-phosphate deaminase 2.0 C00357 KEGG Compound 1.0 Chitin ReactionCatalysis3268 ACTIVATION ReactionCatalysis3269 ACTIVATION ReactionCatalysis3267 ACTIVATION HMDB01311 HMDB C00009 KEGG Compound HMDB00221 HMDB 3616-42-0 CAS C00008 KEGG Compound C00006 KEGG Compound ReactionCatalysis3271 ACTIVATION 1.0 ReactionCatalysis3272 ACTIVATION Hydrogen Ion CHEBI:18009 ChEBI C00001 KEGG Compound C11H18NO8 MurNAc 292.1038 CHEBI:18361 ChEBI C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADPH Phosphocarrier protein HPr C00002 KEGG Compound N-acetylglucosamine-6-phosphate deacetylase ReactionCatalysis3275 ACTIVATION HMDB01429 HMDB ReactionCatalysis3276 ACTIVATION ReactionCatalysis3273 ACTIVATION ReactionCatalysis3274 ACTIVATION ReactionCatalysis3279 ACTIVATION ReactionCatalysis3277 ACTIVATION C11H17NO11P MurNAc-6-P 370.05557 ReactionCatalysis3278 ACTIVATION C17H22N3O18P2 UDP-N-acetyl-α-D-mannosaminuronate 618.039 C20H26N3O19P2 UDP-N-acetyl-α-D-glucosamine-enolpyruvate 674.06525 Coenzyme A ReactionCatalysis3282 ACTIVATION C20H28N3O19P2 UDP-N-acetyl-α-D-muramate 676.0809 C21H28N7O14P2 NAD 664.11694 Chitobiose ReactionCatalysis3280 ACTIVATION ReactionCatalysis3281 ACTIVATION C01342 KEGG Compound C00010 KEGG Compound C00256 KEGG Compound C6H14NO8P Glucosamine 6-phosphate 259.04572 C00013 KEGG Compound CHEBI:7125 ChEBI Glucosamine-6-phosphate deaminase UDP-N-acetylglucosamine 1-carboxyvinyltransferase C00140 KEGG Compound NAD(P) BioCyc D-GLUCOSAMINE-6-P BioCyc 1.0 1.0 562 TAXONOMY H Hydrogen Ion 1.007825 N-acetylglucosamine-6-phosphate deacetylase SubPathwayInteraction1678 SubPathwayReaction SubPathway1678Reaction L-Glutamine 56-65-5 CAS 1.0 53-84-9 CAS ReactionCoupledTransportCatalysis161 ACTIVATION ReactionCoupledTransportCatalysis160 ACTIVATION C00025 KEGG Compound C00024 KEGG Compound CHEBI:16287 ChEBI ACET BioCyc 2.7.1.69 false 2.7.1.69 HPr - phosphorylated + N-Acetyl-D-glucosamine → HPr + N-Acetyl-D-Glucosamine 6-Phosphate LEFT_TO_RIGHT 2.7.1.- false 2.7.1.- HPr - phosphorylated + MurNAc → HPr + MurNAc-6-P LEFT_TO_RIGHT UDP-N-acetyl-D-mannosamine dehydrogenase NADP 577-76-4 CAS C00033 KEGG Compound N-ACETYL-D-GLUCOSAMINE-1-P BioCyc 4.0 CHEBI:70731 ChEBI 2.0 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES [O-]P([O-])(=O)OP([O-])([O-])=O P0AF18 UniProt C00043 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PHOSPHO-ENOL-PYRUVATE BioCyc HMDB00538 HMDB UTP BioCyc SMILES OC(=O)C(=C)OP(O)(O)=O http://identifiers.org/smpdb/SMP00792 SMPDB 389821 ChemSpider CHEBI:70757 ChEBI 5903 ChemSpider 399508 ChemSpider SMILES CC(O)=O 7732-18-5 CAS C28H49N3O16 Chitin 683.3113 56-86-0 CAS P0A749 UniProt 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1 BioCyc NAD HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 445675 PubChem-compound 2.0 C00064 KEGG Compound 1.0 6866-69-9 CAS CHEBI:7212 ChEBI SMILES C[C@@H](O)C(O)=O N-Acetyl-D-Glucosamine 6-Phosphate C00074 KEGG Compound Bifunctional protein glmU P0A759 UniProt HMDB02817 HMDB 1.0 962 PubChem-compound UDP-N-acetyl-α-D-mannosaminuronate N-Acetyl-D-Glucosamine 6-Phosphate N-Acetyl-D-glucosamine SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O N-Acetylglucosamine 6-phosphate 5800 ChemSpider C00075 KEGG Compound P75959 UniProt C01170 KEGG Compound C00080 KEGG Compound 9965052 PubChem-compound 1746-32-3 CAS SMILES N[C@@H](CCC(O)=O)C(O)=O N-Acetyl-glucosamine 1-phosphate CHEBI:42111 ChEBI CHEBI:44897 ChEBI 14265-44-2 CAS 58-64-0 CAS 22833609 PubChem-compound P75949 UniProt UDP-N-acetylglucosamine 2-epimerase Acetic acid 644102 PubChem-compound 444493 PubChem-compound Uridine diphosphate-N-acetylglucosamine SubPathwayInteraction1384 SubPathwayReaction SubPathway1384Reaction Glucose-specific phosphotransferase enzyme IIA component 22833512 PubChem-compound SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 Ammonium 6.0 NADH BioCyc SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O NAD BioCyc N-acetylmuramic acid 6-phosphate etherase MurNAc 102029-88-9 CAS 1.0 CHEBI:57634 ChEBI 1.0 CHEBI:58721 ChEBI SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OP(O)(O)=O 980 ChemSpider Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] UDP-N-acetylglucosamine 1-carboxyvinyltransferase 30572 ChemSpider 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 64-19-7 CAS SMILES O Acetyl-CoA 21252321 PubChem-compound 1.0 N-acetylmuramic acid 6-phosphate etherase D-Glutamine and D-Glutamate Metabolism SubPathway 1005 PubChem-compound 1.0 5961 PubChem-compound D-fructose-6-phosphate aminotransferase P27829 UniProt C3H6O3 D-Lactic acid 90.03169 528-04-1 CAS P0ACC7 UniProt 6816 PubChem-compound CHEBI:15846 ChEBI ADP BioCyc P27828 UniProt 1.0 ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS BioCyc N-ACETYL-D-GLUCOSAMINE-6-P BioCyc 53-59-8 CAS 1038 PubChem-compound C04256 KEGG Compound GO:0005829 GENE ONTOLOGY UDP-N-acetylglucosamine 2-epimerase HMDB00902 HMDB 1.0 PW000959 PathWhiz 393240 ChemSpider CHITOBIOSE BioCyc CHEBI:16908 ChEBI UDP-N-acetylenolpyruvoylglucosamine reductase 55423 ChemSpider N-Acetyl-D-glucosamine 2.0 CHEBI:15713 ChEBI http://identifiers.org/smpdb/SMP00975 SMPDB Pyrophosphate O4P Phosphate 94.95342 GO:0070258 GENE ONTOLOGY Hydrogen ion C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 C8H15NO6 N-Acetyl-D-glucosamine 221.08994 1.0 NADPH BioCyc Secondary Metabolites: enterobacterial common antigen biosynthesis SubPathway Phosphoenolpyruvic acid http://identifiers.org/smpdb/SMP00905 SMPDB 218 ChemSpider 1.0 58-68-4 CAS C9H15N2O15P3 Uridine triphosphate 483.96854 L-Glutamic acid SMILES [O-]P([O-])([O-])=O 1398-61-4 CAS UDP-N-acetylenolpyruvoylglucosamine reductase Amino sugar and nucleotide sugar metabolism I 1.0 C17H27N3O17P2 Uridine diphosphate-N-acetylglucosamine 607.08154 PTS system N-acetylglucosamine-specific EIICBA component β-D-fructofuranose 6-phosphate 1.0 P69783 UniProt Inner Membrane SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O C8H16NO9P N-Acetyl-glucosamine 1-phosphate 301.05627 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc PW000769 PathWhiz GLT BioCyc 1.0 53-57-6 CAS 1.0 UDP-N-acetyl-α-D-glucosamine-enolpyruvate PW000886 PathWhiz 1.0 P77272 UniProt C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase CHEBI:28938 ChEBI Uridine diphosphate-N-acetylglucosamine O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 1.0 CHEBI:68483 ChEBI 5957 PubChem-compound CHEBI:15873 ChEBI P13656 UniProt 440996 PubChem-compound C3H5O6P Phosphoenolpyruvic acid 167.98238 Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 2.0 Beta-hexosaminidase P09323 UniProt N-acetyl-D-glucosamine kinase HMDB03362 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc HMDB01062 HMDB SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 2.0 5682 ChemSpider CHEBI:1146900 ChEBI 14000-31-8 CAS CO-A BioCyc PTS system N-acetylmuramic acid-specific EIIBC component 5675 ChemSpider N-acetyl-D-glucosamine kinase 72-89-9 CAS N-acetylglucosamine PTS permease 1.0 1.0 C21H36N7O16P3S Coenzyme A 767.11523 Adenosine diphosphate 1.0 14798-03-9 CAS Uridine triphosphate P31120 UniProt CHEBI:15784 ChEBI 1.0 CHEBI:15422 ChEBI 6557 ChemSpider P08373 UniProt Phosphoglucosamine mutase SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider β-D-fructofuranose 6-phosphate 1.0 3.0 Beta-hexosaminidase 439217 PubChem-compound 439219 PubChem-compound Water C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] N-acetylmuramic acid 6-phosphate etherase UDP-N-ACETYL-D-GLUCOSAMINE BioCyc SMILES CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O SMILES CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(O)=O)[C@@H]1O CHEBI:16761 ChEBI CHEBI:506227 ChEBI PTS system N-acetylglucosamine-specific EIICBA component SMILES CC(=O)N[C@@H]1[C@H](O)[C@@H](O)[C@H](CO)OC1OP(O)(=O)OP(O)(=O)OC[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)N1C=CC(=O)NC1=O UDP-N-acetyl-D-mannosamine 1.0 CHEBI:15366 ChEBI SMILES CC(OC1C(O)C(CO)OC(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)C1NC(C)=O)C([O-])=O SMILES CC(=O)NC1C(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)OC(CO)C(O)C1OC(=C)C([O-])=O 389248 ChemSpider SMILES CC(=O)NC1C(O)C(O)C(OC1OP([O-])(=O)OP([O-])(=O)OCC1OC(C(O)C1O)N1C=CC(=O)NC1=O)C([O-])=O 1.0 392413 ChemSpider HMDB00290 HMDB PTS system N-acetylmuramic acid-specific EIIBC component Phosphoglucosamine mutase 53481607 PubChem-compound SMILES CC(=O)NC1[C@H](O)OC(CO)[C@@H](COC[C@@H]2OC(CO)[C@@H](COC[C@@H]3OC(CO)[C@@H](O)[C@H](O)C3NC(C)=O)[C@H](O)C2NC(C)=O)[C@@H]1O 5893 PubChem-compound HMDB02111 HMDB 1.0 171 ChemSpider D-Lactic acid CHEBI:15377 ChEBI glucosamine-6-phosphate deaminase CHEBI:15378 ChEBI SMILES [H+] SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound Phosphate 1.0 61503 PubChem-compound HMDB01487 HMDB HMDB01367 HMDB 16741146 PubChem-compound SMILES CC(=O)N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O SMILES N[C@@H](CCC(N)=O)C(O)=O SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OP(O)(O)=O 1.0 1.0 MurNAc-6-P P17169 UniProt