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ReactionCoupledTransportCatalysis177 ACTIVATION 937 ChemSpider ReactionCoupledTransportCatalysis176 ACTIVATION ReactionCoupledTransportCatalysis175 ACTIVATION ReactionCoupledTransportCatalysis174 ACTIVATION Succinic acid 439153 PubChem-compound 110-17-8 CAS 21883788 PubChem-compound SMILES O Porphyrin Metabolism SubPathway 2.0 NADH-quinone oxidoreductase subunit J CHEBI:16389 ChEBI NADH-quinone oxidoreductase subunit F 1.0 succinate dehydrogenase, FeS subunit succinate:quinone oxidoreductase, FAD binding protein Cytochrome o ubiquinol oxidase subunit 3 cytochrome bd-I terminal oxidase - CydX subunit 1.0 cytochrome bd-I terminal oxidase 1.0 succinate dehydrogenase fumarate reductase, membrane anchor subunit succinate dehydrogenase 1.0 NADH-quinone oxidoreductase subunit C/D CHEBI:15846 ChEBI P0AC44 UniProt Cytochrome d ubiquinol oxidase subunit 2 1038 PubChem-compound 952 ChemSpider 1.0 P0AC41 UniProt CHEBI:16908 ChEBI P33602 UniProt NAD Ubiquinol oxidase subunit 2 C14H18O4 Ubiquinone-1 250.12051 Ubiquinol-1 1010 ChemSpider GO:0070258 GENE ONTOLOGY Cytochrome o ubiquinol oxidase protein cyoD P33607 UniProt Cytochrome d ubiquinol oxidase subunit 2 Oxygen cytochrome bd-I terminal oxidase - CydX subunit NADH-quinone oxidoreductase subunit A Ubiquinone-1 P33599 UniProt P31979 UniProt ReactionCatalysis2607 ACTIVATION CPD-6641 BioCyc P0AFE0 UniProt SUC BioCyc P0AFD1 UniProt 58-68-4 CAS cytochrome bd-II terminal oxidase P0AFD4 UniProt P0AFD6 UniProt Hydrogen Ion NADH 4307 ChemSpider C00007 KEGG Compound C00122 KEGG Compound C00001 KEGG Compound SMILES COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O Ubiquinol oxidase subunit 1 Cytochrome bd-II oxidase subunit 1 Cytochrome bd-II oxidase subunit 2 P0AFF0 UniProt C00004 KEGG Compound Inner Membrane C00003 KEGG Compound NADH-quinone oxidoreductase subunit B 5.0 NADH-quinone oxidoreductase subunit A P0AFE4 UniProt Fumaric acid P0AFE8 UniProt C4H4O4 Fumaric acid 116.010956 succinate:quinone oxidoreductase CHEBI:15741 ChEBI C21H28N7O14P2 NAD 664.11694 447920 PubChem-compound Ubiquinol oxidase subunit 2 NADH-quinone oxidoreductase subunit N NADH-quinone oxidoreductase subunit K HMDB0000902 HMDB NADH-quinone oxidoreductase subunit J NADH-quinone oxidoreductase subunit I 1110 PubChem-compound NADH-quinone oxidoreductase subunit H NADH-quinone oxidoreductase subunit I NADH-quinone oxidoreductase subunit E NADH-quinone oxidoreductase subunit N C21H29N7O14P2 NADH 665.12476 NADH-quinone oxidoreductase subunit M NADH-quinone oxidoreductase subunit B C4H6O4 Succinic acid 118.02661 562 TAXONOMY H Hydrogen Ion 1.007825 2.0 Oxidative Phosphorylation 53-84-9 CAS Cytochrome bd-II oxidase subunit 2 4.0 P56100 UniProt 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O C00399 KEGG Compound P0ABI8 UniProt Cytochrome d ubiquinol oxidase subunit 1 5682 ChemSpider HMDB0000134 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000254 HMDB SMILES OC(=O)CCC(O)=O SMP0000936 SMPDB 1.0 Reaction2619 false Succinic acid + Ubiquinone-1 → Fumaric acid + Ubiquinol-1 LEFT_TO_RIGHT P0ABJ1 UniProt P0ABJ3 UniProt NADH-quinone oxidoreductase subunit E C00042 KEGG Compound P0ABJ6 UniProt 1078 ChemSpider NADH:ubiquinone oxidoreductase I P0ABJ9 UniProt Cytochrome bd-II oxidase subunit 1 NADH-quinone oxidoreductase subunit M P26459 UniProt P26458 UniProt 1.6.99.5 false 1.6.99.5 5 Hydrogen Ion + NADH + Ubiquinone-1 → Hydrogen Ion + NAD + Ubiquinol-1 LEFT_TO_RIGHT 1.10.3.10 false 1.10.3.10 4 Hydrogen Ion + Oxygen + 2 Ubiquinol-1 → 4 Hydrogen Ion + 2 Ubiquinone-1 + 2 Water LEFT_TO_RIGHT ReactionCoupledTransport142 false 8 Hydrogen Ion + Oxygen + 2 Ubiquinol-1 → 8 Hydrogen Ion + 2 Ubiquinone-1 + 2 Water LEFT_TO_RIGHT 1.10.3.14 false 1.10.3.14 4 Hydrogen Ion + Oxygen + 2 Ubiquinol-1 → 4 Hydrogen Ion + 2 Ubiquinone-1 + 2 Water LEFT_TO_RIGHT Water 10197150 ChemSpider NADH-quinone oxidoreductase subunit L SubPathwayInteraction1502 SubPathway1502Reaction SubPathwayReaction P0ABK2 UniProt FUM BioCyc Escherichia coli P69054 UniProt 7732-18-5 CAS 388299 ChemSpider SMILES COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC CHEBI:18012 ChEBI Ubiquinol oxidase subunit 1 HMDB0001487 HMDB O2 Oxygen 31.98983 cytochrome bo terminal oxidase SMP0000953 SMPDB 1.0 NADH-quinone oxidoreductase subunit F 7782-44-7 CAS HMDB0001377 HMDB P0AFC3 UniProt P0AFC7 UniProt 962 PubChem-compound 1.0 1.0 C14H20O4 Ubiquinol-1 252.13615 Ubiquinone-1 5893 PubChem-compound C00080 KEGG Compound 110-15-6 CAS SMILES O=O 2.0 succinate:quinone oxidoreductase, FAD binding protein succinate dehydrogenase, FeS subunit NADH-quinone oxidoreductase subunit G HMDB0002111 HMDB PW000936 PathWhiz CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] 1.0 succinate dehydrogenase fumarate reductase, membrane anchor subunit NADH-quinone oxidoreductase subunit H succinate dehydrogenase 4462 PubChem-compound NADH-quinone oxidoreductase subunit L Cytochrome o ubiquinol oxidase subunit 3 NADH-quinone oxidoreductase subunit K NADH-quinone oxidoreductase subunit G 8.0 NADH-quinone oxidoreductase subunit C/D PW000919 PathWhiz 727-81-1 CAS H2O Water 18.010565 1.0 HMDB0002012 HMDB NADH BioCyc NAD BioCyc Ubiquinol-1 977 PubChem-compound HMDB0059597 HMDB P07014 UniProt SMILES OC(=O)\C=C\C(O)=O Cytochrome d ubiquinol oxidase subunit 1 1.0 Cytochrome o ubiquinol oxidase protein cyoD 1.0 succinate dehydrogenase, FeS subunit succinate dehydrogenase succinate dehydrogenase fumarate reductase, membrane anchor subunit succinate:quinone oxidoreductase, FAD binding protein succinate dehydrogenase, FeS subunit succinate dehydrogenase succinate dehydrogenase fumarate reductase, membrane anchor subunit cytochrome bd-I terminal oxidase - CydX subunit Cytochrome bd-II oxidase subunit 1 Cytochrome bd-II oxidase subunit 2 Cytochrome o ubiquinol oxidase protein cyoD Ubiquinol oxidase subunit 2 Ubiquinol oxidase subunit 1 Cytochrome o ubiquinol oxidase subunit 3 NADH-quinone oxidoreductase subunit A NADH-quinone oxidoreductase subunit H NADH-quinone oxidoreductase subunit J NADH-quinone oxidoreductase subunit K NADH-quinone oxidoreductase subunit L NADH-quinone oxidoreductase subunit M NADH-quinone oxidoreductase subunit N NADH-quinone oxidoreductase subunit E NADH-quinone oxidoreductase subunit F NADH-quinone oxidoreductase subunit B NADH-quinone oxidoreductase subunit G NADH-quinone oxidoreductase subunit C/D NADH-quinone oxidoreductase subunit I Cytochrome d ubiquinol oxidase subunit 1 Cytochrome d ubiquinol oxidase subunit 2 cytochrome bd-I terminal oxidase - CydX subunit NADH-quinone oxidoreductase subunit A NADH-quinone oxidoreductase subunit H NADH-quinone oxidoreductase subunit J NADH-quinone oxidoreductase subunit K NADH-quinone oxidoreductase subunit L NADH-quinone oxidoreductase subunit M NADH-quinone oxidoreductase subunit N NADH-quinone oxidoreductase subunit E NADH-quinone oxidoreductase subunit F NADH-quinone oxidoreductase subunit B NADH-quinone oxidoreductase subunit G NADH-quinone oxidoreductase subunit C/D NADH-quinone oxidoreductase subunit I Cytochrome o ubiquinol oxidase protein cyoD Ubiquinol oxidase subunit 2 Ubiquinol oxidase subunit 1 Cytochrome o ubiquinol oxidase subunit 3 Cytochrome d ubiquinol oxidase subunit 2 Succinic acid Ubiquinone-1 Ubiquinol-1 Fumaric acid Succinic acid Ubiquinone-1 Ubiquinol-1 Fumaric acid Succinic acid Ubiquinone-1 Ubiquinol-1 Fumaric acid O 2 H + H 2 O H + O 2 H + H 2 O H + O 2 H + H 2 O H + Ubiquinone-1 NADH H + H + NAD Ubiquinol-1 O 2 H + Ubiquinone-1 H 2 O H + NADH H + H + NAD Ubiquinol-1 O 2 H + H 2 O H + Ubiquinone-1 ferroheme b 4Fe-4S FAD ferroheme b 2Fe-2S 3Fe-4S iron-sulfur cluster 4Fe-4S FAD ferroheme b 2Fe-2S 3Fe-4S iron-sulfur cluster Copper ferroheme b Heme O ferroheme b Heme D Copper ferroheme b Heme O Cytochrome d ubiquinol oxidase subunit 1 Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism succinate:quinone oxidoreductase, FAD binding protein succinate:quinone oxidoreductase, FAD binding protein succinate dehydrogenase, FeS subunit succinate dehydrogenase succinate dehydrogenase fumarate reductase, membrane anchor subunit 4Fe-4S FAD 2Fe-2S ferroheme b Heme D 3Fe-4S iron-sulfur cluster
ReactionCoupledTransportCatalysis177 ACTIVATION 937 ChemSpider ReactionCoupledTransportCatalysis176 ACTIVATION ReactionCoupledTransportCatalysis175 ACTIVATION ReactionCoupledTransportCatalysis174 ACTIVATION Succinic acid 439153 PubChem-compound 110-17-8 CAS 21883788 PubChem-compound SMILES O Porphyrin Metabolism SubPathway 2.0 NADH-quinone oxidoreductase subunit J CHEBI:16389 ChEBI NADH-quinone oxidoreductase subunit F 1.0 succinate dehydrogenase, FeS subunit succinate:quinone oxidoreductase, FAD binding protein Cytochrome o ubiquinol oxidase subunit 3 cytochrome bd-I terminal oxidase - CydX subunit 1.0 cytochrome bd-I terminal oxidase 1.0 succinate dehydrogenase fumarate reductase, membrane anchor subunit succinate dehydrogenase 1.0 NADH-quinone oxidoreductase subunit C/D CHEBI:15846 ChEBI P0AC44 UniProt Cytochrome d ubiquinol oxidase subunit 2 1038 PubChem-compound 952 ChemSpider 1.0 P0AC41 UniProt CHEBI:16908 ChEBI P33602 UniProt NAD Ubiquinol oxidase subunit 2 C14H18O4 Ubiquinone-1 250.12051 Ubiquinol-1 1010 ChemSpider GO:0070258 GENE ONTOLOGY Cytochrome o ubiquinol oxidase protein cyoD P33607 UniProt Cytochrome d ubiquinol oxidase subunit 2 Oxygen cytochrome bd-I terminal oxidase - CydX subunit NADH-quinone oxidoreductase subunit A Ubiquinone-1 P33599 UniProt P31979 UniProt ReactionCatalysis2607 ACTIVATION CPD-6641 BioCyc P0AFE0 UniProt SUC BioCyc P0AFD1 UniProt 58-68-4 CAS cytochrome bd-II terminal oxidase P0AFD4 UniProt P0AFD6 UniProt Hydrogen Ion NADH 4307 ChemSpider C00007 KEGG Compound C00122 KEGG Compound C00001 KEGG Compound SMILES COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O Ubiquinol oxidase subunit 1 Cytochrome bd-II oxidase subunit 1 Cytochrome bd-II oxidase subunit 2 P0AFF0 UniProt C00004 KEGG Compound Inner Membrane C00003 KEGG Compound NADH-quinone oxidoreductase subunit B 5.0 NADH-quinone oxidoreductase subunit A P0AFE4 UniProt Fumaric acid P0AFE8 UniProt C4H4O4 Fumaric acid 116.010956 succinate:quinone oxidoreductase CHEBI:15741 ChEBI C21H28N7O14P2 NAD 664.11694 447920 PubChem-compound Ubiquinol oxidase subunit 2 NADH-quinone oxidoreductase subunit N NADH-quinone oxidoreductase subunit K HMDB0000902 HMDB NADH-quinone oxidoreductase subunit J NADH-quinone oxidoreductase subunit I 1110 PubChem-compound NADH-quinone oxidoreductase subunit H NADH-quinone oxidoreductase subunit I NADH-quinone oxidoreductase subunit E NADH-quinone oxidoreductase subunit N C21H29N7O14P2 NADH 665.12476 NADH-quinone oxidoreductase subunit M NADH-quinone oxidoreductase subunit B C4H6O4 Succinic acid 118.02661 562 TAXONOMY H Hydrogen Ion 1.007825 2.0 Oxidative Phosphorylation 53-84-9 CAS Cytochrome bd-II oxidase subunit 2 4.0 P56100 UniProt 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O C00399 KEGG Compound P0ABI8 UniProt Cytochrome d ubiquinol oxidase subunit 1 5682 ChemSpider HMDB0000134 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000254 HMDB SMILES OC(=O)CCC(O)=O SMP0000936 SMPDB 1.0 Reaction2619 false Succinic acid + Ubiquinone-1 → Fumaric acid + Ubiquinol-1 LEFT_TO_RIGHT P0ABJ1 UniProt P0ABJ3 UniProt NADH-quinone oxidoreductase subunit E C00042 KEGG Compound P0ABJ6 UniProt 1078 ChemSpider NADH:ubiquinone oxidoreductase I P0ABJ9 UniProt Cytochrome bd-II oxidase subunit 1 NADH-quinone oxidoreductase subunit M P26459 UniProt P26458 UniProt 1.6.99.5 false 1.6.99.5 5 Hydrogen Ion + NADH + Ubiquinone-1 → Hydrogen Ion + NAD + Ubiquinol-1 LEFT_TO_RIGHT 1.10.3.10 false 1.10.3.10 4 Hydrogen Ion + Oxygen + 2 Ubiquinol-1 → 4 Hydrogen Ion + 2 Ubiquinone-1 + 2 Water LEFT_TO_RIGHT ReactionCoupledTransport142 false 8 Hydrogen Ion + Oxygen + 2 Ubiquinol-1 → 8 Hydrogen Ion + 2 Ubiquinone-1 + 2 Water LEFT_TO_RIGHT 1.10.3.14 false 1.10.3.14 4 Hydrogen Ion + Oxygen + 2 Ubiquinol-1 → 4 Hydrogen Ion + 2 Ubiquinone-1 + 2 Water LEFT_TO_RIGHT Water 10197150 ChemSpider NADH-quinone oxidoreductase subunit L SubPathwayInteraction1502 SubPathway1502Reaction SubPathwayReaction P0ABK2 UniProt FUM BioCyc Escherichia coli P69054 UniProt 7732-18-5 CAS 388299 ChemSpider SMILES COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC CHEBI:18012 ChEBI Ubiquinol oxidase subunit 1 HMDB0001487 HMDB O2 Oxygen 31.98983 cytochrome bo terminal oxidase SMP0000953 SMPDB 1.0 NADH-quinone oxidoreductase subunit F 7782-44-7 CAS HMDB0001377 HMDB P0AFC3 UniProt P0AFC7 UniProt 962 PubChem-compound 1.0 1.0 C14H20O4 Ubiquinol-1 252.13615 Ubiquinone-1 5893 PubChem-compound C00080 KEGG Compound 110-15-6 CAS SMILES O=O 2.0 succinate:quinone oxidoreductase, FAD binding protein succinate dehydrogenase, FeS subunit NADH-quinone oxidoreductase subunit G HMDB0002111 HMDB PW000936 PathWhiz CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] 1.0 succinate dehydrogenase fumarate reductase, membrane anchor subunit NADH-quinone oxidoreductase subunit H succinate dehydrogenase 4462 PubChem-compound NADH-quinone oxidoreductase subunit L Cytochrome o ubiquinol oxidase subunit 3 NADH-quinone oxidoreductase subunit K NADH-quinone oxidoreductase subunit G 8.0 NADH-quinone oxidoreductase subunit C/D PW000919 PathWhiz 727-81-1 CAS H2O Water 18.010565 1.0 HMDB0002012 HMDB NADH BioCyc NAD BioCyc Ubiquinol-1 977 PubChem-compound HMDB0059597 HMDB P07014 UniProt SMILES OC(=O)\C=C\C(O)=O Cytochrome d ubiquinol oxidase subunit 1 1.0 Cytochrome o ubiquinol oxidase protein cyoD 1.0 Unknown Unknown sdhD SdhA Unknown Unknown sdhD cydX appC appB cyoD cyoA cyoB cyoC nuoA nuoH nuoJ nuoK nuoL nuoM nuoN nuoE nuoF nuoB nuoG nuoC nuoI cydA cydB cydX nuoA nuoH nuoJ nuoK nuoL nuoM nuoN nuoE nuoF nuoB nuoG nuoC nuoI cyoD cyoA cyoB cyoC cydB Succinic acid Ubiquinone-1 Ubiquinol-1 Fumaric acid Succinic acid Ubiquinone-1 Ubiquinol-1 Fumaric acid Succinic acid Ubiquinone-1 Ubiquinol-1 Fumaric acid Oxygen Hydrogen Ion Water Hydrogen Ion Oxygen Hydrogen Ion Water Hydrogen Ion Oxygen Hydrogen Ion Water Hydrogen Ion Ubiquinone-1 NADH Hydrogen Ion Hydrogen Ion NAD Ubiquinol-1 Oxygen Hydrogen Ion Ubiquinone-1 Water Hydrogen Ion NADH Hydrogen Ion Hydrogen Ion NAD Ubiquinol-1 Oxygen Hydrogen Ion Water Hydrogen Ion Ubiquinone-1 cydA Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism Porphyrin Metabolism SdhA SdhA Unknown Unknown sdhD