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CHEBI:16015 ChEBI Glutamate/aspartate transport system permease protein gltK 1.0 6022 PubChem-compound 7722-84-1 CAS 923 PubChem-compound Delta-aminolevulinic acid dehydratase C00430 KEGG Compound Coproporphyrinogen III SubPathwayInteraction1444 SubPathwayReaction SubPathway1444Reaction 937 ChemSpider HMDB00250 HMDB 25245954 PubChem-compound HMDB01341 HMDB Uroporphyrinogen III COPROPORPHYRINOGEN_I BioCyc 1.0 439153 PubChem-compound Uroporphyrinogen-III synthase 1.0 HYDROXYMETHYLBILANE BioCyc SMILES [H]\C(CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC1=C(O)C2=CC=CC=C2C(O)=C1C)=C(\C)CCC=C(C)C SMILES [H]\C(CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC1=C(C)C(=O)C2=CC=CC=C2C1=O)=C(\C)CCC=C(C)C 1.0 C00448 KEGG Compound CHEBI:16027 ChEBI H Hydrogen ion 1.007825 HMDB00148 HMDB SMILES C[C@]1(CC(O)=O)[C@H](CCC(O)=O)C2=N\C1=C/C1=C(CC(O)=O)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(CC(O)=O)=C(CC4=C(CCC(O)=O)C(CC(O)=O)=C(C2)N4)N3)N1 NAD Glutamate/aspartate periplasmic-binding protein ATP BioCyc P29680 UniProt 6137 PubChem-compound 4.0 H4N Ammonium 18.034374 Protoporphyrinogen oxidase CHEBI:28599 ChEBI 559142 ChemSpider Transport369 false L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 1146 ChemSpider SMILES CC1=C(CCC(O)=O)/C2=C/C3=C(CCC(O)=O)C(C)=C(N3)\C=C3/N=C(/C=C4\N=C(\C=C\1/N\2)C(=O)C4(C)CC(O)=O)C(=O)C3(C)CC(O)=O C15H23N6O5S S-Adenosylmethionine 399.14505 Transport370 false L-Glutamic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Extracellular Space to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT 4.0 439182 PubChem-compound 5742 ChemSpider Glutamate/aspartate transport system permease protein gltJ CHEBI:16474 ChEBI 952 ChemSpider HMDB59597 HMDB Reaction5872 false NAD + Precorrin 2 ↔ 2 Hydrogen Ion + NADH + Sirohydrochlorin REVERSIBLE SMILES [H][C@@]1(CCC(O)=O)C2=CC3=C(CC(O)=O)C(CCC(O)=O)=C(CC4=[NH+]C(=CC5=NC(=CC(=N2)[C@@]1(C)CC(O)=O)[C@@]([H])(CCC(O)=O)[C@]5(C)CC(O)=O)C(CC(O)=O)=C4CCC(O)=O)[N-]3 5858 ChemSpider HMDB00245 HMDB SMILES C[C@]1(CC(O)=O)[C@H](CCC(O)=O)\C2=C\C3=N\C(=C/C4=C(CCC(O)=O)C(CC(O)=O)=C(N4)\C=C4/N=C(/C=C1\N2)[C@@H](CCC(O)=O)[C@]4(C)CC(O)=O)\C(CCC(O)=O)=C3CC(O)=O SMILES C[C@]1(CC(O)=O)[C@H](CCC(O)=O)\C2=C\C3=C(CC(O)=O)C(CCC(O)=O)=C4\C=C5/N=C(/C=C6\N([Fe]N34)\C(=C/C1=N2)[C@@H](CCC(O)=O)[C@]6(C)CC(O)=O)C(CC(O)=O)=C5CCC(O)=O CHEBI:16240 ChEBI Proton glutamate symport protein 445713 PubChem-compound 1010 ChemSpider HMDB00241 HMDB Siroheme synthase Glutamyl-tRNA synthetase HMDB41827 HMDB PPI BioCyc Glutamate/aspartate transport ATP-binding protein gltL BiologicalState109 389645 ChemSpider 389644 ChemSpider HMDB00696 HMDB Ammonium ReactionCoupledTransportCatalysis136 ACTIVATION Hydrogen Ion C34H40N4O4 Protoporphyrinogen IX 568.30493 HMDB00217 HMDB C34H34N4O10 Heme D 658.2275 SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 979-92-0 CAS Cytosol CHEBI:17381 ChEBI 5-Aminolevulinic acid Uroporphyrinogen decarboxylase HMDB00692 HMDB Adenosine triphosphate C14H20N6O5S S-Adenosylhomocysteine 384.12158 2.5.1.61 false 2.5.1.61 4 Porphobilinogen + Water → 4 Ammonium + Hydroxymethylbilane LEFT_TO_RIGHT 4.2.1.24 false 4.2.1.24 8 5-Aminolevulinic acid → 4 Hydrogen Ion + 4 Porphobilinogen + 8 Water LEFT_TO_RIGHT 5.4.3.8 false 5.4.3.8 8 (S)-4-amino-5-oxopentanoate → 8 5-Aminolevulinic acid LEFT_TO_RIGHT 1.2.1.70 false 1.2.1.70 8 L-glutamyl-tRNA(Glu) + 8 NADPH → 8 (S)-4-amino-5-oxopentanoate + 8 NADP + 8 tRNA(Glu) LEFT_TO_RIGHT 1.0 Reaction3472 false 8 Adenosine triphosphate + 8 Hydrogen Ion + 8 L-Glutamic acid + 8 tRNA(Glu) → 8 Adenosine monophosphate + 8 L-glutamyl-tRNA(Glu) + 8 Pyrophosphate LEFT_TO_RIGHT 1.0 Reaction3479 true Hydroxymethylbilane → Uroporphyrinogen I + Water LEFT_TO_RIGHT 4.2.1.75 false 4.2.1.75 Hydroxymethylbilane → Uroporphyrinogen III + Water LEFT_TO_RIGHT C42H46N4O16 Precorrin 2 862.2909 C00009 KEGG Compound HMDB00221 HMDB 388325 ChemSpider C00008 KEGG Compound C00007 KEGG Compound C00006 KEGG Compound HMDB00588 HMDB CHEBI:18009 ChEBI C42H44FeN4O16 Siroheme 916.21014 C42H46N4O16 Sirohydrochlorin 862.2909 C00001 KEGG Compound C01330 KEGG Compound CHEBI:18361 ChEBI Glutamate/aspartate transport ATP-binding protein gltL C00005 KEGG Compound CHEBI:18367 ChEBI Farnesyl pyrophosphate C00004 KEGG Compound 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound Hydroxymethylbilane Glutamyl-tRNA reductase HMDB01429 HMDB ReactionCoupledTransport102 false Adenosine triphosphate + L-Glutamic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT Hydrogen ion C00019 KEGG Compound C21H28N7O14P2 NAD 664.11694 1.0 Oxygen-independent coproporphyrinogen-III oxidase C01342 KEGG Compound C00011 KEGG Compound P0A6X1 UniProt SMILES C[C@]1(CC(O)=O)[C@H](CCC(O)=O)\C2=C\C3=C(CC(O)=O)C(CCC(O)=O)=C(CC4=C(CCC(O)=O)C(CC(O)=O)=C(N4)\C=C4/N=C(/C=C1\N2)[C@@H](CCC(O)=O)[C@]4(C)CC(O)=O)N3 Extracellular Space C00013 KEGG Compound SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C5/C=C6\N=C(\C=C\1/N\2[Fe]N45)C(C)=C6C=C)/C(CCC(O)=O)=C3C 25244684 PubChem-compound Protoheme IX farnesyltransferase 4.0 Catalase HPII NAD(P) BioCyc Reaction3492 false Fe2+ + Sirohydrochlorin → 2 Hydrogen Ion + Siroheme LEFT_TO_RIGHT Reaction3491 false NAD + Precorrin-2 → Hydrogen Ion + NADH + Sirohydrochlorin LEFT_TO_RIGHT 562 TAXONOMY 1.0 H Hydrogen Ion 1.007825 388301 ChemSpider S-Adenosylhomocysteine C40H44N4O16 Uroporphyrinogen III 836.2752 C36H44N4O8 Coproporphyrinogen III 660.3159 Reaction3490 false Precorrin-1 + S-Adenosylmethionine → Precorrin-2 + S-Adenosylhomocysteine LEFT_TO_RIGHT Protoporphyrinogen IX 56-65-5 CAS MET BioCyc C00021 KEGG Compound C00020 KEGG Compound 53-84-9 CAS L-Glutamic acid 1.0 Glutamate/aspartate periplasmic-binding protein C00027 KEGG Compound C00025 KEGG Compound L-glutamate metabolism SubPathway 2.5.1.- false 2.5.1.- Farnesyl pyrophosphate + Water + ferroheme b → Heme O + Pyrophosphate LEFT_TO_RIGHT 4.99.1.1 false 4.99.1.1 Fe2+ + Protoporphyrin IX → 2 Hydrogen Ion + ferroheme b LEFT_TO_RIGHT 553-12-8 CAS 1.3.5.3 false 1.3.5.3 Protoporphyrinogen IX + menaquinone-8 → Menaquinol 6 + Protoporphyrin IX LEFT_TO_RIGHT 1.3.5.3 false 1.3.5.3 3 Oxygen + Protoporphyrinogen IX → 3 Hydrogen peroxide + Protoporphyrin IX LEFT_TO_RIGHT Reaction3483 false Coproporphyrinogen III + S-Adenosylmethionine → 5'-Deoxyadenosine + Carbon dioxide + L-Methionine + Protoporphyrinogen IX LEFT_TO_RIGHT 1.0 1.3.3.3 false 1.3.3.3 Coproporphyrinogen III + 2 Hydrogen Ion + Oxygen → 2 Carbon dioxide + Protoporphyrinogen IX + 2 Water LEFT_TO_RIGHT 1.0 Reaction3481 false 4 Hydrogen ion + Uroporphyrinogen I → 4 Carbon dioxide + Coproporphyrinogen I LEFT_TO_RIGHT 4.1.1.37 false 4.1.1.37 4 Hydrogen Ion + Uroporphyrinogen III → 4 Carbon dioxide + Coproporphyrinogen III LEFT_TO_RIGHT 8.0 CHEBI:29101 ChEBI 2.1.1.107 false 2.1.1.107 S-Adenosylmethionine + Uroporphyrinogen III → Hydrogen Ion + Precorrin-1 + S-Adenosylhomocysteine LEFT_TO_RIGHT 1.11.1.6 false 1.11.1.6 Hydrogen peroxide + ferroheme b → Heme D LEFT_TO_RIGHT C5H11NO2S L-Methionine 149.05106 HMDB01983 HMDB Fe Fe2+ 55.93494 1.0 73023-76-4 CAS 372-97-4 CAS P0AAG3 UniProt CHEBI:18151 ChEBI SMILES [Fe].CC1=C(CCC([O-])=O)C2=N\C\1=C/C1=C(C=C)C(C)=C([N-]1)\C=C1/[N-]\C(=C/C3=N/C(=C\2)/C(CCC([O-])=O)=C3C)C(C)=C1C=C 899 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc Water Hydrogen peroxide HYDROGEN-PEROXIDE BioCyc 1.0 CHEBI:29175 ChEBI SMILES [O-]P([O-])(=O)OP([O-])([O-])=O SMILES [H][C@](N)(CCC(O)=O)C=O P06983 UniProt Glutamate-1-semialdehyde 2,1-aminomutase 767 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O glutamate-1-semialdehyde aminotransferase 1.0 763 ChemSpider porphobilinogen synthase 1.0 Ferrochelatase HMDB00538 HMDB 1.0 Hydrogen Ion protoporphyrinogen oxidase 17341-25-2 CAS coproporphyrinogen III oxidase 784 PubChem-compound C15H28O7P2 Farnesyl pyrophosphate 382.131 C40H46N4O17 Hydroxymethylbilane 854.28577 C15672 KEGG Compound 788 PubChem-compound C01024 KEGG Compound 7732-18-5 CAS 1.0 315 ChemSpider 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 Coproporphyrinogen-III oxidase, aerobic PROTOPORPHYRINOGEN BioCyc catalase II 56-86-0 CAS C5H9NO3 5-Aminolevulinic acid 131.05824 63-68-3 CAS 4.0 CHEBI:29033 ChEBI CHEBI:29157 ChEBI 5907 ChemSpider L-Glutamic acid P0AER3 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 P0AER5 UniProt P0AER8 UniProt Delta-aminolevulinic acid dehydratase Fe2+ FARNESYL-PP BioCyc Sodium/glutamate symport carrier protein L-Methionine L-Glutamic acid Glutamate/aspartate transport system permease protein gltK CHEBI:18023 ChEBI Glutamate/aspartate transport system permease protein gltJ SMILES OC(=O)CCC1=C2CC3=C(CC(O)=O)C(CCC(O)=O)=C(CC4=C(CC(O)=O)C(CCC(O)=O)=C(CC5=C(CC(O)=O)C(CCC(O)=O)=C(CC(N2)=C1CC(O)=O)N5)N4)N3 SMILES CC1=C(CCC(O)=O)/C2=C/C3=N/C(=C\C4=C(C)C(C=C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C=C)=C4C)/C(C)=C3CCC(O)=O 8.0 C00073 KEGG Compound SMILES NCC1=C(CC(O)=O)C(CCC(O)=O)=CN1 HMDB01967 HMDB 962 PubChem-compound 31983 ChemSpider 5800 ChemSpider UROPORPHYRINOGEN-III BioCyc 121893 PubChem-compound C05766 KEGG Compound Sodium CO2 Carbon dioxide 43.98983 C05768 KEGG Compound Oxidative phosphorylation SubPathway C00080 KEGG Compound SMILES O=O Periplasmic Space Protoporphyrinogen oxidase C01051 KEGG Compound TransportCatalysis316 ACTIVATION TransportCatalysis315 ACTIVATION SMILES N[C@@H](CCC(O)=O)C(O)=O 1.0 PW000936 PathWhiz 14265-44-2 CAS 1.0 58-64-0 CAS SubPathwayInteraction1499 SubPathway1499Reaction SubPathwayReaction C10H13N5O3 5'-Deoxyadenosine 251.10184 Coproporphyrinogen I 1.0 C36H44N4O8 Coproporphyrinogen I 660.3159 1.0 PW000922 PathWhiz 644102 PubChem-compound 1.0 6083 PubChem-compound 5'-Deoxyadenosine CHEBI:57501 ChEBI Siroheme synthase 22833512 PubChem-compound 995 ChemSpider 25246222 PubChem-compound PW000919 PathWhiz 8.0 H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 Proton glutamate symport protein 1867-62-5 CAS NADH BioCyc 29908-03-0 CAS NAD BioCyc 15438-31-0 CAS HMDB00961 HMDB Na Sodium 22.989769 977 PubChem-compound 31110-56-2 CAS 25394 ChemSpider L-Glutamic acid Carbon dioxide C01079 KEGG Compound Uroporphyrinogen decarboxylase 5-AMINO-LEVULINATE BioCyc C03263 KEGG Compound 10469486 ChemSpider Adenosine diphosphate Porphyrin metabolism COPROPORPHYRINOGEN_III BioCyc 1.0 Porphobilinogen deaminase (S)-4-amino-5-oxopentanoate 30572 ChemSpider 17215925 ChemSpider CHEBI:50602 ChEBI P0ACB2 UniProt NADH P0ACB4 UniProt 134 ChemSpider SMILES O SMILES OO P21179 UniProt C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate 53356674 PubChem-compound 8.0 SMP00953 SMPDB SMILES [Na+] 1.0 ferroheme b Protoporphyrin IX Uroporphyrinogen I 393270 ChemSpider C40H44N4O16 Uroporphyrinogen I 836.2752 Porphobilinogen C02191 KEGG Compound 3571849 ChemSpider CHEBI:15846 ChEBI 8.0 C10H14N2O4 Porphobilinogen 226.09535 ADP BioCyc Glutamyl-tRNA reductase C34H34N4O4 Protoporphyrin IX 562.258 HMDB00939 HMDB 53-59-8 CAS C34H30FeN4O4 ferroheme b 614.1638 8.0 1038 PubChem-compound tRNA(Glu) SMILES [Fe++] glutamate / aspartate ABC transporter L-glutamyl-tRNA(Glu) SMILES CSCC[C@H](N)C(O)=O GO:0005829 GENE ONTOLOGY 8.0 Adenosine monophosphate 274 ChemSpider HMDB00902 HMDB Ferric-Hydroxamate-Complexes BioCyc Protoheme IX farnesyltransferase Catalase HPII CHEBI:16908 ChEBI 137 PubChem-compound ADENOSYL-HOMO-CYS BioCyc C5H9NO3 (S)-4-amino-5-oxopentanoate 131.05824 O4P Phosphate 94.95342 NADPH 1021 PubChem-compound GO:0070258 GENE ONTOLOGY 8.0 137397-56-9 CAS 7412-77-3 CAS NADP ReactionCatalysis5838 ACTIVATION C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 P36553 UniProt 196427 PubChem-compound NADPH BioCyc 8.0 5376507 PubChem-compound P09126 UniProt CH33ADO BioCyc 1.0 27284 PubChem-compound 8.0 CHEBI:58893 ChEBI CPD-6641 BioCyc 218 ChemSpider 321 PubChem-compound 58-68-4 CAS L-Glutamic acid 108741 ChemSpider CHEBI:24480 ChEBI SMILES [O-]P([O-])([O-])=O Oxygen 124-38-9 CAS Hydrogen Ion 4754-39-6 CAS CHEBI:15414 ChEBI Uroporphyrinogen-III synthase Inner Membrane SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 6441040 PubChem-compound GLT BioCyc 1.0 P32131 UniProt CHEBI:44027 ChEBI P04805 UniProt 53-57-6 CAS C00931 KEGG Compound 2.0 SMILES O=C=O S-ADENOSYLMETHIONINE BioCyc CHEBI:28938 ChEBI HMDB01086 HMDB Sodium/glutamate symport carrier protein O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound GO:0005620 GENE ONTOLOGY 1.0 8.0 SMP00936 SMPDB SMP00811 SMPDB 4.0 HMDB01097 HMDB SMP00939 SMPDB SMILES C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 SMILES CC1=C2CC3=C(CCC(O)=O)C(C)=C(CC4=C(CCC(O)=O)C(C)=C(CC5=C(CCC(O)=O)C(C)=C(CC(N2)=C1CCC(O)=O)N5)N4)N3 GO:0005615 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 PORPHOBILINOGEN BioCyc HMDB02158 HMDB HMDB03125 HMDB 1.0 Menaquinol 6 menaquinone-8 Adenosine triphosphate Precorrin-1 C42H48N4O16 Precorrin-2 864.3065 P23871 UniProt CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O Glutamyl-tRNA synthetase HMDB01185 HMDB 5682 ChemSpider 2.0 ReactionCatalysis3468 ACTIVATION CHEBI:28766 ChEBI ReactionCatalysis3469 ACTIVATION ReactionCatalysis3462 ACTIVATION CHEBI:15439 ChEBI ReactionCatalysis3463 ACTIVATION ReactionCatalysis3460 ACTIVATION ReactionCatalysis3461 ACTIVATION ReactionCatalysis3466 ACTIVATION ReactionCatalysis3467 ACTIVATION ReactionCatalysis3464 ACTIVATION 14000-31-8 CAS ReactionCatalysis3465 ACTIVATION Phosphate P37902 UniProt ReactionCatalysis3470 ACTIVATION sulfur metabolism SubPathway 1.0 SMILES OC(=O)CCC1=C2CC3=C(CCC(O)=O)C(CC(O)=O)=C(CC4=C(CC(O)=O)C(CCC(O)=O)=C(CC5=C(CC(O)=O)C(CCC(O)=O)=C(CC(N2)=C1CC(O)=O)N5)N4)N3 SMILES CC1=C2CC3=C(C)C(CCC(O)=O)=C(CC4=C(CCC(O)=O)C(C)=C(CC5=C(CCC(O)=O)C(C)=C(CC(N2)=C1CCC(O)=O)N5)N4)N3 5675 ChemSpider 440776 PubChem-compound 440775 PubChem-compound 439303 PubChem-compound 1.0 14798-03-9 CAS ReactionCatalysis3471 ACTIVATION 2.0 5280516 PubChem-compound Water 8.0 CHEBI:15422 ChEBI Porphobilinogen deaminase Siroheme Precorrin 2 3.0 1976-85-8 CAS P23893 UniProt 106-60-5 CAS HMDB01162 HMDB SubPathwayInteraction1501 SubPathway1501Reaction SubPathwayReaction 388299 ChemSpider Sirohydrochlorin C05198 KEGG Compound O2 Oxygen 31.98983 1.0 4.0 C5H9NO4 L-Glutamic acid 147.05316 C41H58O2 Menaquinol 6 582.44366 33032 PubChem-compound C51H72O2 menaquinone-8 716.5532 SMILES [NH4+] C41H46N4O16 Precorrin-1 850.2909 1.0 CHEBI:16643 ChEBI CHEBI:16645 ChEBI CHEBI:15435 ChEBI Oxygen-independent coproporphyrinogen-III oxidase 1.0 CHEBI:15437 ChEBI CHEBI:16526 ChEBI 487-90-1 CAS CHEBI:28607 ChEBI HEME_O BioCyc 1.0 Heme D CHEBI:16761 ChEBI CHEBI:15430 ChEBI 7782-44-7 CAS 1.0 P21345 UniProt P0AEA5 UniProt 1.0 P0AEA8 UniProt PW000789 PathWhiz C49H58FeN4O5 Heme O 838.3757 CHEBI:17549 ChEBI HMDB01149 HMDB SMILES OCC1=C(CC(O)=O)C(CCC(O)=O)=C(CC2=C(CC(O)=O)C(CCC(O)=O)=C(CC3=C(CC(O)=O)C(CCC(O)=O)=C(CC4=C(CC(O)=O)C(CCC(O)=O)=CN4)N3)N2)N1 1179 PubChem-compound HMDB01261 HMDB 8.0 1.0 5893 PubChem-compound HMDB02111 HMDB SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O glutamyl-tRNA reductase SMILES NCC(=O)CCC(O)=O 1.0 3.0 2.0 4.0 CHEBI:15377 ChEBI Sodium CHEBI:15379 ChEBI 3582 PubChem-compound CHEBI:15378 ChEBI SMILES [H+] CHEBI:17319 ChEBI SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound S-Adenosylmethionine 1.0 280 PubChem-compound PROTOPORPHYRIN_IX BioCyc HMDB01487 HMDB CHEBI:17407 ChEBI 16741146 PubChem-compound Glutamate-1-semialdehyde 2,1-aminomutase SMILES CC1=C2CC3=C(C)C(C=C)=C(CC4=C(C)C(C=C)=C(CC5=C(C)C(CCC(O)=O)=C(CC(N2)=C1CCC(O)=O)N5)N4)N3 Ferrochelatase SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O HMDB02211 HMDB Coproporphyrinogen-III oxidase, aerobic 1.0 C14818 KEGG Compound tRNA(Glu) L-glutamyl-tRNA(Glu) 1.0 2.0 HMDB00045 HMDB HMDB01377 HMDB 1061 PubChem-compound SMILES [H+] HMDB01137 HMDB Hydrogen Ion CHEBI:16680 ChEBI 1.0 Heme O 2624-63-7 CAS Precorrin-2 ReactionCatalysis3459 ACTIVATION 24762165 PubChem-compound ReactionCatalysis3457 ACTIVATION ReactionCatalysis3458 ACTIVATION 2.0 1.0 ReactionCatalysis3455 ACTIVATION ReactionCatalysis3456 ACTIVATION ReactionCatalysis3453 ACTIVATION ReactionCatalysis3454 ACTIVATION