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1005 ChemSpider HMDB00254 HMDB Transport354 false L-Threonine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 6022 PubChem-compound HMDB00379 HMDB 439161 PubChem-compound 937 ChemSpider HMDB00250 HMDB HMDB01341 HMDB 57 ChemSpider Methylmalonyl-CoA decarboxylase 1.0 CHEBI:16027 ChEBI C00683 KEGG Compound OXALACETIC_ACID BioCyc Acetate kinase ATP BioCyc HMDB00142 HMDB H4N Ammonium 18.034374 Formate acetyltransferase 1 559142 ChemSpider 19796801 PubChem-compound 6288 PubChem-compound HMDB00237 HMDB 1.0 CHEBI:15380 ChEBI 5742 ChemSpider Acetyl-coenzyme A synthetase C25H40N7O19P3S Succinyl-CoA 867.1312 Uncharacterized protein ygfH Protein sbm HMDB59597 HMDB 104809-02-1 CAS 5858 ChemSpider HMDB00243 HMDB P31660 UniProt HMDB00005 HMDB C00109 KEGG Compound C00100 KEGG Compound 945 ChemSpider 1010 ChemSpider 439291 PubChem-compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 1.0 Threonine dehydratase biosynthetic 439164 PubChem-compound CHEBI:30768 ChEBI HMDB41827 HMDB PPI BioCyc SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 HMDB01423 HMDB C24H40N7O17P3S Propionyl-CoA 823.1414 Ammonium Hydrogen Ion Cytosol 388310 ChemSpider Adenosine triphosphate SUC BioCyc Phosphate acetyltransferase P42632 UniProt C00009 KEGG Compound C00008 KEGG Compound HMDB00223 HMDB Hydrogen Ion C00001 KEGG Compound PROPIONYL-COA BioCyc threonine biosynthesis SubPathway CHEBI:18361 ChEBI CHEBI:18367 ChEBI 2-OXOBUTANOATE BioCyc 1032 ChemSpider C00002 KEGG Compound 2-methylcitrate synthase 1031 ChemSpider Keto-acid formate acetyltransferase HMDB01429 HMDB P27253 UniProt SubPathwayInteraction1668 SubPathwayReaction SubPathway1668Reaction C01342 KEGG Compound C00011 KEGG Compound C00010 KEGG Compound C00013 KEGG Compound 4.2.1.79 false 4.2.1.79 2-Methylcitric acid → Water + cis-2-Methylaconitate LEFT_TO_RIGHT 2.3.3.5 false 2.3.3.5 Oxalacetic acid + Propionyl-CoA + Water → 2-Methylcitric acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT Threonine/serine transporter tdcC 6.2.1.1 false 6.2.1.1 Adenosine triphosphate + Coenzyme A + Propionic acid → Adenosine monophosphate + Propionyl-CoA + Pyrophosphate LEFT_TO_RIGHT 2.7.2.1 false 2.7.2.1 Adenosine diphosphate + propanoyl phosphate → Adenosine triphosphate + Propionic acid LEFT_TO_RIGHT 2.3.1.8 false 2.3.1.8 Phosphate + Propionyl-CoA → Coenzyme A + propanoyl phosphate LEFT_TO_RIGHT 2.3.1.- false 2.3.1.- 2-Ketobutyric acid + Coenzyme A → Formic acid + Propionyl-CoA LEFT_TO_RIGHT 4.2.1.3 false 4.2.1.3 cis-2-Methylaconitate → Methylisocitric acid + Water LEFT_TO_RIGHT 388424 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider 1.0 C00022 KEGG Compound 56-65-5 CAS C00020 KEGG Compound Methylmalonyl-CoA Propionyl-CoA 317-66-8 CAS L-Threonine 2-methylcitrate dehydratase C25H40N7O19P3S Methylmalonyl-CoA 867.1312 2.0 P27550 UniProt Sodium/proline symporter Propionic acid C00036 KEGG Compound Water AMP BioCyc SMILES OC(=O)CCC(O)=O 2.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O SMILES CCC(=O)OP([O-])([O-])=O 515 PubChem-compound 6.0 513 PubChem-compound C00163 KEGG Compound C00042 KEGG Compound C7H8O6 cis-2-Methylaconitate 188.03209 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Methylisocitrate lyase 1.0 Propionate--CoA ligase 604-98-8 CAS CHEBI:58739 ChEBI HMDB00538 HMDB threonine deaminase cis-2-Methylaconitate Propionate kinase SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS 1.0 C00058 KEGG Compound 61-19-8 CAS phosphate acetyltransferase / phosphate propionyltransferase SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 pyruvate formate-lyase / 2-ketobutyrate formate-lyase Aconitate hydratase 2 SMILES CC(C(O)=O)C(O)(CC(O)=O)C(O)=O 6061-96-7 CAS FORMATE BioCyc C10H16N5O13P3 Adenosine triphosphate 506.99576 C00188 KEGG Compound SMILES CCC(O)=O SMILES CC(=O)C(O)=O methylmalonyl-CoA mutase bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase 2-methylisocitrate lyase 2-methylcitrate synthase 4.0 HMDB01967 HMDB methylmalonyl-CoA decarboxylase 962 PubChem-compound 1.0 C4H9NO3 L-Threonine 119.05824 Transport431 false Propionic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT PW000940 PathWhiz SMILES CCC(=N)C([O-])=O 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound Periplasmic Space PW000817 PathWhiz SMILES OC=O 14265-44-2 CAS 1.0 PYRUVATE BioCyc 58-64-0 CAS 2-Ketobutyric acid C00091 KEGG Compound Protein sbm Acetyl-coenzyme A synthetase METHYL-MALONYL-COA BioCyc Uncharacterized protein ygfH C4H6O3 2-Ketobutyric acid 102.03169 PROPIONATE BioCyc 644102 PubChem-compound CPD-1136 BioCyc 6083 PubChem-compound 64-18-6 CAS B1XGT1 UniProt H2O Water 18.010565 1.0 propanoate metabolism Propionic acid Carbon dioxide L-Threonine 970 PubChem-compound C04225 KEGG Compound C04593 KEGG Compound 500 ChemSpider Methylisocitric acid C7H10O7 Methylisocitric acid 206.04265 TransportCatalysis300 ACTIVATION 2.0 1.0 C4H4O5 Oxalacetic acid 132.00587 propanoyl phosphate HMDB06357 HMDB Succinic acid 498 ChemSpider HMDB06471 HMDB SMILES O C7H10O7 2-Methylcitric acid 206.04265 Phosphate acetyltransferase C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate TransportCatalysis374 ACTIVATION SMP00957 SMPDB SMP00837 SMPDB C3H6O2 Propionic acid 74.03678 1.0 6816 PubChem-compound 328-42-7 CAS SMILES CC(O)(C(CC(O)=O)C(O)=O)C(O)=O Pyruvic acid CHEBI:15607 ChEBI ADP BioCyc 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 P04968 UniProt Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc Propionic acid 1038 PubChem-compound 2-Methylcitric acid 1032 PubChem-compound GO:0005829 GENE ONTOLOGY 278 ChemSpider Adenosine monophosphate 274 ChemSpider 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT P36683 UniProt C3H5O5P propanoyl phosphate 151.98856 O4P Phosphate 94.95342 Oxalacetic acid SMILES CC=C(N)C([O-])=O SMILES C\C(C(O)=O)=C(/CC(O)=O)C(O)=O 600-18-0 CAS CHEBI:16857 ChEBI PW000785 PathWhiz 22003434 PubChem-compound 218 ChemSpider 72-19-5 CAS SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 1.0 Formic acid 6061-93-4 CAS 2-iminobutanoate P09373 UniProt C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 6051 ChemSpider (2Z)-2-aminobut-2-enoate P0A9M8 UniProt 1.0 CHEBI:15741 ChEBI C4H6NO2 2-iminobutanoate 100.040405 Acetate kinase 3080625 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI Formate acetyltransferase 1 SMILES C[C@@H](O)[C@H](N)C(O)=O 1110 PubChem-compound SMP00807 SMPDB O7P2 Pyrophosphate 173.91193 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 1.0 1.0 Adenosine diphosphate ReactionCatalysis2888 ACTIVATION C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES CCC(=O)C(O)=O 79-09-4 CAS CHEBI:16717 ChEBI P77495 UniProt P0A6A3 UniProt Threonine dehydratase biosynthetic CPD-8587 BioCyc CHEBI:30831 ChEBI CHEBI:1146900 ChEBI CHEBI:30835 ChEBI 14000-31-8 CAS P77243 UniProt 4.0 CO-A BioCyc glycolysis and pyruvate dehydrogenase SubPathway 1078 ChemSpider Coenzyme A ReactionCatalysis3479 ACTIVATION C21H36N7O16P3S Coenzyme A 767.11523 1.0 14798-03-9 CAS SMILES C[C@@H](C(O)=O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N ReactionCatalysis3473 ACTIVATION 18971002 PubChem-compound ReactionCatalysis3474 ACTIVATION ReactionCatalysis3472 ACTIVATION ReactionCatalysis3477 ACTIVATION ReactionCatalysis3478 ACTIVATION ReactionCatalysis3475 ACTIVATION ReactionCatalysis3476 ACTIVATION CHEBI:15422 ChEBI 2-methylcitrate synthase 6.0 ReactionCatalysis3480 ACTIVATION SubPathwayInteraction1503 SubPathwayReaction SubPathway1503Reaction ReactionCatalysis3481 ACTIVATION 6557 ChemSpider Keto-acid formate acetyltransferase L-Threonine Threonine/serine transporter tdcC CH2O2 Formic acid 46.005478 127-17-3 CAS 1.0 CHEBI:15539 ChEBI ReactionCatalysis3484 ACTIVATION ReactionCatalysis3485 ACTIVATION ReactionCatalysis3482 ACTIVATION ReactionCatalysis3483 ACTIVATION SMILES [NH4+] 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI 1.0 1.0 HMDB01269 HMDB 1.0 2-methylcitrate dehydratase 1.0 HMDB02111 HMDB HMDB01022 HMDB 110-15-6 CAS CHEBI:30751 ChEBI 1.0 CHEBI:32816 ChEBI CPD-618 BioCyc CHEBI:15377 ChEBI P52043 UniProt P07117 UniProt P52045 UniProt CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA Sodium/proline symporter SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Methylmalonyl-CoA decarboxylase HMDB01275 HMDB 1.0 1.0 280 PubChem-compound CHEBI:30744 ChEBI 4.1.1.41 false 4.1.1.41 Hydrogen Ion + Methylmalonyl-CoA → Carbon dioxide + Propionyl-CoA LEFT_TO_RIGHT 5.4.99.2 false 5.4.99.2 Succinyl-CoA → Methylmalonyl-CoA LEFT_TO_RIGHT 2.8.3.- false 2.8.3.- Propionyl-CoA + Succinic acid → Propionic acid + Succinyl-CoA LEFT_TO_RIGHT 4.1.3.30 false 4.1.3.30 Methylisocitric acid → Pyruvic acid + Succinic acid LEFT_TO_RIGHT 2.0 CHEBI:15466 ChEBI 16741146 PubChem-compound Methylisocitrate lyase SMILES CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N P11868 UniProt Propionate--CoA ligase 2338376 ChemSpider 1.0 3-METHYLBENZYLSUCCINYL-COA BioCyc HMDB00045 HMDB 1060 PubChem-compound HMDB00167 HMDB 1061 PubChem-compound Hydrogen Ion Propionate kinase Aconitate hydratase 2 1.0 85-61-0 CAS P77541 UniProt 1.0 Threonine/serine transporter tdcC Sodium/proline symporter Threonine dehydratase biosynthetic Keto-acid formate acetyltransferase Phosphate acetyltransferase 2-methylcitrate synthase 2-methylcitrate dehydratase Aconitate hydratase 2 Methylisocitrate lyase Uncharacterized protein ygfH Protein sbm Methylmalonyl- CoA decarboxylase L-Threonine L-Threonine H + H + Propionic acid Propionic acid L-Threonine H + H 2 O (2Z)-2- aminobut-2- enoate 2- iminobutanoate H 2 O H + Ammonium 2-Ketobutyric acid CoA Formic acid Propionyl-CoA P i CoA propanoyl phosphate ADP ATP Propionic acid ATP CoA Propionyl-CoA AMP PP i H 2 O Oxalacetic acid CoA H + 2-Methylcitric acid H 2 O cis-2- Methylaconitate H 2 O Methylisocitric acid Succinic acid Pyruvic acid Propionyl-CoA Propionic acid Succinyl-CoA Methylmalonyl- CoA H + CO 2 Propionyl-CoA 4Fe-4S Magnesium Adenosylcobalamin glycolysis and pyruvate dehydrogenase threonine biosynthesis Formate acetyltransferase 1 Acetate kinase Propionate kinase Acetyl-coenzyme A synthetase Propionate--CoA ligase Magnesium Magnesium
1005 ChemSpider HMDB00254 HMDB Transport354 false L-Threonine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 6022 PubChem-compound HMDB00379 HMDB 439161 PubChem-compound 937 ChemSpider HMDB00250 HMDB HMDB01341 HMDB 57 ChemSpider Methylmalonyl-CoA decarboxylase 1.0 CHEBI:16027 ChEBI C00683 KEGG Compound OXALACETIC_ACID BioCyc Acetate kinase ATP BioCyc HMDB00142 HMDB H4N Ammonium 18.034374 Formate acetyltransferase 1 559142 ChemSpider 19796801 PubChem-compound 6288 PubChem-compound HMDB00237 HMDB 1.0 CHEBI:15380 ChEBI 5742 ChemSpider Acetyl-coenzyme A synthetase C25H40N7O19P3S Succinyl-CoA 867.1312 Uncharacterized protein ygfH Protein sbm HMDB59597 HMDB 104809-02-1 CAS 5858 ChemSpider HMDB00243 HMDB P31660 UniProt HMDB00005 HMDB C00109 KEGG Compound C00100 KEGG Compound 945 ChemSpider 1010 ChemSpider 439291 PubChem-compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 1.0 Threonine dehydratase biosynthetic 439164 PubChem-compound CHEBI:30768 ChEBI HMDB41827 HMDB PPI BioCyc SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 HMDB01423 HMDB C24H40N7O17P3S Propionyl-CoA 823.1414 Ammonium Hydrogen Ion Cytosol 388310 ChemSpider Adenosine triphosphate SUC BioCyc Phosphate acetyltransferase P42632 UniProt C00009 KEGG Compound C00008 KEGG Compound HMDB00223 HMDB Hydrogen Ion C00001 KEGG Compound PROPIONYL-COA BioCyc CHEBI:18361 ChEBI CHEBI:18367 ChEBI 2-OXOBUTANOATE BioCyc 1032 ChemSpider C00002 KEGG Compound 2-methylcitrate synthase 1031 ChemSpider Keto-acid formate acetyltransferase HMDB01429 HMDB P27253 UniProt SubPathwayInteraction1668 SubPathwayReaction SubPathway1668Reaction C01342 KEGG Compound C00011 KEGG Compound C00010 KEGG Compound C00013 KEGG Compound 4.2.1.79 false 4.2.1.79 2-Methylcitric acid → Water + cis-2-Methylaconitate LEFT_TO_RIGHT 2.3.3.5 false 2.3.3.5 Oxalacetic acid + Propionyl-CoA + Water → 2-Methylcitric acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT Threonine/serine transporter tdcC 6.2.1.1 false 6.2.1.1 Adenosine triphosphate + Coenzyme A + Propionic acid → Adenosine monophosphate + Propionyl-CoA + Pyrophosphate LEFT_TO_RIGHT 2.7.2.1 false 2.7.2.1 Adenosine diphosphate + propanoyl phosphate → Adenosine triphosphate + Propionic acid LEFT_TO_RIGHT 2.3.1.8 false 2.3.1.8 Phosphate + Propionyl-CoA → Coenzyme A + propanoyl phosphate LEFT_TO_RIGHT 2.3.1.- false 2.3.1.- 2-Ketobutyric acid + Coenzyme A → Formic acid + Propionyl-CoA LEFT_TO_RIGHT 4.2.1.3 false 4.2.1.3 cis-2-Methylaconitate → Methylisocitric acid + Water LEFT_TO_RIGHT 388424 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider 1.0 C00022 KEGG Compound 56-65-5 CAS C00020 KEGG Compound Methylmalonyl-CoA Propionyl-CoA 317-66-8 CAS L-Threonine 2-methylcitrate dehydratase C25H40N7O19P3S Methylmalonyl-CoA 867.1312 2.0 P27550 UniProt Sodium/proline symporter Propionic acid C00036 KEGG Compound Water AMP BioCyc SMILES OC(=O)CCC(O)=O 2.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O SMILES CCC(=O)OP([O-])([O-])=O 515 PubChem-compound 6.0 513 PubChem-compound C00163 KEGG Compound C00042 KEGG Compound C7H8O6 cis-2-Methylaconitate 188.03209 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Methylisocitrate lyase 1.0 Propionate--CoA ligase 604-98-8 CAS CHEBI:58739 ChEBI HMDB00538 HMDB threonine deaminase cis-2-Methylaconitate Propionate kinase SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS 1.0 C00058 KEGG Compound 61-19-8 CAS phosphate acetyltransferase / phosphate propionyltransferase SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 pyruvate formate-lyase / 2-ketobutyrate formate-lyase Aconitate hydratase 2 SMILES CC(C(O)=O)C(O)(CC(O)=O)C(O)=O 6061-96-7 CAS FORMATE BioCyc C10H16N5O13P3 Adenosine triphosphate 506.99576 C00188 KEGG Compound SMILES CCC(O)=O SMILES CC(=O)C(O)=O methylmalonyl-CoA mutase bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase 2-methylisocitrate lyase 2-methylcitrate synthase 4.0 HMDB01967 HMDB methylmalonyl-CoA decarboxylase 962 PubChem-compound 1.0 C4H9NO3 L-Threonine 119.05824 Transport431 false Propionic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT PW000940 PathWhiz SMILES CCC(=N)C([O-])=O 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound Periplasmic Space PW000817 PathWhiz SMILES OC=O 14265-44-2 CAS 1.0 PYRUVATE BioCyc 58-64-0 CAS 2-Ketobutyric acid C00091 KEGG Compound Protein sbm Acetyl-coenzyme A synthetase METHYL-MALONYL-COA BioCyc Uncharacterized protein ygfH C4H6O3 2-Ketobutyric acid 102.03169 PROPIONATE BioCyc 644102 PubChem-compound CPD-1136 BioCyc 6083 PubChem-compound 64-18-6 CAS B1XGT1 UniProt H2O Water 18.010565 1.0 propanoate metabolism Propionic acid Carbon dioxide L-Threonine 970 PubChem-compound C04225 KEGG Compound C04593 KEGG Compound 500 ChemSpider Methylisocitric acid C7H10O7 Methylisocitric acid 206.04265 TransportCatalysis300 ACTIVATION 2.0 1.0 C4H4O5 Oxalacetic acid 132.00587 propanoyl phosphate HMDB06357 HMDB Succinic acid 498 ChemSpider HMDB06471 HMDB SMILES O C7H10O7 2-Methylcitric acid 206.04265 Phosphate acetyltransferase C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate TransportCatalysis374 ACTIVATION http://identifiers.org/smpdb/SMP00957 SMPDB http://identifiers.org/smpdb/SMP00837 SMPDB C3H6O2 Propionic acid 74.03678 1.0 6816 PubChem-compound 328-42-7 CAS SMILES CC(O)(C(CC(O)=O)C(O)=O)C(O)=O Pyruvic acid CHEBI:15607 ChEBI ADP BioCyc 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 P04968 UniProt Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc Propionic acid 1038 PubChem-compound 2-Methylcitric acid 1032 PubChem-compound GO:0005829 GENE ONTOLOGY 278 ChemSpider Adenosine monophosphate 274 ChemSpider 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT P36683 UniProt C3H5O5P propanoyl phosphate 151.98856 O4P Phosphate 94.95342 Oxalacetic acid SMILES CC=C(N)C([O-])=O SMILES C\C(C(O)=O)=C(/CC(O)=O)C(O)=O 600-18-0 CAS glycolysis and pyruvate dehydrogenase SubPathway CHEBI:16857 ChEBI PW000785 PathWhiz 22003434 PubChem-compound 218 ChemSpider 72-19-5 CAS SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 1.0 Formic acid 6061-93-4 CAS 2-iminobutanoate P09373 UniProt C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 6051 ChemSpider (2Z)-2-aminobut-2-enoate P0A9M8 UniProt 1.0 CHEBI:15741 ChEBI C4H6NO2 2-iminobutanoate 100.040405 Acetate kinase 3080625 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI Formate acetyltransferase 1 SMILES C[C@@H](O)[C@H](N)C(O)=O 1110 PubChem-compound http://identifiers.org/smpdb/SMP00807 SMPDB O7P2 Pyrophosphate 173.91193 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 1.0 1.0 Adenosine diphosphate ReactionCatalysis2888 ACTIVATION C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES CCC(=O)C(O)=O 79-09-4 CAS CHEBI:16717 ChEBI P77495 UniProt P0A6A3 UniProt Threonine dehydratase biosynthetic CPD-8587 BioCyc CHEBI:30831 ChEBI CHEBI:1146900 ChEBI CHEBI:30835 ChEBI 14000-31-8 CAS P77243 UniProt 4.0 CO-A BioCyc 1078 ChemSpider Coenzyme A ReactionCatalysis3479 ACTIVATION C21H36N7O16P3S Coenzyme A 767.11523 1.0 14798-03-9 CAS SMILES C[C@@H](C(O)=O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N ReactionCatalysis3473 ACTIVATION 18971002 PubChem-compound ReactionCatalysis3474 ACTIVATION ReactionCatalysis3472 ACTIVATION ReactionCatalysis3477 ACTIVATION ReactionCatalysis3478 ACTIVATION ReactionCatalysis3475 ACTIVATION ReactionCatalysis3476 ACTIVATION CHEBI:15422 ChEBI 2-methylcitrate synthase 6.0 ReactionCatalysis3480 ACTIVATION SubPathwayInteraction1503 SubPathwayReaction SubPathway1503Reaction ReactionCatalysis3481 ACTIVATION 6557 ChemSpider threonine biosynthesis SubPathway Keto-acid formate acetyltransferase L-Threonine Threonine/serine transporter tdcC CH2O2 Formic acid 46.005478 127-17-3 CAS 1.0 CHEBI:15539 ChEBI ReactionCatalysis3484 ACTIVATION ReactionCatalysis3485 ACTIVATION ReactionCatalysis3482 ACTIVATION ReactionCatalysis3483 ACTIVATION SMILES [NH4+] 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI 1.0 1.0 HMDB01269 HMDB 1.0 2-methylcitrate dehydratase 1.0 HMDB02111 HMDB HMDB01022 HMDB 110-15-6 CAS CHEBI:30751 ChEBI 1.0 CHEBI:32816 ChEBI CPD-618 BioCyc CHEBI:15377 ChEBI P52043 UniProt P07117 UniProt P52045 UniProt CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA Sodium/proline symporter SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Methylmalonyl-CoA decarboxylase HMDB01275 HMDB 1.0 1.0 280 PubChem-compound CHEBI:30744 ChEBI 4.1.1.41 false 4.1.1.41 Hydrogen Ion + Methylmalonyl-CoA → Carbon dioxide + Propionyl-CoA LEFT_TO_RIGHT 5.4.99.2 false 5.4.99.2 Succinyl-CoA → Methylmalonyl-CoA LEFT_TO_RIGHT 2.8.3.- false 2.8.3.- Propionyl-CoA + Succinic acid → Propionic acid + Succinyl-CoA LEFT_TO_RIGHT 4.1.3.30 false 4.1.3.30 Methylisocitric acid → Pyruvic acid + Succinic acid LEFT_TO_RIGHT 2.0 CHEBI:15466 ChEBI 16741146 PubChem-compound Methylisocitrate lyase SMILES CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N P11868 UniProt Propionate--CoA ligase 2338376 ChemSpider 1.0 3-METHYLBENZYLSUCCINYL-COA BioCyc HMDB00045 HMDB 1060 PubChem-compound HMDB00167 HMDB 1061 PubChem-compound Hydrogen Ion Propionate kinase Aconitate hydratase 2 1.0 85-61-0 CAS P77541 UniProt 1.0