Loading Pathway...
1005 ChemSpider Transport354 false L-Threonine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 6022 PubChem-compound 439161 PubChem-compound 937 ChemSpider 57 ChemSpider Methylmalonyl-CoA decarboxylase 1.0 CHEBI:16027 ChEBI Threonine Biosynthesis SubPathway Propanoate Metabolism C00683 KEGG Compound OXALACETIC_ACID BioCyc Acetate kinase ATP BioCyc H4N Ammonium 18.034374 Formate acetyltransferase 1 559142 ChemSpider 19796801 PubChem-compound 6288 PubChem-compound 1.0 CHEBI:15380 ChEBI 5742 ChemSpider Acetyl-coenzyme A synthetase C25H40N7O19P3S Succinyl-CoA 867.1312 Uncharacterized protein ygfH Protein sbm 104809-02-1 CAS 5858 ChemSpider P31660 UniProt C00109 KEGG Compound C00100 KEGG Compound 945 ChemSpider 1010 ChemSpider 439291 PubChem-compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 Threonine dehydratase biosynthetic 439164 PubChem-compound CHEBI:30768 ChEBI PPI BioCyc SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 C24H40N7O17P3S Propionyl-CoA 823.1414 Ammonium Hydrogen Ion Cytosol 388310 ChemSpider Adenosine triphosphate SUC BioCyc Phosphate acetyltransferase P42632 UniProt C00009 KEGG Compound C00008 KEGG Compound Hydrogen Ion C00001 KEGG Compound PROPIONYL-COA BioCyc CHEBI:18361 ChEBI CHEBI:18367 ChEBI 2-OXOBUTANOATE BioCyc 1032 ChemSpider C00002 KEGG Compound 2-methylcitrate synthase 1031 ChemSpider Keto-acid formate acetyltransferase P27253 UniProt Glycolysis and Pyruvate Dehydrogenase SubPathway SubPathwayInteraction1668 SubPathwayReaction SubPathway1668Reaction C01342 KEGG Compound C00011 KEGG Compound C00010 KEGG Compound C00013 KEGG Compound 4.2.1.79 false 4.2.1.79 2-Methylcitric acid → Water + cis-2-Methylaconitate LEFT_TO_RIGHT 2.3.3.5 false 2.3.3.5 Oxalacetic acid + Propionyl-CoA + Water → 2-Methylcitric acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT Threonine/serine transporter tdcC 6.2.1.1 false 6.2.1.1 Adenosine triphosphate + Coenzyme A + Propionic acid → Adenosine monophosphate + Propionyl-CoA + Pyrophosphate LEFT_TO_RIGHT 2.7.2.1 false 2.7.2.1 Adenosine diphosphate + propanoyl phosphate → Adenosine triphosphate + Propionic acid LEFT_TO_RIGHT 2.3.1.8 false 2.3.1.8 Phosphate + Propionyl-CoA → Coenzyme A + propanoyl phosphate LEFT_TO_RIGHT 2.3.1.- false 2.3.1.- 2-Ketobutyric acid + Coenzyme A → Formic acid + Propionyl-CoA LEFT_TO_RIGHT 562 TAXONOMY 4.2.1.3 false 4.2.1.3 cis-2-Methylaconitate → Methylisocitric acid + Water LEFT_TO_RIGHT 388424 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider 1.0 C00022 KEGG Compound 56-65-5 CAS C00020 KEGG Compound Methylmalonyl-CoA Propionyl-CoA 317-66-8 CAS L-Threonine 2-methylcitrate dehydratase C25H40N7O19P3S Methylmalonyl-CoA 867.1312 2.0 P27550 UniProt Sodium/proline symporter Propionic acid SMP0000807 SMPDB C00036 KEGG Compound HMDB0000254 HMDB Water AMP BioCyc SMILES OC(=O)CCC(O)=O 2.0 HMDB0000379 HMDB HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB SMILES CCC(=O)OP([O-])([O-])=O 515 PubChem-compound 6.0 513 PubChem-compound C00163 KEGG Compound C00042 KEGG Compound C7H8O6 cis-2-Methylaconitate 188.03209 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Methylisocitrate lyase 1.0 Propionate--CoA ligase 604-98-8 CAS CHEBI:58739 ChEBI threonine deaminase HMDB0000142 HMDB cis-2-Methylaconitate Propionate kinase SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS 1.0 C00058 KEGG Compound 61-19-8 CAS phosphate acetyltransferase / phosphate propionyltransferase SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 pyruvate formate-lyase / 2-ketobutyrate formate-lyase Aconitate hydratase 2 SMILES CC(C(O)=O)C(O)(CC(O)=O)C(O)=O 6061-96-7 CAS FORMATE BioCyc SMP0000957 SMPDB SMP0000837 SMPDB C10H16N5O13P3 Adenosine triphosphate 506.99576 C00188 KEGG Compound SMILES CCC(O)=O HMDB0000167 HMDB HMDB0000045 HMDB SMILES CC(=O)C(O)=O methylmalonyl-CoA mutase bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase 2-methylisocitrate lyase 2-methylcitrate synthase 4.0 methylmalonyl-CoA decarboxylase 962 PubChem-compound 1.0 C4H9NO3 L-Threonine 119.05824 Transport431 false Propionic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT PW000940 PathWhiz SMILES CCC(=N)C([O-])=O 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound HMDB0001269 HMDB Periplasmic Space HMDB0002111 HMDB PW000817 PathWhiz SMILES OC=O HMDB0001022 HMDB 14265-44-2 CAS 1.0 PYRUVATE BioCyc 58-64-0 CAS 2-Ketobutyric acid C00091 KEGG Compound Protein sbm Acetyl-coenzyme A synthetase METHYL-MALONYL-COA BioCyc Uncharacterized protein ygfH C4H6O3 2-Ketobutyric acid 102.03169 HMDB0001275 HMDB PROPIONATE BioCyc 644102 PubChem-compound CPD-1136 BioCyc 6083 PubChem-compound 64-18-6 CAS B1XGT1 UniProt H2O Water 18.010565 1.0 HMDB0059597 HMDB HMDB0041827 HMDB Propionic acid Carbon dioxide L-Threonine 970 PubChem-compound C04225 KEGG Compound C04593 KEGG Compound 500 ChemSpider Methylisocitric acid C7H10O7 Methylisocitric acid 206.04265 TransportCatalysis300 ACTIVATION 2.0 1.0 C4H4O5 Oxalacetic acid 132.00587 propanoyl phosphate Succinic acid 498 ChemSpider SMILES O C7H10O7 2-Methylcitric acid 206.04265 Phosphate acetyltransferase C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate TransportCatalysis374 ACTIVATION C3H6O2 Propionic acid 74.03678 HMDB0000538 HMDB 1.0 6816 PubChem-compound 328-42-7 CAS SMILES CC(O)(C(CC(O)=O)C(O)=O)C(O)=O Pyruvic acid CHEBI:15607 ChEBI ADP BioCyc 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 P04968 UniProt Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc Propionic acid 1038 PubChem-compound 2-Methylcitric acid 1032 PubChem-compound GO:0005829 GENE ONTOLOGY 278 ChemSpider Adenosine monophosphate 274 ChemSpider 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT P36683 UniProt C3H5O5P propanoyl phosphate 151.98856 O4P Phosphate 94.95342 Oxalacetic acid SMILES CC=C(N)C([O-])=O SMILES C\C(C(O)=O)=C(/CC(O)=O)C(O)=O 600-18-0 CAS CHEBI:16857 ChEBI PW000785 PathWhiz 22003434 PubChem-compound 218 ChemSpider 72-19-5 CAS HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 1.0 Formic acid 6061-93-4 CAS 2-iminobutanoate P09373 UniProt HMDB0001429 HMDB C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 6051 ChemSpider HMDB0000223 HMDB (2Z)-2-aminobut-2-enoate P0A9M8 UniProt 1.0 CHEBI:15741 ChEBI C4H6NO2 2-iminobutanoate 100.040405 Acetate kinase 3080625 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI Formate acetyltransferase 1 SMILES C[C@@H](O)[C@H](N)C(O)=O 1110 PubChem-compound O7P2 Pyrophosphate 173.91193 HMDB0000237 HMDB 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 1.0 1.0 Adenosine diphosphate HMDB0000243 HMDB ReactionCatalysis2888 ACTIVATION C10H15N5O10P2 Adenosine diphosphate 427.02942 HMDB0000005 HMDB SMILES CCC(=O)C(O)=O 79-09-4 CAS CHEBI:16717 ChEBI P77495 UniProt HMDB0006471 HMDB P0A6A3 UniProt Threonine dehydratase biosynthetic CPD-8587 BioCyc CHEBI:30831 ChEBI CHEBI:1146900 ChEBI CHEBI:30835 ChEBI HMDB0006357 HMDB 14000-31-8 CAS P77243 UniProt 4.0 CO-A BioCyc 1078 ChemSpider Coenzyme A ReactionCatalysis3479 ACTIVATION C21H36N7O16P3S Coenzyme A 767.11523 1.0 14798-03-9 CAS SMILES C[C@@H](C(O)=O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N ReactionCatalysis3473 ACTIVATION 18971002 PubChem-compound ReactionCatalysis3474 ACTIVATION ReactionCatalysis3472 ACTIVATION ReactionCatalysis3477 ACTIVATION ReactionCatalysis3478 ACTIVATION ReactionCatalysis3475 ACTIVATION ReactionCatalysis3476 ACTIVATION CHEBI:15422 ChEBI 2-methylcitrate synthase 6.0 ReactionCatalysis3480 ACTIVATION SubPathwayInteraction1503 SubPathwayReaction SubPathway1503Reaction ReactionCatalysis3481 ACTIVATION 6557 ChemSpider Escherichia coli Keto-acid formate acetyltransferase L-Threonine Threonine/serine transporter tdcC CH2O2 Formic acid 46.005478 127-17-3 CAS 1.0 CHEBI:15539 ChEBI ReactionCatalysis3484 ACTIVATION ReactionCatalysis3485 ACTIVATION ReactionCatalysis3482 ACTIVATION ReactionCatalysis3483 ACTIVATION SMILES [NH4+] 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI 1.0 1.0 1.0 2-methylcitrate dehydratase 1.0 110-15-6 CAS CHEBI:30751 ChEBI 1.0 CHEBI:32816 ChEBI CPD-618 BioCyc CHEBI:15377 ChEBI P52043 UniProt P07117 UniProt P52045 UniProt CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA Sodium/proline symporter SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Methylmalonyl-CoA decarboxylase 1.0 1.0 280 PubChem-compound CHEBI:30744 ChEBI 4.1.1.41 false 4.1.1.41 Hydrogen Ion + Methylmalonyl-CoA → Carbon dioxide + Propionyl-CoA LEFT_TO_RIGHT 5.4.99.2 false 5.4.99.2 Succinyl-CoA → Methylmalonyl-CoA LEFT_TO_RIGHT 2.8.3.- false 2.8.3.- Propionyl-CoA + Succinic acid → Propionic acid + Succinyl-CoA LEFT_TO_RIGHT 4.1.3.30 false 4.1.3.30 Methylisocitric acid → Pyruvic acid + Succinic acid LEFT_TO_RIGHT 2.0 CHEBI:15466 ChEBI 16741146 PubChem-compound Methylisocitrate lyase SMILES CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N P11868 UniProt Propionate--CoA ligase 2338376 ChemSpider 1.0 3-METHYLBENZYLSUCCINYL-COA BioCyc 1060 PubChem-compound 1061 PubChem-compound Hydrogen Ion Propionate kinase HMDB0001967 HMDB Aconitate hydratase 2 1.0 85-61-0 CAS P77541 UniProt 1.0 Threonine/serine transporter tdcC Sodium/proline symporter Threonine dehydratase biosynthetic Keto-acid formate acetyltransferase Phosphate acetyltransferase 2-methylcitrate synthase 2-methylcitrate dehydratase Aconitate hydratase 2 Methylisocitrate lyase Uncharacterized protein ygfH Protein sbm Methylmalonyl- CoA decarboxylase L-Threonine L-Threonine H + H + Propionic acid Propionic acid L-Threonine H + H 2 O (2Z)-2- aminobut-2- enoate 2- iminobutanoate H 2 O H + Ammonium 2-Ketobutyric acid CoA Formic acid Propionyl-CoA P i CoA propanoyl phosphate ADP ATP Propionic acid ATP CoA Propionyl-CoA AMP PP i H 2 O Oxalacetic acid CoA H + 2-Methylcitric acid H 2 O cis-2- Methylaconitate H 2 O Methylisocitric acid Succinic acid Pyruvic acid Propionyl-CoA Propionic acid Succinyl-CoA Methylmalonyl- CoA H + CO 2 Propionyl-CoA 4Fe-4S Magnesium Adenosylcobalamin Glycolysis and Pyruvate Dehydrogenase Threonine Biosynthesis Formate acetyltransferase 1 Acetate kinase Propionate kinase Acetyl-coenzyme A synthetase Propionate--CoA ligase Magnesium Magnesium
1005 ChemSpider Transport354 false L-Threonine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 6022 PubChem-compound 439161 PubChem-compound 937 ChemSpider 57 ChemSpider Methylmalonyl-CoA decarboxylase 1.0 CHEBI:16027 ChEBI Threonine Biosynthesis SubPathway Propanoate Metabolism C00683 KEGG Compound OXALACETIC_ACID BioCyc Acetate kinase ATP BioCyc H4N Ammonium 18.034374 Formate acetyltransferase 1 559142 ChemSpider 19796801 PubChem-compound 6288 PubChem-compound 1.0 CHEBI:15380 ChEBI 5742 ChemSpider Acetyl-coenzyme A synthetase C25H40N7O19P3S Succinyl-CoA 867.1312 Uncharacterized protein ygfH Protein sbm 104809-02-1 CAS 5858 ChemSpider P31660 UniProt C00109 KEGG Compound C00100 KEGG Compound 945 ChemSpider 1010 ChemSpider 439291 PubChem-compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 Threonine dehydratase biosynthetic 439164 PubChem-compound CHEBI:30768 ChEBI PPI BioCyc SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 C24H40N7O17P3S Propionyl-CoA 823.1414 Ammonium Hydrogen Ion Cytosol 388310 ChemSpider Adenosine triphosphate SUC BioCyc Phosphate acetyltransferase P42632 UniProt C00009 KEGG Compound C00008 KEGG Compound Hydrogen Ion C00001 KEGG Compound PROPIONYL-COA BioCyc CHEBI:18361 ChEBI CHEBI:18367 ChEBI 2-OXOBUTANOATE BioCyc 1032 ChemSpider C00002 KEGG Compound 2-methylcitrate synthase 1031 ChemSpider Keto-acid formate acetyltransferase P27253 UniProt Glycolysis and Pyruvate Dehydrogenase SubPathway SubPathwayInteraction1668 SubPathwayReaction SubPathway1668Reaction C01342 KEGG Compound C00011 KEGG Compound C00010 KEGG Compound C00013 KEGG Compound 4.2.1.79 false 4.2.1.79 2-Methylcitric acid → Water + cis-2-Methylaconitate LEFT_TO_RIGHT 2.3.3.5 false 2.3.3.5 Oxalacetic acid + Propionyl-CoA + Water → 2-Methylcitric acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT Threonine/serine transporter tdcC 6.2.1.1 false 6.2.1.1 Adenosine triphosphate + Coenzyme A + Propionic acid → Adenosine monophosphate + Propionyl-CoA + Pyrophosphate LEFT_TO_RIGHT 2.7.2.1 false 2.7.2.1 Adenosine diphosphate + propanoyl phosphate → Adenosine triphosphate + Propionic acid LEFT_TO_RIGHT 2.3.1.8 false 2.3.1.8 Phosphate + Propionyl-CoA → Coenzyme A + propanoyl phosphate LEFT_TO_RIGHT 2.3.1.- false 2.3.1.- 2-Ketobutyric acid + Coenzyme A → Formic acid + Propionyl-CoA LEFT_TO_RIGHT 562 TAXONOMY 4.2.1.3 false 4.2.1.3 cis-2-Methylaconitate → Methylisocitric acid + Water LEFT_TO_RIGHT 388424 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider 1.0 C00022 KEGG Compound 56-65-5 CAS C00020 KEGG Compound Methylmalonyl-CoA Propionyl-CoA 317-66-8 CAS L-Threonine 2-methylcitrate dehydratase C25H40N7O19P3S Methylmalonyl-CoA 867.1312 2.0 P27550 UniProt Sodium/proline symporter Propionic acid SMP0000807 SMPDB C00036 KEGG Compound HMDB0000254 HMDB Water AMP BioCyc SMILES OC(=O)CCC(O)=O 2.0 HMDB0000379 HMDB HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB SMILES CCC(=O)OP([O-])([O-])=O 515 PubChem-compound 6.0 513 PubChem-compound C00163 KEGG Compound C00042 KEGG Compound C7H8O6 cis-2-Methylaconitate 188.03209 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Methylisocitrate lyase 1.0 Propionate--CoA ligase 604-98-8 CAS CHEBI:58739 ChEBI threonine deaminase HMDB0000142 HMDB cis-2-Methylaconitate Propionate kinase SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS 1.0 C00058 KEGG Compound 61-19-8 CAS phosphate acetyltransferase / phosphate propionyltransferase SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 pyruvate formate-lyase / 2-ketobutyrate formate-lyase Aconitate hydratase 2 SMILES CC(C(O)=O)C(O)(CC(O)=O)C(O)=O 6061-96-7 CAS FORMATE BioCyc SMP0000957 SMPDB SMP0000837 SMPDB C10H16N5O13P3 Adenosine triphosphate 506.99576 C00188 KEGG Compound SMILES CCC(O)=O HMDB0000167 HMDB HMDB0000045 HMDB SMILES CC(=O)C(O)=O methylmalonyl-CoA mutase bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase 2-methylisocitrate lyase 2-methylcitrate synthase 4.0 methylmalonyl-CoA decarboxylase 962 PubChem-compound 1.0 C4H9NO3 L-Threonine 119.05824 Transport431 false Propionic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT PW000940 PathWhiz SMILES CCC(=N)C([O-])=O 5800 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound HMDB0001269 HMDB Periplasmic Space HMDB0002111 HMDB PW000817 PathWhiz SMILES OC=O HMDB0001022 HMDB 14265-44-2 CAS 1.0 PYRUVATE BioCyc 58-64-0 CAS 2-Ketobutyric acid C00091 KEGG Compound Protein sbm Acetyl-coenzyme A synthetase METHYL-MALONYL-COA BioCyc Uncharacterized protein ygfH C4H6O3 2-Ketobutyric acid 102.03169 HMDB0001275 HMDB PROPIONATE BioCyc 644102 PubChem-compound CPD-1136 BioCyc 6083 PubChem-compound 64-18-6 CAS B1XGT1 UniProt H2O Water 18.010565 1.0 HMDB0059597 HMDB HMDB0041827 HMDB Propionic acid Carbon dioxide L-Threonine 970 PubChem-compound C04225 KEGG Compound C04593 KEGG Compound 500 ChemSpider Methylisocitric acid C7H10O7 Methylisocitric acid 206.04265 TransportCatalysis300 ACTIVATION 2.0 1.0 C4H4O5 Oxalacetic acid 132.00587 propanoyl phosphate Succinic acid 498 ChemSpider SMILES O C7H10O7 2-Methylcitric acid 206.04265 Phosphate acetyltransferase C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate TransportCatalysis374 ACTIVATION C3H6O2 Propionic acid 74.03678 HMDB0000538 HMDB 1.0 6816 PubChem-compound 328-42-7 CAS SMILES CC(O)(C(CC(O)=O)C(O)=O)C(O)=O Pyruvic acid CHEBI:15607 ChEBI ADP BioCyc 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 P04968 UniProt Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc Propionic acid 1038 PubChem-compound 2-Methylcitric acid 1032 PubChem-compound GO:0005829 GENE ONTOLOGY 278 ChemSpider Adenosine monophosphate 274 ChemSpider 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT P36683 UniProt C3H5O5P propanoyl phosphate 151.98856 O4P Phosphate 94.95342 Oxalacetic acid SMILES CC=C(N)C([O-])=O SMILES C\C(C(O)=O)=C(/CC(O)=O)C(O)=O 600-18-0 CAS CHEBI:16857 ChEBI PW000785 PathWhiz 22003434 PubChem-compound 218 ChemSpider 72-19-5 CAS HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 1.0 Formic acid 6061-93-4 CAS 2-iminobutanoate P09373 UniProt HMDB0001429 HMDB C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 6051 ChemSpider HMDB0000223 HMDB (2Z)-2-aminobut-2-enoate P0A9M8 UniProt 1.0 CHEBI:15741 ChEBI C4H6NO2 2-iminobutanoate 100.040405 Acetate kinase 3080625 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI Formate acetyltransferase 1 SMILES C[C@@H](O)[C@H](N)C(O)=O 1110 PubChem-compound O7P2 Pyrophosphate 173.91193 HMDB0000237 HMDB 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 1.0 1.0 Adenosine diphosphate HMDB0000243 HMDB ReactionCatalysis2888 ACTIVATION C10H15N5O10P2 Adenosine diphosphate 427.02942 HMDB0000005 HMDB SMILES CCC(=O)C(O)=O 79-09-4 CAS CHEBI:16717 ChEBI P77495 UniProt HMDB0006471 HMDB P0A6A3 UniProt Threonine dehydratase biosynthetic CPD-8587 BioCyc CHEBI:30831 ChEBI CHEBI:1146900 ChEBI CHEBI:30835 ChEBI HMDB0006357 HMDB 14000-31-8 CAS P77243 UniProt 4.0 CO-A BioCyc 1078 ChemSpider Coenzyme A ReactionCatalysis3479 ACTIVATION C21H36N7O16P3S Coenzyme A 767.11523 1.0 14798-03-9 CAS SMILES C[C@@H](C(O)=O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N ReactionCatalysis3473 ACTIVATION 18971002 PubChem-compound ReactionCatalysis3474 ACTIVATION ReactionCatalysis3472 ACTIVATION ReactionCatalysis3477 ACTIVATION ReactionCatalysis3478 ACTIVATION ReactionCatalysis3475 ACTIVATION ReactionCatalysis3476 ACTIVATION CHEBI:15422 ChEBI 2-methylcitrate synthase 6.0 ReactionCatalysis3480 ACTIVATION SubPathwayInteraction1503 SubPathwayReaction SubPathway1503Reaction ReactionCatalysis3481 ACTIVATION 6557 ChemSpider Escherichia coli Keto-acid formate acetyltransferase L-Threonine Threonine/serine transporter tdcC CH2O2 Formic acid 46.005478 127-17-3 CAS 1.0 CHEBI:15539 ChEBI ReactionCatalysis3484 ACTIVATION ReactionCatalysis3485 ACTIVATION ReactionCatalysis3482 ACTIVATION ReactionCatalysis3483 ACTIVATION SMILES [NH4+] 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI 1.0 1.0 1.0 2-methylcitrate dehydratase 1.0 110-15-6 CAS CHEBI:30751 ChEBI 1.0 CHEBI:32816 ChEBI CPD-618 BioCyc CHEBI:15377 ChEBI P52043 UniProt P07117 UniProt P52045 UniProt CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA Sodium/proline symporter SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Methylmalonyl-CoA decarboxylase 1.0 1.0 280 PubChem-compound CHEBI:30744 ChEBI 4.1.1.41 false 4.1.1.41 Hydrogen Ion + Methylmalonyl-CoA → Carbon dioxide + Propionyl-CoA LEFT_TO_RIGHT 5.4.99.2 false 5.4.99.2 Succinyl-CoA → Methylmalonyl-CoA LEFT_TO_RIGHT 2.8.3.- false 2.8.3.- Propionyl-CoA + Succinic acid → Propionic acid + Succinyl-CoA LEFT_TO_RIGHT 4.1.3.30 false 4.1.3.30 Methylisocitric acid → Pyruvic acid + Succinic acid LEFT_TO_RIGHT 2.0 CHEBI:15466 ChEBI 16741146 PubChem-compound Methylisocitrate lyase SMILES CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N P11868 UniProt Propionate--CoA ligase 2338376 ChemSpider 1.0 3-METHYLBENZYLSUCCINYL-COA BioCyc 1060 PubChem-compound 1061 PubChem-compound Hydrogen Ion Propionate kinase HMDB0001967 HMDB Aconitate hydratase 2 1.0 85-61-0 CAS P77541 UniProt 1.0