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HMDB00058 HMDB DNA-binding transcriptional repressor 1.0 1.0 RNA polymerase, sigma 70 (sigma D) factor 76293 ChemSpider 1.0 63-42-3 CAS DNA-directed RNA polymerase subunit beta LACTOSE BioCyc DNA-directed RNA polymerase subunit beta' CHEBI:36219 ChEBI DNA-directed RNA polymerase subunit beta' DNA-directed RNA polymerase subunit beta Reaction3679 false Activator-(CAP) binding site → Promoter LEFT_TO_RIGHT Reaction3678 false cAMP+CAP → Activator-(CAP) binding site + cAMP+CAP LEFT_TO_RIGHT 1.0 Reaction3677 false 2 Cyclic AMP + cAMP-activated global transcriptional regulator CRP → cAMP+CAP LEFT_TO_RIGHT cAMP-activated global transcriptional regulator CRP DNA-binding transcriptional repressor C12H22O11 Alpha-Lactose 342.1162 cAMP-activated global transcriptional regulator CRP RNA polymerase, sigma 70 (sigma D) factor C00243 KEGG Compound 2.0 HMDB00186 HMDB Cyclic AMP P0A8V2 UniProt DNA-directed RNA polymerase subunit alpha DNA-directed RNA polymerase subunit alpha C10H12N5O6P Cyclic AMP 329.05252 1.0 Lac Operon CHEBI:17489 ChEBI 84571 PubChem-compound CAMP BioCyc operator 1.0 Beta-galactosidase Activator-(CAP) binding site Activator-(CAP) binding site Promoter operator Promoter Alpha-Lactose C00575 KEGG Compound P0A7Z4 UniProt Beta-galactosidase PW000955 PathWhiz 2.0 P00579 UniProt 6076 PubChem-compound 5851 ChemSpider 1.0 P0ACJ8 UniProt SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O Reaction3684 false Alpha-Lactose + DNA-binding transcriptional repressor → Blocked DNA-binding transcriptional repressor LEFT_TO_RIGHT Reaction3683 false RNA polymerase sigma 70 → RNA polymerase sigma 70 LEFT_TO_RIGHT SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Reaction3682 false RNA polymerase sigma 70 → RNA polymerase sigma 70 + Promoter LEFT_TO_RIGHT Reaction3681 false operator → Beta-galactosidase LEFT_TO_RIGHT Reaction3680 false Promoter → operator LEFT_TO_RIGHT 1.0 1.0 60-92-4 CAS P0A8T7 UniProt SMP00971 SMPDB cAMP+CAP RNA polymerase sigma 70 cAMP-activated global transcriptional regulator CRP 2.0 Lactose permease Beta- galactosidase Galactoside O- acetyltransferase cAMP-activated global transcriptional regulator CRP cAMP-activated global transcriptional regulator CRP cAMP-activated global transcriptional regulator CRP DNA-directed RNA polymerase subunit beta DNA-directed RNA polymerase subunit alpha DNA-directed RNA polymerase subunit beta' RNA polymerase, sigma 70 (sigma D) factor DNA-directed RNA polymerase subunit beta DNA-directed RNA polymerase subunit alpha DNA-directed RNA polymerase subunit beta' RNA polymerase, sigma 70 (sigma D) factor DNA-directed RNA polymerase subunit beta DNA-directed RNA polymerase subunit alpha DNA-directed RNA polymerase subunit beta' RNA polymerase, sigma 70 (sigma D) factor DNA-directed RNA polymerase subunit beta DNA-directed RNA polymerase subunit alpha DNA-directed RNA polymerase subunit beta' RNA polymerase, sigma 70 (sigma D) factor DNA-binding transcriptional repressor DNA-binding transcriptional repressor Cyclic AMP Alpha-Lactose Alpha-Lactose D-Glucose Cyclic AMP Cyclic AMP Alpha-Lactose Activator-(CAP) binding site Activator-(CAP) binding site Promoter operator lacZ Promoter lacY lacA Bacterial Transcription and Translation No Glucose Lactose
HMDB00058 HMDB DNA-binding transcriptional repressor 1.0 1.0 RNA polymerase, sigma 70 (sigma D) factor 76293 ChemSpider 1.0 63-42-3 CAS DNA-directed RNA polymerase subunit beta LACTOSE BioCyc DNA-directed RNA polymerase subunit beta' CHEBI:36219 ChEBI DNA-directed RNA polymerase subunit beta' DNA-directed RNA polymerase subunit beta Reaction3679 false Activator-(CAP) binding site → Promoter LEFT_TO_RIGHT Reaction3678 false cAMP+CAP → Activator-(CAP) binding site + cAMP+CAP LEFT_TO_RIGHT 1.0 Reaction3677 false 2 Cyclic AMP + cAMP-activated global transcriptional regulator CRP → cAMP+CAP LEFT_TO_RIGHT cAMP-activated global transcriptional regulator CRP DNA-binding transcriptional repressor C12H22O11 Alpha-Lactose 342.1162 cAMP-activated global transcriptional regulator CRP RNA polymerase, sigma 70 (sigma D) factor C00243 KEGG Compound 2.0 HMDB00186 HMDB Cyclic AMP P0A8V2 UniProt DNA-directed RNA polymerase subunit alpha DNA-directed RNA polymerase subunit alpha C10H12N5O6P Cyclic AMP 329.05252 1.0 Lac Operon CHEBI:17489 ChEBI 84571 PubChem-compound CAMP BioCyc operator 1.0 Beta-galactosidase Activator-(CAP) binding site Activator-(CAP) binding site Promoter operator Promoter Alpha-Lactose C00575 KEGG Compound P0A7Z4 UniProt Beta-galactosidase PW000955 PathWhiz 2.0 P00579 UniProt 6076 PubChem-compound 5851 ChemSpider 1.0 P0ACJ8 UniProt SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O Reaction3684 false Alpha-Lactose + DNA-binding transcriptional repressor → Blocked DNA-binding transcriptional repressor LEFT_TO_RIGHT Reaction3683 false RNA polymerase sigma 70 → RNA polymerase sigma 70 LEFT_TO_RIGHT SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Reaction3682 false RNA polymerase sigma 70 → RNA polymerase sigma 70 + Promoter LEFT_TO_RIGHT Reaction3681 false operator → Beta-galactosidase LEFT_TO_RIGHT Reaction3680 false Promoter → operator LEFT_TO_RIGHT 1.0 1.0 60-92-4 CAS P0A8T7 UniProt http://identifiers.org/smpdb/SMP00971 SMPDB cAMP+CAP RNA polymerase sigma 70 cAMP-activated global transcriptional regulator CRP 2.0 lacY lacZ lacA crp crp crp rpoB rpoA rpoC rpoD rpoB rpoA rpoC rpoD rpoB rpoA rpoC rpoD rpoB rpoA rpoC rpoD lacI lacI Cyclic AMP Alpha-Lactose Alpha-Lactose D-Glucose Activator- (CAP) binding site Activator- (CAP) binding site Promoter operator Beta- galactosidase Promoter Lactose permease Galactoside O- acetyltransferase