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Lactose operon repressor cAMP-activated global transcriptional regulator CRP Beta- galactosidase Lactose permease Galactoside O- acetyltransferase cAMP-activated global transcriptional regulator CRP Beta- galactosidase Allolactose D-Glucose cAMP α-Lactose cAMP operator Activator binding site Promoter lacZ lacY lacA ρ-independent terminator Allolactose binds to the repressor, inactivating it and allowing transcription cAMP binds to the transcriptional regulator CRP, allowing it to bind to the activator binding site
lacI crp lacZ lacY lacA crp lacZ Allolactose D-Glucose cAMP α-Lactose operator Activator binding site Promoter lacZ lacY lacA ρ- independent terminator
lacI crp lacZ lacY lacA crp lacZ L-Ara4n D-Glc cAMP Lactin cAMP Operato ABS P βG LP GOA ρIT Allolactose binds to the repressor, inactivating it and allowing transcription cAMP binds to the transcriptional regulator CRP, allowing it to bind to the activator binding site
lacI crp lacZ lacY lacA crp lacZ L-Ara4n D-Glc cAMP Lactin Operato ABS P βG LP GOA ρIT