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CHEBI:16015 ChEBI HMDB00134 HMDB 1.0 388359 ChemSpider 1.0 CHEBI:17345 ChEBI 6022 PubChem-compound CHEBI:18319 ChEBI 937 ChemSpider Adenylate kinase HMDB00250 HMDB SubPathwayInteraction1682 SubPathwayReaction SubPathway1682Reaction 4.0 CHEBI:16497 ChEBI Ribonucleoside-diphosphate reductase 2 subunit beta ATP synthase subunit c HMDB01341 HMDB SubPathwayInteraction1683 SubPathway1683Reaction SubPathwayReaction Reaction3432 false Adenosine triphosphate + dGDP → Adenosine diphosphate + dGTP LEFT_TO_RIGHT 165388 PubChem-compound 1.17.4.2 false 1.17.4.2 Guanosine diphosphate + reduced thioredoxin → Water + dGDP + oxidized thioredoxin LEFT_TO_RIGHT 1.17.4.2 false 1.17.4.2 Guanosine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dGTP LEFT_TO_RIGHT 439153 PubChem-compound 110-17-8 CAS 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + dADP → Adenosine diphosphate + dATP LEFT_TO_RIGHT Reaction3437 false Adenosine diphosphate + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dADP LEFT_TO_RIGHT 10-FORMYL-THF BioCyc Reaction3436 false Adenosine diphosphate + reduced thioredoxin ↔ Water + dADP + oxidized thioredoxin REVERSIBLE Reaction3435 false Adenosine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dATP LEFT_TO_RIGHT 1.0 3.6.3.14 false 3.6.3.14 Adenosine diphosphate + 4 Hydrogen Ion + Phosphate ↔ Adenosine triphosphate + 3 Hydrogen Ion + Water REVERSIBLE 1.17.4.1 false 1.17.4.1 Guanosine diphosphate + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dGDP LEFT_TO_RIGHT 85-32-5 CAS C00206 KEGG Compound C8H14N3O7P 5-Aminoimidazole ribonucleotide 295.05695 HMDB01235 HMDB CHEBI:16027 ChEBI HMDB00148 HMDB 1.0 NAD ATP BioCyc HMDB00142 HMDB 4.0 CHEBI:17111 ChEBI 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc 2.1.2.3 false 2.1.2.3 10-Formyltetrahydrofolate + AICAR → FAICAR + tetrahydropteroyl mono-L-glutamate LEFT_TO_RIGHT 4.3.2.2 false 4.3.2.2 SAICAR → AICAR + Fumaric acid LEFT_TO_RIGHT 1.0 1.0 559142 ChemSpider 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + Guanosine diphosphate → Adenosine diphosphate + Guanosine triphosphate LEFT_TO_RIGHT 2.7.4.8 false 2.7.4.8 Adenosine triphosphate + Guanosine monophosphate → Adenosine diphosphate + Guanosine diphosphate LEFT_TO_RIGHT 6.3.5.2 false 6.3.5.2 Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid → Adenosine monophosphate + Guanosine monophosphate + 2 Hydrogen Ion + L-Glutamic acid + Pyrophosphate LEFT_TO_RIGHT 2.7.4.3 false 2.7.4.3 Adenosine monophosphate → Adenosine diphosphate + Adenosine triphosphate LEFT_TO_RIGHT Reaction3425 false N(6)-(1,2-dicarboxyethyl)AMP → Adenosine monophosphate + Fumaric acid LEFT_TO_RIGHT Reaction3424 false Guanosine triphosphate + Inosinic acid + L-Aspartic acid → Guanosine diphosphate + 2 Hydrogen Ion + N(6)-(1,2-dicarboxyethyl)AMP + Phosphate LEFT_TO_RIGHT 1.1.1.205 false 1.1.1.205 Inosinic acid + NAD + Water → Hydrogen Ion + NADH + Xanthylic acid LEFT_TO_RIGHT 2.1.2.3 false 2.1.2.3 FAICAR ↔ Inosinic acid + Water REVERSIBLE HMDB00595 HMDB HMDB01201 HMDB CHEBI:17202 ChEBI CHEBI:18413 ChEBI 8582 PubChem-compound 5746 ChemSpider 1.0 HCO3 BioCyc 5745 ChemSpider GMP synthase [glutamine-hydrolyzing] 5742 ChemSpider Ribonucleoside-diphosphate reductase 1 subunit beta ATP synthase epsilon chain Phosphoribosylamine--glycine ligase 5-Aminoimidazole ribonucleotide L-ASPARTATE BioCyc Bifunctional purine biosynthesis protein purH Inosine-5'-monophosphate dehydrogenase Phosphoribosylformylglycinamidine synthase HMDB01440 HMDB 7540-64-9 CAS HMDB59597 HMDB 17216355 ChemSpider SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 N(6)-(1,2-dicarboxyethyl)AMP 5858 ChemSpider HMDB00123 HMDB C04823 KEGG Compound 1010 ChemSpider C10H15N5O11P2 Guanosine diphosphate 443.02432 CHEBI:15033 ChEBI 1.0 Anaerobic ribonucleoside-triphosphate reductase PPI BioCyc C00119 KEGG Compound 1.0 ReactionCatalysis3381 ACTIVATION SMILES NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N2)N1 C10H16N5O14P3 Guanosine triphosphate 522.99066 ReactionCatalysis3382 ACTIVATION C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion ReactionCatalysis3380 ACTIVATION 10-Formyltetrahydrofolate CHEBI:16174 ChEBI C00234 KEGG Compound Adenosine triphosphate P0A763 UniProt 1.0 141854 ChemSpider Ribonucleoside-diphosphate reductase 2 subunit alpha 122347 PubChem-compound ReactionCatalysis3385 ACTIVATION ReactionCatalysis3386 ACTIVATION ReactionCatalysis3383 ACTIVATION ReactionCatalysis3384 ACTIVATION ReactionCatalysis3389 ACTIVATION ReactionCatalysis3387 ACTIVATION P39452 UniProt ReactionCatalysis3388 ACTIVATION C00009 KEGG Compound C00008 KEGG Compound C13H19N4O12P SAICAR 454.0737 HMDB01554 HMDB 1.0 ReactionCatalysis3392 ACTIVATION 1.0 ReactionCatalysis3393 ACTIVATION 53477733 PubChem-compound ReactionCatalysis3390 ACTIVATION ReactionCatalysis3391 ACTIVATION C00001 KEGG Compound C00122 KEGG Compound CHEBI:18361 ChEBI C00361 KEGG Compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 CHEBI:18367 ChEBI C00004 KEGG Compound 1032 ChemSpider C00003 KEGG Compound dGDP C00002 KEGG Compound 73323 PubChem-compound P15254 UniProt 66054 ChemSpider 5-Phosphoribosylamine HMDB01429 HMDB HMDB01308 HMDB ReactionCatalysis3396 ACTIVATION 1.0 C5H12NO7P 5-Phosphoribosylamine 229.03514 ReactionCatalysis3397 ACTIVATION ReactionCatalysis3394 ACTIVATION ReactionCatalysis3395 ACTIVATION P37146 UniProt ReactionCatalysis3398 ACTIVATION ReactionCatalysis3399 ACTIVATION HMDB00797 HMDB C21H28N7O14P2 NAD 664.11694 44367445 PubChem-compound 7339 PubChem-compound C00130 KEGG Compound SAICAR 6157-85-3 CAS C00013 KEGG Compound HMDB01517 HMDB H Hydrogen Ion 1.007825 PRPP Biosynthesis SubPathway C00144 KEGG Compound L-Glutamine 56-65-5 CAS 53-84-9 CAS C00020 KEGG Compound Folate Biosynthesis SubPathway C00025 KEGG Compound Guanosine triphosphate Nucleoside diphosphate kinase DGDP BioCyc ATP synthase subunit b ATP synthase subunit a Adenylosuccinate lyase Phosphoribosylaminoimidazole carboxylase catalytic subunit Amidophosphoribosyltransferase 769 PubChem-compound Phosphoribosylglycinamide formyltransferase 2 1.0 Adenylosuccinate synthetase C04751 KEGG Compound ATP synthase subunit beta C00037 KEGG Compound ATP synthase subunit alpha ATP synthase gamma chain C00035 KEGG Compound ATP synthase subunit delta SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Water AMP BioCyc 22833657 PubChem-compound Phosphoribosylaminoimidazole-succinocarboxamide synthase 8.0 AICAR BioCyc SMILES [O-]P([O-])(=O)OP([O-])([O-])=O C00044 KEGG Compound C00286 KEGG Compound C00049 KEGG Compound C04640 KEGG Compound C03794 KEGG Compound 56-85-9 CAS C00288 KEGG Compound 25244572 PubChem-compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 7062 ChemSpider Guanylate kinase 1.0 SMILES OC1C(COP(O)(O)=O)OC(C1O)N1C=NC=C1NC(O)=O HMDB00538 HMDB 1.0 HMDB01508 HMDB 2.0 1.0 10197150 ChemSpider C10H15N5O10P2 dGDP 427.02942 FUM BioCyc 7732-18-5 CAS C00058 KEGG Compound CHEBI:18012 ChEBI 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES NC1=C(N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(O)=O 56-86-0 CAS 4.0 2.0 FORMATE BioCyc HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 C20H23N7O7 10-Formyltetrahydrofolate 473.1659 CHEBI:17053 ChEBI 56-40-6 CAS SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O XANTHOSINE-5-PHOSPHATE BioCyc C00064 KEGG Compound 2800-34-2 CAS 1.0 Ribonucleoside-diphosphate reductase 2 subunit beta ATP synthase subunit c Adenylate kinase CHEBI:18381 ChEBI 962 PubChem-compound HMDB00972 HMDB 2564-35-4 CAS 5800 ChemSpider C04677 KEGG Compound 2.0 Phosphate DADP BioCyc 1.0 C00080 KEGG Compound 730 ChemSpider HMDB06273 HMDB P15640 UniProt C14H18N5O11P N(6)-(1,2-dicarboxyethyl)AMP 463.07404 1.0 SMILES N[C@@H](CCC(O)=O)C(O)=O 1.0 SMILES OC=O 14265-44-2 CAS C10H13N4O8P Inosinic acid 348.0471 58-64-0 CAS GTP BioCyc 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine Bifunctional purine biosynthesis protein purH Inosine-5'-monophosphate dehydrogenase Phosphoribosylformylglycinamidine synthase SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1NC(=O)NC2=O C6H12N3O8P 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine 285.0362 L-Aspartic acid Phosphoribosylamine--glycine ligase C4H7NO4 L-Aspartic acid 133.0375 439905 PubChem-compound PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE BioCyc 10.0 644102 PubChem-compound SMILES [H]C(=O)NC1=CN(N=C1C(N)=O)C1OC(COP(O)(O)=O)C(O)C1O 6083 PubChem-compound Inosinic acid 64-18-6 CAS 144983 ChemSpider C03373 KEGG Compound CHEBI:18050 ChEBI 1.0 H2O Water 18.010565 SMILES NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O SMILES NCC(O)=O SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O 388939 ChemSpider NADH BioCyc SMILES NC1=NC=NC2=C1N=CN2C1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1 NAD BioCyc HMDB00960 HMDB 25635-88-5 CAS P0AG16 UniProt 56-84-8 CAS 749 ChemSpider 71-52-3 CAS P0AG18 UniProt SMILES [NH3+]CC(=O)NC1OC(COP([O-])([O-])=O)C(O)C1O SMILES [H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1C=NC2=C(N)N=CN=C12 SMILES OC(=O)\C=C\C(O)=O PW000909 PathWhiz PW000908 PathWhiz Hydrogen carbonate 146-91-8 CAS 5-P-BETA-D-RIBOSYL-AMINE BioCyc 1.0 CHO3 Hydrogen carbonate 60.99257 2.0 Anaerobic ribonucleoside-triphosphate reductase DGTP BioCyc 30572 ChemSpider purine nucleotides de novo biosynthesis 1435709748 C10H15N4O9P FAICAR 366.05768 adenylosuccinate synthase 65110 PubChem-compound 1.0 P0ABA0 UniProt NADH ribonucleoside-diphosphate reductase 2 3031-94-5 CAS ATP synthase / thiamin triphosphate synthase ribonucleoside-triphosphate reductase ribonucleoside diphosphate reductase 1 21883788 PubChem-compound guanylate kinase SMILES O nucleoside diphosphate kinase Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE BioCyc 65103 PubChem-compound P60546 UniProt C9H14N3O9P 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate 339.04675 C7H14N2O8P N1-(5-phospho-β-D-ribosyl)glycinamide 285.04932 C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 5961 PubChem-compound P0ABB0 UniProt C10H12N5O12P3 dATP 486.97174 1.0 P0ABA4 UniProt P0ABA6 UniProt 131-99-7 CAS CHEBI:37737 ChEBI SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc 2.0 Phosphoribosylformylglycinamidine cyclo-ligase PW000960 PathWhiz 2.0 HMDB06211 HMDB 2793-06-8 CAS 1038 PubChem-compound C04376 KEGG Compound 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate 5'-Phosphoribosyl-N-formylglycinamide 3031-95-6 CAS P0ABB4 UniProt ReactionCatalysis3402 ACTIVATION 278 ChemSpider Nucleoside diphosphate kinase ReactionCatalysis3403 ACTIVATION 1.0 Adenosine monophosphate CPD0-181 BioCyc HMDB00902 HMDB ReactionCatalysis3400 ACTIVATION ReactionCatalysis3401 ACTIVATION CHEBI:16908 ChEBI SMP00976 SMPDB O4P Phosphate 94.95342 25201011 PubChem-compound 6830 PubChem-compound P69441 UniProt P15639 UniProt ATP synthase gamma chain P0ADG7 UniProt ATP synthase subunit alpha dGTP ATP synthase subunit b ATP synthase subunit delta C10H16N5O13P3 dGTP 506.99576 ATP synthase subunit beta Adenylosuccinate synthetase Amidophosphoribosyltransferase Phosphoribosylaminoimidazole carboxylase catalytic subunit CHEBI:61404 ChEBI ATP synthase subunit a Adenylosuccinate lyase 1.0 GLY BioCyc Phosphoribosylaminoimidazole carboxylase ATPase subunit oxidized thioredoxin reduced thioredoxin 447145 PubChem-compound P0A6E6 UniProt 141175 ChemSpider 58-68-4 CAS L-Glutamic acid C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 CHEBI:28843 ChEBI SMILES [O-]P([O-])([O-])=O GMP BioCyc C9H15N4O8P AICAR 338.06274 Phosphoribosylaminoimidazole-succinocarboxamide synthase CHEBI:15637 ChEBI C2H5NO2 Glycine 75.03203 Formic acid C10H15N5O9P2 dADP 411.03452 CHEBI:15652 ChEBI 1.0 a reduced NrdH glutaredoxin-like protein 1.0 19046-78-7 CAS an oxidized flavodoxin an oxidized NrdH glutaredoxin-like protein a reduced flavodoxin 5257127 PubChem-compound P68699 UniProt 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Fumaric acid GLN BioCyc SMILES NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)N1 GLT BioCyc 394323 ChemSpider P33221 UniProt C4H4O4 Fumaric acid 116.010956 P09029 UniProt an oxidized flavodoxin 1.0 a reduced flavodoxin SMP00925 SMPDB P08178 UniProt an oxidized NrdH glutaredoxin-like protein a reduced NrdH glutaredoxin-like protein dATP amidophosphoribosyl transferase N1-(5-phospho-β-D-ribosyl)glycinamide SMP00926 SMPDB 8264 ChemSpider O7P2 Pyrophosphate 173.91193 AICAR SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CNC2=O C21H29N7O14P2 NADH 665.12476 dADP Glycine 3493-09-2 CAS 5957 PubChem-compound 6804 PubChem-compound C03090 KEGG Compound P28903 UniProt Phosphoribosyl pyrophosphate GMP synthase [glutamine-hydrolyzing] CHEBI:15996 ChEBI ATP synthase epsilon chain 1.0 Ribonucleoside-diphosphate reductase 1 subunit beta GMP synthetase FAICAR reduced thioredoxin 2.0 adenylosuccinate lyase Adenosine diphosphate N5-Carboxyaminoimidazole ribonucleotide N5-carboxyaminoimidazole ribonucleotide mutase phosphoribosylaminoimidazole-succinocarboxamide synthase C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoribosylformylglycinamide cyclo-ligase 3.0 N5-carboxyaminoimidazole ribonucleotide synthetase C9H14N3O9P N5-Carboxyaminoimidazole ribonucleotide 339.04675 SMILES N[C@@H](CC(O)=O)C(O)=O 1.0 SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]1NC(=N)NC=O IMP dehydrogenase 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL BioCyc P0AB89 UniProt 1.0 58620 ChemSpider 1.0 161500 PubChem-compound CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider oxidized thioredoxin 1.0 IMP BioCyc C10H14N5O8P Guanosine monophosphate 363.058 14000-31-8 CAS 1.0 P0A7D4 UniProt 2.0 P0A7D7 UniProt Ribonucleoside-diphosphate reductase 2 subunit alpha 1.0 18971002 PubChem-compound P0AB98 UniProt CHEBI:15422 ChEBI 1.0 HMDB00191 HMDB 388299 ChemSpider 1.0 CHEBI:28862 ChEBI CH2O2 Formic acid 46.005478 SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C(N[C@@H](CC(O)=O)C(O)=O)N=CN=C12 Guanosine monophosphate 1.0 4.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 349-34-8 CAS 6545 ChemSpider 1.0 160666 PubChem-compound 1.0 8977 PubChem-compound CHEBI:16761 ChEBI SMILES NC1=CN=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O C10H13N4O9P Xanthylic acid 364.04202 Xanthylic acid CHEBI:15428 ChEBI 115687 ChemSpider ReactionCatalysis3378 ACTIVATION ReactionCatalysis3379 ACTIVATION ReactionCatalysis3377 ACTIVATION Guanosine diphosphate CHEBI:17544 ChEBI P04079 UniProt 25790919 PubChem-compound SMILES NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O2)C(=O)N1 130805 PubChem-compound 8630 ChemSpider 1.0 HMDB00175 HMDB 5893 PubChem-compound 3.0 HMDB02111 HMDB CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 HMDB59653 HMDB 25320183 PubChem-compound 3.0 CHEBI:15377 ChEBI 2.0 CHEBI:15378 ChEBI SMILES [H+] Phosphoribosylglycinamide formyltransferase 2 CHEBI:18406 ChEBI tetrahydropteroyl mono-L-glutamate 6569 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O CHEBI:17552 ChEBI Phosphoribosylformylglycinamidine cyclo-ligase HMDB01273 HMDB HMDB01397 HMDB Guanylate kinase 4.0 1.0 439220 PubChem-compound C19H21N7O6 tetrahydropteroyl mono-L-glutamate 443.15643 HMDB01487 HMDB C00655 KEGG Compound HMDB01128 HMDB 6.3.2.6 false 6.3.2.6 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + Hydrogen Ion + Phosphate + SAICAR LEFT_TO_RIGHT SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 SMILES N[C@@H](CCC(N)=O)C(O)=O PRPP BioCyc 2.4.2.14 false 2.4.2.14 L-Glutamine + Phosphoribosyl pyrophosphate + Water → 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate LEFT_TO_RIGHT 5.4.99.18 false 5.4.99.18 N5-Carboxyaminoimidazole ribonucleotide → 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate LEFT_TO_RIGHT 6.3.4.18 false 6.3.4.18 5-Aminoimidazole ribonucleotide + Adenosine triphosphate + Hydrogen carbonate → Adenosine diphosphate + 2 Hydrogen Ion + N5-Carboxyaminoimidazole ribonucleotide + Phosphate LEFT_TO_RIGHT 3.0 6.3.3.1 false 6.3.3.1 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine triphosphate → 5-Aminoimidazole ribonucleotide + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 6.3.5.3 false 6.3.5.3 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT HMDB12268 HMDB 86-01-1 CAS 2.1.2.- false 2.1.2.- Adenosine triphosphate + Formic acid + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 6.3.4.13 false 6.3.4.13 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Hydrogen Ion + N1-(5-phospho-β-D-ribosyl)glycinamide + Phosphate LEFT_TO_RIGHT 2.0 1.0 HMDB00045 HMDB 58613 ChemSpider 1061 PubChem-compound 523-98-8 CAS 109092 ChemSpider HMDB00280 HMDB SMILES NC1=C(N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC(O)=O)C(O)=O Phosphoribosylaminoimidazole carboxylase ATPase subunit CHEBI:28413 ChEBI SMILES N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O P69924 UniProt 2.0 dGTP Amidophosphoribosyltransferase Phosphoribosylamine- -glycine ligase Phosphoribosylglycinamide formyltransferase 2 Phosphoribosylformylglycinamidine synthase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylaminoimidazole carboxylase ATPase subunit Phosphoribosylaminoimidazole carboxylase catalytic subunit Phosphoribosylaminoimidazole- succinocarboxamide synthase Adenylosuccinate lyase Bifunctional purine biosynthesis protein purH Bifunctional purine biosynthesis protein purH Inosine-5'- monophosphate dehydrogenase Adenylosuccinate synthetase Adenylosuccinate lyase Adenylate kinase GMP synthase [glutamine- hydrolyzing] Guanylate kinase Nucleoside diphosphate kinase Anaerobic ribonucleoside- triphosphate reductase Ribonucleoside- diphosphate reductase 1 subunit beta Nucleoside diphosphate kinase Ribonucleoside- diphosphate reductase 2 subunit beta ATP synthase subunit c ATP synthase subunit b ATP synthase subunit a ATP synthase epsilon chain ATP synthase subunit delta ATP synthase subunit alpha ATP synthase gamma chain ATP synthase subunit beta Anaerobic ribonucleoside- triphosphate reductase Anaerobic ribonucleoside- triphosphate reductase Ribonucleoside- diphosphate reductase 1 subunit beta Ribonucleoside- diphosphate reductase 2 subunit alpha Ribonucleoside- diphosphate reductase 2 subunit beta Nucleoside diphosphate kinase Phosphoribosyl pyrophosphate H 2 O L-Glutamine 5- Phosphoribosylamine L-Glutamic acid PP i Glycine ATP N1-(5- phospho-β-D- ribosyl)glycinamide P i ADP H + ATP Formic acid 5'- Phosphoribosyl- N- formylglycinamide ADP P i H + H 2 O L-Glutamine ATP 2- (Formamido)- N1-(5- phospho-D- ribosyl)acetamidine L-Glutamic acid P i ADP H + ATP 5- Aminoimidazole ribonucleotide P i ADP H + HCO 3 - ATP N5- Carboxyaminoimidazole ribonucleotide ADP P i H + 5-amino-1-(5- phospho-D- ribosyl)imidazole- 4-carboxylate L-Aspartic acid ATP SAICAR P i ADP H + AICAR Fumaric acid FAICAR Inosinic acid H 2 O NAD H 2 O NADH H + Xanthylic acid L-Aspartic acid GTP GDP P i H + N(6)-(1,2- dicarboxyethyl)AMP Fumaric acid Adenosine monophosphate ATP Adenosine diphosphate ATP L-Glutamine H 2 O AMP PP i L-Glutamic acid H + Guanosine monophosphate ATP ADP Guanosine diphosphate ATP ADP Guanosine triphosphate H 2 O H 2 O