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CHEBI:16015 ChEBI CHEBI:16136 ChEBI 30572 ChemSpider 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 Hydrogen sulfide C23H38N7O17P3S Acetyl-CoA 809.1258 SMILES N[C@@H](CS)C(O)=O 937 ChemSpider 2.0 CYS BioCyc NADH NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG 439153 PubChem-compound 18779926 PubChem-compound 64-19-7 CAS 6.0 SMILES O PW000977 PathWhiz 2.0 5147-00-2 CAS 50 ChemSpider HMDB00807 HMDB 1.0 CHEBI:17115 ChEBI HMDB00148 HMDB NAD P16703 UniProt 1.0 1.0 6816 PubChem-compound 51 PubChem-compound 89874 ChemSpider CHEBI:15846 ChEBI 1.0 D-3-phosphoglycerate dehydrogenase SMP00847 SMPDB 53-59-8 CAS HMDB01206 HMDB C3H8NO6P DL-O-Phosphoserine 185.00893 1.0 SMILES CC(=O)OC[C@H](N)C(O)=O 1038 PubChem-compound 17885-08-4 CAS CHEBI:17561 ChEBI 4.0 CHEBI:16474 ChEBI 4.0 1.0 HMDB59597 HMDB ReactionCatalysis5828 ACTIVATION C5H6O5 Oxoglutaric acid 146.02153 P39831 UniProt HMDB00902 HMDB 391 ChemSpider CHEBI:16908 ChEBI 5736 ChemSpider C3H5O7P Phosphohydroxypyruvic acid 183.9773 1.0 O4P Phosphate 94.95342 Acetyl-CoA Cysteine synthase B Serine acetyltransferase 704 ChemSpider NADPH 5862 PubChem-compound 1010 ChemSpider SER BioCyc Acetic acid SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Phosphoserine phosphatase NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000827 PathWhiz 1.1.1.- false 1.1.1.- 2-Aminomalonate semialdehyde + Hydrogen Ion + NADPH ↔ L-Serine + NADP REVERSIBLE Secondary Metabolites: cysteine biosynthesis from serine HMDB00574 HMDB 1.0 HMDB01423 HMDB NADPH BioCyc 3913-50-6 CAS Hydrogen Ion HMDB00217 HMDB C00597 KEGG Compound 58-68-4 CAS Cysteine synthase A L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB00208 HMDB CHEBI:30915 ChEBI C00009 KEGG Compound HMDB00221 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI 3-Phosphoglyceric acid C00001 KEGG Compound SMILES OC(=O)C(=O)COP(O)(O)=O C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O D-3-phosphoglycerate dehydrogenase 6971051 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O HMDB01429 HMDB GLT BioCyc 7783-06-4 CAS 1.0 53-57-6 CAS 105 PubChem-compound CHEBI:58671 ChEBI C21H28N7O14P2 NAD 664.11694 106 PubChem-compound 2.5.1.47 false 2.5.1.47 Hydrogen sulfide + O-Acetylserine → Acetic acid + Hydrogen Ion + L-Cysteine LEFT_TO_RIGHT C00010 KEGG Compound 5951 PubChem-compound C21H29N7O14P2 NADH 665.12476 NAD(P) BioCyc 3.1.3.3 false 3.1.3.3 DL-O-Phosphoserine + Water → L-Serine + Phosphate LEFT_TO_RIGHT 2.3.1.30 false 2.3.1.30 Acetyl-CoA + L-Serine → Coenzyme A + O-Acetylserine LEFT_TO_RIGHT 1.1.1.95 false 1.1.1.95 3-Phosphoglyceric acid + NAD → Hydrogen Ion + NADH + Phosphohydroxypyruvic acid LEFT_TO_RIGHT 2.6.1.52 false 2.6.1.52 L-Glutamic acid + Phosphohydroxypyruvic acid → DL-O-Phosphoserine + Oxoglutaric acid LEFT_TO_RIGHT H2S Hydrogen sulfide 33.98772 H Hydrogen Ion 1.007825 SMILES N[C@@H](C=O)C(O)=O 53-84-9 CAS 5653 ChemSpider 3-P-HYDROXYPYRUVATE BioCyc C00026 KEGG Compound 1.0 C00025 KEGG Compound C00024 KEGG Compound HMDB03276 HMDB Phosphoserine phosphatase cysteine synthase 104 ChemSpider SMILES N[C@@H](CO)C(O)=O serine acetyltransferase 103 ChemSpider O-acetylserine sulfhydrylase A D-3-phosphoglycerate dehydrogenase / α-ketoglutarate reductase SMILES NC(COP(O)(O)=O)C(O)=O ACET BioCyc 3-phosphoserine aminotransferase / phosphohydroxythreonine aminotransferase 1.0 1.0 SubPathwayInteraction1722 SubPathway1722Reaction SubPathwayReaction ReactionCatalysis2806 ACTIVATION ReactionCatalysis2805 ACTIVATION C00033 KEGG Compound 52-90-4 CAS SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc C5H9NO4 O-Acetylserine 147.05316 ReactionCatalysis2807 ACTIVATION CHEBI:17981 ChEBI C01005 KEGG Compound ReactionCatalysis2809 ACTIVATION Phosphoserine aminotransferase 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 328-50-7 CAS CHEBI:1146900 ChEBI P0AGB0 UniProt Water ReactionCatalysis2810 ACTIVATION C00283 KEGG Compound C3H5NO3 2-Aminomalonate semialdehyde 103.02694 CO-A BioCyc 5675 ChemSpider 72-89-9 CAS SMILES S Cysteine synthase A HMDB03011 HMDB L-Cysteine Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 C3H7O7P 3-Phosphoglyceric acid 185.99294 HMDB01721 HMDB 6557 ChemSpider C00979 KEGG Compound SMILES CC(O)=O P0ABK5 UniProt SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 7732-18-5 CAS 3-hydroxy acid dehydrogenase CHEBI:30933 ChEBI 56-86-0 CAS C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 1.0 1.0 1.0 C00065 KEGG Compound 1.0 1.0 O-Acetylserine CHEBI:17050 ChEBI 1.0 962 PubChem-compound CHEBI:15366 ChEBI HMDB01024 HMDB 724 PubChem-compound 2-KETOGLUTARATE BioCyc 392413 ChemSpider CHEBI:37712 ChEBI SMILES OC(COP(O)(O)=O)C(O)=O Phosphate 5893 PubChem-compound 1.0 Phosphohydroxypyruvic acid HMDB02111 HMDB C00080 KEGG Compound Oxoglutaric acid 171 ChemSpider SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS Phosphoserine aminotransferase P0A9D4 UniProt 56-45-1 CAS 5886 PubChem-compound C03232 KEGG Compound DL-O-Phosphoserine 25244138 PubChem-compound HMDB00187 HMDB P0A9T0 UniProt G3P BioCyc 1.0 L-Serine SMP00993 SMPDB ACETYLSERINE BioCyc C3H7NO3 L-Serine 105.042595 HMDB01487 HMDB C3H7NO2S L-Cysteine 121.01975 444493 PubChem-compound 2-Aminomalonate semialdehyde C00097 KEGG Compound HS BioCyc 22833512 PubChem-compound ACETYL-COA BioCyc Serine acetyltransferase H2O Water 18.010565 Cysteine synthase B NADH BioCyc NAD BioCyc 1061 PubChem-compound 2.0 glycolate and glyoxylate degradation SubPathway CHEBI:15351 ChEBI HMDB00042 HMDB 176 PubChem-compound 3-P-SERINE BioCyc P23721 UniProt ReactionCatalysis2804 ACTIVATION 85-61-0 CAS 820-11-1 CAS D-3- phosphoglycerate dehydrogenase Phosphoserine aminotransferase Phosphoserine phosphatase Serine acetyltransferase NADP-dependent L-serine/L- allo- threonine dehydrogenase ydfG 3- Phosphoglyceric acid NAD NADH H + Phosphohydroxypyruvic acid L-Glutamic acid Oxoglutaric acid DL-O- Phosphoserine H 2 O P i L-Serine Acetyl-CoA CoA O-Acetylserine Hydrogen sulfide H + Acetic acid L-Cysteine 2-Aminomalonate semialdehyde NADPH H + NADP glycolate and glyoxylate degradation Cysteine synthase B Cysteine synthase A
CHEBI:16015 ChEBI CHEBI:16136 ChEBI 30572 ChemSpider 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 Hydrogen sulfide C23H38N7O17P3S Acetyl-CoA 809.1258 SMILES N[C@@H](CS)C(O)=O 937 ChemSpider 2.0 CYS BioCyc NADH NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG 439153 PubChem-compound 18779926 PubChem-compound 64-19-7 CAS 6.0 SMILES O PW000977 PathWhiz 2.0 5147-00-2 CAS 50 ChemSpider HMDB00807 HMDB 1.0 CHEBI:17115 ChEBI HMDB00148 HMDB NAD P16703 UniProt 1.0 1.0 6816 PubChem-compound 51 PubChem-compound 89874 ChemSpider CHEBI:15846 ChEBI 1.0 D-3-phosphoglycerate dehydrogenase http://identifiers.org/smpdb/SMP00847 SMPDB 53-59-8 CAS HMDB01206 HMDB C3H8NO6P DL-O-Phosphoserine 185.00893 1.0 SMILES CC(=O)OC[C@H](N)C(O)=O 1038 PubChem-compound 17885-08-4 CAS CHEBI:17561 ChEBI 4.0 CHEBI:16474 ChEBI 4.0 1.0 HMDB59597 HMDB ReactionCatalysis5828 ACTIVATION C5H6O5 Oxoglutaric acid 146.02153 P39831 UniProt HMDB00902 HMDB 391 ChemSpider CHEBI:16908 ChEBI 5736 ChemSpider C3H5O7P Phosphohydroxypyruvic acid 183.9773 1.0 O4P Phosphate 94.95342 Acetyl-CoA Cysteine synthase B Serine acetyltransferase 704 ChemSpider NADPH 5862 PubChem-compound 1010 ChemSpider SER BioCyc Acetic acid SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Phosphoserine phosphatase NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000827 PathWhiz 1.1.1.- false 1.1.1.- 2-Aminomalonate semialdehyde + Hydrogen Ion + NADPH ↔ L-Serine + NADP REVERSIBLE Secondary Metabolites: cysteine biosynthesis from serine HMDB00574 HMDB 1.0 HMDB01423 HMDB NADPH BioCyc 3913-50-6 CAS Hydrogen Ion HMDB00217 HMDB C00597 KEGG Compound 58-68-4 CAS Cysteine synthase A L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB00208 HMDB CHEBI:30915 ChEBI C00009 KEGG Compound HMDB00221 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI 3-Phosphoglyceric acid C00001 KEGG Compound SMILES OC(=O)C(=O)COP(O)(O)=O C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O D-3-phosphoglycerate dehydrogenase 6971051 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O HMDB01429 HMDB GLT BioCyc 7783-06-4 CAS 1.0 53-57-6 CAS 105 PubChem-compound CHEBI:58671 ChEBI C21H28N7O14P2 NAD 664.11694 106 PubChem-compound 2.5.1.47 false 2.5.1.47 Hydrogen sulfide + O-Acetylserine → Acetic acid + Hydrogen Ion + L-Cysteine LEFT_TO_RIGHT C00010 KEGG Compound 5951 PubChem-compound C21H29N7O14P2 NADH 665.12476 NAD(P) BioCyc 3.1.3.3 false 3.1.3.3 DL-O-Phosphoserine + Water → L-Serine + Phosphate LEFT_TO_RIGHT 2.3.1.30 false 2.3.1.30 Acetyl-CoA + L-Serine → Coenzyme A + O-Acetylserine LEFT_TO_RIGHT 1.1.1.95 false 1.1.1.95 3-Phosphoglyceric acid + NAD → Hydrogen Ion + NADH + Phosphohydroxypyruvic acid LEFT_TO_RIGHT 2.6.1.52 false 2.6.1.52 L-Glutamic acid + Phosphohydroxypyruvic acid → DL-O-Phosphoserine + Oxoglutaric acid LEFT_TO_RIGHT H2S Hydrogen sulfide 33.98772 H Hydrogen Ion 1.007825 SMILES N[C@@H](C=O)C(O)=O 53-84-9 CAS 5653 ChemSpider 3-P-HYDROXYPYRUVATE BioCyc C00026 KEGG Compound 1.0 C00025 KEGG Compound C00024 KEGG Compound HMDB03276 HMDB Phosphoserine phosphatase cysteine synthase 104 ChemSpider SMILES N[C@@H](CO)C(O)=O serine acetyltransferase 103 ChemSpider O-acetylserine sulfhydrylase A D-3-phosphoglycerate dehydrogenase / α-ketoglutarate reductase SMILES NC(COP(O)(O)=O)C(O)=O ACET BioCyc 3-phosphoserine aminotransferase / phosphohydroxythreonine aminotransferase 1.0 1.0 SubPathwayInteraction1722 SubPathway1722Reaction SubPathwayReaction ReactionCatalysis2806 ACTIVATION ReactionCatalysis2805 ACTIVATION C00033 KEGG Compound 52-90-4 CAS SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc C5H9NO4 O-Acetylserine 147.05316 ReactionCatalysis2807 ACTIVATION CHEBI:17981 ChEBI C01005 KEGG Compound ReactionCatalysis2809 ACTIVATION Phosphoserine aminotransferase 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 328-50-7 CAS CHEBI:1146900 ChEBI P0AGB0 UniProt Water ReactionCatalysis2810 ACTIVATION C00283 KEGG Compound C3H5NO3 2-Aminomalonate semialdehyde 103.02694 CO-A BioCyc 5675 ChemSpider 72-89-9 CAS SMILES S Cysteine synthase A HMDB03011 HMDB L-Cysteine Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 C3H7O7P 3-Phosphoglyceric acid 185.99294 HMDB01721 HMDB 6557 ChemSpider C00979 KEGG Compound SMILES CC(O)=O P0ABK5 UniProt SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 7732-18-5 CAS 3-hydroxy acid dehydrogenase CHEBI:30933 ChEBI 56-86-0 CAS C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 1.0 glycolate and glyoxylate degradation SubPathway 1.0 1.0 C00065 KEGG Compound 1.0 1.0 O-Acetylserine CHEBI:17050 ChEBI 1.0 962 PubChem-compound CHEBI:15366 ChEBI HMDB01024 HMDB 724 PubChem-compound 2-KETOGLUTARATE BioCyc 392413 ChemSpider CHEBI:37712 ChEBI SMILES OC(COP(O)(O)=O)C(O)=O Phosphate 5893 PubChem-compound 1.0 Phosphohydroxypyruvic acid HMDB02111 HMDB C00080 KEGG Compound Oxoglutaric acid 171 ChemSpider SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS Phosphoserine aminotransferase P0A9D4 UniProt 56-45-1 CAS 5886 PubChem-compound C03232 KEGG Compound DL-O-Phosphoserine 25244138 PubChem-compound HMDB00187 HMDB P0A9T0 UniProt G3P BioCyc 1.0 L-Serine http://identifiers.org/smpdb/SMP00993 SMPDB ACETYLSERINE BioCyc C3H7NO3 L-Serine 105.042595 HMDB01487 HMDB C3H7NO2S L-Cysteine 121.01975 444493 PubChem-compound 2-Aminomalonate semialdehyde C00097 KEGG Compound HS BioCyc 22833512 PubChem-compound ACETYL-COA BioCyc Serine acetyltransferase H2O Water 18.010565 Cysteine synthase B NADH BioCyc NAD BioCyc 1061 PubChem-compound 2.0 CHEBI:15351 ChEBI HMDB00042 HMDB 176 PubChem-compound 3-P-SERINE BioCyc P23721 UniProt ReactionCatalysis2804 ACTIVATION 85-61-0 CAS 820-11-1 CAS serA serC serB cysE ydfG 3- Phosphoglyceric acid NAD NADH Hydrogen Ion Phosphohydroxypyruvic acid L-Glutamic acid Oxoglutaric acid DL-O- Phosphoserine Water Phosphate L-Serine Acetyl-CoA Coenzyme A O-Acetylserine Hydrogen sulfide Hydrogen Ion Acetic acid L-Cysteine 2-Aminomalonate semialdehyde NADPH Hydrogen Ion NADP glycolate and glyoxylate degradation cysM cysK