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Acetolactate synthase isozyme 3 large subunit Acetolactate synthase isozyme 3 small subunit Ketol-acid reductoisomerase Dihydroxy-acid dehydratase 2- isopropylmalate synthase Branched- chain-amino- acid aminotransferase 3- isopropylmalate dehydratase large subunit 3- isopropylmalate dehydratase small subunit 3- isopropylmalate dehydratase large subunit 3- isopropylmalate dehydratase small subunit Branched- chain-amino- acid aminotransferase Ketol-acid reductoisomerase Pyruvic acid H + CO 2 (S)-2- Acetolactate H + NADPH NADP (R) 2,3- Dihydroxy-3- methylvalerate H 2 O 3-Methyl-2- oxovaleric acid H 2 O Acetyl-CoA CoA H + 2- Isopropylmalic acid L-Glutamic acid Oxoglutaric acid L-Valine H 2 O Isopropylmaleate H 2 O 3- Isopropylmalate NAD NADH H + 2-Isopropyl- 3- oxosuccinate H + CO 2 Ketoleucine L-Glutamic acid Oxoglutaric acid L-Leucine 3-Hydroxy-3- methyl-2- oxobutanoic acid Glycolysis and Pyruvate Dehydrogenase D-malate dehydrogenase [decarboxylating] 3- isopropylmalate dehydrogenase
ilvI ilvH ilvC ilvD leuA ilvE leuC leuD leuC leuD ilvE ilvC Pyruvic acid Hydrogen Ion Carbon dioxide (S)-2- Acetolactate Hydrogen Ion NADPH NADP (R) 2,3- Dihydroxy-3- methylvalerate Water 3-Methyl-2- oxovaleric acid Water Acetyl-CoA Coenzyme A Hydrogen Ion 2- Isopropylmalic acid L-Glutamic acid Oxoglutaric acid L-Valine Water Isopropylmaleate Water 3- Isopropylmalate NAD NADH Hydrogen Ion 2-Isopropyl- 3- oxosuccinate Hydrogen Ion Carbon dioxide Ketoleucine L-Glutamic acid Oxoglutaric acid L-Leucine 3-Hydroxy-3- methyl-2- oxobutanoic acid Glycolysis and Pyruvate Dehydrogenase dmlA leuB