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CHEBI:16015 ChEBI C5H11NO2 L-Valine 117.07898 4444155 ChemSpider 30572 ChemSpider 17215925 ChemSpider C23H38N7O17P3S Acetyl-CoA 809.1258 CHEBI:15603 ChEBI 937 ChemSpider HMDB00491 HMDB 2-isopropylmalate synthase C04236 KEGG Compound 4.0 NADH HMDB12241 HMDB 5462261 PubChem-compound 439153 PubChem-compound Acetolactate synthase isozyme 3 small subunit SMILES O PW000978 PathWhiz 1.0 3-isopropylmalate dehydratase small subunit ReactionCatalysis2893 ACTIVATION 50 ChemSpider 1.0 HMDB00148 HMDB C02504 KEGG Compound 5462259 PubChem-compound Branched-chain-amino-acid aminotransferase 3-isopropylmalate dehydratase large subunit NAD isopropylmalate isomerase branched-chain amino-acid aminotransferase 3-isopropylmalate dehydrogenase 1.0 6816 PubChem-compound 51 PubChem-compound 46 ChemSpider Pyruvic acid CHEBI:15846 ChEBI C3H4O3 Pyruvic acid 88.016045 6287 PubChem-compound 562-43-6 CAS 53-59-8 CAS Reaction2927 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT 49601-06-1 CAS HMDB01206 HMDB 1.0 C02631 KEGG Compound SMILES CC(C)CC(=O)C(O)=O 1038 PubChem-compound CHEBI:16474 ChEBI CHEBI:48430 ChEBI SMILES CC(=O)[C@](C)(O)C(O)=O acetolactate synthase / acetohydroxybutanoate synthase HMDB59597 HMDB dihydroxy acid dehydratase 274 ChemSpider acetohydroxy acid isomeroreductase Valine Transaminase C5H6O5 Oxoglutaric acid 146.02153 CHEBI:18409 ChEBI HMDB00902 HMDB C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 CHEBI:16908 ChEBI HMDB00243 HMDB L-Valine 3-Hydroxy-3-methyl-2-oxobutanoic acid Acetyl-CoA NADPH 1010 ChemSpider C5H10O4 (R)-2,3-Dihydroxy-isovalerate 134.0579 440279 PubChem-compound C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 1.0 (R)-2,3-Dihydroxy-isovalerate (R) 2,3-Dihydroxy-3-methylvalerate 69 ChemSpider C04272 KEGG Compound NADP 70 PubChem-compound C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 Secondary Metabolites: Valine and I-leucine biosynthesis from pyruvate Acetolactate synthase isozyme 3 large subunit 1.0 HMDB00695 HMDB NADPH BioCyc HMDB01423 HMDB Hydrogen Ion PW000785 PathWhiz HMDB00217 HMDB Dihydroxy-acid dehydratase 6106 PubChem-compound 3-isopropylmalate dehydrogenase C00233 KEGG Compound 5880 ChemSpider 58-68-4 CAS SMILES CCC(C)C(=O)C(O)=O L-Glutamic acid CHEBI:27512 ChEBI 3-isopropylmalate dehydratase small subunit SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS HMDB00208 HMDB CHEBI:30915 ChEBI 1.0 HMDB00221 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI 2-isopropylmalate synthase C00001 KEGG Compound 1460-34-0 CAS C7H10O5 2-Isopropyl-3-oxosuccinate 174.05283 1.0 Acetolactate synthase isozyme 3 small subunit CHEBI:35128 ChEBI LEU BioCyc C00005 KEGG Compound C00004 KEGG Compound CHEBI:17275 ChEBI C00003 KEGG Compound 1031 ChemSpider C00123 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 3-Isopropylmalate Ketol-acid reductoisomerase 6050 ChemSpider SMILES CC(C)(O)[C@@H](O)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C7H12O5 3-Isopropylmalate 176.06847 D-malate dehydrogenase [decarboxylating] SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O GLT BioCyc 53-57-6 CAS 1.0 C21H28N7O14P2 NAD 664.11694 3-isopropylmalate dehydratase large subunit C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound 2-Isopropyl-3-oxosuccinate SMP00807 SMPDB NAD(P) BioCyc C21H29N7O14P2 NADH 665.12476 1.0 SMILES CC(C)C(=C\C(O)=O)\C(O)=O 47 PubChem-compound H Hydrogen Ion 1.007825 2.0 4444164 ChemSpider HMDB00687 HMDB C00022 KEGG Compound 440878 PubChem-compound 53-84-9 CAS C06007 KEGG Compound C00026 KEGG Compound P09151 UniProt C00025 KEGG Compound DIOH-ISOVALERATE BioCyc C00024 KEGG Compound C06010 KEGG Compound 1.0 1.0 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound CHEBI:15684 ChEBI C6H10O3 Ketoleucine 130.06299 1.0 1.0 SubPathwayInteraction1723 SubPathwayReaction SubPathway1723Reaction CHEBI:16414 ChEBI C7H12O5 2-Isopropylmalic acid 176.06847 P0A6A6 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider 5280523 PubChem-compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI Water 2.0 P0AB80 UniProt Reaction3714 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Valine + Oxoglutaric acid LEFT_TO_RIGHT 4575349 ChemSpider 4575347 ChemSpider ReactionCatalysis5880 ACTIVATION 395044 ChemSpider CO-A BioCyc Dihydroxy-acid dehydratase C5H8O4 (S)-2-Acetolactate 132.04225 5675 ChemSpider 72-89-9 CAS Coenzyme A Ketol-acid reductoisomerase C21H36N7O16P3S Coenzyme A 767.11523 HMDB06855 HMDB SMILES CC(C)(O)C(=O)C(O)=O 6557 ChemSpider 1.1.1.86 false 1.1.1.86 (S)-2-Acetolactate ↔ 3-Hydroxy-3-methyl-2-oxobutanoic acid REVERSIBLE D-malate dehydrogenase [decarboxylating] SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS CPD-9451 BioCyc 388299 ChemSpider (S)-2-Acetolactate SMILES CC(C)[C@H](N)C(O)=O C04411 KEGG Compound 72-18-4 CAS 2.6.1.42 false 2.6.1.42 Ketoleucine + L-Glutamic acid → L-Leucine + Oxoglutaric acid LEFT_TO_RIGHT 2.2.1.6 false 2.2.1.6 Hydrogen Ion + 2 Pyruvic acid → (S)-2-Acetolactate + Carbon dioxide LEFT_TO_RIGHT 127-17-3 CAS 1.0 Reaction2880 true 2-Isopropyl-3-oxosuccinate + Hydrogen Ion → Carbon dioxide + Ketoleucine LEFT_TO_RIGHT C00183 KEGG Compound ReactionCatalysis2837 ACTIVATION ReactionCatalysis2836 ACTIVATION 56-86-0 CAS P00893 UniProt P00894 UniProt CHEBI:1467 ChEBI 6.0 1.0 1.1.1.86 false 1.1.1.86 (R)-2,3-Dihydroxy-isovalerate + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound P05793 UniProt 389710 ChemSpider HMDB00883 HMDB P05791 UniProt P76251 UniProt HMDB00402 HMDB 1.0 CHEBI:16526 ChEBI ReactionCatalysis2838 ACTIVATION 2-Isopropylmalic acid 2.0 1.0 1.0 816-66-0 CAS Ketoleucine ReactionCatalysis2842 ACTIVATION SMILES CC(=O)C(O)=O ReactionCatalysis2841 ACTIVATION ReactionCatalysis2844 ACTIVATION 5280533 PubChem-compound ReactionCatalysis2845 ACTIVATION CHEBI:35932 ChEBI L-Leucine ReactionCatalysis2847 ACTIVATION 2K-4CH3-PENTANOATE BioCyc HMDB01967 HMDB 1.1.1.83 false 1.1.1.83 3-Isopropylmalate + NAD → 2-Isopropyl-3-oxosuccinate + Hydrogen Ion + NADH LEFT_TO_RIGHT 4.2.1.33 false 4.2.1.33 2-Isopropylmalic acid → Isopropylmaleate + Water LEFT_TO_RIGHT C6H13NO2 L-Leucine 131.09464 Reaction2877 false Isopropylmaleate + Water → 3-Isopropylmalate LEFT_TO_RIGHT 2.3.3.13 false 2.3.3.13 3-Methyl-2-oxovaleric acid + Acetyl-CoA + Water → 2-Isopropylmalic acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT 962 PubChem-compound CHEBI:17667 ChEBI C5H8O4 3-Hydroxy-3-methyl-2-oxobutanoic acid 132.04225 P30126 UniProt 2-KETOGLUTARATE BioCyc P30125 UniProt 392413 ChemSpider 61-90-5 CAS 2-KETO-3-METHYL-VALERATE BioCyc CO2 Carbon dioxide 43.98983 Branched-chain-amino-acid aminotransferase 2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE BioCyc 2.0 C03465 KEGG Compound 5893 PubChem-compound HMDB02111 HMDB C00080 KEGG Compound C7H10O4 Isopropylmaleate 158.0579 Oxoglutaric acid 1.0 3-Methyl-2-oxovaleric acid CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc CPD-7100 BioCyc 5886 PubChem-compound 2.0 389255 ChemSpider VAL BioCyc 1.0 SMILES CC(C)[C@@](O)(CC(O)=O)C(O)=O 280 PubChem-compound SMILES CC(C)C[C@H](N)C(O)=O SMP00994 SMPDB 921-28-8 CAS HMDB12156 HMDB HMDB01487 HMDB 444493 PubChem-compound 440248 PubChem-compound 22833512 PubChem-compound HMDB12141 HMDB ACETYL-COA BioCyc HMDB12140 HMDB H2O Water 18.010565 Isopropylmaleate HMDB12149 HMDB NADH BioCyc ReactionCatalysis3687 ACTIVATION NAD BioCyc 1.0 1060 PubChem-compound CHEBI:43468 ChEBI Carbon dioxide glycolysis and pyruvate dehydrogenase SubPathway CHEBI:15351 ChEBI Acetolactate synthase isozyme 3 large subunit 1.0 SMILES CC(C)[C@H](C(O)=O)C(=O)C(O)=O SMILES CC(C)[C@@H]([C@@H](O)C(O)=O)C(O)=O 3-isopropylmalate dehydrogenase 85-61-0 CAS Acetolactate synthase isozyme 3 large subunit Acetolactate synthase isozyme 3 small subunit Ketol-acid reductoisomerase Dihydroxy-acid dehydratase 2- isopropylmalate synthase Branched- chain-amino- acid aminotransferase 3- isopropylmalate dehydratase large subunit 3- isopropylmalate dehydratase small subunit 3- isopropylmalate dehydratase large subunit 3- isopropylmalate dehydratase small subunit Branched- chain-amino- acid aminotransferase Ketol-acid reductoisomerase Pyruvic acid H + CO 2 (S)-2- Acetolactate H + NADPH NADP (R) 2,3- Dihydroxy-3- methylvalerate H 2 O 3-Methyl-2- oxovaleric acid H 2 O Acetyl-CoA CoA H + 2- Isopropylmalic acid L-Glutamic acid Oxoglutaric acid L-Valine H 2 O Isopropylmaleate H 2 O 3- Isopropylmalate NAD NADH H + 2-Isopropyl- 3- oxosuccinate H + CO 2 Ketoleucine L-Glutamic acid Oxoglutaric acid L-Leucine 3-Hydroxy-3- methyl-2- oxobutanoic acid glycolysis and pyruvate dehydrogenase D-malate dehydrogenase [decarboxylating] 3- isopropylmalate dehydrogenase
CHEBI:16015 ChEBI C5H11NO2 L-Valine 117.07898 4444155 ChemSpider 30572 ChemSpider 17215925 ChemSpider C23H38N7O17P3S Acetyl-CoA 809.1258 CHEBI:15603 ChEBI 937 ChemSpider HMDB00491 HMDB 2-isopropylmalate synthase C04236 KEGG Compound 4.0 NADH HMDB12241 HMDB 5462261 PubChem-compound 439153 PubChem-compound Acetolactate synthase isozyme 3 small subunit SMILES O PW000978 PathWhiz 1.0 3-isopropylmalate dehydratase small subunit ReactionCatalysis2893 ACTIVATION 50 ChemSpider 1.0 HMDB00148 HMDB C02504 KEGG Compound 5462259 PubChem-compound Branched-chain-amino-acid aminotransferase 3-isopropylmalate dehydratase large subunit NAD isopropylmalate isomerase branched-chain amino-acid aminotransferase 3-isopropylmalate dehydrogenase 1.0 6816 PubChem-compound 51 PubChem-compound 46 ChemSpider Pyruvic acid CHEBI:15846 ChEBI C3H4O3 Pyruvic acid 88.016045 6287 PubChem-compound 562-43-6 CAS 53-59-8 CAS Reaction2927 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT 49601-06-1 CAS HMDB01206 HMDB 1.0 C02631 KEGG Compound SMILES CC(C)CC(=O)C(O)=O 1038 PubChem-compound CHEBI:16474 ChEBI CHEBI:48430 ChEBI SMILES CC(=O)[C@](C)(O)C(O)=O acetolactate synthase / acetohydroxybutanoate synthase HMDB59597 HMDB dihydroxy acid dehydratase 274 ChemSpider acetohydroxy acid isomeroreductase Valine Transaminase C5H6O5 Oxoglutaric acid 146.02153 CHEBI:18409 ChEBI HMDB00902 HMDB C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 CHEBI:16908 ChEBI HMDB00243 HMDB L-Valine 3-Hydroxy-3-methyl-2-oxobutanoic acid Acetyl-CoA NADPH 1010 ChemSpider C5H10O4 (R)-2,3-Dihydroxy-isovalerate 134.0579 440279 PubChem-compound C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 1.0 (R)-2,3-Dihydroxy-isovalerate (R) 2,3-Dihydroxy-3-methylvalerate 69 ChemSpider C04272 KEGG Compound NADP 70 PubChem-compound C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 glycolysis and pyruvate dehydrogenase SubPathway Secondary Metabolites: Valine and I-leucine biosynthesis from pyruvate Acetolactate synthase isozyme 3 large subunit 1.0 HMDB00695 HMDB NADPH BioCyc HMDB01423 HMDB Hydrogen Ion PW000785 PathWhiz HMDB00217 HMDB Dihydroxy-acid dehydratase 6106 PubChem-compound 3-isopropylmalate dehydrogenase C00233 KEGG Compound 5880 ChemSpider 58-68-4 CAS SMILES CCC(C)C(=O)C(O)=O L-Glutamic acid CHEBI:27512 ChEBI 3-isopropylmalate dehydratase small subunit SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS HMDB00208 HMDB CHEBI:30915 ChEBI 1.0 HMDB00221 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI 2-isopropylmalate synthase C00001 KEGG Compound 1460-34-0 CAS C7H10O5 2-Isopropyl-3-oxosuccinate 174.05283 1.0 Acetolactate synthase isozyme 3 small subunit CHEBI:35128 ChEBI LEU BioCyc C00005 KEGG Compound C00004 KEGG Compound CHEBI:17275 ChEBI C00003 KEGG Compound 1031 ChemSpider C00123 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 3-Isopropylmalate Ketol-acid reductoisomerase 6050 ChemSpider SMILES CC(C)(O)[C@@H](O)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C7H12O5 3-Isopropylmalate 176.06847 D-malate dehydrogenase [decarboxylating] SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O GLT BioCyc 53-57-6 CAS 1.0 C21H28N7O14P2 NAD 664.11694 3-isopropylmalate dehydratase large subunit C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound 2-Isopropyl-3-oxosuccinate http://identifiers.org/smpdb/SMP00807 SMPDB NAD(P) BioCyc C21H29N7O14P2 NADH 665.12476 1.0 SMILES CC(C)C(=C\C(O)=O)\C(O)=O 47 PubChem-compound H Hydrogen Ion 1.007825 2.0 4444164 ChemSpider HMDB00687 HMDB C00022 KEGG Compound 440878 PubChem-compound 53-84-9 CAS C06007 KEGG Compound C00026 KEGG Compound P09151 UniProt C00025 KEGG Compound DIOH-ISOVALERATE BioCyc C00024 KEGG Compound C06010 KEGG Compound 1.0 1.0 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound CHEBI:15684 ChEBI C6H10O3 Ketoleucine 130.06299 1.0 1.0 SubPathwayInteraction1723 SubPathwayReaction SubPathway1723Reaction CHEBI:16414 ChEBI C7H12O5 2-Isopropylmalic acid 176.06847 P0A6A6 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider 5280523 PubChem-compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI Water 2.0 P0AB80 UniProt Reaction3714 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Valine + Oxoglutaric acid LEFT_TO_RIGHT 4575349 ChemSpider 4575347 ChemSpider ReactionCatalysis5880 ACTIVATION 395044 ChemSpider CO-A BioCyc Dihydroxy-acid dehydratase C5H8O4 (S)-2-Acetolactate 132.04225 5675 ChemSpider 72-89-9 CAS Coenzyme A Ketol-acid reductoisomerase C21H36N7O16P3S Coenzyme A 767.11523 HMDB06855 HMDB SMILES CC(C)(O)C(=O)C(O)=O 6557 ChemSpider 1.1.1.86 false 1.1.1.86 (S)-2-Acetolactate ↔ 3-Hydroxy-3-methyl-2-oxobutanoic acid REVERSIBLE D-malate dehydrogenase [decarboxylating] SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS CPD-9451 BioCyc 388299 ChemSpider (S)-2-Acetolactate SMILES CC(C)[C@H](N)C(O)=O C04411 KEGG Compound 72-18-4 CAS 2.6.1.42 false 2.6.1.42 Ketoleucine + L-Glutamic acid → L-Leucine + Oxoglutaric acid LEFT_TO_RIGHT 2.2.1.6 false 2.2.1.6 Hydrogen Ion + 2 Pyruvic acid → (S)-2-Acetolactate + Carbon dioxide LEFT_TO_RIGHT 127-17-3 CAS 1.0 Reaction2880 true 2-Isopropyl-3-oxosuccinate + Hydrogen Ion → Carbon dioxide + Ketoleucine LEFT_TO_RIGHT C00183 KEGG Compound ReactionCatalysis2837 ACTIVATION ReactionCatalysis2836 ACTIVATION 56-86-0 CAS P00893 UniProt P00894 UniProt CHEBI:1467 ChEBI 6.0 1.0 1.1.1.86 false 1.1.1.86 (R)-2,3-Dihydroxy-isovalerate + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound P05793 UniProt 389710 ChemSpider HMDB00883 HMDB P05791 UniProt P76251 UniProt HMDB00402 HMDB 1.0 CHEBI:16526 ChEBI ReactionCatalysis2838 ACTIVATION 2-Isopropylmalic acid 2.0 1.0 1.0 816-66-0 CAS Ketoleucine ReactionCatalysis2842 ACTIVATION SMILES CC(=O)C(O)=O ReactionCatalysis2841 ACTIVATION ReactionCatalysis2844 ACTIVATION 5280533 PubChem-compound ReactionCatalysis2845 ACTIVATION CHEBI:35932 ChEBI L-Leucine ReactionCatalysis2847 ACTIVATION 2K-4CH3-PENTANOATE BioCyc HMDB01967 HMDB 1.1.1.83 false 1.1.1.83 3-Isopropylmalate + NAD → 2-Isopropyl-3-oxosuccinate + Hydrogen Ion + NADH LEFT_TO_RIGHT 4.2.1.33 false 4.2.1.33 2-Isopropylmalic acid → Isopropylmaleate + Water LEFT_TO_RIGHT C6H13NO2 L-Leucine 131.09464 Reaction2877 false Isopropylmaleate + Water → 3-Isopropylmalate LEFT_TO_RIGHT 2.3.3.13 false 2.3.3.13 3-Methyl-2-oxovaleric acid + Acetyl-CoA + Water → 2-Isopropylmalic acid + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT 962 PubChem-compound CHEBI:17667 ChEBI C5H8O4 3-Hydroxy-3-methyl-2-oxobutanoic acid 132.04225 P30126 UniProt 2-KETOGLUTARATE BioCyc P30125 UniProt 392413 ChemSpider 61-90-5 CAS 2-KETO-3-METHYL-VALERATE BioCyc CO2 Carbon dioxide 43.98983 Branched-chain-amino-acid aminotransferase 2-D-THREO-HYDROXY-3-CARBOXY-ISOCAPROATE BioCyc 2.0 C03465 KEGG Compound 5893 PubChem-compound HMDB02111 HMDB C00080 KEGG Compound C7H10O4 Isopropylmaleate 158.0579 Oxoglutaric acid 1.0 3-Methyl-2-oxovaleric acid CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc CPD-7100 BioCyc 5886 PubChem-compound 2.0 389255 ChemSpider VAL BioCyc 1.0 SMILES CC(C)[C@@](O)(CC(O)=O)C(O)=O 280 PubChem-compound SMILES CC(C)C[C@H](N)C(O)=O http://identifiers.org/smpdb/SMP00994 SMPDB 921-28-8 CAS HMDB12156 HMDB HMDB01487 HMDB 444493 PubChem-compound 440248 PubChem-compound 22833512 PubChem-compound HMDB12141 HMDB ACETYL-COA BioCyc HMDB12140 HMDB H2O Water 18.010565 Isopropylmaleate HMDB12149 HMDB NADH BioCyc ReactionCatalysis3687 ACTIVATION NAD BioCyc 1.0 1060 PubChem-compound CHEBI:43468 ChEBI Carbon dioxide CHEBI:15351 ChEBI Acetolactate synthase isozyme 3 large subunit 1.0 SMILES CC(C)[C@H](C(O)=O)C(=O)C(O)=O SMILES CC(C)[C@@H]([C@@H](O)C(O)=O)C(O)=O 3-isopropylmalate dehydrogenase 85-61-0 CAS ilvI ilvH ilvC ilvD leuA ilvE leuC leuD leuC leuD ilvE ilvC Pyruvic acid Hydrogen Ion Carbon dioxide (S)-2- Acetolactate Hydrogen Ion NADPH NADP (R) 2,3- Dihydroxy-3- methylvalerate Water 3-Methyl-2- oxovaleric acid Water Acetyl-CoA Coenzyme A Hydrogen Ion 2- Isopropylmalic acid L-Glutamic acid Oxoglutaric acid L-Valine Water Isopropylmaleate Water 3- Isopropylmalate NAD NADH Hydrogen Ion 2-Isopropyl- 3- oxosuccinate Hydrogen Ion Carbon dioxide Ketoleucine L-Glutamic acid Oxoglutaric acid L-Leucine 3-Hydroxy-3- methyl-2- oxobutanoic acid glycolysis and pyruvate dehydrogenase dmlA leuB