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ATP phosphoribosyltransferase Histidine biosynthesis bifunctional protein hisIE Histidine biosynthesis bifunctional protein hisIE 1-(5- phosphoribosyl)- 5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase Imidazole glycerol phosphate synthase subunit hisH Imidazole glycerol phosphate synthase subunit hisF Histidine biosynthesis bifunctional protein hisB Histidinol- phosphate aminotransferase Histidine biosynthesis bifunctional protein hisB Histidinol dehydrogenase Histidinol dehydrogenase Phosphoribosyl pyrophosphate H + PP i Phosphoribosyl- ATP H 2 O H + PP i Phosphoribosyl- AMP H 2 O 1-(5'- Phosphoribosyl)- 5-amino-4- imidazolecarboxamide PhosphoribosylformiminoAICAR- phosphate L-Glutamine L-Glutamic acid H + 5- Aminoimidazole- 4-carboxamide D-Erythro- imidazole- glycerol- phosphate H 2 O Imidazole acetol- phosphate L-Glutamic acid Oxoglutaric acid L-histidinol- phosphate H 2 O P i L-Histidinol NAD NADH H + Histidinal H 2 O NAD H + NADH L-Histidine PRPP Biosynthesis
hisG hisI hisI hisA hisH hisF hisB hisC hisB hisD hisD Phosphoribosyl pyrophosphate Hydrogen Ion Pyrophosphate Phosphoribosyl- ATP Water Hydrogen Ion Pyrophosphate Phosphoribosyl- AMP Water 1-(5'- Phosphoribosyl)- 5-amino-4- imidazolecarboxamide PhosphoribosylformiminoAICAR- phosphate L-Glutamine L-Glutamic acid Hydrogen Ion 5- Aminoimidazole- 4-carboxamide D-Erythro- imidazole- glycerol- phosphate Water Imidazole acetol- phosphate L-Glutamic acid Oxoglutaric acid L-histidinol- phosphate Water Phosphate L-Histidinol NAD NADH Hydrogen Ion Histidinal Water NAD Hydrogen Ion NADH L-Histidine PRPP Biosynthesis