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Pathway Description
Secondary Metabolites: Shikimate Pathway
Escherichia coli
Metabolic Pathway
The biosynthesis of shikimate starts with D-Erythrose-4-phosphate getting transformed into 3-deoxy-D-arabino-heptulosonate-7-phosphate through a phospho-2-dehydro-3-deoxyheptonate aldolase. This is followed by a 3-dehydroquinate synthase converting the 3-deoxy-D-arabino-heptulosonate-7-phosphate into a 3-dehydroquinate which in turn is conveted to 3-dehydroshikimate through a 3-dehydroquinate dehydratase. A this point 3-dehydroshikimate can be turned into Shikimic acid through 2 different reactions involving an NADPH driven Quinate/shikimate dehydrogenase or a NADPH driven shikimate dehydrogenase 2.
Shikimate can also be transported through a shikimate:H+ symporter.
References
Secondary Metabolites: Shikimate Pathway References
Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.
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