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17215925 ChemSpider C02737 KEGG Compound 1.0 937 ChemSpider 439162 PubChem-compound Cytidine triphosphate SMILES O 56-81-5 CAS HMDB0000095 HMDB Pyrophosphate 1.0 Phosphatidylglycerophosphatase A 6131 PubChem-compound CHEBI:17115 ChEBI 1.0 1-acyl-sn-glycerol-3-phosphate acyltransferase C00681 KEGG Compound Dihydroxyacetone phosphate P18200 UniProt 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Putative cardiolipin synthase ybhO 559142 ChemSpider Phospholipid Biosynthesis CDP-diacylglycerol--serine O-phosphatidyltransferase ReactionCatalysis3084 ACTIVATION 53-59-8 CAS 700 PubChem-compound 1038 PubChem-compound CHEBI:16474 ChEBI P26647 UniProt 274 ChemSpider ReactionCatalysis3089 ACTIVATION 5736 ChemSpider PW001001 PathWhiz Cardiolipin synthase O4P Phosphate 94.95342 NADPH CHEBI:16000 ChEBI 1010 ChemSpider SER BioCyc SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 Glycerol-3-phosphate acyltransferase 63-37-6 CAS 1.0 NADPH BioCyc C00116 KEGG Compound Hydrogen Ion PW000785 PathWhiz SMP0001017 SMPDB Glycerol-3-phosphate dehydrogenase [NAD(P)+] C00111 KEGG Compound 1.0 C00350 KEGG Compound 1.1.1.94 false 1.1.1.94 Dihydroxyacetone phosphate + Hydrogen Ion + NADPH → Glycerol 3-phosphate + NADP LEFT_TO_RIGHT Ethanolamine HMDB0001423 HMDB CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Phosphatidate cytidylyltransferase Phosphatidylglycerophosphatase A SMILES [O-]P([O-])([O-])=O HMDB0000217 HMDB 1.0 124-38-9 CAS 4.1.1.65 false 4.1.1.65 Hydrogen Ion + an L-1-phosphatidylserine → Carbon dioxide + an L-1-phosphatidylethanolamine LEFT_TO_RIGHT C00009 KEGG Compound a holo-[acyl-carrier protein] C00006 KEGG Compound CHEBI:18009 ChEBI Lysophosphatidic acid 1.0 C00001 KEGG Compound HMDB0001429 HMDB CTP BioCyc CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Glycerol C3H9O6P Glycerol 3-phosphate 172.01367 CDP-diacylglycerol--serine O-phosphatidyltransferase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 13835336 ChemSpider 57-04-5 CAS Glycerol 3-phosphate cardiolipin synthase c C3H8O3 Glycerol 92.04734 1.0 53-57-6 CAS Glycolysis and Pyruvate Dehydrogenase SubPathway CHEBI:17361 ChEBI C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound Putative cardiolipin synthase ybhO 5951 PubChem-compound a holo-[acyl-carrier protein] C00013 KEGG Compound 1.0 ReactionCatalysis101125 ACTIVATION O7P2 Pyrophosphate 173.91193 ReactionCatalysis101124 ACTIVATION ReactionCatalysis101123 ACTIVATION ReactionCatalysis101122 ACTIVATION NAD(P) BioCyc ReactionCatalysis101121 ACTIVATION ReactionCatalysis101120 ACTIVATION CHEBI:15978 ChEBI C9H16N3O14P3 Cytidine triphosphate 482.9845 P0A8K1 UniProt 562 TAXONOMY H Hydrogen Ion 1.007825 P0A6H8 UniProt 388308 ChemSpider 1.0 Cytidine monophosphate Glycerol-3-phosphate acyltransferase SMILES N[C@@H](CO)C(O)=O HMDB0000126 HMDB long-chain fatty acyl-CoA 1.0 ReactionCatalysis101119 ACTIVATION ReactionCatalysis101118 ACTIVATION ReactionCatalysis101117 ACTIVATION C9H14N3O8P Cytidine monophosphate 323.05185 Phosphatidylserine decarboxylase proenzyme 1.0 CPD-8587 BioCyc SMP0000807 SMPDB CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase CHEBI:1146900 ChEBI Water SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Phosphatidic Acid HMDB0000250 HMDB Phosphatidylglycerophosphatase B a cardiolipin SMILES [O-]P([O-])(=O)OP([O-])([O-])=O a CDP-diacylglycerol  14000-31-8 CAS 2.7.8.- false 2.7.8.- an L-1-phosphatidyl-glycerol  + an L-1-phosphatidylethanolamine → Ethanolamine + a cardiolipin LEFT_TO_RIGHT HMDB0000131 HMDB 753 PubChem-compound CO-A BioCyc GLYCEROL BioCyc 5675 ChemSpider 648 ChemSpider cardiolipin synthase c Phosphatidate cytidylyltransferase Coenzyme A SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O C21H36N7O16P3S Coenzyme A 767.11523 1.0 HMDB0000149 HMDB an L-1-phosphatidyl-glycerol  an L-1-phosphatidylethanolamine an L-1-phosphatidylglycerol-phosphate  1.0 HMDB0001473 HMDB 5901 ChemSpider an L-1-phosphatidylglycerol-phosphate  an L-1-phosphatidylserine 6557 ChemSpider 668 PubChem-compound C00055 KEGG Compound Escherichia coli 7732-18-5 CAS 1.0 ReactionCatalysis3127 ACTIVATION 1.0 C00063 KEGG Compound P0A6S7 UniProt ETHANOL-AMINE BioCyc 1.0 an L-1-phosphatidyl-glycerol  P0AA84 UniProt an L-1-phosphatidylethanolamine C2H7NO Ethanolamine 61.052765 DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 CHEBI:16526 ChEBI C00065 KEGG Compound C00189 KEGG Compound 65-47-4 CAS acyl-[acp] Phosphatidylserine decarboxylase proenzyme SMILES OCC(=O)COP(O)(O)=O Phosphatidic Acid a cardiolipin a CDP-diacylglycerol  Reaction110825 false Lysophosphatidic acid + long-chain fatty acyl-CoA → Coenzyme A + Phosphatidic Acid LEFT_TO_RIGHT 962 PubChem-compound 2.3.1.51 false 2.3.1.51 Lysophosphatidic acid + acyl-[acp] → Phosphatidic Acid + a holo-[acyl-carrier protein] LEFT_TO_RIGHT Reaction110823 false Glycerol 3-phosphate + acyl-[acp] → Lysophosphatidic acid + a holo-[acyl-carrier protein] LEFT_TO_RIGHT Reaction110824 false Glycerol 3-phosphate + long-chain fatty acyl-CoA → Coenzyme A + Lysophosphatidic acid LEFT_TO_RIGHT Reaction110829 false L-Serine + a CDP-diacylglycerol  → Cytidine monophosphate + Hydrogen Ion + an L-1-phosphatidylserine LEFT_TO_RIGHT Reaction110827 false Cytidine triphosphate + Hydrogen Ion + Phosphatidic Acid → Pyrophosphate + a CDP-diacylglycerol  LEFT_TO_RIGHT Reaction110828 false Glycerol 3-phosphate + a CDP-diacylglycerol  → Cytidine monophosphate + Hydrogen Ion + an L-1-phosphatidylglycerol-phosphate  LEFT_TO_RIGHT glycerol-3-phosphate dehydrogenase (aerobic) CO2 Carbon dioxide 43.98983 Phosphate 1.0 733 ChemSpider CMP BioCyc C00080 KEGG Compound Phosphatidylglycerophosphatase B SMILES NCCO P23830 UniProt 1-acyl-sn-glycerol-3-phosphate acyltransferase P0A924 UniProt long-chain fatty acyl-CoA 1.0 HMDB0002111 HMDB CHEBI:17677 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] 6176 PubChem-compound 14265-44-2 CAS SubPathwayInteraction1810 SubPathway1810Reaction SubPathwayReaction CHEBI:16108 ChEBI 17989-41-2 CAS 56-45-1 CAS 5886 PubChem-compound 1.0 GLYCEROL-3P BioCyc 280 PubChem-compound phosphatidylglycerophosphatase C00093 KEGG Compound L-Serine 1.0 C3H7NO3 L-Serine 105.042595 HMDB0000187 HMDB 3.1.3.27 false 3.1.3.27 Water + an L-1-phosphatidylglycerol-phosphate  → Phosphate + an L-1-phosphatidyl-glycerol  LEFT_TO_RIGHT 2.7.8.- false 2.7.8.- an L-1-phosphatidyl-glycerol  → Glycerol + a cardiolipin LEFT_TO_RIGHT 644102 PubChem-compound CHEBI:17522 ChEBI an L-1-phosphatidylserine 5941 ChemSpider P0ABG1 UniProt P0A7A7 UniProt Cardiolipin synthase 22833512 PubChem-compound P0ABF8 UniProt 1.0 H2O Water 18.010565 1061 PubChem-compound 1.0 HMDB0059597 HMDB 1.0 Lysophosphatidic acid 1.0 141-43-5 CAS Carbon dioxide HMDB0001967 HMDB Glycerol-3-phosphate dehydrogenase [NAD(P)+] P75919 UniProt acyl-[acp] 2.0 SMILES OCC(O)CO cardiolipin synthase HMDB0000082 HMDB 85-61-0 CAS SMILES OC[C@@H](O)COP(O)(O)=O Glycerol-3- phosphate dehydrogenase [NAD(P)+] Glycerol-3- phosphate acyltransferase Glycerol-3- phosphate acyltransferase 1-acyl-sn- glycerol-3- phosphate acyltransferase Phosphatidate cytidylyltransferase CDP- diacylglycerol- -glycerol-3- phosphate 3- phosphatidyltransferase CDP- diacylglycerol- -serine O- phosphatidyltransferase Phosphatidylserine decarboxylase proenzyme Phosphatidylglycerophosphatase B Phosphatidylglycerophosphatase A cardiolipin synthase c Putative cardiolipin synthase ybhO Cardiolipin synthase Dihydroxyacetone phosphate H + NADPH NADP Glycerol 3-phosphate CoA CoA Cytidine triphosphate H + PP i Glycerol 3-phosphate Cytidine monophosphate H + L-Serine Cytidine monophosphate H + H + CO 2 H 2 O P i Ethanolamine Glycerol acyl-[acp] a holo-[acyl- carrier protein] Lysophosphatidic acid long-chain fatty acyl-CoA Lysophosphatidic acid long-chain fatty acyl-CoA Phosphatidic Acid acyl-[acp] a holo-[acyl- carrier protein] a CDP- diacylglycerol an L-1- phosphatidylglycerol- phosphate an L-1- phosphatidylserine an L-1- phosphatidylethanolamine an L-1- phosphatidyl- glycerol a cardiolipin a cardiolipin Glycolysis and Pyruvate Dehydrogenase 1-acyl-sn- glycerol-3- phosphate acyltransferase
17215925 ChemSpider C02737 KEGG Compound 1.0 937 ChemSpider 439162 PubChem-compound Cytidine triphosphate SMILES O 56-81-5 CAS HMDB0000095 HMDB Pyrophosphate 1.0 Phosphatidylglycerophosphatase A 6131 PubChem-compound CHEBI:17115 ChEBI 1.0 1-acyl-sn-glycerol-3-phosphate acyltransferase C00681 KEGG Compound Dihydroxyacetone phosphate P18200 UniProt 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Putative cardiolipin synthase ybhO 559142 ChemSpider Phospholipid Biosynthesis CDP-diacylglycerol--serine O-phosphatidyltransferase ReactionCatalysis3084 ACTIVATION 53-59-8 CAS 700 PubChem-compound 1038 PubChem-compound CHEBI:16474 ChEBI P26647 UniProt 274 ChemSpider ReactionCatalysis3089 ACTIVATION 5736 ChemSpider PW001001 PathWhiz Cardiolipin synthase O4P Phosphate 94.95342 NADPH CHEBI:16000 ChEBI 1010 ChemSpider SER BioCyc SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 Glycerol-3-phosphate acyltransferase 63-37-6 CAS 1.0 NADPH BioCyc C00116 KEGG Compound Hydrogen Ion PW000785 PathWhiz SMP0001017 SMPDB Glycerol-3-phosphate dehydrogenase [NAD(P)+] C00111 KEGG Compound 1.0 C00350 KEGG Compound 1.1.1.94 false 1.1.1.94 Dihydroxyacetone phosphate + Hydrogen Ion + NADPH → Glycerol 3-phosphate + NADP LEFT_TO_RIGHT Ethanolamine HMDB0001423 HMDB CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Phosphatidate cytidylyltransferase Phosphatidylglycerophosphatase A SMILES [O-]P([O-])([O-])=O HMDB0000217 HMDB 1.0 124-38-9 CAS 4.1.1.65 false 4.1.1.65 Hydrogen Ion + an L-1-phosphatidylserine → Carbon dioxide + an L-1-phosphatidylethanolamine LEFT_TO_RIGHT C00009 KEGG Compound a holo-[acyl-carrier protein] C00006 KEGG Compound CHEBI:18009 ChEBI Lysophosphatidic acid 1.0 C00001 KEGG Compound HMDB0001429 HMDB CTP BioCyc CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Glycerol C3H9O6P Glycerol 3-phosphate 172.01367 CDP-diacylglycerol--serine O-phosphatidyltransferase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 13835336 ChemSpider 57-04-5 CAS Glycerol 3-phosphate cardiolipin synthase c C3H8O3 Glycerol 92.04734 1.0 53-57-6 CAS Glycolysis and Pyruvate Dehydrogenase SubPathway CHEBI:17361 ChEBI C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound Putative cardiolipin synthase ybhO 5951 PubChem-compound a holo-[acyl-carrier protein] C00013 KEGG Compound 1.0 ReactionCatalysis101125 ACTIVATION O7P2 Pyrophosphate 173.91193 ReactionCatalysis101124 ACTIVATION ReactionCatalysis101123 ACTIVATION ReactionCatalysis101122 ACTIVATION NAD(P) BioCyc ReactionCatalysis101121 ACTIVATION ReactionCatalysis101120 ACTIVATION CHEBI:15978 ChEBI C9H16N3O14P3 Cytidine triphosphate 482.9845 P0A8K1 UniProt 562 TAXONOMY H Hydrogen Ion 1.007825 P0A6H8 UniProt 388308 ChemSpider 1.0 Cytidine monophosphate Glycerol-3-phosphate acyltransferase SMILES N[C@@H](CO)C(O)=O HMDB0000126 HMDB long-chain fatty acyl-CoA 1.0 ReactionCatalysis101119 ACTIVATION ReactionCatalysis101118 ACTIVATION ReactionCatalysis101117 ACTIVATION C9H14N3O8P Cytidine monophosphate 323.05185 Phosphatidylserine decarboxylase proenzyme 1.0 CPD-8587 BioCyc SMP0000807 SMPDB CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase CHEBI:1146900 ChEBI Water SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Phosphatidic Acid HMDB0000250 HMDB Phosphatidylglycerophosphatase B a cardiolipin SMILES [O-]P([O-])(=O)OP([O-])([O-])=O a CDP-diacylglycerol  14000-31-8 CAS 2.7.8.- false 2.7.8.- an L-1-phosphatidyl-glycerol  + an L-1-phosphatidylethanolamine → Ethanolamine + a cardiolipin LEFT_TO_RIGHT HMDB0000131 HMDB 753 PubChem-compound CO-A BioCyc GLYCEROL BioCyc 5675 ChemSpider 648 ChemSpider cardiolipin synthase c Phosphatidate cytidylyltransferase Coenzyme A SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O C21H36N7O16P3S Coenzyme A 767.11523 1.0 HMDB0000149 HMDB an L-1-phosphatidyl-glycerol  an L-1-phosphatidylethanolamine an L-1-phosphatidylglycerol-phosphate  1.0 HMDB0001473 HMDB 5901 ChemSpider an L-1-phosphatidylglycerol-phosphate  an L-1-phosphatidylserine 6557 ChemSpider 668 PubChem-compound C00055 KEGG Compound Escherichia coli 7732-18-5 CAS 1.0 ReactionCatalysis3127 ACTIVATION 1.0 C00063 KEGG Compound P0A6S7 UniProt ETHANOL-AMINE BioCyc 1.0 an L-1-phosphatidyl-glycerol  P0AA84 UniProt an L-1-phosphatidylethanolamine C2H7NO Ethanolamine 61.052765 DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 CHEBI:16526 ChEBI C00065 KEGG Compound C00189 KEGG Compound 65-47-4 CAS acyl-[acp] Phosphatidylserine decarboxylase proenzyme SMILES OCC(=O)COP(O)(O)=O Phosphatidic Acid a cardiolipin a CDP-diacylglycerol  Reaction110825 false Lysophosphatidic acid + long-chain fatty acyl-CoA → Coenzyme A + Phosphatidic Acid LEFT_TO_RIGHT 962 PubChem-compound 2.3.1.51 false 2.3.1.51 Lysophosphatidic acid + acyl-[acp] → Phosphatidic Acid + a holo-[acyl-carrier protein] LEFT_TO_RIGHT Reaction110823 false Glycerol 3-phosphate + acyl-[acp] → Lysophosphatidic acid + a holo-[acyl-carrier protein] LEFT_TO_RIGHT Reaction110824 false Glycerol 3-phosphate + long-chain fatty acyl-CoA → Coenzyme A + Lysophosphatidic acid LEFT_TO_RIGHT Reaction110829 false L-Serine + a CDP-diacylglycerol  → Cytidine monophosphate + Hydrogen Ion + an L-1-phosphatidylserine LEFT_TO_RIGHT Reaction110827 false Cytidine triphosphate + Hydrogen Ion + Phosphatidic Acid → Pyrophosphate + a CDP-diacylglycerol  LEFT_TO_RIGHT Reaction110828 false Glycerol 3-phosphate + a CDP-diacylglycerol  → Cytidine monophosphate + Hydrogen Ion + an L-1-phosphatidylglycerol-phosphate  LEFT_TO_RIGHT glycerol-3-phosphate dehydrogenase (aerobic) CO2 Carbon dioxide 43.98983 Phosphate 1.0 733 ChemSpider CMP BioCyc C00080 KEGG Compound Phosphatidylglycerophosphatase B SMILES NCCO P23830 UniProt 1-acyl-sn-glycerol-3-phosphate acyltransferase P0A924 UniProt long-chain fatty acyl-CoA 1.0 HMDB0002111 HMDB CHEBI:17677 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] 6176 PubChem-compound 14265-44-2 CAS SubPathwayInteraction1810 SubPathway1810Reaction SubPathwayReaction CHEBI:16108 ChEBI 17989-41-2 CAS 56-45-1 CAS 5886 PubChem-compound 1.0 GLYCEROL-3P BioCyc 280 PubChem-compound phosphatidylglycerophosphatase C00093 KEGG Compound L-Serine 1.0 C3H7NO3 L-Serine 105.042595 HMDB0000187 HMDB 3.1.3.27 false 3.1.3.27 Water + an L-1-phosphatidylglycerol-phosphate  → Phosphate + an L-1-phosphatidyl-glycerol  LEFT_TO_RIGHT 2.7.8.- false 2.7.8.- an L-1-phosphatidyl-glycerol  → Glycerol + a cardiolipin LEFT_TO_RIGHT 644102 PubChem-compound CHEBI:17522 ChEBI an L-1-phosphatidylserine 5941 ChemSpider P0ABG1 UniProt P0A7A7 UniProt Cardiolipin synthase 22833512 PubChem-compound P0ABF8 UniProt 1.0 H2O Water 18.010565 1061 PubChem-compound 1.0 HMDB0059597 HMDB 1.0 Lysophosphatidic acid 1.0 141-43-5 CAS Carbon dioxide HMDB0001967 HMDB Glycerol-3-phosphate dehydrogenase [NAD(P)+] P75919 UniProt acyl-[acp] 2.0 SMILES OCC(O)CO cardiolipin synthase HMDB0000082 HMDB 85-61-0 CAS SMILES OC[C@@H](O)COP(O)(O)=O gpsA plsB plsB plsC cdsA pgsA pssA psd pgpB pgpA clsC ybhO cls Dihydroxyacetone phosphate Hydrogen Ion NADPH NADP Glycerol 3-phosphate Coenzyme A Coenzyme A Cytidine triphosphate Hydrogen Ion Pyrophosphate Glycerol 3-phosphate Cytidine monophosphate Hydrogen Ion L-Serine Cytidine monophosphate Hydrogen Ion Hydrogen Ion Carbon dioxide Water Phosphate Ethanolamine Glycerol acyl-[acp] a holo-[acyl- carrier protein] Lysophosphatidic acid long-chain fatty acyl-CoA Lysophosphatidic acid long-chain fatty acyl-CoA Phosphatidic Acid acyl-[acp] a holo-[acyl- carrier protein] a CDP- diacylglycerol an L-1- phosphatidylglycerol- phosphate an L-1- phosphatidylserine an L-1- phosphatidylethanolamine an L-1- phosphatidyl- glycerol a cardiolipin a cardiolipin Glycolysis and Pyruvate Dehydrogenase plsC