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454-29-5 CAS P0ABQ4 UniProt 1.0 HMDB01227 HMDB 365-07-1 CAS Methionine synthase 937 ChemSpider 964-26-1 CAS CHEBI:16134 ChEBI 58-05-9 CAS 10-FORMYL-THF BioCyc 1.0 C03838 KEGG Compound HMDB01354 HMDB CHEBI:20506 ChEBI CHEBI:17115 ChEBI 7444-29-3 CAS C19H21N7O6 Dihydrofolic acid 443.15533 C10H15N2O8P 5-Thymidylic acid 322.0566 CHEBI:17119 ChEBI C00440 KEGG Compound CHEBI:17230 ChEBI S-Aminomethyldihydrolipoylprotein; 6137 PubChem-compound C00445 KEGG Compound HMDB00142 HMDB 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc 5-METHYL-THF BioCyc Aminomethyltransferase 18714427 ChemSpider 1.0 1.0 1.0 SMILES [H][C@]1(COP(O)(=O)OP(O)(=O)O[C@@]2([H])OC[C@]([H])(N=CO)[C@]([H])(O)[C@@]2([H])O)O[C@@]([H])(N2C=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])O Dihydrofolic acid 5-Thymidylic acid Bifunctional purine biosynthesis protein purH HMDB01562 HMDB CHEBI:16474 ChEBI SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O HMDB59597 HMDB 439175 PubChem-compound 5736 ChemSpider HMDB00123 HMDB HMDB02305 HMDB METHYLENE-THF BioCyc 1010 ChemSpider HMDB00121 HMDB 6037 PubChem-compound C00101 KEGG Compound 1.0 10074-18-7 CAS P0AEZ1 UniProt 1.0 HMDB00696 HMDB C15H23N3O16P2 UDP-4-Deoxy-4-formamido-beta-L-arabinose 563.05536 Hydrogen Ion HMDB00217 HMDB 10-Formyltetrahydrofolate C00234 KEGG Compound 5-FORMYL-THF BioCyc 1.0 P0A884 UniProt 122347 PubChem-compound HMDB00221 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI C00364 KEGG Compound C00001 KEGG Compound 5,10-methylenetetrahydrofolate reductase C00005 KEGG Compound 135-16-0 CAS 388320 ChemSpider C00365 KEGG Compound 1.5.1.3 false 1.5.1.3 Folic acid + 2 Hydrogen Ion + 2 NADPH → 2 NADP + Tetrahydrofolic acid LEFT_TO_RIGHT HMDB01308 HMDB 1.0 2.0 1.0 C00014 KEGG Compound P37051 UniProt NAD(P) BioCyc H Hydrogen Ion 1.007825 CHEBI:18349 ChEBI HMDB01533 HMDB SMILES [H][C@]1(COP(O)(=O)OP(O)(=O)O[C@@]2([H])OC[C@]([H])(N)[C@]([H])(O)[C@@]2([H])O)O[C@@]([H])(N2C=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])O 58574 ChemSpider P27248 UniProt C00143 KEGG Compound MET BioCyc CHEBI:17013 ChEBI 3432-99-3 CAS HMDB01409 HMDB 1.0 C5H11NO2S L-Methionine 149.05106 2.0 Phosphoribosylglycinamide formyltransferase 2 1.0 C00037 KEGG Compound C03541 KEGG Compound Bifunctional polymyxin resistance protein ArnA Water http://identifiers.org/smpdb/SMP01750 SMPDB 98792 PubChem-compound L-methionyl-tRNA(Met) N-formylmethionyl-tRNA(fMet) 644350 PubChem-compound C04640 KEGG Compound Serine hydroxymethyltransferase DIHYDROFOLATE BioCyc Dihydrofolate reductase Methionyl-tRNA formyltransferase 7732-18-5 CAS P24186 UniProt C00058 KEGG Compound AMMONIA BioCyc SMILES N Bifunctional protein folD 63-68-3 CAS FORMATE BioCyc 5907 ChemSpider C20H23N7O7 10-Formyltetrahydrofolate 473.1659 56-40-6 CAS Methionine synthase C00065 KEGG Compound SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE BioCyc 2800-34-2 CAS L-Methionine 4033-27-6 CAS Thymidylate synthase C19H23N7O6 Tetrahydrofolate 445.171 Formyltetrahydrofolate deformylase C00073 KEGG Compound CHEBI:18381 ChEBI Tetrahydrofolate HMDB01846 HMDB 962 PubChem-compound HMDB00972 HMDB C8H16N3O8P 5'-phosphoribosyl-a-N-formylglycineamidine 313.0675 6.0 C00080 KEGG Compound Tetrahydrofolic acid 730 ChemSpider C4H9NO2S Homocysteine 135.0354 SMILES OC=O TMP BioCyc 5,10-Methenyltetrahydrofolic acid 5,10-methenyl-thf BioCyc 10-Formyltetrahydrofolate HMDB00742 HMDB C03479 KEGG Compound dihydrolipoylprotein HOMO-CYS BioCyc CHEBI:209153 ChEBI SMILES NC1=NC2=C(N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 FOLATE BioCyc Bifunctional purine biosynthesis protein purH SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 L-Serine C3H7NO3 L-Serine 105.042595 Aminomethyltransferase SMILES [H]C(=O)NC1=CN(N=C1C(N)=O)C1OC(COP(O)(O)=O)C(O)C1O 160913 PubChem-compound SMILES NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 64-18-6 CAS P13009 UniProt 757 ChemSpider SMILES [H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O SMILES NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1 22833512 PubChem-compound Homocysteine H2O Water 18.010565 SMILES NCC(O)=O P0A825 UniProt 5815 ChemSpider 559356 ChemSpider 5'-phosphoribosyl-a-N-formylglycineamidine PW000908 PathWhiz SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O 134-35-0 CAS 141370 ChemSpider 1.0 17215925 ChemSpider C10H15N4O9P FAICAR 366.05768 C9H15N4O8P 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide 338.06274 1.0 1.0 C05330 KEGG Compound 5,10-methylenetetrahydrofolate reductase SMILES O H3N Ammonia 17.026548 C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 1.0 SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 49791978 PubChem-compound 1.0 53-59-8 CAS 1038 PubChem-compound C04376 KEGG Compound SMILES CSCC[C@H](N)C(O)=O 5'-Phosphoribosyl-N-formylglycinamide 143 PubChem-compound 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 Ammonia DUMP BioCyc NADPH 1.0 SER BioCyc P15639 UniProt 149 ChemSpider Glycineamideribotide NADP C7H15N2O8P Glycineamideribotide 286.0566 C21H30N7O17P3 NADPH 745.0911 140 ChemSpider C21H29N7O17P3 NADP 744.08325 THF BioCyc 1.0 CHEBI:15641 ChEBI NADPH BioCyc GLY BioCyc S-Aminomethyldihydrolipoylprotein; 1.0 217 ChemSpider SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 C20H21N7O6 5,10-Methenyltetrahydrofolic acid 455.15533 1.0 One Carbon Pool by Folate I CHEBI:15637 ChEBI C2H5NO2 Glycine 75.03203 1.0 C19H19N7O6 Folic acid 441.13968 Formic acid 9319 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 5,10-Methylene-THF Serine hydroxymethyltransferase 5257127 PubChem-compound ReactionCatalysis2505 ACTIVATION ReactionCatalysis2504 ACTIVATION SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H23N7O6 5,10-Methylene-THF 457.171 ReactionCatalysis2507 ACTIVATION SMILES NCC(=O)N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 7664-41-7 CAS P33221 UniProt Dihydrofolate reductase PW001735 PathWhiz 1.0 53-57-6 CAS http://identifiers.org/smpdb/SMP00925 SMPDB ReactionCatalysis2509 ACTIVATION ReactionCatalysis2508 ACTIVATION SMILES N\C(CNC=O)=N/C1OC(COP(O)(O)=O)C(O)C1O 5951 PubChem-compound 222 PubChem-compound 1.0 ReactionCatalysis2512 ACTIVATION ReactionCatalysis2511 ACTIVATION 5,10-Methenyltetrahydrofolic acid ReactionCatalysis2514 ACTIVATION Thymidylate synthase ReactionCatalysis2516 ACTIVATION Glycine ReactionCatalysis2515 ACTIVATION ReactionCatalysis2518 ACTIVATION Folic acid ReactionCatalysis2517 ACTIVATION 1.0 SMILES NC(CCS)C(O)=O ReactionCatalysis2510 ACTIVATION P77398 UniProt 5,10-Methenyltetrahydrofolic acid 10-Formyltetrahydrofolate CHEBI:15633 ChEBI CHEBI:15636 ChEBI 1.0 ReactionCatalysis2519 ACTIVATION FAICAR 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide SMILES N[C@@H](CO)C(O)=O ReactionCatalysis2520 ACTIVATION CHEBI:17622 ChEBI 1.0 1.0 C9H13N2O8P dUMP 308.04095 C14H23N3O15P2 4-Amino-4-deoxy-L-arabinose 535.0604 5675 ChemSpider 65063 PubChem-compound ReactionCatalysis5899 ACTIVATION 1.0 dihydrolipoylprotein 18971002 PubChem-compound CHEBI:16635 ChEBI CH2O2 Formic acid 46.005478 SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(=O)NC1=O 1.0 dUMP C00504 KEGG Compound UDP-4-Deoxy-4-formamido-beta-L-arabinose 9700 PubChem-compound CHEBI:16643 ChEBI 349-34-8 CAS P23882 UniProt SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1 HMDB02022 HMDB HMDB01056 HMDB N5-Formyl-THF 5-Methyltetrahydrofolic acid 1.0 C20H23N7O7 N5-Formyl-THF 473.1659 C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 CHEBI:15428 ChEBI 115687 ChemSpider 1.0 130805 PubChem-compound UDP-L-Ara4N formyltransferase / UDP-GlcA C-4"-decarboxylase HMDB00051 HMDB HMDB02111 HMDB 2.1.1.45 false 2.1.1.45 5-Thymidylic acid + Dihydrofolic acid → 5,10-Methylene-THF + dUMP LEFT_TO_RIGHT 1.5.1.20 false 1.5.1.20 5,10-Methylene-THF + Hydrogen Ion + NADPH → 5-Methyltetrahydrofolic acid + NADP LEFT_TO_RIGHT 439234 PubChem-compound CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 Reaction5935 false 10-Formyltetrahydrofolate + 4-Amino-4-deoxy-L-arabinose → Tetrahydrofolate + UDP-4-Deoxy-4-formamido-beta-L-arabinose LEFT_TO_RIGHT 3.5.1.10 false 3.5.1.10 Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Water LEFT_TO_RIGHT 2.1.2.9 false 2.1.2.9 N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid ? 10-Formyltetrahydrofolate + L-methionyl-tRNA(Met) CHEBI:27470 ChEBI 2.1.2.- false 2.1.2.- 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Glycineamideribotide LEFT_TO_RIGHT 2.1.2.1 false 2.1.2.1 L-Serine + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Glycine + Water REVERSIBLE Reaction2545 false FAICAR + Tetrahydrofolic acid → 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + 10-Formyltetrahydrofolate LEFT_TO_RIGHT 2.1.1.13 false 2.1.1.13 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid LEFT_TO_RIGHT 2.1.2.10 false 2.1.2.10 S-Aminomethyldihydrolipoylprotein; + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Ammonia + dihydrolipoylprotein REVERSIBLE CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] Phosphoribosylglycinamide formyltransferase 2 CHEBI:18406 ChEBI 56-45-1 CAS 5886 PubChem-compound Bifunctional polymyxin resistance protein ArnA HMDB01396 HMDB HMDB00187 HMDB 154 PubChem-compound ReactionCatalysis4647 ACTIVATION 1.0 1.5.1.3 false 1.5.1.3 Dihydrofolic acid + NADP → Folic acid + Hydrogen Ion + NADPH LEFT_TO_RIGHT 1.5.1.3 false 1.5.1.3 Dihydrofolic acid + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid LEFT_TO_RIGHT 1.0 C00415 KEGG Compound 89228 ChemSpider Methionyl-tRNA formyltransferase N-formylmethionyl-tRNA(fMet) 388371 ChemSpider L-methionyl-tRNA(Met) 17756769 PubChem-compound 4-Amino-4-deoxy-L-arabinose 2.0 SubPathwayInteraction2806 SubPathwayReaction SubPathway2806Reaction 109092 ChemSpider Folate Biosynthesis SubPathway Bifunctional protein folD Formyltetrahydrofolate deformylase 1.5.1.5 false 1.5.1.5 10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water REVERSIBLE 2.1.2.10 false 2.1.2.10 5,10-Methenyltetrahydrofolic acid + Water → N5-Formyl-THF LEFT_TO_RIGHT 2.1.2.- false 2.1.2.- 5'-phosphoribosyl-a-N-formylglycineamidine + Tetrahydrofolic acid → 5,10-Methenyltetrahydrofolic acid + Glycineamideribotide + Water LEFT_TO_RIGHT 13781857 PubChem-compound 59-30-3 CAS 1.5.1.5 false 1.5.1.5 5,10-Methenyltetrahydrofolic acid + NADPH → 5,10-Methylene-THF + NADP LEFT_TO_RIGHT Dihydrofolate reductase Dihydrofolate reductase Trimethoprim resistant dihydrofolate reductase Thymidylate synthase 5,10- methylenetetrahydrofolate reductase Methionine synthase Serine hydroxymethyltransferase Bifunctional purine biosynthesis protein purH Phosphoribosylglycinamide formyltransferase 2 Formyltetrahydrofolate deformylase Methionyl-tRNA formyltransferase Phosphoribosylglycinamide formyltransferase 2 Bifunctional protein folD Aminomethyltransferase Bifunctional protein folD Aminomethyltransferase Bifunctional polymyxin resistance protein ArnA Dihydrofolic acid NADP Folic acid NADPH H + Dihydrofolic acid NADPH H + Tetrahydrofolic acid NADP Folic acid NADPH H + Tetrahydrofolic acid NADP Dihydrofolic acid 5-Thymidylic acid 5,10- Methylene-THF dUMP 5,10- Methylene-THF NADPH H + 5- Methyltetrahydrofolic acid NADP 5- Methyltetrahydrofolic acid Homocysteine Tetrahydrofolic acid L-Methionine Tetrahydrofolic acid L-Serine Glycine H 2 O Tetrahydrofolic acid FAICAR 10- Formyltetrahydrofolate 1-(5'- Phosphoribosyl)- 5-amino-4- imidazolecarboxamide Tetrahydrofolic acid 5'- Phosphoribosyl- N- formylglycinamide 10- Formyltetrahydrofolate Glycineamideribotide Formic acid Tetrahydrofolic acid H 2 O 10- Formyltetrahydrofolate Tetrahydrofolic acid 10- Formyltetrahydrofolate 5'- phosphoribosyl- a-N- formylglycineamidine Tetrahydrofolic acid H 2 O Glycineamideribotide 5,10- Methenyltetrahydrofolic acid 10- Formyltetrahydrofolate H + H 2 O H 2 O N5-Formyl-THF NADPH NADP Tetrahydrofolic acid 5,10- Methylene-THF NH 3 4-Amino-4- deoxy-L- arabinose Tetrahydrofolate UDP-4-Deoxy- 4-formamido- beta-L- arabinose S- Aminomethyldihydrolipoylprotein; dihydrolipoylprotein N- formylmethionyl- tRNA(fMet) L-methionyl- tRNA(Met) Folate Biosynthesis
454-29-5 CAS P0ABQ4 UniProt 1.0 HMDB01227 HMDB 365-07-1 CAS Methionine synthase 937 ChemSpider 964-26-1 CAS CHEBI:16134 ChEBI 58-05-9 CAS 10-FORMYL-THF BioCyc 1.0 C03838 KEGG Compound HMDB01354 HMDB CHEBI:20506 ChEBI CHEBI:17115 ChEBI 7444-29-3 CAS C19H21N7O6 Dihydrofolic acid 443.15533 C10H15N2O8P 5-Thymidylic acid 322.0566 CHEBI:17119 ChEBI C00440 KEGG Compound CHEBI:17230 ChEBI S-Aminomethyldihydrolipoylprotein; 6137 PubChem-compound C00445 KEGG Compound HMDB00142 HMDB 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc 5-METHYL-THF BioCyc Aminomethyltransferase 18714427 ChemSpider 1.0 1.0 1.0 SMILES [H][C@]1(COP(O)(=O)OP(O)(=O)O[C@@]2([H])OC[C@]([H])(N=CO)[C@]([H])(O)[C@@]2([H])O)O[C@@]([H])(N2C=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])O Dihydrofolic acid 5-Thymidylic acid Bifunctional purine biosynthesis protein purH HMDB01562 HMDB CHEBI:16474 ChEBI SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O HMDB59597 HMDB 439175 PubChem-compound 5736 ChemSpider HMDB00123 HMDB HMDB02305 HMDB METHYLENE-THF BioCyc 1010 ChemSpider HMDB00121 HMDB 6037 PubChem-compound C00101 KEGG Compound 1.0 10074-18-7 CAS P0AEZ1 UniProt 1.0 HMDB00696 HMDB C15H23N3O16P2 UDP-4-Deoxy-4-formamido-beta-L-arabinose 563.05536 Hydrogen Ion HMDB00217 HMDB 10-Formyltetrahydrofolate C00234 KEGG Compound 5-FORMYL-THF BioCyc 1.0 P0A884 UniProt 122347 PubChem-compound HMDB00221 HMDB C00006 KEGG Compound CHEBI:18009 ChEBI C00364 KEGG Compound C00001 KEGG Compound 5,10-methylenetetrahydrofolate reductase C00005 KEGG Compound 135-16-0 CAS 388320 ChemSpider C00365 KEGG Compound 1.5.1.3 false 1.5.1.3 Folic acid + 2 Hydrogen Ion + 2 NADPH → 2 NADP + Tetrahydrofolic acid LEFT_TO_RIGHT HMDB01308 HMDB 1.0 2.0 1.0 C00014 KEGG Compound P37051 UniProt NAD(P) BioCyc H Hydrogen Ion 1.007825 CHEBI:18349 ChEBI HMDB01533 HMDB SMILES [H][C@]1(COP(O)(=O)OP(O)(=O)O[C@@]2([H])OC[C@]([H])(N)[C@]([H])(O)[C@@]2([H])O)O[C@@]([H])(N2C=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])O 58574 ChemSpider P27248 UniProt C00143 KEGG Compound MET BioCyc CHEBI:17013 ChEBI 3432-99-3 CAS HMDB01409 HMDB 1.0 C5H11NO2S L-Methionine 149.05106 2.0 Phosphoribosylglycinamide formyltransferase 2 1.0 C00037 KEGG Compound C03541 KEGG Compound Bifunctional polymyxin resistance protein ArnA Water http://identifiers.org/smpdb/SMP01750 SMPDB 98792 PubChem-compound L-methionyl-tRNA(Met) N-formylmethionyl-tRNA(fMet) 644350 PubChem-compound C04640 KEGG Compound Serine hydroxymethyltransferase DIHYDROFOLATE BioCyc Dihydrofolate reductase Methionyl-tRNA formyltransferase 7732-18-5 CAS P24186 UniProt C00058 KEGG Compound AMMONIA BioCyc SMILES N Bifunctional protein folD 63-68-3 CAS FORMATE BioCyc 5907 ChemSpider C20H23N7O7 10-Formyltetrahydrofolate 473.1659 56-40-6 CAS Methionine synthase C00065 KEGG Compound SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE BioCyc 2800-34-2 CAS L-Methionine 4033-27-6 CAS Thymidylate synthase C19H23N7O6 Tetrahydrofolate 445.171 Formyltetrahydrofolate deformylase C00073 KEGG Compound CHEBI:18381 ChEBI Tetrahydrofolate HMDB01846 HMDB 962 PubChem-compound HMDB00972 HMDB C8H16N3O8P 5'-phosphoribosyl-a-N-formylglycineamidine 313.0675 6.0 C00080 KEGG Compound Tetrahydrofolic acid 730 ChemSpider C4H9NO2S Homocysteine 135.0354 SMILES OC=O TMP BioCyc 5,10-Methenyltetrahydrofolic acid 5,10-methenyl-thf BioCyc 10-Formyltetrahydrofolate HMDB00742 HMDB C03479 KEGG Compound dihydrolipoylprotein HOMO-CYS BioCyc CHEBI:209153 ChEBI SMILES NC1=NC2=C(N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 FOLATE BioCyc Bifunctional purine biosynthesis protein purH SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 L-Serine C3H7NO3 L-Serine 105.042595 Aminomethyltransferase SMILES [H]C(=O)NC1=CN(N=C1C(N)=O)C1OC(COP(O)(O)=O)C(O)C1O 160913 PubChem-compound SMILES NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 64-18-6 CAS P13009 UniProt 757 ChemSpider SMILES [H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O SMILES NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1 22833512 PubChem-compound Homocysteine H2O Water 18.010565 SMILES NCC(O)=O P0A825 UniProt 5815 ChemSpider 559356 ChemSpider 5'-phosphoribosyl-a-N-formylglycineamidine PW000908 PathWhiz SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O 134-35-0 CAS 141370 ChemSpider 1.0 17215925 ChemSpider C10H15N4O9P FAICAR 366.05768 C9H15N4O8P 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide 338.06274 1.0 1.0 C05330 KEGG Compound 5,10-methylenetetrahydrofolate reductase SMILES O H3N Ammonia 17.026548 C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 1.0 SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 49791978 PubChem-compound 1.0 53-59-8 CAS 1038 PubChem-compound C04376 KEGG Compound SMILES CSCC[C@H](N)C(O)=O 5'-Phosphoribosyl-N-formylglycinamide 143 PubChem-compound 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 Ammonia DUMP BioCyc NADPH 1.0 SER BioCyc P15639 UniProt 149 ChemSpider Glycineamideribotide NADP C7H15N2O8P Glycineamideribotide 286.0566 C21H30N7O17P3 NADPH 745.0911 140 ChemSpider C21H29N7O17P3 NADP 744.08325 THF BioCyc 1.0 CHEBI:15641 ChEBI NADPH BioCyc GLY BioCyc S-Aminomethyldihydrolipoylprotein; 1.0 217 ChemSpider SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 C20H21N7O6 5,10-Methenyltetrahydrofolic acid 455.15533 1.0 One Carbon Pool by Folate I CHEBI:15637 ChEBI C2H5NO2 Glycine 75.03203 1.0 C19H19N7O6 Folic acid 441.13968 Formic acid 9319 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 5,10-Methylene-THF Serine hydroxymethyltransferase 5257127 PubChem-compound ReactionCatalysis2505 ACTIVATION ReactionCatalysis2504 ACTIVATION SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H23N7O6 5,10-Methylene-THF 457.171 ReactionCatalysis2507 ACTIVATION SMILES NCC(=O)N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 7664-41-7 CAS P33221 UniProt Dihydrofolate reductase PW001735 PathWhiz 1.0 53-57-6 CAS http://identifiers.org/smpdb/SMP00925 SMPDB ReactionCatalysis2509 ACTIVATION ReactionCatalysis2508 ACTIVATION SMILES N\C(CNC=O)=N/C1OC(COP(O)(O)=O)C(O)C1O 5951 PubChem-compound 222 PubChem-compound 1.0 ReactionCatalysis2512 ACTIVATION ReactionCatalysis2511 ACTIVATION 5,10-Methenyltetrahydrofolic acid ReactionCatalysis2514 ACTIVATION Thymidylate synthase ReactionCatalysis2516 ACTIVATION Glycine ReactionCatalysis2515 ACTIVATION ReactionCatalysis2518 ACTIVATION Folic acid ReactionCatalysis2517 ACTIVATION 1.0 SMILES NC(CCS)C(O)=O ReactionCatalysis2510 ACTIVATION P77398 UniProt 5,10-Methenyltetrahydrofolic acid 10-Formyltetrahydrofolate CHEBI:15633 ChEBI CHEBI:15636 ChEBI 1.0 ReactionCatalysis2519 ACTIVATION FAICAR 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide SMILES N[C@@H](CO)C(O)=O ReactionCatalysis2520 ACTIVATION CHEBI:17622 ChEBI 1.0 1.0 C9H13N2O8P dUMP 308.04095 C14H23N3O15P2 4-Amino-4-deoxy-L-arabinose 535.0604 5675 ChemSpider 65063 PubChem-compound ReactionCatalysis5899 ACTIVATION 1.0 dihydrolipoylprotein 18971002 PubChem-compound CHEBI:16635 ChEBI CH2O2 Formic acid 46.005478 SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(=O)NC1=O 1.0 dUMP C00504 KEGG Compound UDP-4-Deoxy-4-formamido-beta-L-arabinose 9700 PubChem-compound CHEBI:16643 ChEBI 349-34-8 CAS P23882 UniProt SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1 HMDB02022 HMDB HMDB01056 HMDB N5-Formyl-THF 5-Methyltetrahydrofolic acid 1.0 C20H23N7O7 N5-Formyl-THF 473.1659 C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 CHEBI:15428 ChEBI 115687 ChemSpider 1.0 130805 PubChem-compound UDP-L-Ara4N formyltransferase / UDP-GlcA C-4"-decarboxylase HMDB00051 HMDB HMDB02111 HMDB 2.1.1.45 false 2.1.1.45 5-Thymidylic acid + Dihydrofolic acid → 5,10-Methylene-THF + dUMP LEFT_TO_RIGHT 1.5.1.20 false 1.5.1.20 5,10-Methylene-THF + Hydrogen Ion + NADPH → 5-Methyltetrahydrofolic acid + NADP LEFT_TO_RIGHT 439234 PubChem-compound CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 Reaction5935 false 10-Formyltetrahydrofolate + 4-Amino-4-deoxy-L-arabinose → Tetrahydrofolate + UDP-4-Deoxy-4-formamido-beta-L-arabinose LEFT_TO_RIGHT 3.5.1.10 false 3.5.1.10 Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Water LEFT_TO_RIGHT 2.1.2.9 false 2.1.2.9 N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid ? 10-Formyltetrahydrofolate + L-methionyl-tRNA(Met) CHEBI:27470 ChEBI 2.1.2.- false 2.1.2.- 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Glycineamideribotide LEFT_TO_RIGHT 2.1.2.1 false 2.1.2.1 L-Serine + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Glycine + Water REVERSIBLE Reaction2545 false FAICAR + Tetrahydrofolic acid → 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + 10-Formyltetrahydrofolate LEFT_TO_RIGHT 2.1.1.13 false 2.1.1.13 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid LEFT_TO_RIGHT 2.1.2.10 false 2.1.2.10 S-Aminomethyldihydrolipoylprotein; + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Ammonia + dihydrolipoylprotein REVERSIBLE CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] Phosphoribosylglycinamide formyltransferase 2 CHEBI:18406 ChEBI 56-45-1 CAS 5886 PubChem-compound Bifunctional polymyxin resistance protein ArnA HMDB01396 HMDB HMDB00187 HMDB 154 PubChem-compound ReactionCatalysis4647 ACTIVATION 1.0 1.5.1.3 false 1.5.1.3 Dihydrofolic acid + NADP → Folic acid + Hydrogen Ion + NADPH LEFT_TO_RIGHT 1.5.1.3 false 1.5.1.3 Dihydrofolic acid + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid LEFT_TO_RIGHT 1.0 C00415 KEGG Compound 89228 ChemSpider Methionyl-tRNA formyltransferase N-formylmethionyl-tRNA(fMet) 388371 ChemSpider L-methionyl-tRNA(Met) 17756769 PubChem-compound 4-Amino-4-deoxy-L-arabinose 2.0 SubPathwayInteraction2806 SubPathwayReaction SubPathway2806Reaction 109092 ChemSpider Folate Biosynthesis SubPathway Bifunctional protein folD Formyltetrahydrofolate deformylase 1.5.1.5 false 1.5.1.5 10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water REVERSIBLE 2.1.2.10 false 2.1.2.10 5,10-Methenyltetrahydrofolic acid + Water → N5-Formyl-THF LEFT_TO_RIGHT 2.1.2.- false 2.1.2.- 5'-phosphoribosyl-a-N-formylglycineamidine + Tetrahydrofolic acid → 5,10-Methenyltetrahydrofolic acid + Glycineamideribotide + Water LEFT_TO_RIGHT 13781857 PubChem-compound 59-30-3 CAS 1.5.1.5 false 1.5.1.5 5,10-Methenyltetrahydrofolic acid + NADPH → 5,10-Methylene-THF + NADP LEFT_TO_RIGHT