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CHEBI:16015 ChEBI 30572 ChemSpider 17215925 ChemSpider 6022 PubChem-compound CHEBI:12575 ChEBI C23H38N7O17P3S Acetyl-CoA 809.1258 CHEBI:16934 ChEBI L-Glutamine 937 ChemSpider CHEBI:16134 ChEBI HMDB01341 HMDB N-Acetyl-L-alanine Gamma-glutamyltranspeptidase ReactionCatalysis2659 ACTIVATION SMILES O H3N Ammonia 17.026548 ReactionCatalysis5122 ACTIVATION 50 ChemSpider 1.0 1.0 1.0 HMDB00148 HMDB SMILES NC(CCC(O)=NC(CC#N)C(O)=O)C(O)=O ATP BioCyc 5961 PubChem-compound http://identifiers.org/smpdb/SMP00959 SMPDB 1.0 H4N Ammonium 18.034374 1.0 6816 PubChem-compound 51 PubChem-compound ADP BioCyc 1.0 P00370 UniProt 53-59-8 CAS 5746 ChemSpider HMDB01206 HMDB 1.0 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI Amino-acid acetyltransferase Ammonia HMDB59597 HMDB C5H6O5 Oxoglutaric acid 146.02153 1.0 NADP-specific glutamate dehydrogenase 3-Cyano-L-alanine O4P Phosphate 94.95342 Acetyl-CoA NADPH 1010 ChemSpider GO:0070258 GENE ONTOLOGY SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS HMDB41827 HMDB NADP TCA cycle SubPathway C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000942 PathWhiz L-alanine metabolism SubPathway BiologicalState109 Escherichia coli, Inner Membrane 1.0 NADPH BioCyc HMDB01423 HMDB Ammonium C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion HMDB00217 HMDB 218 ChemSpider 217 ChemSpider L-Glutamic acid Glutamine transport ATP-binding protein glnQ SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB00208 HMDB CHEBI:30915 ChEBI PW000779 PathWhiz Hydrogen Ion HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound ACETYL-GLU BioCyc ReactionCoupledTransportCatalysis141 ACTIVATION P0A6W0 UniProt C00005 KEGG Compound CHEBI:18367 ChEBI Inner Membrane 1032 ChemSpider N-Acetylglutamic acid Gamma-glutamyltranspeptidase C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O ReactionCoupledTransport107 false Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate LEFT_TO_RIGHT 439742 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc HMDB01429 HMDB GLT BioCyc 7664-41-7 CAS 53-57-6 CAS http://identifiers.org/smpdb/SMP00802 SMPDB C01342 KEGG Compound glutaminase 1 CHEBI:28938 ChEBI C00010 KEGG Compound 440768 PubChem-compound 222 PubChem-compound C00014 KEGG Compound NAD(P) BioCyc glutaminase 2 5957 PubChem-compound 1188-37-0 CAS 97-69-8 CAS 562 TAXONOMY H Hydrogen Ion 1.007825 C5H9NO3 N-Acetyl-L-alanine 131.05824 http://identifiers.org/smpdb/SMP01900 SMPDB http://identifiers.org/smpdb/SMP00810 SMPDB L-Glutamine 56-65-5 CAS C00026 KEGG Compound C00025 KEGG Compound Amino-acid acetyltransferase C00024 KEGG Compound C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 glutaminase Glutamine transport system permease protein glnP Glutamine-binding periplasmic protein SubPathwayInteraction2936 SubPathwayReaction SubPathway2936Reaction SubPathwayInteraction2937 SubPathway2937Reaction SubPathwayReaction SubPathwayInteraction2935 SubPathway2935Reaction SubPathwayReaction Adenosine triphosphate 1.0 CPD-8587 BioCyc P18956 UniProt gamma-Glutamyl-beta-cyanoalanine 328-50-7 CAS CHEBI:1146900 ChEBI Water 2.0 79449 ChemSpider Phosphate CO-A BioCyc 1.0 SMILES C[C@H](NC(C)=O)C(O)=O 5675 ChemSpider 72-89-9 CAS 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 14798-03-9 CAS HMDB00538 HMDB L-glutamate metabolism II SMILES [H][C@](N)(CC#N)C(O)=O Water CHEBI:15422 ChEBI C7H11NO5 N-Acetylglutamic acid 189.06372 P0AEQ3 UniProt P0A6C5 UniProt 6557 ChemSpider P0AEQ6 UniProt SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS Glutamine transport system permease protein glnP AMMONIA BioCyc SMILES N 56-86-0 CAS 2.3.2.2 false 2.3.2.2 3-Cyano-L-alanine + L-Glutamic acid → Water + gamma-Glutamyl-beta-cyanoalanine LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] C00624 KEGG Compound PW001886 PathWhiz HMDB00641 HMDB P10346 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 HMDB00766 HMDB 1.0 glutaminase 1 C9H13N3O5 gamma-Glutamyl-beta-cyanoalanine 243.08553 glutaminase 2 C00064 KEGG Compound 1.0 CHEBI:16761 ChEBI 88064 PubChem-compound 3.5.1.2 false 3.5.1.2 L-Glutamine + Water → Ammonia + L-Glutamic acid LEFT_TO_RIGHT PW000788 PathWhiz pyrimidine metabolism SubPathway 962 PubChem-compound C4H6N2O2 3-Cyano-L-alanine 114.04293 2-KETOGLUTARATE BioCyc glutamine ABC transporter 5800 ChemSpider 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O HMDB00051 HMDB HMDB02111 HMDB C00080 KEGG Compound Oxoglutaric acid 1.0 SMILES N[C@@H](CCC(O)=O)C(O)=O Reaction2666 false Ammonium + Hydrogen Ion + NADPH + Oxoglutaric acid → L-Glutamic acid + NADP + Water LEFT_TO_RIGHT P77454 UniProt CHEBI:15377 ChEBI NADP-specific glutamate dehydrogenase CHEBI:15378 ChEBI SMILES [H+] Glutamine-binding periplasmic protein 14265-44-2 CAS 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 Glutamine transport ATP-binding protein glnQ 1.0 1.0 2.0 444493 PubChem-compound 16741146 PubChem-compound 185 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 22833512 PubChem-compound ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 1061 PubChem-compound CHEBI:40992 ChEBI HMDB01138 HMDB CHEBI:15351 ChEBI 1.0 2.3.1.1 false 2.3.1.1 Acetyl-CoA + L-Glutamic acid ↔ Coenzyme A + Hydrogen Ion + N-Acetyl-L-alanine + N-Acetylglutamic acid REVERSIBLE ReactionCatalysis5879 ACTIVATION ReactionCatalysis2481 ACTIVATION Adenosine diphosphate 85-61-0 CAS 180 ChemSpider 1.0 glutaminase 2 glutaminase 1 NADP-specific glutamate dehydrogenase Amino-acid acetyltransferase Gamma- glutamyltranspeptidase Glutamine transport ATP-binding protein glnQ Glutamine transport system permease protein glnP Glutamine- binding periplasmic protein L-Glutamine H 2 O L-Glutamic acid NH 3 Oxoglutaric acid NADPH Ammonium H + H 2 O NADP Acetyl-CoA N-Acetyl-L- alanine CoA H + N- Acetylglutamic acid 3-Cyano-L- alanine H 2 O gamma- Glutamyl- beta- cyanoalanine L-Glutamine ATP H 2 O ADP P i H + L-Glutamine TCA cycle
CHEBI:16015 ChEBI 30572 ChemSpider 17215925 ChemSpider 6022 PubChem-compound CHEBI:12575 ChEBI C23H38N7O17P3S Acetyl-CoA 809.1258 CHEBI:16934 ChEBI L-Glutamine 937 ChemSpider CHEBI:16134 ChEBI HMDB01341 HMDB N-Acetyl-L-alanine Gamma-glutamyltranspeptidase ReactionCatalysis2659 ACTIVATION SMILES O H3N Ammonia 17.026548 ReactionCatalysis5122 ACTIVATION 50 ChemSpider 1.0 1.0 1.0 HMDB00148 HMDB SMILES NC(CCC(O)=NC(CC#N)C(O)=O)C(O)=O ATP BioCyc 5961 PubChem-compound http://identifiers.org/smpdb/SMP00959 SMPDB 1.0 H4N Ammonium 18.034374 1.0 6816 PubChem-compound 51 PubChem-compound ADP BioCyc 1.0 P00370 UniProt 53-59-8 CAS 5746 ChemSpider HMDB01206 HMDB 1.0 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI Amino-acid acetyltransferase Ammonia HMDB59597 HMDB C5H6O5 Oxoglutaric acid 146.02153 1.0 NADP-specific glutamate dehydrogenase 3-Cyano-L-alanine O4P Phosphate 94.95342 Acetyl-CoA NADPH 1010 ChemSpider GO:0070258 GENE ONTOLOGY SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS HMDB41827 HMDB NADP TCA cycle SubPathway C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 PW000942 PathWhiz L-alanine metabolism SubPathway BiologicalState109 Escherichia coli, Inner Membrane 1.0 NADPH BioCyc HMDB01423 HMDB Ammonium C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion HMDB00217 HMDB 218 ChemSpider 217 ChemSpider L-Glutamic acid Glutamine transport ATP-binding protein glnQ SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB00208 HMDB CHEBI:30915 ChEBI PW000779 PathWhiz Hydrogen Ion HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound ACETYL-GLU BioCyc ReactionCoupledTransportCatalysis141 ACTIVATION P0A6W0 UniProt C00005 KEGG Compound CHEBI:18367 ChEBI Inner Membrane 1032 ChemSpider N-Acetylglutamic acid Gamma-glutamyltranspeptidase C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O ReactionCoupledTransport107 false Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate LEFT_TO_RIGHT 439742 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc HMDB01429 HMDB GLT BioCyc 7664-41-7 CAS 53-57-6 CAS http://identifiers.org/smpdb/SMP00802 SMPDB C01342 KEGG Compound glutaminase 1 CHEBI:28938 ChEBI C00010 KEGG Compound 440768 PubChem-compound 222 PubChem-compound C00014 KEGG Compound NAD(P) BioCyc glutaminase 2 5957 PubChem-compound 1188-37-0 CAS 97-69-8 CAS 562 TAXONOMY H Hydrogen Ion 1.007825 C5H9NO3 N-Acetyl-L-alanine 131.05824 http://identifiers.org/smpdb/SMP01900 SMPDB http://identifiers.org/smpdb/SMP00810 SMPDB L-Glutamine 56-65-5 CAS C00026 KEGG Compound C00025 KEGG Compound Amino-acid acetyltransferase C00024 KEGG Compound C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 glutaminase Glutamine transport system permease protein glnP Glutamine-binding periplasmic protein SubPathwayInteraction2936 SubPathwayReaction SubPathway2936Reaction SubPathwayInteraction2937 SubPathway2937Reaction SubPathwayReaction SubPathwayInteraction2935 SubPathway2935Reaction SubPathwayReaction Adenosine triphosphate 1.0 CPD-8587 BioCyc P18956 UniProt gamma-Glutamyl-beta-cyanoalanine 328-50-7 CAS CHEBI:1146900 ChEBI Water 2.0 79449 ChemSpider Phosphate CO-A BioCyc 1.0 SMILES C[C@H](NC(C)=O)C(O)=O 5675 ChemSpider 72-89-9 CAS 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 14798-03-9 CAS HMDB00538 HMDB L-glutamate metabolism II SMILES [H][C@](N)(CC#N)C(O)=O Water CHEBI:15422 ChEBI C7H11NO5 N-Acetylglutamic acid 189.06372 P0AEQ3 UniProt P0A6C5 UniProt 6557 ChemSpider P0AEQ6 UniProt SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS Glutamine transport system permease protein glnP AMMONIA BioCyc SMILES N 56-86-0 CAS 2.3.2.2 false 2.3.2.2 3-Cyano-L-alanine + L-Glutamic acid → Water + gamma-Glutamyl-beta-cyanoalanine LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] C00624 KEGG Compound PW001886 PathWhiz HMDB00641 HMDB P10346 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 HMDB00766 HMDB 1.0 glutaminase 1 C9H13N3O5 gamma-Glutamyl-beta-cyanoalanine 243.08553 glutaminase 2 C00064 KEGG Compound 1.0 CHEBI:16761 ChEBI 88064 PubChem-compound 3.5.1.2 false 3.5.1.2 L-Glutamine + Water → Ammonia + L-Glutamic acid LEFT_TO_RIGHT PW000788 PathWhiz pyrimidine metabolism SubPathway 962 PubChem-compound C4H6N2O2 3-Cyano-L-alanine 114.04293 2-KETOGLUTARATE BioCyc glutamine ABC transporter 5800 ChemSpider 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O HMDB00051 HMDB HMDB02111 HMDB C00080 KEGG Compound Oxoglutaric acid 1.0 SMILES N[C@@H](CCC(O)=O)C(O)=O Reaction2666 false Ammonium + Hydrogen Ion + NADPH + Oxoglutaric acid → L-Glutamic acid + NADP + Water LEFT_TO_RIGHT P77454 UniProt CHEBI:15377 ChEBI NADP-specific glutamate dehydrogenase CHEBI:15378 ChEBI SMILES [H+] Glutamine-binding periplasmic protein 14265-44-2 CAS 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 Glutamine transport ATP-binding protein glnQ 1.0 1.0 2.0 444493 PubChem-compound 16741146 PubChem-compound 185 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 22833512 PubChem-compound ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 1061 PubChem-compound CHEBI:40992 ChEBI HMDB01138 HMDB CHEBI:15351 ChEBI 1.0 2.3.1.1 false 2.3.1.1 Acetyl-CoA + L-Glutamic acid ↔ Coenzyme A + Hydrogen Ion + N-Acetyl-L-alanine + N-Acetylglutamic acid REVERSIBLE ReactionCatalysis5879 ACTIVATION ReactionCatalysis2481 ACTIVATION Adenosine diphosphate 85-61-0 CAS 180 ChemSpider 1.0 glsB glsA gdhA argA ggt glnQ glnP glnH L-Glutamine Water L-Glutamic acid Ammonia Oxoglutaric acid NADPH Ammonium Hydrogen Ion Water NADP Acetyl-CoA N-Acetyl-L- alanine Coenzyme A Hydrogen Ion N- Acetylglutamic acid 3-Cyano-L- alanine Water gamma- Glutamyl- beta- cyanoalanine L-Glutamine Adenosine triphosphate Water Adenosine diphosphate Phosphate Hydrogen Ion L-Glutamine TCA cycle