Loading Pathway...
6.3.4.20 false 6.3.4.20 7-Deaza-7-carboxyguanine + Adenosine triphosphate + Ammonium → 7-Cyano-7-carbaguanine + Adenosine diphosphate + Hydrogen Ion + Phosphate + Water LEFT_TO_RIGHT 6022 PubChem-compound 17215925 ChemSpider 72496-59-4 CAS 1.7.1.13 false 1.7.1.13 7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 7-Aminomethyl-7-carbaguanine + 2 NADP LEFT_TO_RIGHT 7-Cyano-7-carbaguanine Reaction5182 false 7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 2 NADP + Queuine LEFT_TO_RIGHT 2.4.2.29 false 2.4.2.29 7-Aminomethyl-7-carbaguanine + tRNA guanine → 7-aminomethyl-7-deazaguanosine34 in tRNA + Guanine LEFT_TO_RIGHT Reaction5184 true 7-Aminomethyl-7-carbaguanine ↔ 7-Aminomethyl-7-deazaguanosine REVERSIBLE 937 ChemSpider 13344694 PubChem-compound HMDB01341 HMDB HMDB00132 HMDB GTP cyclohydrolase 1 SMILES O 7-aminomethyl-7-deazaguanosine34 in tRNA SMILES NC1=NC2=C(NC(CN2)C(O)=O)C(=O)N1 tRNA guanine 4.1.2.50 false 4.1.2.50 7,8-dihydroneopterin 3'-triphosphate + Water → 6-Carboxy-5,6,7,8-tetrahydropterin + Acetaldehyde + 2 Hydrogen Ion + Triphosphate LEFT_TO_RIGHT Reaction5179 true 6-Carboxy-5,6,7,8-tetrahydropterin + Hydrogen Ion → 7-Deaza-7-carboxyguanine + Ammonium LEFT_TO_RIGHT 1.0 SMILES [H]C12OC1([H])C([H])(NCC1=CN(C3=C1C(O)=NC(=N)N3)[C@]1([H])O[C@]([H])(CO)[C@@]([H])(O)[C@@]1([H])O)C([H])(O)C2([H])O SMILES [H]OC(=O)C1=C([H])N([H])C2=C1C(=O)N=C(N([H])[H])N2[H] C9H12N5O13P3 7,8-dihydroneopterin 3'-triphosphate 490.96664 ATP BioCyc 6137 PubChem-compound HMDB00142 HMDB H4N Ammonium 18.034374 1.0 NADPH-dependent 7-cyano-7-deazaguanine reductase QUEUINE BioCyc 1.0 191792 PubChem-compound ADP BioCyc 1.0 CHEBI:16235 ChEBI C15H23N6O5S S-Adenosylmethionine 399.14505 53-59-8 CAS 1.0 446357 PubChem-compound 2683694 ChemSpider 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI SMILES CSCC[C@H](N)C(O)=O 7-cyano-7-deazaguanine synthase 278 ChemSpider HMDB59597 HMDB P77756 UniProt SMILES [H][C@]1(CO)O[C@@]([H])(N2C=C(CN)C3=C2NC(=N)N=C3O)[C@]([H])(O)[C@]1([H])O ReactionCatalysis5149 ACTIVATION ReactionCatalysis5148 ACTIVATION C7H5N5O 7-Cyano-7-carbaguanine 175.04941 ReactionCatalysis5152 ACTIVATION ReactionCatalysis5153 ACTIVATION ReactionCatalysis5150 ACTIVATION ReactionCatalysis5151 ACTIVATION O4P Phosphate 94.95342 NADPH 6830 PubChem-compound 1010 ChemSpider 1.0 Adenine HMDB41827 HMDB NADP C21H30N7O17P3 NADPH 745.0911 2.4.99.17 false 2.4.99.17 7-aminomethyl-7-deazaguanosine34 in tRNA + S-Adenosylmethionine → Adenine + Hydrogen Ion + L-Methionine + epoxyqueuosine LEFT_TO_RIGHT C5H5N5 Adenine 135.05449 C21H29N7O17P3 NADP 744.08325 C01449 KEGG Compound NADPH BioCyc HMDB00696 HMDB Ammonium C10H16N5O14P3 Guanosine triphosphate 522.99066 Hydrogen Ion HMDB00217 HMDB SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 Triphosphate 218 ChemSpider Adenosine triphosphate 1.0 C7H9N5O 7-Aminomethyl-7-carbaguanine 179.0807 14127-68-5 CAS SMILES [O-]P([O-])([O-])=O Formic acid C12H17N5O5 7-Aminomethyl-7-deazaguanosine 311.12296 CHEBI:61032 ChEBI C00009 KEGG Compound HMDB00221 HMDB C00008 KEGG Compound C00006 KEGG Compound 53477731 PubChem-compound CHEBI:15414 ChEBI ADENINE BioCyc CHEBI:18009 ChEBI C00001 KEGG Compound C00242 KEGG Compound 1.0 C00005 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider GTP cyclohydrolase 1 P65870 UniProt C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Guanine Queuine tRNA-ribosyltransferase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O SMILES NC1=C2NC=NC2=NC=N1 HMDB01429 HMDB C5H5N5O Guanine 151.04941 GTP cyclohydrolase I 53-57-6 CAS 2.0 tRNA guanine 7-aminomethyl-7-deazaguanosine34 in tRNA C00019 KEGG Compound 1.0 GUANINE BioCyc 1.0 C01342 KEGG Compound S-ADENOSYLMETHIONINE BioCyc CHEBI:28938 ChEBI NADPH-dependent 7-cyano-7-deazaguanine reductase 7,8-dihydroneopterin 3'-triphosphate HMDB11690 HMDB NAD(P) BioCyc 7-Aminomethyl-7-carbaguanine 5957 PubChem-compound CHEBI:45126 ChEBI CHEBI:16708 ChEBI H Hydrogen Ion 1.007825 CHEBI:15996 ChEBI 56-65-5 CAS MET BioCyc C00147 KEGG Compound 1.0 http://identifiers.org/smpdb/SMP01907 SMPDB Guanosine triphosphate Adenosine diphosphate C12H15N5O3 Queuine 277.1175 C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 Queuine 73-24-5 CAS 764 PubChem-compound C5H11NO2S L-Methionine 149.05106 epoxyqueuosine 2.0 6-Carboxy-5,6,7,8-tetrahydropterin 7-Deaza-7-carboxyguanine preQ0 metabolism CPD-8587 BioCyc CHEBI:18036 ChEBI HMDB01185 HMDB Water 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT 1.0 P0A847 UniProt SMILES OC1=NC(=N)NC2=C1C(=CN2)C#N 6.0 HMDB03379 HMDB C00044 KEGG Compound 5675 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES O[C@@H]1C=C[C@@H](NCC2=CNC3=C2C(=O)NC(=N)N3)[C@@H]1O 73-40-5 CAS 14798-03-9 CAS 18971002 PubChem-compound HMDB00538 HMDB CHEBI:15422 ChEBI PW001893 PathWhiz 7732-18-5 CAS Queuine tRNA-ribosyltransferase C00058 KEGG Compound HMDB00990 HMDB S-adenosylmethionine:tRNA ribosyltransferase-isomerase CH2O2 Formic acid 46.005478 ReactionCatalysis3364 ACTIVATION 63-68-3 CAS FORMATE BioCyc 7-Aminomethyl-7-deazaguanosine 10.0 1.0 5907 ChemSpider C7H9N5O3 6-Carboxy-5,6,7,8-tetrahydropterin 211.07054 C7H6N4O3 7-Deaza-7-carboxyguanine 194.04399 SMILES [NH4+] 44123380 PubChem-compound CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 C17H23N5O8 epoxyqueuosine 425.15466 1.0 P0A7F9 UniProt Acetaldehyde O10P3 Triphosphate 252.87044 L-Methionine CHEBI:16761 ChEBI P0A6T5 UniProt 1.0 C00073 KEGG Compound 25201779 PubChem-compound C2H4O Acetaldehyde 44.026215 3440921 PubChem-compound 6-carboxy-5,6,7,8-tetrahydropterin synthase CHEBI:61125 ChEBI 962 PubChem-compound 31983 ChemSpider 2.0 5800 ChemSpider Phosphate 1.0 HMDB02111 HMDB C00080 KEGG Compound CHEBI:30751 ChEBI C00084 KEGG Compound 75-07-0 CAS 172 ChemSpider 3.0 SMILES OC=O CHEBI:15377 ChEBI CHEBI:17433 ChEBI 30776547 ChemSpider CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS 6569 ChemSpider ACETALD BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound HMDB01273 HMDB GTP BioCyc S-Adenosylmethionine SMILES [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O 1.0 1.0 1.0 CHEBI:45075 ChEBI SMILES CC=O 166 ChemSpider tRNA-guanine transglycosylase 7-cyano-7-deazaguanine reductase 6-carboxy-5,6,7,8-tetrahydropterin synthase 3.0 HMDB00034 HMDB CHEBI:15343 ChEBI C00536 KEGG Compound 1.0 16741146 PubChem-compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 64-18-6 CAS 22833512 PubChem-compound 7-cyano-7-deazaguanine synthase 1.0 H2O Water 18.010565 SMILES NCC1=CNC2=C1C(=O)NC(N)=N2 190 PubChem-compound 1.0 86-01-1 CAS C16675 KEGG Compound 2.0 29908-03-0 CAS 1061 PubChem-compound SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1 Q46920 UniProt 171 PubChem-compound 177 PubChem-compound S-adenosylmethionine:tRNA ribosyltransferase-isomerase HMDB01495 HMDB 744 ChemSpider 24762165 PubChem-compound 6-carboxy-5,6,7,8-tetrahydropterin synthase SMILES NC1=NC(=O)C2=C(N1)N=CN2 1.0 185 ChemSpider GTP cyclohydrolase 1 6-carboxy- 5,6,7,8- tetrahydropterin synthase 7-cyano-7- deazaguanine synthase NADPH-dependent 7-cyano-7- deazaguanine reductase NADPH-dependent 7-cyano-7- deazaguanine reductase Queuine tRNA- ribosyltransferase S- adenosylmethionine:tRNA ribosyltransferase- isomerase Guanosine triphosphate H 2 O Formic acid H + 7,8- dihydroneopterin 3'-triphosphate H 2 O Acetaldehyde Triphosphate H + 6-Carboxy- 5,6,7,8- tetrahydropterin H + 7-Deaza-7- carboxyguanine Ammonium ATP Ammonium H 2 O P i ADP H + 7-Cyano-7- carbaguanine H + NADPH NADP 7- Aminomethyl- 7- carbaguanine H + NADPH Queuine NADP Guanine 7- Aminomethyl- 7- deazaguanosine S- Adenosylmethionine H + L-Methionine Adenine epoxyqueuosine Zinc (II) ion tRNA guanine 7- aminomethyl- 7- deazaguanosine34 in tRNA
6.3.4.20 false 6.3.4.20 7-Deaza-7-carboxyguanine + Adenosine triphosphate + Ammonium → 7-Cyano-7-carbaguanine + Adenosine diphosphate + Hydrogen Ion + Phosphate + Water LEFT_TO_RIGHT 6022 PubChem-compound 17215925 ChemSpider 72496-59-4 CAS 1.7.1.13 false 1.7.1.13 7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 7-Aminomethyl-7-carbaguanine + 2 NADP LEFT_TO_RIGHT 7-Cyano-7-carbaguanine Reaction5182 false 7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 2 NADP + Queuine LEFT_TO_RIGHT 2.4.2.29 false 2.4.2.29 7-Aminomethyl-7-carbaguanine + tRNA guanine → 7-aminomethyl-7-deazaguanosine34 in tRNA + Guanine LEFT_TO_RIGHT Reaction5184 true 7-Aminomethyl-7-carbaguanine ↔ 7-Aminomethyl-7-deazaguanosine REVERSIBLE 937 ChemSpider 13344694 PubChem-compound HMDB01341 HMDB HMDB00132 HMDB GTP cyclohydrolase 1 SMILES O 7-aminomethyl-7-deazaguanosine34 in tRNA SMILES NC1=NC2=C(NC(CN2)C(O)=O)C(=O)N1 tRNA guanine 4.1.2.50 false 4.1.2.50 7,8-dihydroneopterin 3'-triphosphate + Water → 6-Carboxy-5,6,7,8-tetrahydropterin + Acetaldehyde + 2 Hydrogen Ion + Triphosphate LEFT_TO_RIGHT Reaction5179 true 6-Carboxy-5,6,7,8-tetrahydropterin + Hydrogen Ion → 7-Deaza-7-carboxyguanine + Ammonium LEFT_TO_RIGHT 1.0 SMILES [H]C12OC1([H])C([H])(NCC1=CN(C3=C1C(O)=NC(=N)N3)[C@]1([H])O[C@]([H])(CO)[C@@]([H])(O)[C@@]1([H])O)C([H])(O)C2([H])O SMILES [H]OC(=O)C1=C([H])N([H])C2=C1C(=O)N=C(N([H])[H])N2[H] C9H12N5O13P3 7,8-dihydroneopterin 3'-triphosphate 490.96664 ATP BioCyc 6137 PubChem-compound HMDB00142 HMDB H4N Ammonium 18.034374 1.0 NADPH-dependent 7-cyano-7-deazaguanine reductase QUEUINE BioCyc 1.0 191792 PubChem-compound ADP BioCyc 1.0 CHEBI:16235 ChEBI C15H23N6O5S S-Adenosylmethionine 399.14505 53-59-8 CAS 1.0 446357 PubChem-compound 2683694 ChemSpider 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI SMILES CSCC[C@H](N)C(O)=O 7-cyano-7-deazaguanine synthase 278 ChemSpider HMDB59597 HMDB P77756 UniProt SMILES [H][C@]1(CO)O[C@@]([H])(N2C=C(CN)C3=C2NC(=N)N=C3O)[C@]([H])(O)[C@]1([H])O ReactionCatalysis5149 ACTIVATION ReactionCatalysis5148 ACTIVATION C7H5N5O 7-Cyano-7-carbaguanine 175.04941 ReactionCatalysis5152 ACTIVATION ReactionCatalysis5153 ACTIVATION ReactionCatalysis5150 ACTIVATION ReactionCatalysis5151 ACTIVATION O4P Phosphate 94.95342 NADPH 6830 PubChem-compound 1010 ChemSpider 1.0 Adenine HMDB41827 HMDB NADP C21H30N7O17P3 NADPH 745.0911 2.4.99.17 false 2.4.99.17 7-aminomethyl-7-deazaguanosine34 in tRNA + S-Adenosylmethionine → Adenine + Hydrogen Ion + L-Methionine + epoxyqueuosine LEFT_TO_RIGHT C5H5N5 Adenine 135.05449 C21H29N7O17P3 NADP 744.08325 C01449 KEGG Compound NADPH BioCyc HMDB00696 HMDB Ammonium C10H16N5O14P3 Guanosine triphosphate 522.99066 Hydrogen Ion HMDB00217 HMDB SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 Triphosphate 218 ChemSpider Adenosine triphosphate 1.0 C7H9N5O 7-Aminomethyl-7-carbaguanine 179.0807 14127-68-5 CAS SMILES [O-]P([O-])([O-])=O Formic acid C12H17N5O5 7-Aminomethyl-7-deazaguanosine 311.12296 CHEBI:61032 ChEBI C00009 KEGG Compound HMDB00221 HMDB C00008 KEGG Compound C00006 KEGG Compound 53477731 PubChem-compound CHEBI:15414 ChEBI ADENINE BioCyc CHEBI:18009 ChEBI C00001 KEGG Compound C00242 KEGG Compound 1.0 C00005 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider GTP cyclohydrolase 1 P65870 UniProt C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Guanine Queuine tRNA-ribosyltransferase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O SMILES NC1=C2NC=NC2=NC=N1 HMDB01429 HMDB C5H5N5O Guanine 151.04941 GTP cyclohydrolase I 53-57-6 CAS 2.0 tRNA guanine 7-aminomethyl-7-deazaguanosine34 in tRNA C00019 KEGG Compound 1.0 GUANINE BioCyc 1.0 C01342 KEGG Compound S-ADENOSYLMETHIONINE BioCyc CHEBI:28938 ChEBI NADPH-dependent 7-cyano-7-deazaguanine reductase 7,8-dihydroneopterin 3'-triphosphate HMDB11690 HMDB NAD(P) BioCyc 7-Aminomethyl-7-carbaguanine 5957 PubChem-compound CHEBI:45126 ChEBI CHEBI:16708 ChEBI H Hydrogen Ion 1.007825 CHEBI:15996 ChEBI 56-65-5 CAS MET BioCyc C00147 KEGG Compound 1.0 http://identifiers.org/smpdb/SMP01907 SMPDB Guanosine triphosphate Adenosine diphosphate C12H15N5O3 Queuine 277.1175 C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 Queuine 73-24-5 CAS 764 PubChem-compound C5H11NO2S L-Methionine 149.05106 epoxyqueuosine 2.0 6-Carboxy-5,6,7,8-tetrahydropterin 7-Deaza-7-carboxyguanine preQ0 metabolism CPD-8587 BioCyc CHEBI:18036 ChEBI HMDB01185 HMDB Water 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT 1.0 P0A847 UniProt SMILES OC1=NC(=N)NC2=C1C(=CN2)C#N 6.0 HMDB03379 HMDB C00044 KEGG Compound 5675 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES O[C@@H]1C=C[C@@H](NCC2=CNC3=C2C(=O)NC(=N)N3)[C@@H]1O 73-40-5 CAS 14798-03-9 CAS 18971002 PubChem-compound HMDB00538 HMDB CHEBI:15422 ChEBI PW001893 PathWhiz 7732-18-5 CAS Queuine tRNA-ribosyltransferase C00058 KEGG Compound HMDB00990 HMDB S-adenosylmethionine:tRNA ribosyltransferase-isomerase CH2O2 Formic acid 46.005478 ReactionCatalysis3364 ACTIVATION 63-68-3 CAS FORMATE BioCyc 7-Aminomethyl-7-deazaguanosine 10.0 1.0 5907 ChemSpider C7H9N5O3 6-Carboxy-5,6,7,8-tetrahydropterin 211.07054 C7H6N4O3 7-Deaza-7-carboxyguanine 194.04399 SMILES [NH4+] 44123380 PubChem-compound CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 C17H23N5O8 epoxyqueuosine 425.15466 1.0 P0A7F9 UniProt Acetaldehyde O10P3 Triphosphate 252.87044 L-Methionine CHEBI:16761 ChEBI P0A6T5 UniProt 1.0 C00073 KEGG Compound 25201779 PubChem-compound C2H4O Acetaldehyde 44.026215 3440921 PubChem-compound 6-carboxy-5,6,7,8-tetrahydropterin synthase CHEBI:61125 ChEBI 962 PubChem-compound 31983 ChemSpider 2.0 5800 ChemSpider Phosphate 1.0 HMDB02111 HMDB C00080 KEGG Compound CHEBI:30751 ChEBI C00084 KEGG Compound 75-07-0 CAS 172 ChemSpider 3.0 SMILES OC=O CHEBI:15377 ChEBI CHEBI:17433 ChEBI 30776547 ChemSpider CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS 6569 ChemSpider ACETALD BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound HMDB01273 HMDB GTP BioCyc S-Adenosylmethionine SMILES [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O 1.0 1.0 1.0 CHEBI:45075 ChEBI SMILES CC=O 166 ChemSpider tRNA-guanine transglycosylase 7-cyano-7-deazaguanine reductase 6-carboxy-5,6,7,8-tetrahydropterin synthase 3.0 HMDB00034 HMDB CHEBI:15343 ChEBI C00536 KEGG Compound 1.0 16741146 PubChem-compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 64-18-6 CAS 22833512 PubChem-compound 7-cyano-7-deazaguanine synthase 1.0 H2O Water 18.010565 SMILES NCC1=CNC2=C1C(=O)NC(N)=N2 190 PubChem-compound 1.0 86-01-1 CAS C16675 KEGG Compound 2.0 29908-03-0 CAS 1061 PubChem-compound SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1 Q46920 UniProt 171 PubChem-compound 177 PubChem-compound S-adenosylmethionine:tRNA ribosyltransferase-isomerase HMDB01495 HMDB 744 ChemSpider 24762165 PubChem-compound 6-carboxy-5,6,7,8-tetrahydropterin synthase SMILES NC1=NC(=O)C2=C(N1)N=CN2 1.0 185 ChemSpider folE queD queC queF queF tgt queA Guanosine triphosphate Water Formic acid Hydrogen Ion 7,8- dihydroneopterin 3'-triphosphate Water Acetaldehyde Triphosphate Hydrogen Ion 6-Carboxy- 5,6,7,8- tetrahydropterin Hydrogen Ion 7-Deaza-7- carboxyguanine Ammonium Adenosine triphosphate Ammonium Water Phosphate Adenosine diphosphate Hydrogen Ion 7-Cyano-7- carbaguanine Hydrogen Ion NADPH NADP 7- Aminomethyl- 7- carbaguanine Hydrogen Ion NADPH Queuine NADP Guanine 7- Aminomethyl- 7- deazaguanosine S- Adenosylmethionine Hydrogen Ion L-Methionine Adenine epoxyqueuosine tRNA guanine 7- aminomethyl- 7- deazaguanosine34 in tRNA