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GTP cyclohydrolase 1 6-carboxy- 5,6,7,8- tetrahydropterin synthase 7-cyano-7- deazaguanine synthase NADPH-dependent 7-cyano-7- deazaguanine reductase NADPH-dependent 7-cyano-7- deazaguanine reductase Queuine tRNA- ribosyltransferase S- adenosylmethionine:tRNA ribosyltransferase- isomerase Guanosine triphosphate H 2 O Formic acid H + 7,8- dihydroneopterin 3'-triphosphate H 2 O Acetaldehyde Triphosphate H + 6-Carboxy- 5,6,7,8- tetrahydropterin H + 7-Deaza-7- carboxyguanine Ammonium ATP Ammonium H 2 O P i ADP H + 7-Cyano-7- carbaguanine H + NADPH NADP 7- Aminomethyl- 7- carbaguanine H + NADPH Queuine NADP Guanine 7- Aminomethyl- 7- deazaguanosine S- Adenosylmethionine H + L-Methionine Adenine epoxyqueuosine Zinc (II) ion tRNA guanine 7- aminomethyl- 7- deazaguanosine34 in tRNA
folE queD queC queF queF tgt queA Guanosine triphosphate Water Formic acid Hydrogen Ion 7,8- dihydroneopterin 3'-triphosphate Water Acetaldehyde Triphosphate Hydrogen Ion 6-Carboxy- 5,6,7,8- tetrahydropterin Hydrogen Ion 7-Deaza-7- carboxyguanine Ammonium Adenosine triphosphate Ammonium Water Phosphate Adenosine diphosphate Hydrogen Ion 7-Cyano-7- carbaguanine Hydrogen Ion NADPH NADP 7- Aminomethyl- 7- carbaguanine Hydrogen Ion NADPH Queuine NADP Guanine 7- Aminomethyl- 7- deazaguanosine S- Adenosylmethionine Hydrogen Ion L-Methionine Adenine epoxyqueuosine tRNA guanine 7- aminomethyl- 7- deazaguanosine34 in tRNA