Loading Pathway...
1.0 17215925 ChemSpider C01529 KEGG Compound C01528 KEGG Compound HMDB01349 HMDB Respiratory nitrate reductase 1 alpha chain 937 ChemSpider 936 ChemSpider 1.0 SMILES OP(O)([O-])=[Se] Selenodiglutathione Probable nitrate reductase molybdenum cofactor assembly chaperone NarW Respiratory nitrate reductase 2 beta chain Respiratory nitrate reductase 2 alpha chain SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 1.0 14124-67-5 CAS Transport484 false Selenite (→), Selenic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT H Hydrogen ion 1.007825 CHEBI:16027 ChEBI 1.0 P16701 UniProt ATP BioCyc C05697 KEGG Compound CHEBI:16144 ChEBI 1.0 Respiratory nitrate reductase 2 gamma chain CHEBI:16234 ChEBI 53-59-8 CAS 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI GO:0005829 GENE ONTOLOGY 950 ChemSpider HMDB59597 HMDB Adenosine monophosphate 289702-60-9 CAS 5858 ChemSpider Selenic acid Reaction5190 false Hydrogen Ion + NADPH + Water + glutathioselenol ↔ Glutathione + Hydrogen selenide + Hydroxide + NADP REVERSIBLE HMDB00125 HMDB Reaction5191 false glutathioselenol → Hydrogen ion + glutathioselenium LEFT_TO_RIGHT Reaction5192 false Water + glutathioselenium → Glutathione + Selenium LEFT_TO_RIGHT 14280-30-9 CAS HMDB11119 HMDB O4P Phosphate 94.95342 C20H32N6O12S2Se Selenodiglutathione 692.0685 P19319 UniProt Sulfate/thiosulfate import ATP-binding protein cysA P19318 UniProt HO Hydroxide 17.002739 NADPH 1010 ChemSpider 2.0 SEPO3 BioCyc HMDB60694 HMDB P19317 UniProt NADP C21H30N7O17P3 NADPH 745.0911 Reaction5187 false 2 Electron + 2 Hydrogen Ion + Selenic acid → Selenite + Water LEFT_TO_RIGHT ReactionCatalysis5155 ACTIVATION Reaction5188 false 4 Glutathione + 2 Hydrogen Ion + Selenite → Hydroxide + Oxidized glutathione + Selenodiglutathione + 2 Water LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Reaction5189 false Hydrogen Ion + NADPH + Selenodiglutathione → Glutathione + NADP + glutathioselenol LEFT_TO_RIGHT C01328 KEGG Compound 1.0 1.0 NADPH BioCyc Hydrogen Ion CHEBI:16856 ChEBI HMDB00217 HMDB 124886 PubChem-compound Cytosol Adenosine triphosphate P0AEB0 UniProt HMDB11110 HMDB Se Selenium 79.91652 SMILES [O-]P([O-])([O-])=O Hydrogen selenide 1.0 Electron SMILES [OH-] HMDB00221 HMDB C00009 KEGG Compound C00127 KEGG Compound C00006 KEGG Compound CHEBI:16503 ChEBI CHEBI:18009 ChEBI Respiratory nitrate reductase 1 alpha chain C00001 KEGG Compound Respiratory nitrate reductase 2 alpha chain Respiratory nitrate reductase 2 beta chain C00005 KEGG Compound Probable nitrate reductase molybdenum cofactor assembly chaperone NarW CHEBI:18367 ChEBI C20H32N6O12S2 Oxidized glutathione 612.152 1.0 1032 ChemSpider cytochrom c550 subunit nitrate reductase 7782-49-2 CAS C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Respiratory nitrate reductase 2 gamma chain C10H17N3O6S Glutathione 307.0838 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O HMDB01429 HMDB Glutathione 53-57-6 CAS Hydrogen ion P11349 UniProt SMILES O[Se](O)(=O)=O 1.0 Oxidized glutathione CHEBI:18212 ChEBI P33937 UniProt NAD(P) BioCyc Selenium 5957 PubChem-compound GO:0005620 GENE ONTOLOGY Sulfate transport system permease protein cysW 1059 ChemSpider H Hydrogen Ion 1.007825 1058 ChemSpider SMILES [H]\C(=C(\[H])C1=CC=C[C@@]([H])(O)[C@@]1([H])O)C([O-])=O 27471292 ChemSpider 1.0 56-65-5 CAS C00020 KEGG Compound SMILES N[C@@H](CCC(=O)N[C@@H](CS[Se-])C(=O)NCC(O)=O)C(O)=O http://identifiers.org/smpdb/SMP01908 SMPDB P09152 UniProt P11350 UniProt 1.0 SMILES [SeH-] 7822178 ChemSpider CHEBI:60871 ChEBI 70-18-8 CAS OXIDIZED-GLUTATHIONE BioCyc 1.0 1090 PubChem-compound H2O4Se Selenic acid 145.91183 Selenium metabolism CPD-8587 BioCyc Selenite Water 5255796 PubChem-compound AMP BioCyc 1.0 CHEBI:64729 ChEBI 9543205 PubChem-compound hydrogen selenide ion NH4OH BioCyc 7783-08-6 CAS HMDB06407 HMDB Respiratory nitrate reductase 1 beta chain 108069 PubChem-compound C9H9O4 glutathioselenol 181.05063 Periplasmic nitrate reductase 5675 ChemSpider C10H16N3O6SSe glutathioselenium 385.99304 SMILES N[C@@H](CCC(=O)N[C@@H](CS[Se]SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O Respiratory nitrate reductase 1 gamma chain Selenophosphate 1089 PubChem-compound C00051 KEGG Compound HMDB00538 HMDB Selenic acid 1.0 Reaction5201 false Hydrogen selenide ↔ Hydrogen Ion + hydrogen selenide ion REVERSIBLE Reaction5202 false Adenosine triphosphate + hydrogen selenide ion → Adenosine monophosphate + Phosphate + Selenophosphate LEFT_TO_RIGHT HSe hydrogen selenide ion 80.9249 cytochrom c550 subunit nitrate reductase CHEBI:15422 ChEBI Electron PW001894 PathWhiz P0AF26 UniProt Selenite 7732-18-5 CAS H2Se Hydrogen selenide 81.932175 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 Sulfate transport system permease protein cysW P16676 UniProt Nitrate reductase molybdenum cofactor assembly chaperone NarJ 533 PubChem-compound P0AF32 UniProt 7783-07-5 CAS 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17858 ChEBI P0ABL3 UniProt O3Se Selenite 127.90127 Selenite Sulfate transport system permease protein cysT 962 PubChem-compound 961 PubChem-compound Hydroxide Phosphate 1.0 HMDB02111 HMDB 1.0 1.0 C00080 KEGG Compound Periplasmic Space SMILES [SeH2] 1.0 1.0 CHEBI:15377 ChEBI HMDB03337 HMDB CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS HMDB01039 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 Nitrate Reductase SMILES [O-][Se]([O-])=O 111188 ChemSpider C05172 KEGG Compound Respiratory nitrate reductase 1 gamma chain Respiratory nitrate reductase 1 beta chain 27025-41-8 CAS 6083 PubChem-compound Periplasmic nitrate reductase 4.0 H2O3PSe Selenophosphate 160.89067 518 ChemSpider glutathioselenol glutathioselenium Selenite/selenate symporter 22833512 PubChem-compound H2O Water 18.010565 Sulfate/thiosulfate import ATP-binding protein cysA TransportCatalysis416 ACTIVATION CHEBI:18170 ChEBI 1.0 SMILES [Se++] 2.0 HMDB00045 HMDB SMILES [H+] 1061 PubChem-compound Selenic acid 1.0 Nitrate reductase molybdenum cofactor assembly chaperone NarJ SMILES NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O C05684 KEGG Compound 2.0 Sulfate transport system permease protein cysT SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O Sulfate transport system permease protein cysT Sulfate/thiosulfate import ATP-binding protein cysA Sulfate transport system permease protein cysW Respiratory nitrate reductase 1 alpha chain Respiratory nitrate reductase 1 beta chain Nitrate reductase molybdenum cofactor assembly chaperone NarJ Respiratory nitrate reductase 1 gamma chain Respiratory nitrate reductase 2 gamma chain Probable nitrate reductase molybdenum cofactor assembly chaperone NarW Respiratory nitrate reductase 2 beta chain Respiratory nitrate reductase 2 alpha chain Periplasmic nitrate reductase cytochrom c550 subunit nitrate reductase Selenite Selenite Selenic acid Selenic acid Selenic acid H + Electron H 2 O H + Glutathione H 2 O Hydroxide Oxidized glutathione Selenodiglutathione NADPH H + NADP Glutathione glutathioselenol NADPH H + H 2 O Glutathione NADP Hydroxide Hydrogen selenide Hydrogen ion glutathioselenium H 2 O Glutathione Selenium hydrogen selenide ion H + ATP AMP P i Selenophosphate
1.0 17215925 ChemSpider C01529 KEGG Compound C01528 KEGG Compound HMDB01349 HMDB Respiratory nitrate reductase 1 alpha chain 937 ChemSpider 936 ChemSpider 1.0 SMILES OP(O)([O-])=[Se] Selenodiglutathione Probable nitrate reductase molybdenum cofactor assembly chaperone NarW Respiratory nitrate reductase 2 beta chain Respiratory nitrate reductase 2 alpha chain SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 1.0 14124-67-5 CAS Transport484 false Selenite (→), Selenic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT H Hydrogen ion 1.007825 CHEBI:16027 ChEBI 1.0 P16701 UniProt ATP BioCyc C05697 KEGG Compound CHEBI:16144 ChEBI 1.0 Respiratory nitrate reductase 2 gamma chain CHEBI:16234 ChEBI 53-59-8 CAS 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI GO:0005829 GENE ONTOLOGY 950 ChemSpider HMDB59597 HMDB Adenosine monophosphate 289702-60-9 CAS 5858 ChemSpider Selenic acid Reaction5190 false Hydrogen Ion + NADPH + Water + glutathioselenol ↔ Glutathione + Hydrogen selenide + Hydroxide + NADP REVERSIBLE HMDB00125 HMDB Reaction5191 false glutathioselenol → Hydrogen ion + glutathioselenium LEFT_TO_RIGHT Reaction5192 false Water + glutathioselenium → Glutathione + Selenium LEFT_TO_RIGHT 14280-30-9 CAS HMDB11119 HMDB O4P Phosphate 94.95342 C20H32N6O12S2Se Selenodiglutathione 692.0685 P19319 UniProt Sulfate/thiosulfate import ATP-binding protein cysA P19318 UniProt HO Hydroxide 17.002739 NADPH 1010 ChemSpider 2.0 SEPO3 BioCyc HMDB60694 HMDB P19317 UniProt NADP C21H30N7O17P3 NADPH 745.0911 Reaction5187 false 2 Electron + 2 Hydrogen Ion + Selenic acid → Selenite + Water LEFT_TO_RIGHT ReactionCatalysis5155 ACTIVATION Reaction5188 false 4 Glutathione + 2 Hydrogen Ion + Selenite → Hydroxide + Oxidized glutathione + Selenodiglutathione + 2 Water LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Reaction5189 false Hydrogen Ion + NADPH + Selenodiglutathione → Glutathione + NADP + glutathioselenol LEFT_TO_RIGHT C01328 KEGG Compound 1.0 1.0 NADPH BioCyc Hydrogen Ion CHEBI:16856 ChEBI HMDB00217 HMDB 124886 PubChem-compound Cytosol Adenosine triphosphate P0AEB0 UniProt HMDB11110 HMDB Se Selenium 79.91652 SMILES [O-]P([O-])([O-])=O Hydrogen selenide 1.0 Electron SMILES [OH-] HMDB00221 HMDB C00009 KEGG Compound C00127 KEGG Compound C00006 KEGG Compound CHEBI:16503 ChEBI CHEBI:18009 ChEBI Respiratory nitrate reductase 1 alpha chain C00001 KEGG Compound Respiratory nitrate reductase 2 alpha chain Respiratory nitrate reductase 2 beta chain C00005 KEGG Compound Probable nitrate reductase molybdenum cofactor assembly chaperone NarW CHEBI:18367 ChEBI C20H32N6O12S2 Oxidized glutathione 612.152 1.0 1032 ChemSpider cytochrom c550 subunit nitrate reductase 7782-49-2 CAS C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Respiratory nitrate reductase 2 gamma chain C10H17N3O6S Glutathione 307.0838 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O HMDB01429 HMDB Glutathione 53-57-6 CAS Hydrogen ion P11349 UniProt SMILES O[Se](O)(=O)=O 1.0 Oxidized glutathione CHEBI:18212 ChEBI P33937 UniProt NAD(P) BioCyc Selenium 5957 PubChem-compound GO:0005620 GENE ONTOLOGY Sulfate transport system permease protein cysW 1059 ChemSpider H Hydrogen Ion 1.007825 1058 ChemSpider SMILES [H]\C(=C(\[H])C1=CC=C[C@@]([H])(O)[C@@]1([H])O)C([O-])=O 27471292 ChemSpider 1.0 56-65-5 CAS C00020 KEGG Compound SMILES N[C@@H](CCC(=O)N[C@@H](CS[Se-])C(=O)NCC(O)=O)C(O)=O http://identifiers.org/smpdb/SMP01908 SMPDB P09152 UniProt P11350 UniProt 1.0 SMILES [SeH-] 7822178 ChemSpider CHEBI:60871 ChEBI 70-18-8 CAS OXIDIZED-GLUTATHIONE BioCyc 1.0 1090 PubChem-compound H2O4Se Selenic acid 145.91183 Selenium metabolism CPD-8587 BioCyc Selenite Water 5255796 PubChem-compound AMP BioCyc 1.0 CHEBI:64729 ChEBI 9543205 PubChem-compound hydrogen selenide ion NH4OH BioCyc 7783-08-6 CAS HMDB06407 HMDB Respiratory nitrate reductase 1 beta chain 108069 PubChem-compound C9H9O4 glutathioselenol 181.05063 Periplasmic nitrate reductase 5675 ChemSpider C10H16N3O6SSe glutathioselenium 385.99304 SMILES N[C@@H](CCC(=O)N[C@@H](CS[Se]SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O Respiratory nitrate reductase 1 gamma chain Selenophosphate 1089 PubChem-compound C00051 KEGG Compound HMDB00538 HMDB Selenic acid 1.0 Reaction5201 false Hydrogen selenide ↔ Hydrogen Ion + hydrogen selenide ion REVERSIBLE Reaction5202 false Adenosine triphosphate + hydrogen selenide ion → Adenosine monophosphate + Phosphate + Selenophosphate LEFT_TO_RIGHT HSe hydrogen selenide ion 80.9249 cytochrom c550 subunit nitrate reductase CHEBI:15422 ChEBI Electron PW001894 PathWhiz P0AF26 UniProt Selenite 7732-18-5 CAS H2Se Hydrogen selenide 81.932175 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 Sulfate transport system permease protein cysW P16676 UniProt Nitrate reductase molybdenum cofactor assembly chaperone NarJ 533 PubChem-compound P0AF32 UniProt 7783-07-5 CAS 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17858 ChEBI P0ABL3 UniProt O3Se Selenite 127.90127 Selenite Sulfate transport system permease protein cysT 962 PubChem-compound 961 PubChem-compound Hydroxide Phosphate 1.0 HMDB02111 HMDB 1.0 1.0 C00080 KEGG Compound Periplasmic Space SMILES [SeH2] 1.0 1.0 CHEBI:15377 ChEBI HMDB03337 HMDB CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS HMDB01039 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 Nitrate Reductase SMILES [O-][Se]([O-])=O 111188 ChemSpider C05172 KEGG Compound Respiratory nitrate reductase 1 gamma chain Respiratory nitrate reductase 1 beta chain 27025-41-8 CAS 6083 PubChem-compound Periplasmic nitrate reductase 4.0 H2O3PSe Selenophosphate 160.89067 518 ChemSpider glutathioselenol glutathioselenium Selenite/selenate symporter 22833512 PubChem-compound H2O Water 18.010565 Sulfate/thiosulfate import ATP-binding protein cysA TransportCatalysis416 ACTIVATION CHEBI:18170 ChEBI 1.0 SMILES [Se++] 2.0 HMDB00045 HMDB SMILES [H+] 1061 PubChem-compound Selenic acid 1.0 Nitrate reductase molybdenum cofactor assembly chaperone NarJ SMILES NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O C05684 KEGG Compound 2.0 Sulfate transport system permease protein cysT SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O cysU cysA cysW narG narH narJ narI narV narW narY narZ napA napB Selenite Selenite Selenic acid Selenic acid Selenic acid Hydrogen Ion Water Hydrogen Ion Glutathione Water Hydroxide Oxidized glutathione Selenodiglutathione NADPH Hydrogen Ion NADP Glutathione glutathioselenol NADPH Hydrogen Ion Water Glutathione NADP Hydroxide Hydrogen selenide Hydrogen ion glutathioselenium Water Glutathione Selenium hydrogen selenide ion Hydrogen Ion Adenosine triphosphate Adenosine monophosphate Phosphate Selenophosphate