PathWhiz

Pathway Description

Curcumin Degradation

Escherichia coli

Metabolic Pathway

Curcumin is metabolized by being reduced through a NADPH dependent curcumin reductase resulting in a dihydrocurcumin. This compound is then reduced again through a NADPH-dependent dihydrocurcumin reductase resulting in a tetrahydrocurcumin. It is not know yet how this compound enters E.coli

References

Curcumin Degradation References

Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M: Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20. doi: 10.1073/pnas.1016217108. Epub 2011 Apr 5.

Pubmed: 21467222

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW001896

Highlighted elements will appear in red.

Highlight Compounds

	Curcumin
	Dihydrocurcumin
	Hydrogen Ion
	NADP
	NADPH
	Tetrahydrocurcumin

Highlight Proteins

NADPH-dependent curcumin/dihydrocurcumin reductase

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data