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Pathway Description
D-Sorbitol Degradation II
Escherichia coli
Metabolic Pathway
E. coli K-12 can utilize six existing hexitols as source of carbon and energy. Hexitols can enter bacterial cell by specific phosphotransferase system, which is consisted of mannose permease IID component, mannose permease IIC component and PTS system mannose-specific EIIAB component. Sorbitol-6-phosphate will be converted to fructose 6-phosphate by sorbitol-6-phosphate dehydrogenase with cofactor NAD. Sorbitol-6-phosphate will be transformed into β-D-Fructose 6-phosphate spontaneously, which the later product will undergo glycolysis I.
References
D-Sorbitol Degradation II References
Diaz-Mejia JJ, Babu M, Emili A: Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome. FEMS Microbiol Rev. 2009 Jan;33(1):66-97. doi: 10.1111/j.1574-6976.2008.00141.x. Epub 2008 Nov 27.
Pubmed: 19054114
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