PathWhiz

Pathway Description

Oleic Acid Oxidation

Escherichia coli

Metabolic Pathway

The process of oleic acid B-oxidation starts with a 2-trans,5-cis-tetradecadienoyl-CoA that can be either be processed by an enoyl-CoA hydratase by interacting with a water molecules resulting in a 3-hydroxy-5-cis-tetradecenoyl-CoA, which can be oxidized in the fatty acid beta-oxidation. On the other hand 2-trans,5-cis-tetradecadienoyl-CoA can become a 3-trans,5-cis-tetradecadienoyl-CoA through a isomerase. This results interact with a water molecule through a acyl-CoA thioesterase resulting in a hydrogen ion, a coenzyme A and a 3,5-tetradecadienoate

References

Oleic Acid Oxidation References

Nie L, Ren Y, Schulz H: Identification and characterization of Escherichia coli thioesterase III that functions in fatty acid beta-oxidation. Biochemistry. 2008 Jul 22;47(29):7744-51. doi: 10.1021/bi800595f. Epub 2008 Jun 25.

Pubmed: 18576672

Ren Y, Aguirre J, Ntamack AG, Chu C, Schulz H: An alternative pathway of oleate beta-oxidation in Escherichia coli involving the hydrolysis of a dead end intermediate by a thioesterase. J Biol Chem. 2004 Mar 19;279(12):11042-50. doi: 10.1074/jbc.M310032200. Epub 2004 Jan 5.

Pubmed: 14707139

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW002025

Highlighted elements will appear in red.

Highlight Compounds

	2-trans,5-cis-tetradecadienoyl-CoA
	3,5-tetradecadienoate
	3,5-Tetradecadienoyl-CoA
	3-hydroxy-5-cis-tetradecenoyl-CoA
	Coenzyme A
	Hydrogen Ion
	Water

Highlight Proteins

	Fatty acid oxidation complex subunit alpha
	Long-chain acyl-CoA thioesterase FadM

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