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CHEBI:16015 ChEBI 30572 ChemSpider 6022 PubChem-compound 937 ChemSpider HMDB00250 HMDB 4-amino-2-methyl-5-phosphomethylpyrimidine 4.0 4-amino-2-methyl-5-diphosphomethylpyrimidine 1132 PubChem-compound HMDB01341 HMDB C20H21N7O7 10-formyl-tetrahydrofolate mono-L-glutamate 471.15134 SMILES O Pyrophosphate 1.0 Thiamine-phosphate pyrophosphorylase C8H14N3O7P 5-Aminoimidazole ribonucleotide 295.05695 HMDB01235 HMDB 3382778 PubChem-compound HMDB00148 HMDB 1.0 C7H14N2O8P N1-(5-phospho-β-D-ribosyl)glycinamide 285.04932 C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 1.0 ATP BioCyc 5961 PubChem-compound 6137 PubChem-compound HMDB00142 HMDB CHEBI:17111 ChEBI 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc 1.0 1.0 1.0 CHEBI:37737 ChEBI 559142 ChemSpider ADP BioCyc 1.0 Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase CHEBI:18413 ChEBI C15H23N6O5S S-Adenosylmethionine 399.14505 THIAMINE-P BioCyc 5746 ChemSpider 1.0 2.0 Phosphomethylpyrimidine synthase HMDB06211 HMDB 439182 PubChem-compound 5742 ChemSpider CHEBI:58354 ChEBI 1038 PubChem-compound Phosphoribosylamine--glycine ligase C04376 KEGG Compound 5-Aminoimidazole ribonucleotide 5'-Phosphoribosyl-N-formylglycinamide Phosphoribosylformylglycinamidine synthase SMILES CSCC[C@H](N)C(O)=O 7540-64-9 CAS 278 ChemSpider HMDB59597 HMDB 275 ChemSpider 274 ChemSpider 154-87-0 CAS 17216355 ChemSpider P76422 UniProt 495-23-8 CAS HMDB00123 HMDB HMDB02666 HMDB C6H8N3O4P 4-amino-2-methyl-5-phosphomethylpyrimidine 217.02634 O4P Phosphate 94.95342 C6H8N3O7P2 4-amino-2-methyl-5-diphosphomethylpyrimidine 295.98538 1010 ChemSpider 1.0 PPI BioCyc Amidophosphoribosyltransferase C00119 KEGG Compound GLY BioCyc HMDB00696 HMDB C00237 KEGG Compound Thiamin diphosphate biosynthesis SMILES NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N2)N1 ReactionCatalysis3381 ACTIVATION 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion ReactionCatalysis3380 ACTIVATION SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 CH33ADO BioCyc P0AGG0 UniProt Adenosine triphosphate L-Glutamic acid C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 CHEBI:28843 ChEBI SMILES [O-]P([O-])([O-])=O Thiamine-phosphate pyrophosphorylase 141854 ChemSpider Thiamine-monophosphate kinase 124-38-9 CAS C2H5NO2 Glycine 75.03203 Thiamine pyrophosphate Formic acid C00009 KEGG Compound 388325 ChemSpider C00008 KEGG Compound 4754-39-6 CAS CHEBI:15414 ChEBI 1.0 C00001 KEGG Compound CHEBI:57454 ChEBI 1.0 CHEBI:18361 ChEBI 1.0 CHEBI:18367 ChEBI 1032 ChemSpider Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C00002 KEGG Compound P15254 UniProt 5257127 PubChem-compound 5-Phosphoribosylamine 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE BioCyc GLN BioCyc HMDB01429 HMDB HMDB01308 HMDB 1.0 C5H12NO7P 5-Phosphoribosylamine 229.03514 GLT BioCyc P33221 UniProt Carbon monoxide CO Carbon monoxide 27.994915 PW002028 PathWhiz C00019 KEGG Compound P08178 UniProt P08179 UniProt amidophosphoribosyl transferase N1-(5-phospho-β-D-ribosyl)glycinamide S-ADENOSYLMETHIONINE BioCyc C00011 KEGG Compound SMILES O=C=O SMILES CC1=C(CCO[P@](O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N 7339 PubChem-compound 6157-85-3 CAS CHEBI:17245 ChEBI C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 hydroxymethylpyrimidine kinase / phosphohydroxymethylpyrimidine kinase 10-formyl-tetrahydrofolate mono-L-glutamate Glycine 5957 PubChem-compound C03090 KEGG Compound Phosphoribosyl pyrophosphate 1.0 H Hydrogen Ion 1.007825 C7H7NO6PS 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate 263.97318 L-Glutamine 1.0 56-65-5 CAS MET BioCyc C00025 KEGG Compound SMILES C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoribosylformylglycinamide cyclo-ligase 1.0 Amidophosphoribosyltransferase SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]1NC(=N)NC=O 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL BioCyc C5H11NO2S L-Methionine 149.05106 HMDB01983 HMDB 1.0 Phosphoribosylglycinamide formyltransferase 2 161500 PubChem-compound CPD-8587 BioCyc C00037 KEGG Compound HMDB01185 HMDB 46878370 PubChem-compound C04752 KEGG Compound http://identifiers.org/smpdb/SMP02042 SMPDB Water 22833657 PubChem-compound Thiamine-monophosphate kinase SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS 2-(alpha-lactyl)-thpp BioCyc 1.0 SMILES CC1=NC=C(COP([O-])(=O)OP([O-])([O-])=O)C(=N)N1 SMILES CC1=NC=C(COP([O-])([O-])=O)C(=N)N1 1.0 C04640 KEGG Compound 56-85-9 CAS 25244572 PubChem-compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 7062 ChemSpider 1.0 CHEBI:9532 ChEBI 18971002 PubChem-compound ReactionCatalysis5894 ACTIVATION HMDB00538 HMDB ReactionCatalysis5898 ACTIVATION ReactionCatalysis5897 ACTIVATION ReactionCatalysis5896 ACTIVATION ReactionCatalysis5895 ACTIVATION 2627905 ChemSpider CHEBI:15422 ChEBI Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 7732-18-5 CAS C00058 KEGG Compound CHEBI:37574 ChEBI C05198 KEGG Compound CH2O2 Formic acid 46.005478 1.0 56-86-0 CAS 1.0 63-68-3 CAS FORMATE BioCyc C12H19N4O7P2S Thiamine pyrophosphate 425.04498 C5H9NO4 L-Glutamic acid 147.05316 5907 ChemSpider 33032 PubChem-compound HMDB00641 HMDB CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:16526 ChEBI 349-34-8 CAS 56-40-6 CAS SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O C00064 KEGG Compound L-Methionine CHEBI:16761 ChEBI SMILES NC1=CN=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 630-08-0 CAS C00068 KEGG Compound 1.0 C00073 KEGG Compound CHEBI:15428 ChEBI HMDB01967 HMDB 115687 ChemSpider ReactionCatalysis3378 ACTIVATION ReactionCatalysis3379 ACTIVATION ReactionCatalysis3377 ACTIVATION 962 PubChem-compound 31983 ChemSpider 5800 ChemSpider 1.0 25790919 PubChem-compound 130805 PubChem-compound C04556 KEGG Compound 281 PubChem-compound CO2 Carbon dioxide 43.98983 C12H17N4O4PS Thiamine monophosphate 344.0708 Phosphate 1.0 HMDB02111 HMDB CHEBI:57841 ChEBI 2.1.2.2 false 2.1.2.2 10-formyl-tetrahydrofolate mono-L-glutamate + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Hydrogen Ion + tetrahydropteroyl mono-L-glutamate LEFT_TO_RIGHT 1.0 C00080 KEGG Compound 4.1.99.17 false 4.1.99.17 5-Aminoimidazole ribonucleotide + S-Adenosylmethionine → 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-Deoxyadenosine + Carbon monoxide + Formic acid + 3 Hydrogen Ion + L-Methionine LEFT_TO_RIGHT 730 ChemSpider 2.7.1.49 false 2.7.1.49 4-amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → 4-amino-2-methyl-5-diphosphomethylpyrimidine + Adenosine diphosphate LEFT_TO_RIGHT CHEBI:30751 ChEBI 2.5.1.3 false 2.5.1.3 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + 4-amino-2-methyl-5-diphosphomethylpyrimidine + Hydrogen Ion → Carbon dioxide + Pyrophosphate + Thiamine monophosphate LEFT_TO_RIGHT 2.7.4.16 false 2.7.4.16 Adenosine triphosphate + Thiamine monophosphate → Adenosine diphosphate + Thiamine pyrophosphate LEFT_TO_RIGHT P15640 UniProt SMILES [H]\C(COP([O-])([O-])=O)=C1\SC(N=C1C)C([O-])=O SMILES N[C@@H](CCC(O)=O)C(O)=O 3.0 SMILES OC=O SMILES CC1=C(CCO[P@](O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N CHEBI:15377 ChEBI Phosphoribosylglycinamide formyltransferase 14265-44-2 CAS CHEBI:15378 ChEBI SMILES [H+] 4.0 CHEBI:17319 ChEBI Phosphoribosylglycinamide formyltransferase 2 tetrahydropteroyl mono-L-glutamate 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Phosphomethylpyrimidine synthase Phosphoribosylformylglycinamidine cyclo-ligase C10H13N5O3 5'-Deoxyadenosine 251.10184 1.0 S-Adenosylmethionine 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine 1.0 Phosphoribosylformylglycinamidine synthase C6H12N3O8P 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine 285.0362 280 PubChem-compound Phosphoribosylamine--glycine ligase 439905 PubChem-compound C19H21N7O6 tetrahydropteroyl mono-L-glutamate 443.15643 644102 PubChem-compound HMDB01128 HMDB 5'-Deoxyadenosine SMILES N[C@@H](CCC(N)=O)C(O)=O 64-18-6 CAS SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(C=C1)N(C[C@@]1([H])CNC2=C(N1)C([O-])=NC(=N)N2)C=O)C(O)=O 1100 ChemSpider HMDB01361 HMDB PRPP BioCyc 2.4.2.14 false 2.4.2.14 L-Glutamine + Phosphoribosyl pyrophosphate + Water → 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate LEFT_TO_RIGHT C03373 KEGG Compound CHEBI:18050 ChEBI H2O Water 18.010565 SMILES NCC(O)=O SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O 388939 ChemSpider 6.3.3.1 false 6.3.3.1 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine triphosphate → 5-Aminoimidazole ribonucleotide + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 6.3.5.3 false 6.3.5.3 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT 2.1.2.- false 2.1.2.- Adenosine triphosphate + Formic acid + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 6.3.4.13 false 6.3.4.13 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Hydrogen Ion + N1-(5-phospho-β-D-ribosyl)glycinamide + Phosphate LEFT_TO_RIGHT 29908-03-0 CAS 1061 PubChem-compound P30137 UniProt P30136 UniProt 25635-88-5 CAS Carbon dioxide Thiamine monophosphate P0AG16 UniProt HMDB00280 HMDB HMDB01372 HMDB SMILES [NH3+]CC(=O)NC1OC(COP([O-])([O-])=O)C(O)C1O 24762165 PubChem-compound C01081 KEGG Compound SMILES N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 5-P-BETA-D-RIBOSYL-AMINE BioCyc Amidophosphoribosyltransferase Phosphoribosylamine- -glycine ligase Phosphoribosylglycinamide formyltransferase 2 Phosphoribosylglycinamide formyltransferase Phosphoribosylformylglycinamidine synthase Phosphoribosylformylglycinamidine cyclo-ligase Phosphomethylpyrimidine synthase Thiamine- phosphate pyrophosphorylase Thiamine- monophosphate kinase Phosphoribosyl pyrophosphate H 2 O L-Glutamine 5- Phosphoribosylamine L-Glutamic acid PP i Glycine ATP N1-(5- phospho-β-D- ribosyl)glycinamide P i ADP H + ATP Formic acid 5'- Phosphoribosyl- N- formylglycinamide ADP P i H + 10-formyl- tetrahydrofolate mono-L- glutamate H + tetrahydropteroyl mono-L- glutamate 5'- Phosphoribosyl- N- formylglycinamide H 2 O L-Glutamine ATP 2- (Formamido)- N1-(5- phospho-D- ribosyl)acetamidine L-Glutamic acid P i ADP H + ATP 5- Aminoimidazole ribonucleotide P i ADP H + S- Adenosylmethionine H + Carbon monoxide Formic acid L-Methionine 5'- Deoxyadenosine 4-amino-2- methyl-5- phosphomethylpyrimidine ATP ADP 4-amino-2- methyl-5- diphosphomethylpyrimidine 2-((2R,5Z)-2- Carboxy-4- methylthiazol- 5(2H)- ylidene)ethyl phosphate H + CO 2 PP i Thiamine monophosphate ATP ADP Thiamine pyrophosphate Magnesium Magnesium Potassium Magnesium NADPH NADH NADPH S- Adenosylmethionine Magnesium Magnesium Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
CHEBI:16015 ChEBI 30572 ChemSpider 6022 PubChem-compound 937 ChemSpider HMDB00250 HMDB 4-amino-2-methyl-5-phosphomethylpyrimidine 4.0 4-amino-2-methyl-5-diphosphomethylpyrimidine 1132 PubChem-compound HMDB01341 HMDB C20H21N7O7 10-formyl-tetrahydrofolate mono-L-glutamate 471.15134 SMILES O Pyrophosphate 1.0 Thiamine-phosphate pyrophosphorylase C8H14N3O7P 5-Aminoimidazole ribonucleotide 295.05695 HMDB01235 HMDB 3382778 PubChem-compound HMDB00148 HMDB 1.0 C7H14N2O8P N1-(5-phospho-β-D-ribosyl)glycinamide 285.04932 C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 1.0 ATP BioCyc 5961 PubChem-compound 6137 PubChem-compound HMDB00142 HMDB CHEBI:17111 ChEBI 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc 1.0 1.0 1.0 CHEBI:37737 ChEBI 559142 ChemSpider ADP BioCyc 1.0 Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase CHEBI:18413 ChEBI C15H23N6O5S S-Adenosylmethionine 399.14505 THIAMINE-P BioCyc 5746 ChemSpider 1.0 2.0 Phosphomethylpyrimidine synthase HMDB06211 HMDB 439182 PubChem-compound 5742 ChemSpider CHEBI:58354 ChEBI 1038 PubChem-compound Phosphoribosylamine--glycine ligase C04376 KEGG Compound 5-Aminoimidazole ribonucleotide 5'-Phosphoribosyl-N-formylglycinamide Phosphoribosylformylglycinamidine synthase SMILES CSCC[C@H](N)C(O)=O 7540-64-9 CAS 278 ChemSpider HMDB59597 HMDB 275 ChemSpider 274 ChemSpider 154-87-0 CAS 17216355 ChemSpider P76422 UniProt 495-23-8 CAS HMDB00123 HMDB HMDB02666 HMDB C6H8N3O4P 4-amino-2-methyl-5-phosphomethylpyrimidine 217.02634 O4P Phosphate 94.95342 C6H8N3O7P2 4-amino-2-methyl-5-diphosphomethylpyrimidine 295.98538 1010 ChemSpider 1.0 PPI BioCyc Amidophosphoribosyltransferase C00119 KEGG Compound GLY BioCyc HMDB00696 HMDB C00237 KEGG Compound Thiamin diphosphate biosynthesis SMILES NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N2)N1 ReactionCatalysis3381 ACTIVATION 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion ReactionCatalysis3380 ACTIVATION SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 CH33ADO BioCyc P0AGG0 UniProt Adenosine triphosphate L-Glutamic acid C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 CHEBI:28843 ChEBI SMILES [O-]P([O-])([O-])=O Thiamine-phosphate pyrophosphorylase 141854 ChemSpider Thiamine-monophosphate kinase 124-38-9 CAS C2H5NO2 Glycine 75.03203 Thiamine pyrophosphate Formic acid C00009 KEGG Compound 388325 ChemSpider C00008 KEGG Compound 4754-39-6 CAS CHEBI:15414 ChEBI 1.0 C00001 KEGG Compound CHEBI:57454 ChEBI 1.0 CHEBI:18361 ChEBI 1.0 CHEBI:18367 ChEBI 1032 ChemSpider Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C00002 KEGG Compound P15254 UniProt 5257127 PubChem-compound 5-Phosphoribosylamine 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE BioCyc GLN BioCyc HMDB01429 HMDB HMDB01308 HMDB 1.0 C5H12NO7P 5-Phosphoribosylamine 229.03514 GLT BioCyc P33221 UniProt Carbon monoxide CO Carbon monoxide 27.994915 PW002028 PathWhiz C00019 KEGG Compound P08178 UniProt P08179 UniProt amidophosphoribosyl transferase N1-(5-phospho-β-D-ribosyl)glycinamide S-ADENOSYLMETHIONINE BioCyc C00011 KEGG Compound SMILES O=C=O SMILES CC1=C(CCO[P@](O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N 7339 PubChem-compound 6157-85-3 CAS CHEBI:17245 ChEBI C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 hydroxymethylpyrimidine kinase / phosphohydroxymethylpyrimidine kinase 10-formyl-tetrahydrofolate mono-L-glutamate Glycine 5957 PubChem-compound C03090 KEGG Compound Phosphoribosyl pyrophosphate 1.0 H Hydrogen Ion 1.007825 C7H7NO6PS 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate 263.97318 L-Glutamine 1.0 56-65-5 CAS MET BioCyc C00025 KEGG Compound SMILES C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoribosylformylglycinamide cyclo-ligase 1.0 Amidophosphoribosyltransferase SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]1NC(=N)NC=O 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL BioCyc C5H11NO2S L-Methionine 149.05106 HMDB01983 HMDB 1.0 Phosphoribosylglycinamide formyltransferase 2 161500 PubChem-compound CPD-8587 BioCyc C00037 KEGG Compound HMDB01185 HMDB 46878370 PubChem-compound C04752 KEGG Compound http://identifiers.org/smpdb/SMP02042 SMPDB Water 22833657 PubChem-compound Thiamine-monophosphate kinase SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS 2-(alpha-lactyl)-thpp BioCyc 1.0 SMILES CC1=NC=C(COP([O-])(=O)OP([O-])([O-])=O)C(=N)N1 SMILES CC1=NC=C(COP([O-])([O-])=O)C(=N)N1 1.0 C04640 KEGG Compound 56-85-9 CAS 25244572 PubChem-compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 7062 ChemSpider 1.0 CHEBI:9532 ChEBI 18971002 PubChem-compound ReactionCatalysis5894 ACTIVATION HMDB00538 HMDB ReactionCatalysis5898 ACTIVATION ReactionCatalysis5897 ACTIVATION ReactionCatalysis5896 ACTIVATION ReactionCatalysis5895 ACTIVATION 2627905 ChemSpider CHEBI:15422 ChEBI Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 7732-18-5 CAS C00058 KEGG Compound CHEBI:37574 ChEBI C05198 KEGG Compound CH2O2 Formic acid 46.005478 1.0 56-86-0 CAS 1.0 63-68-3 CAS FORMATE BioCyc C12H19N4O7P2S Thiamine pyrophosphate 425.04498 C5H9NO4 L-Glutamic acid 147.05316 5907 ChemSpider 33032 PubChem-compound HMDB00641 HMDB CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:16526 ChEBI 349-34-8 CAS 56-40-6 CAS SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O C00064 KEGG Compound L-Methionine CHEBI:16761 ChEBI SMILES NC1=CN=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 630-08-0 CAS C00068 KEGG Compound 1.0 C00073 KEGG Compound CHEBI:15428 ChEBI HMDB01967 HMDB 115687 ChemSpider ReactionCatalysis3378 ACTIVATION ReactionCatalysis3379 ACTIVATION ReactionCatalysis3377 ACTIVATION 962 PubChem-compound 31983 ChemSpider 5800 ChemSpider 1.0 25790919 PubChem-compound 130805 PubChem-compound C04556 KEGG Compound 281 PubChem-compound CO2 Carbon dioxide 43.98983 C12H17N4O4PS Thiamine monophosphate 344.0708 Phosphate 1.0 HMDB02111 HMDB CHEBI:57841 ChEBI 2.1.2.2 false 2.1.2.2 10-formyl-tetrahydrofolate mono-L-glutamate + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Hydrogen Ion + tetrahydropteroyl mono-L-glutamate LEFT_TO_RIGHT 1.0 C00080 KEGG Compound 4.1.99.17 false 4.1.99.17 5-Aminoimidazole ribonucleotide + S-Adenosylmethionine → 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-Deoxyadenosine + Carbon monoxide + Formic acid + 3 Hydrogen Ion + L-Methionine LEFT_TO_RIGHT 730 ChemSpider 2.7.1.49 false 2.7.1.49 4-amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → 4-amino-2-methyl-5-diphosphomethylpyrimidine + Adenosine diphosphate LEFT_TO_RIGHT CHEBI:30751 ChEBI 2.5.1.3 false 2.5.1.3 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + 4-amino-2-methyl-5-diphosphomethylpyrimidine + Hydrogen Ion → Carbon dioxide + Pyrophosphate + Thiamine monophosphate LEFT_TO_RIGHT 2.7.4.16 false 2.7.4.16 Adenosine triphosphate + Thiamine monophosphate → Adenosine diphosphate + Thiamine pyrophosphate LEFT_TO_RIGHT P15640 UniProt SMILES [H]\C(COP([O-])([O-])=O)=C1\SC(N=C1C)C([O-])=O SMILES N[C@@H](CCC(O)=O)C(O)=O 3.0 SMILES OC=O SMILES CC1=C(CCO[P@](O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N CHEBI:15377 ChEBI Phosphoribosylglycinamide formyltransferase 14265-44-2 CAS CHEBI:15378 ChEBI SMILES [H+] 4.0 CHEBI:17319 ChEBI Phosphoribosylglycinamide formyltransferase 2 tetrahydropteroyl mono-L-glutamate 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Phosphomethylpyrimidine synthase Phosphoribosylformylglycinamidine cyclo-ligase C10H13N5O3 5'-Deoxyadenosine 251.10184 1.0 S-Adenosylmethionine 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine 1.0 Phosphoribosylformylglycinamidine synthase C6H12N3O8P 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine 285.0362 280 PubChem-compound Phosphoribosylamine--glycine ligase 439905 PubChem-compound C19H21N7O6 tetrahydropteroyl mono-L-glutamate 443.15643 644102 PubChem-compound HMDB01128 HMDB 5'-Deoxyadenosine SMILES N[C@@H](CCC(N)=O)C(O)=O 64-18-6 CAS SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(C=C1)N(C[C@@]1([H])CNC2=C(N1)C([O-])=NC(=N)N2)C=O)C(O)=O 1100 ChemSpider HMDB01361 HMDB PRPP BioCyc 2.4.2.14 false 2.4.2.14 L-Glutamine + Phosphoribosyl pyrophosphate + Water → 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate LEFT_TO_RIGHT C03373 KEGG Compound CHEBI:18050 ChEBI H2O Water 18.010565 SMILES NCC(O)=O SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O 388939 ChemSpider 6.3.3.1 false 6.3.3.1 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine triphosphate → 5-Aminoimidazole ribonucleotide + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 6.3.5.3 false 6.3.5.3 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT 2.1.2.- false 2.1.2.- Adenosine triphosphate + Formic acid + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 6.3.4.13 false 6.3.4.13 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Hydrogen Ion + N1-(5-phospho-β-D-ribosyl)glycinamide + Phosphate LEFT_TO_RIGHT 29908-03-0 CAS 1061 PubChem-compound P30137 UniProt P30136 UniProt 25635-88-5 CAS Carbon dioxide Thiamine monophosphate P0AG16 UniProt HMDB00280 HMDB HMDB01372 HMDB SMILES [NH3+]CC(=O)NC1OC(COP([O-])([O-])=O)C(O)C1O 24762165 PubChem-compound C01081 KEGG Compound SMILES N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 5-P-BETA-D-RIBOSYL-AMINE BioCyc