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388356 ChemSpider 6022 PubChem-compound C2H4O2 Acetic acid 60.02113 1.0 937 ChemSpider HMDB01341 HMDB 9271300 ChemSpider 64-19-7 CAS SMILES O C11H19NO9 N-Acetylneuraminic acid 309.106 1.0 CHEBI:62165 ChEBI Glucosamine 6-phosphate N-ACETYL-D-MANNOSAMINE-6P BioCyc ATP BioCyc C8H16NO9P N-Acetyl-D-Glucosamine 6-Phosphate 301.05627 H4N Ammonium 18.034374 1.0 glucosamine-6-phosphate deaminase N-acetylglucosamine-6-phosphate deacetylase Pyruvic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 3.5.1.25 false 3.5.1.25 N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate LEFT_TO_RIGHT 1.0 N-acetylglucosamine-6-phosphate deacetylase N-Acetyl-D-Glucosamine 6-Phosphate N-ACETYL-D-GLUCOSAMINE-6-P BioCyc 1.0 Transport492 false Hydrogen Ion (→), N-Acetylneuraminic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 5742 ChemSpider 1038 PubChem-compound HMDB00230 HMDB C04257 KEGG Compound GO:0005829 GENE ONTOLOGY Putative N-acetylmannosamine-6-phosphate 2-epimerase HMDB59597 HMDB N-Acetylneuraminic acid Glucosamine-6-phosphate deaminase HMDB00243 HMDB CHEBI:63154 ChEBI 1010 ChemSpider Acetic acid 440273 PubChem-compound HMDB41827 HMDB P0A6L4 UniProt glycolysis and pyruvate dehydrogenase SubPathway Ammonium 392810 ChemSpider Hydrogen Ion PW000785 PathWhiz 873185-52-5 CAS C00352 KEGG Compound Cytosol C00357 KEGG Compound N-acetylneuraminate lyase 218 ChemSpider 4.0 Adenosine triphosphate 131-48-6 CAS N-ACETYLNEURAMINATE BioCyc ReactionCatalysis3268 ACTIVATION C00008 KEGG Compound 3616-42-0 CAS β-D-fructofuranose 6-phosphate C8H16NO9P N-Acetyl-D-mannosamine 6-phosphate 301.05627 Hydrogen Ion 1.0 PW002030 PathWhiz C00001 KEGG Compound 1.0 N-Acetylmannosamine N-acetylmannosamine kinase 1031 ChemSpider C00002 KEGG Compound N-acetylglucosamine-6-phosphate deacetylase 1.0 C8H15NO6 N-Acetylmannosamine 221.08994 445063 PubChem-compound 1.0 C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 N-Acetyl-D-mannosamine 6-phosphate C01342 KEGG Compound CHEBI:28938 ChEBI Putative sialic acid transporter http://identifiers.org/smpdb/SMP00807 SMPDB C6H14NO8P Glucosamine 6-phosphate 259.04572 Putative N-acetylmannosamine-6-phosphate 2-epimerase ReactionCatalysis5902 ACTIVATION ReactionCatalysis5901 ACTIVATION Glucosamine-6-phosphate deaminase ReactionCatalysis5900 ACTIVATION 5957 PubChem-compound ReactionCatalysis5903 ACTIVATION D-GLUCOSAMINE-6-P BioCyc GO:0005620 GENE ONTOLOGY H Hydrogen Ion 1.007825 CHEBI:15873 ChEBI C00022 KEGG Compound 56-65-5 CAS 6.0 N-acetylneuraminate and N-acetylmannosamine and N-acetylglucosamine degradation N-Acetylneuraminic acid 440996 PubChem-compound Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 ACET BioCyc C4ZSW2 UniProt D-glucosamine 6-phosphate 4.0 C6H14NO8P D-glucosamine 6-phosphate 259.04572 N-ACETYL-D-MANNOSAMINE BioCyc SubPathwayInteraction3106 SubPathway3106Reaction SubPathwayReaction C00033 KEGG Compound HMDB01062 HMDB SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O Water P45425 UniProt http://identifiers.org/smpdb/SMP02044 SMPDB 3615-17-6 CAS N-acetyl-β-neuraminate lyase / N-acetylneuraminate lyase P0AF18 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 14798-03-9 CAS HMDB00538 HMDB CHEBI:15784 ChEBI 389821 ChemSpider CHEBI:15422 ChEBI N-acetylmannosamine kinase SMILES CC(O)=O 1.0 7732-18-5 CAS 1.0 11096158 PubChem-compound 127-17-3 CAS SMILES CC(=O)N[C@@H]1[C@@H](O)C[C@](O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O 439217 PubChem-compound 1.0 SMILES [NH4+] C10H16N5O13P3 Adenosine triphosphate 506.99576 Putative sialic acid transporter SMILES CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O CHEBI:16761 ChEBI P0A761 UniProt SMILES CC(=O)C(O)=O P0A759 UniProt C19910 KEGG Compound 962 PubChem-compound CHEBI:15366 ChEBI 389249 ChemSpider 1.0 SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O 5800 ChemSpider 5.1.3.9 false 5.1.3.9 N-Acetyl-D-mannosamine 6-phosphate ↔ N-Acetyl-D-Glucosamine 6-Phosphate REVERSIBLE Reaction5939 true Glucosamine 6-phosphate → D-glucosamine 6-phosphate LEFT_TO_RIGHT HMDB02111 HMDB C00080 KEGG Compound Periplasmic Space 4.1.3.3 false 4.1.3.3 N-Acetylneuraminic acid → N-Acetylmannosamine + Pyruvic acid LEFT_TO_RIGHT 2.7.1.60 false 2.7.1.60 Adenosine triphosphate + N-Acetylmannosamine → Adenosine diphosphate + Hydrogen Ion + N-Acetyl-D-mannosamine 6-phosphate LEFT_TO_RIGHT 171 ChemSpider CHEBI:32816 ChEBI CHEBI:15377 ChEBI N-Acetylneuraminic acid C00645 KEGG Compound CHEBI:15378 ChEBI SMILES [H+] CHEBI:45744 ChEBI PYRUVATE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 1.0 1.0 SMILES N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O HMDB01129 HMDB 16741146 PubChem-compound HMDB01121 HMDB H2O Water 18.010565 1.0 1060 PubChem-compound Hydrogen Ion SMILES CC(=O)N[C@@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 102029-88-9 CAS HMDB00042 HMDB CHEBI:57634 ChEBI HMDB01254 HMDB 176 PubChem-compound N-acetylneuraminate lyase SMILES [H][C@@]1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1NC(C)=O 1.0 TransportCatalysis423 ACTIVATION Reaction5940 false D-glucosamine 6-phosphate + Water → Ammonium + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT Putative sialic acid transporter N- acetylneuraminate lyase N- acetylmannosamine kinase Putative N- acetylmannosamine- 6-phosphate 2-epimerase N- acetylglucosamine- 6-phosphate deacetylase Glucosamine- 6-phosphate deaminase H + H + N- Acetylneuraminic acid N- Acetylneuraminic acid Pyruvic acid N- Acetylmannosamine ATP ADP H + N-Acetyl-D- mannosamine 6-phosphate N-Acetyl-D- Glucosamine 6-Phosphate H 2 O Acetic acid Glucosamine 6-phosphate D-glucosamine 6-phosphate D-glucosamine 6-phosphate H 2 O Ammonium β-D- fructofuranose 6-phosphate glycolysis and pyruvate dehydrogenase
388356 ChemSpider 6022 PubChem-compound C2H4O2 Acetic acid 60.02113 1.0 937 ChemSpider HMDB01341 HMDB 9271300 ChemSpider 64-19-7 CAS SMILES O C11H19NO9 N-Acetylneuraminic acid 309.106 1.0 CHEBI:62165 ChEBI Glucosamine 6-phosphate N-ACETYL-D-MANNOSAMINE-6P BioCyc ATP BioCyc C8H16NO9P N-Acetyl-D-Glucosamine 6-Phosphate 301.05627 H4N Ammonium 18.034374 1.0 glucosamine-6-phosphate deaminase N-acetylglucosamine-6-phosphate deacetylase Pyruvic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 3.5.1.25 false 3.5.1.25 N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate LEFT_TO_RIGHT 1.0 N-acetylglucosamine-6-phosphate deacetylase N-Acetyl-D-Glucosamine 6-Phosphate N-ACETYL-D-GLUCOSAMINE-6-P BioCyc 1.0 Transport492 false Hydrogen Ion (→), N-Acetylneuraminic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 5742 ChemSpider 1038 PubChem-compound HMDB00230 HMDB C04257 KEGG Compound GO:0005829 GENE ONTOLOGY Putative N-acetylmannosamine-6-phosphate 2-epimerase HMDB59597 HMDB N-Acetylneuraminic acid Glucosamine-6-phosphate deaminase HMDB00243 HMDB CHEBI:63154 ChEBI 1010 ChemSpider Acetic acid 440273 PubChem-compound HMDB41827 HMDB P0A6L4 UniProt glycolysis and pyruvate dehydrogenase SubPathway Ammonium 392810 ChemSpider Hydrogen Ion PW000785 PathWhiz 873185-52-5 CAS C00352 KEGG Compound Cytosol C00357 KEGG Compound N-acetylneuraminate lyase 218 ChemSpider 4.0 Adenosine triphosphate 131-48-6 CAS N-ACETYLNEURAMINATE BioCyc ReactionCatalysis3268 ACTIVATION C00008 KEGG Compound 3616-42-0 CAS β-D-fructofuranose 6-phosphate C8H16NO9P N-Acetyl-D-mannosamine 6-phosphate 301.05627 Hydrogen Ion 1.0 PW002030 PathWhiz C00001 KEGG Compound 1.0 N-Acetylmannosamine N-acetylmannosamine kinase 1031 ChemSpider C00002 KEGG Compound N-acetylglucosamine-6-phosphate deacetylase 1.0 C8H15NO6 N-Acetylmannosamine 221.08994 445063 PubChem-compound 1.0 C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 N-Acetyl-D-mannosamine 6-phosphate C01342 KEGG Compound CHEBI:28938 ChEBI Putative sialic acid transporter http://identifiers.org/smpdb/SMP00807 SMPDB C6H14NO8P Glucosamine 6-phosphate 259.04572 Putative N-acetylmannosamine-6-phosphate 2-epimerase ReactionCatalysis5902 ACTIVATION ReactionCatalysis5901 ACTIVATION Glucosamine-6-phosphate deaminase ReactionCatalysis5900 ACTIVATION 5957 PubChem-compound ReactionCatalysis5903 ACTIVATION D-GLUCOSAMINE-6-P BioCyc GO:0005620 GENE ONTOLOGY H Hydrogen Ion 1.007825 CHEBI:15873 ChEBI C00022 KEGG Compound 56-65-5 CAS 6.0 N-acetylneuraminate and N-acetylmannosamine and N-acetylglucosamine degradation N-Acetylneuraminic acid 440996 PubChem-compound Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 ACET BioCyc C4ZSW2 UniProt D-glucosamine 6-phosphate 4.0 C6H14NO8P D-glucosamine 6-phosphate 259.04572 N-ACETYL-D-MANNOSAMINE BioCyc SubPathwayInteraction3106 SubPathway3106Reaction SubPathwayReaction C00033 KEGG Compound HMDB01062 HMDB SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O Water P45425 UniProt http://identifiers.org/smpdb/SMP02044 SMPDB 3615-17-6 CAS N-acetyl-β-neuraminate lyase / N-acetylneuraminate lyase P0AF18 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 14798-03-9 CAS HMDB00538 HMDB CHEBI:15784 ChEBI 389821 ChemSpider CHEBI:15422 ChEBI N-acetylmannosamine kinase SMILES CC(O)=O 1.0 7732-18-5 CAS 1.0 11096158 PubChem-compound 127-17-3 CAS SMILES CC(=O)N[C@@H]1[C@@H](O)C[C@](O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O 439217 PubChem-compound 1.0 SMILES [NH4+] C10H16N5O13P3 Adenosine triphosphate 506.99576 Putative sialic acid transporter SMILES CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O CHEBI:16761 ChEBI P0A761 UniProt SMILES CC(=O)C(O)=O P0A759 UniProt C19910 KEGG Compound 962 PubChem-compound CHEBI:15366 ChEBI 389249 ChemSpider 1.0 SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O 5800 ChemSpider 5.1.3.9 false 5.1.3.9 N-Acetyl-D-mannosamine 6-phosphate ↔ N-Acetyl-D-Glucosamine 6-Phosphate REVERSIBLE Reaction5939 true Glucosamine 6-phosphate → D-glucosamine 6-phosphate LEFT_TO_RIGHT HMDB02111 HMDB C00080 KEGG Compound Periplasmic Space 4.1.3.3 false 4.1.3.3 N-Acetylneuraminic acid → N-Acetylmannosamine + Pyruvic acid LEFT_TO_RIGHT 2.7.1.60 false 2.7.1.60 Adenosine triphosphate + N-Acetylmannosamine → Adenosine diphosphate + Hydrogen Ion + N-Acetyl-D-mannosamine 6-phosphate LEFT_TO_RIGHT 171 ChemSpider CHEBI:32816 ChEBI CHEBI:15377 ChEBI N-Acetylneuraminic acid C00645 KEGG Compound CHEBI:15378 ChEBI SMILES [H+] CHEBI:45744 ChEBI PYRUVATE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 1.0 1.0 SMILES N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O HMDB01129 HMDB 16741146 PubChem-compound HMDB01121 HMDB H2O Water 18.010565 1.0 1060 PubChem-compound Hydrogen Ion SMILES CC(=O)N[C@@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 102029-88-9 CAS HMDB00042 HMDB CHEBI:57634 ChEBI HMDB01254 HMDB 176 PubChem-compound N-acetylneuraminate lyase SMILES [H][C@@]1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1NC(C)=O 1.0 TransportCatalysis423 ACTIVATION Reaction5940 false D-glucosamine 6-phosphate + Water → Ammonium + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT nanT nanA nanK nanE nagA nagB Hydrogen Ion Hydrogen Ion N- Acetylneuraminic acid N- Acetylneuraminic acid Pyruvic acid N- Acetylmannosamine Adenosine triphosphate Adenosine diphosphate Hydrogen Ion N-Acetyl-D- mannosamine 6-phosphate N-Acetyl-D- Glucosamine 6-Phosphate Water Acetic acid Glucosamine 6-phosphate D-glucosamine 6-phosphate D-glucosamine 6-phosphate Water Ammonium β-D- fructofuranose 6-phosphate glycolysis and pyruvate dehydrogenase