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GTP cyclohydrolase 1 D-erythro- 7,8- dihydroneopterin triphosphate epimerase Dihydrofolate reductase folM GTP H 2 O Formic acid H + 7,8- dihydroneopterin 3'-triphosphate Dihydromonapterin- triphosphate H 2 O Dihydromethysticin P i H + NADPH H + Tetrahydromonapterin NADP Excretion
folE folX folM Guanosine triphosphate Water Formic acid Hydrogen Ion 7,8- dihydroneopterin 3'-triphosphate Dihydromonapterin- triphosphate Water Dihydromethysticin Phosphate Hydrogen Ion NADPH Hydrogen Ion Tetrahydromonapterin NADP