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GTP cyclohydrolase 1 D-erythro- 7,8- dihydroneopterin triphosphate epimerase Dihydrofolate reductase folM GTP H2O Formic acid H+ 7,8- dihydroneopterin 3'-triphosphate Dihydromonapterin- triphosphate H2O Dihydromethysticin Pi H+ NADPH H+ Tetrahydromonapterin NADP Excretion
folE folX folM Guanosine triphosphate Water Formic acid Hydrogen Ion 7,8- dihydroneopterin 3'-triphosphate Dihydromonapterin- triphosphate Water Dihydromethysticin Phosphate Hydrogen Ion NADPH Hydrogen Ion Tetrahydromonapterin NADP
folE folX folM GTP H2O Formate H+ 78D3T DHMP-TP H2O Dihydr2 Pi H+ NADPH H+ Tetrahy NADP Excretion
folE folX folM GTP H2O Formate H+ 78D3T DHMP-TP H2O Dihydr2 Pi H+ NADPH H+ Tetrahy NADP