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Pathway Description
Fructoselysine and Psicoselysine Degradation
Escherichia coli
Metabolic Pathway
Fructosamines are compounds that result from glycation reactions between a sugar and a primary amine, followed by isomerization via the Amadori rearrangement. In fructoselysine degradation, fructoselysine firstly converts to 1-[(5-Amino-5-carboxypentyl)amino]-1-deoxyfructose by protein frlC, and then 1-[(5-Amino-5-carboxypentyl)amino]-1-deoxyfructose is transformed to fructoselysine-6-phosphate by fructoselysine kinase which is powered by ATP. Fructoselysine-6-phosphate finally degrades to β-D-Glucose 6-phosphate and L-lysine by fructoselysine 6-phosphate deglycase.
References
Fructoselysine and Psicoselysine Degradation References
Wiame E, Delpierre G, Collard F, Van Schaftingen E: Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli. J Biol Chem. 2002 Nov 8;277(45):42523-9. doi: 10.1074/jbc.M200863200. Epub 2002 Jul 29.
Pubmed: 12147680
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