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Pathway Description
Putrescine Degradation II
Escherichia coli
Metabolic Pathway
This pathway demonstrates the degradation of extracellular putrescine in E.coli. Putrescine is imported by putrescine transporter (encoded by puuP gene). Putrescine is γ-glutamylated by activation of ATP which generates γ-glutamyl-putrescine, phosphate, and ADP. γ-glutamyl-putrescine is oxidized by gamma-glutamylputrescine oxidoreductase to form γ-glutamyl-γ-butyraldehyde, also produce ammonium and water. Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase dehydrogenates γ-glutamyl-γ-butyraldehyde to γ-glutamyl-γ-aminobutyrate, which is then dehydrogenated into γ-Aminobutyric acid and L-Glutamic acid by γ-glutamyl-γ-aminobutyrate hydrolase.
References
Putrescine Degradation II References
Abraham KA: Studies on DNA-dependent RNA polymerase from Escherichia coli. 1. The mechanism of polyamine induced stimulation of enzyme activity. Eur J Biochem. 1968 Jun;5(1):143-6.
Pubmed: 4873311
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