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Pathway Description
Conversion of Succinate to Propanoate
Escherichia coli
Metabolic Pathway
The enzymes involved in the decarboxylation of succinate to propionate are encoded in the Escherichia coli operon. A CoA transferase reaction is catalyzed by YgfH with succinyl CoA and propionyl CoA donating and succinate and propionate accepting. Sbm, sleeping beauty mutase or methylmalonyl-CoA mutase, is an apoenzyme that is activated by binding of adenosylcobalamin. Sbm catalyzes the methylmalonyl CoA mutase reaction. The metabolic function if this pathway is still unknown.
References
Conversion of Succinate to Propanoate References
Benning MM, Haller T, Gerlt JA, Holden HM: New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli. Biochemistry. 2000 Apr 25;39(16):4630-9. doi: 10.1021/bi9928896.
Pubmed: 10769118
Haller T, Buckel T, Retey J, Gerlt JA: Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. Biochemistry. 2000 Apr 25;39(16):4622-9.
Pubmed: 10769117
Froese DS, Dobson CM, White AP, Wu X, Padovani D, Banerjee R, Haller T, Gerlt JA, Surette MG, Gravel RA: Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli. Microbiol Res. 2009;164(1):1-8. doi: 10.1016/j.micres.2008.08.006. Epub 2008 Oct 23.
Pubmed: 18950999
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